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Glycopeptides (5):
Recent article
Glycopeptides
Xenobiotica (41)5 2011
Abstract
We present an automated tool, SimGlycan, for this purpose, which accepts raw/standard MS data files as input and characterizes the associated glycan structure with high accuracy using database searching and scoring techniques. Not only does it predict the glycan structure using an MS/MS database sea...
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PMID: 19882135
PDF is available here.
PDF is available here.
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Journal of Antibiotics (63)12 2010
Abstract
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We report in this paper the first chemoenzymatic synthesis of homogeneous CD52 glycoforms carrying both N- and O-glycans. The synthetic strategy consists of two key steps: monosaccharide primers GlcNAc and GalNAc were first installed at the pre-determined N- and O-glycosylation sites by a facile sol...
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PMID: 20848033
PDF is available here.
PDF is available here.
Abstract
We demonstrate that effective identification and characterization of both peptides and glycopeptides mixtures, and their constituent glycan structures, can be achieved from a single sample injection event....
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PMID: 19882125
PDF is available here.
PDF is available here.
Abstract
This review aims to analyze the relationships between arginine vasopressin (AVP) and chronic kidney disease (CKD) and to define the potential of vasopressin receptor antagonists beyond the treatment of water metabolism disorders.
Experimental studies in rat and observational studies in humans sugges...
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PMID: 20689424
PDF is available here.
PDF is available here.
Abstract
We measured copeptin in serum by a sandwich immunoassay. Injury severity was assessed by Glasgow Coma Score (GCS) and computed tomography, and recovery by Glasgow Outcome Score (GOS). Neuroendocrine and osmoregulation regulation were examined on day 0, 3 and 7, and 24 months post-injury. Copeptin wa...
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PMID: 19812953
PDF is available here.
PDF is available here.
Abstract
An efficient strategy for the preparation of N-linked glycopeptides is described. The method relies on the use of side chain protecting groups on aspartic acid residues, namely the allyl and Dmab esters, which are orthogonal to those utilised in Fmoc-strategy SPPS. After peptide assembly these prote...
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PMID: 20567757
PDF is available here.
PDF is available here.
Chemical Communications (46)31 2010
Abstract
MUC1 glycopeptide was efficiently coupled to glycosylphosphatidylinositol (GPI) derivatives by sortase A (SrtA), verifying that SrtA can accept sterically hindered glycopeptide as substrate for ligation with GPIs. This work has established a practical method for the chemoenzymatic synthesis of GPI-l...
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PMID: 20574591
PDF is available here.
PDF is available here.
Abstract
We describe a standardized approach for searching potent and selective inhibitors of glycosyltransferases by high throughput quantitative MALDI-TOFMS-based screening of focused compound libraries constructed by 1,3-dipolar cycloaddition of the desired azidosugar nucleotides with various alkynes. An...
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PMID: 20684602
PDF is available here.
PDF is available here.
Abstract
Bacterial peptidoglycan and its muropeptide derivatives potently activate mammalian innate immune system and are promising immunomodulators and vaccine adjuvants. However, their effects on human antigen-presenting cells, such as dendritic cells (DCs) and Mphi, are not fully understoo...
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PMID: 20438865
PDF is available here.
PDF is available here.
Circulation Research (107)2 2010
Abstract
The stimulated exocytotic release of ET-1 is dramatically increased in aged endothelium. This reflects increased reactivity of exocytosis, increased expression and storage of ET-1 precursor peptides, and increased expression of ECE-1. Altered endothelial exocytosis of ET-1 and other mediators may co...
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PMID: 20522806
PDF is available here.
PDF is available here.
Abstract
E-cadherin is one of the critical molecules involved in the metastatic process in many types of cancer. Once combined, E-cadherin exceeds the amount of membranous E-cadherin on the cellular surface by activation of intracellular signaling cascades. Studies on transformed keratinocytes of the HaCat c...
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PMID: 20403671
PDF is available here.
PDF is available here.
Abstract
We show that phosphorylation and glycosylation can affect folding and aggregation kinetics differently. Incorporation of phosphoserines, regardless of their quantity and position, turned out to be most efficient in preventing amyloid formation, whereas O-glycosylation has a more subtle effect. The i...
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PMID: 20491120
PDF is available here.
PDF is available here.
Abstract
Copeptin levels are a useful, complementary tool to predict functional outcome and mortality 1 year after stroke. CLINICAL TRIAL REGISTRATION: ISCTRN 00390962; clinicaltrials.gov No. NCT00390962....
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PMID: 20508186
PDF is available here.
PDF is available here.
Journal of Infection (61)1 2010
Abstract
Clinical Chemistry (56)7 2010
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The biological response modifier AM3 reverses the concurrent inflammatory immune system activation in peripheral blood and liver of experimental established cirrhosis, which results in reductions of hepatic fibrosis, portal pressure and peripheral vasodilation....
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PMID: 20442198
PDF is available here.
PDF is available here.
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We report the structural basis of binding of a complex of a monoclonal antibody (237mAb) with a truly tumor-specific glycopeptide containing the Tn antigen. In contrast to glycopeptide-specific antibodies in complex with simple peptides, 237mAb does not recognize a conformational epitope induced in...
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PMID: 20479270
PDF is available here.
PDF is available here.
Abstract
In triage of chest pain patients, determination of copeptin in addition to troponin improves diagnostic performance, especially early after CPO. Combined determination of troponin and copeptin provides a remarkable negative predictive value virtually independent of CPO time and therefore aids in ear...
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PMID: 20447532
PDF is available here.
PDF is available here.
Abstract
Dalbavancin, oritavancin and telavancin are semisynthetic lipoglycopeptides that demonstrate promise for the treatment of patients with infections caused by multi-drug-resistant Gram-positive pathogens. Each of these agents contains a heptapeptide core, common to all glycopeptides, which enables them...
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PMID: 20426497
PDF is available here.
PDF is available here.
Abstract
We show that a proteasome-independent peptide derived from the human tumor protein MAGE-A3 is produced directly by insulin-degrading enzyme (IDE), a cytosolic metallopeptidase. Cytotoxic T lymphocyte recognition of tumor cells was reduced after metallopeptidase inhibition or IDE silencing. Separate...
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PMID: 20364150
PDF is available here.
PDF is available here.
Abstract
The asymmetric synthesis of the nonproteinogenic amino acids (2S,3S,4'S)-beta-hydroxyenduracididine 3 and (2R,3S,4'S)-beta-hydroxyenduracididine 4 in orthogonally protected form in 15 total steps from Garner's aldehyde is reported. The former and N-glycosylated form of the latter are found in the gl...
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PMID: 20232818
PDF is available here.
PDF is available here.
Abstract
We recently found that the azido group could be used as an amino protecting group in the peptide condensation by the thioester method. In this study, we synthesized the glycosylated mouse pro-opiomelanocortin (1-74) by the thioester method. The N-terminal peptide thioester segment, whose Lys side ch...
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PMID: 20449504
PDF is available here.
PDF is available here.
Abstract
We also confirmed the genetic linkage of vanA to unknown transferable replicons. PCR-based replicon typing, linked to the detection of other important plasmid-encoded traits, seems to be a feasible tool for tracing disseminating resistance plasmids stably maintained in various environments....
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PMID: 20015231
PDF is available here.
PDF is available here.
Abstract
IMPORTANCE OF THE FIELD: Antibacterial drug discovery and development has slowed considerably in recent years, with novel classes discovered decades ago and regulatory approvals tougher to get. Traditional approaches and the newer genomic mining approaches have not yielded novel classes of antibacte...
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PMID: 20053150
PDF is available here.
PDF is available here.
Abstract
Van-M-02, a novel glycopeptide, was revealed to exert potent activities against Gram-positive bacteria, including vancomycin-resistant enterococci (VRE) and vancomycin-resistant Staphylococcus aureus (VRSA). A crude assay system was then used to study the mode of action of Van-M-02 as a peptidoglyca...
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PMID: 19933802
PDF is available here.
PDF is available here.
Abstract
Gene swapping is a simple but effective genetic tool for characterizing the functioning of a gene, where the gene in question is known to fulfil a distinctive biological role in the cell. VanS is a sensor kinase which, in conjunction with its cognate response regulator VanR, triggers resistance to v...
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PMID: 20401585
PDF is available here.
PDF is available here.
Abstract
We describe the steps required to characterize prokaryotic glycoproteins by mass spectrometry, using flagellin isolated from Clostridium botulinum strain Langeland as an example. Both "top-down" and "bottom-up" approaches will be described for characterizing the purified glycoprotein at the whole pr...
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PMID: 19882124
PDF is available here.
PDF is available here.
Abstract
Glycomics which is the study of saccharides and genes responsible for their formation requires the continuous development of rapid and sensitive methods for the identification of glycan structures. It involves glycoanalysis which relies upon the development of methods for determining the structure a...
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PMID: 19882127
PDF is available here.
PDF is available here.
Abstract
We used mass spectrometric analysis to search for specific structures in IgA1 hinge glycopeptides in 30 IgAN patients contrasted with 30 healthy controls. METHOD: IgA1 hinge glycopeptides were individually purified from the sera of 30 biopsy-proven IgAN patients and 30 healthy controls. The structur...
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PMID: 20091489
PDF is available here.
PDF is available here.
Swiss medical weekly : official journal of the Swiss Society of Infectious Diseases, the Swiss Society of Internal Medicine, the Swiss Society of Pneumology (140) 2010
Abstract
We have shown that copeptin more subtly mirrors the individual stress level compared to cortisol. Due to the positive association of copeptin with the severity of illness and outcome, copeptin has been proposed as a prognostic marker in acute illness. The prognostic accuracy of copeptin has been ana...
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PMID: 20872295
PDF is available here.
PDF is available here.
Abstract
We illustrate the importance of the complementary information in the mass spectrometry survey scans as well as the different tandem mass spectrometry techniques. We also present some unique features offered by Protein Prospector that are advantageous in glycopeptide analysis: (i) considering a modif...
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PMID: 20530845
PDF is available here.
PDF is available here.
BMC Neurology (10) 2010
Abstract
Copeptin is a new prognostic marker in patients with an ICH. If this finding can be confirmed in larger studies, copeptin might be an additional valuable tool for risk stratification and decision-making in the acute phase of ICH....
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PMID: 20504314
PDF is available here.
PDF is available here.
Pharmacotherapy (30)1 2010
Abstract
Resistance to antibiotics among gram-positive bacteria, especially enterococci and staphylococci, has led to the need to develop new antibiotics. Vancomycin, a glycopeptide antibiotic, has been used for over 3 decades to treat serious methicillin-resistant Staphylococcus aureus infections. The incre...
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PMID: 20030476
PDF is available here.
PDF is available here.
Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine (11)4 2009
Abstract
We describe novel antibacterial agents in the late stages of clinical development that show potential for treating methicillin-resistant Staphylococcus aureus (MRSA) infections. These include the fifth-generation cephalosporins, ceftaroline and ceftobiprole; the glycopeptides, dalbavancin, oritavanc...
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PMID: 20001879
PDF is available here.
PDF is available here.
Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia (22)4 2009
Abstract
This article reviews the concepts of heteroresistance and tolerance to glycopeptides in gram-positive bacteria isolated from hospitalised patients. Heteroresistance (resistant subpopulations among the total bacterial population of the strain, that can be selected by the treatment) and tolerance (cap...
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PMID: 20082037
PDF is available here.
PDF is available here.
Therapeutische Umschau (66)11 2009
Abstract
Copeptin denominates the C-terminal fragment of the vasopressin (AVP) precursor hormone. Circulating copeptin levels reflect the activity of the AVP system and correlate closely with plasma osmolality. The measurement of stimulated plasma AVP levels is crucial in the differential diagnosis of diabet...
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PMID: 19885789
PDF is available here.
PDF is available here.
Proteomics (9)22 2009
Abstract
In this study, an on-plate-selective enrichment method is developed for fast and efficient glycopeptide investigation. Gold nanoparticles were first spotted and sintered on a stainless-steel plate, then modified with 4-mercaptophenylboronic acid to provide porous substrate with large...
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PMID: 19834891
PDF is available here.
PDF is available here.
Zhonghua Yixue Zazhi (89)36 2009
Abstract
A total of 397 cases were reviewed, 75 cases discussed at expert committee meetings and 58 feedback letters delivered to responsible doctors. The consumption of both carbapenems and glycopeptides decreased. The appropriate use of carbapenems and glycopeptides increased from 37.8% (45/119) to 53.5% (...
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PMID: 20137618
PDF is available here.
PDF is available here.
Biochemistry (Washington) (48)35 2009
Abstract
Our data support the identification of a novel fungicide and the compound has been named occidiofungin, meaning fungal killer....
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PMID: 19673482
PDF is available here.
PDF is available here.
Abstract
Poly(ethylene glycol) (PEG) chains were used to decorate microparticles with long adhesion ligands to emulate the efficacy of selectin-mediated leukocyte homing mechanisms. Ligands for P-selectin, an endothelial cell inflammatory marker, were coupled to PEG spacers of two sizes (MW 3400 and 10,000 D...
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PMID: 19621909
PDF is available here.
PDF is available here.
Magnesium Research (22)3 2009
Abstract
We found that pharmacological inhibition of NEP by phosphoramidon resulted in elevated plasma levels of SP and greater oxidative stress. We also observed that hypomagnesemia reduced cardiac and intestinal expression of NEP. In these magnesium-deficient rats increased intestinal permeability and impa...
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PMID: 19780404
PDF is available here.
PDF is available here.
Abstract
The present study sought to examine the mechanism of substance P to modulate the antinociceptive action of intrathecal (i.t.) morphine in paw-licking/biting response evoked by subcutaneous injection of capsaicin into the plantar surface of the hindpaw in mice. The i.t. injection of morphine inhibite...
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PMID: 19520130
PDF is available here.
PDF is available here.
Abstract
We developed a novel enrichment procedure for sulfated glycopeptides. The procedure consists of anion exchange chromatography and a sulfate emerging (SE) method which controls the net charge of peptides by utilizing limited proteolyzes and modification with acetohydrazide. Using this procedure, we a...
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PMID: 19572564
PDF is available here.
PDF is available here.
Biochemistry (Washington) (48)30 2009
Abstract
Mycobacterium tuberculosis and other members of the actinomycete family produce mycothiol (MSH or acetylcysteine-glucosamine-inositol, AcCys-GlcN-Ins) to protect the organism against oxidative and antibiotic stress. The biosynthesis of MSH proceeds via a five-step process that involves four unique e...
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PMID: 19505149
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (284)30 2009
Abstract
We have obtained the peptide and glycopeptide specificities of ppGalNAc T10 for comparison with ppGalNAc T1 and T2. For the glycopeptide substrates, ppGalNAc T10 exhibited a single large preference for Ser/Thr-O-GalNAc at the +1 (C-terminal) position relative to the Ser or Thr acceptor site. ppGalNA...
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PMID: 19460755
PDF is available here.
PDF is available here.