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Oligopeptides (26):
- Pepstatins
- Gonadotropin-Releasing Hormone
- Antipain
- Thymic Factor, Circulating
- Tetragastrin
- Glutathione
- Chalones
- Pentagastrin
- Netropsin
- Angiotensins
- Leupeptins
- Technetium Tc 99m Mertiatide
- Vasopressins
- Thyrotropin-Releasing Hormone
- Tachykinins
- Peptide T
- Delta Sleep-Inducing Peptide
- Tuftsin
- Caerulein
- Amanitins
- N-Formylmethionine Leucyl-Phenylalanine
- Bradykinin
- Teprotide
- Phalloidine
- Dipeptides
- Peptichemio
Recent article
Oligopeptides
New England Journal of Medicine (365)11 2011
Abstract
We designed a noninferiority trial (noninferiority margin, -10.5%) to compare rates of sustained virologic response among patients receiving two treatment durations.
We enrolled patients with chronic infection with HCV genotype 1 who had not previously received treatment. All patient...
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PMID: 21916639
PDF is available here.
PDF is available here.
| < More recent | Older article > |
British Journal of Cancer (105)4 2011
Abstract
Chronic treatment of SLK cells with one of the five HIV-PIs alone or together resulted in increased resistance to doxorubicin. Co-treatment with one of the HIV-PIs in combination with doxorubicin resulted in a synergistic increase in resistance to doxorubicin, and the degree of resistance was found t...
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PMID: 21829205
PDF is available here.
PDF is available here.
Abstract
Poly(N,N-diethylacrylamide) (PDEAAm) hydrogel scaffolds were prepared by radical copolymerization of N,N-diethylacrylamide (DEAAm), N,N'-methylenebisacrylamide and methacrylic acid in the presence of (NH₄)₂SO₄ or NaCl. The hydrogels were characterized by low-vacuum scanning ele...
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PMID: 21563303
PDF is available here.
PDF is available here.
New England Journal of Medicine (364)25 2011
Abstract
We assigned 1088 patients with HCV genotype 1 infection who had not received previous treatment for the infection to one of three groups: a group receiving telaprevir combined with peginterferon alfa-2a and ribavirin for 12 weeks (T12PR group), followed by peginterferon-ribavirin alone for 12 weeks...
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PMID: 21696307
PDF is available here.
PDF is available here.
Abstract
We found that the degradation of aqueous based silk is much faster than HFIP based silk scaffolds. Also, HFIP based silk scaffolds supported the soft dental pulp formation better than the aqueous based silk scaffolds. No distinct hard tissue regeneration was found in any of the implants, with or wit...
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PMID: 21484985
PDF is available here.
PDF is available here.
Abstract
Abstract
Nature Immunology (12)5 2011
Abstract
We show that the saturated fatty acid palmitate, but not unsaturated oleate, induces the activation of the NLRP3-ASC inflammasome, causing caspase-1, IL-1β and IL-18 production. This pathway involves mitochondrial reactive oxygen species and the AMP-activated protein kinase and unc-51-like kinase-1...
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PMID: 21478880
PDF is available here.
PDF is available here.
Abstract
We were not able to determine serum stability; the peptide consisting of 36 amino acid residues is subject to cleavage by endopetidases. Three of the homologated compounds, 2b, 2c, and 5c, were shown to be agonists (Fig. 7 and 11). A comparison of terminal homologation with other stability-increas...
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PMID: 21560227
PDF is available here.
PDF is available here.
Abstract
We previously examined the functional roles of adipokinetic hormone in Manduca sexta L. (Lepidoptera: Sphingidae). Here we report the cloning of the full-length cDNA encoding the putative adipokinetic hormone receptor from the fat body of M. sexta. The sequence analysis shows that the deduced amino...
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PMID: 21529255
PDF is available here.
PDF is available here.
Abstract
These results support hypotheses as to why certain Cu(i) binding amino acids are preferred over others in proteins expressed at different pH and exposed to oxidative environments. The results also have implications for interpreting site-directed mutagenesis studies aimed at identifying copper bindin...
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PMID: 21553704
PDF is available here.
PDF is available here.
Science Signaling (4)181 2011
Abstract
We show that Mrgprs (Mas-related G protein-coupled receptors), particularly MrgprC11, rather than PAR2 (protease-activated receptor 2) as previously thought, mediate this type of itch. A shorter peptide, SLIGR, which specifically activates PAR2 but not MrgprC11, induced thermal pain hypersensitivity...
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PMID: 21775281
PDF is available here.
PDF is available here.
Abstract
This review summarizes current knowledge of adenosine analogues and conjugates with promising therapeutic properties. Adenosine is a signaling molecule that triggers numerous physiological responses. It acts through the adenosine receptors (ARs), belonging to the family of G-protein-...
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PMID: 21857072
PDF is available here.
PDF is available here.
Abstract
We have examined the function and regulation of members of this gene family in epithelial cell invasion using cultures of highly invasive extravillous cytotrophoblasts and the poorly invasive JEG-3 cytotrophoblast cell line as model systems. Of the multiple ADAMTS subtypes identified in first trimes...
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PMID: 21494557
PDF is available here.
PDF is available here.
Acta Biomaterialia (7)1 2011
Abstract
Cardiac tissue engineering aims to regenerate damaged myocardial tissues by applying heart patches created in vitro. The present study was undertaken to explore the possible role of matrix-attached RGD peptide in the engineering of cardiac tissue within macroporous scaffolds. Neonata...
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PMID: 20688198
PDF is available here.
PDF is available here.
Abstract
We hypothesized that the Fn synergy site is critical to the regulation of epithelial cell phenotype by directing integrin specificity. Epithelial cells were cultured on Fn fragments displaying stabilized synergy and RGD (FnIII9'10), or RGD alone (FnIII10) and cell phenotype analyzed by cytoskeleton...
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PMID: 20695776
PDF is available here.
PDF is available here.
Abstract
Spontaneous formation of endothelial tubules was restricted to patterned micron-scale regions presenting cell adhesion ligands and angiogenic signaling protein on poly(ethylene glycol) hydrogels. Arginine-glycine-aspartic acid-serine (RGDS), an integrin ligand, and vascular endotheli...
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PMID: 20712418
PDF is available here.
PDF is available here.
Abstract
We describe the identification of the agr as a quorum sensing system in Staphylococcus aureus and the isolation of agr autoinducers and inhibitors by northern blotting, real-time RT-PCR, and β-lactamase reporter cells assays....
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PMID: 21031303
PDF is available here.
PDF is available here.
Clinical calcium (21)6 2011
Abstract
We describe the recent progress of bio-molecular imaging of articular cartilage including our fluorescent-labeled glycosaminoglycan-binding octaarginine....
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PMID: 21628805
PDF is available here.
PDF is available here.
Abstract
We determined if CD36 participates in oxLDL uptake in RPE and correspondingly in clearance of sub-retinal deposits. Uptake of oxLDL by RPEin vitro and in vivo was CD36-dependent. CD36 deficiency in mice resulted in age-associated accumulation of oxLDL and sub-retinal BM thickening, despite fed a reg...
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PMID: 21098885
PDF is available here.
PDF is available here.
Abstract
The crystal structure of the neuropeptide proctolin (Arg-Tyr-Leu-Pro-Thr) is reported revealing the solid-state conformation of its molecules and their association in the crystal.
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PMID: 20838690
PDF is available here.
PDF is available here.
Abstract
New multivalent RGD-containing macromolecules were designed by exploiting two orthogonal chemoselective ligations. They were next applied to a competitive cell adhesion assay and used for the non invasive optical imaging of tumour in small animals.
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PMID: 20835451
PDF is available here.
PDF is available here.
Chemical Communications (46)42 2010
Abstract
A very short and efficient synthesis of the important drug candidate telaprevir, featuring a biocatalytic desymmetrization and two multicomponent reactions as the key steps, is presented. The classical issue of lack of stereoselectivity in Ugi- and Passerini-type reactions is circumvented. The atom...
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PMID: 20856952
PDF is available here.
PDF is available here.
Abstract
Implanted polymeric materials, such as medical devices, provoke the body to initiate an inflammatory reaction, known as the foreign body response (FBR), which causes several complications. In this study, polyurethane (Tecoflex®, PU) surface modified with the nonionic surfactant Tween80® (PU/T80) a...
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PMID: 20648535
PDF is available here.
PDF is available here.
YAKUGAKU ZASSHI (130)11 2010
Abstract
We have previously found a new member of L-amino acid ligase, RizA, from B. subtilis NBRC3134, a microorganism that produces the peptide-antibiotic rhizocticin. We newly found that a gene at approximately 9 kbp upstream of rizA encoded a novel L-amino acid ligase RizB. Recombinant RizB synthesized h...
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PMID: 21048404
PDF is available here.
PDF is available here.
Trends in Parasitology (26)11 2010
Abstract
I (MHC I) and ultimately, more precisely the Ld region. This is consistent with contemporary functional studies that demonstrated a protective role for CD8(+) T cells. Recent studies have demonstrated that the Ld gene product presents a number of immunodominant Toxoplasma gondii-derived peptides in...
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PMID: 20580611
PDF is available here.
PDF is available here.
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition (41)6 2010
Abstract
To investigate the impact of RGD peptides on cell adhesion to acellularized procine aortic valve.
The acellular porcine aorta valve (APAV) was prepared by removing the cells and cellular components from porcine aortic valve using trypsin and hyposmosis TritonX-100. Wi...
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PMID: 21265104
PDF is available here.
PDF is available here.
Cell Biology International (34)11 2010
Abstract
We show that KLK induces an increase of the intracellular Ca²(+) concentration in human T24 cells. The effect of KLK is buffer-sensitive, as it is detected when HBSS buffer is used, but not with PBS. This, together with the lack of effect of the middle leucine-to-proline-substituted peptide derivat...
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PMID: 20695847
PDF is available here.
PDF is available here.
Abstract
We postulated that the combination of overexpression of CXCR4 in mesenchymal stem cells (MSC) with diprotin A would enhance MSC recruitment and penetration into ischemic myocardium, leading to an improvement in heart function after myocardial infarction (MI). Male rat MSC were genetically engineered...
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PMID: 20802132
PDF is available here.
PDF is available here.
Abstract
β-Turns are secondary structure elements not only exposed on protein surfaces, but also frequently found to be buried in protein-protein interfaces. Protein engineering so far considered mainly the backbone-constraining properties of synthetic β-turn mimics as parts of surface-exposed loops. A β-...
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PMID: 20937907
PDF is available here.
PDF is available here.
Abstract
We observed negative values of ΔG(tr)' for Gly(3) and Gly(4) from water to buffer, indicating that the interactions are favorable. However, the ΔG(tr)' values are positive for Gly and Gly(2), revealing unfavorable interactions, which except for the latter in TRIS buffer are negative. The surprisin...
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PMID: 20820555
PDF is available here.
PDF is available here.
Abstract
A novel synthesis of 4-[(18)F]fluorobenzylamine ([(18)F]FBA) by means of transition metal-assisted sodium borohydride reduction of 4-[(18)F]fluorobenzonitrile ([(18)F]FBN) is described. This approach could successfully be extended to borohydride exchange resin (BER) enabling a viable option for use...
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PMID: 20740244
PDF is available here.
PDF is available here.
Abstract
We have used this self-amplifying homing system to develop theranostic nanoparticles that simultaneously serve as an imaging agent and inhibit tumor growth by obstructing tumor circulation through blood clotting. The CREKA nanoparticles were combined with nanoparticles coated with another tumor-homi...
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PMID: 20587786
PDF is available here.
PDF is available here.
Biomedical Materials (5)5 2010
Abstract
Aligned and randomly oriented chitosan nanofibers were prepared by electrospinning. The fibers were modified with the RGD cell-adhesive peptide through a heterobifunctional crosslinker containing a segment of poly(ethylene glycol) (PEG). PEG rendered the surface hydrophilic and provi...
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PMID: 20876956
PDF is available here.
PDF is available here.
Biomedical Materials (5)5 2010
Abstract
Chitosan, a biocompatible material that has been widely used in bone tissue engineering, is believed to have a high affinity to osteoblastic cells. This research is the first to prove this hypothesis. By using atomic force microscopy (AFM) with a chitosan-modified cantilever, quantit...
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PMID: 20876961
PDF is available here.
PDF is available here.
Abstract
We report 3D growth and proliferation of mammalian cells (HeLa and L929) on a dipeptide hydrogel chemically functionalized with a pentapeptide containing Arg-Gly-Asp (RGD) motif. The method of functionalization is simple, direct and can be adapted to other functional moieties as well. The functional...
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PMID: 20886861
PDF is available here.
PDF is available here.
Anticancer Research (30)10 2010
Abstract
These results indicated that BLI could be used to monitor the growth of tumour. High uptake of (177)Lu-AMBA in PC-3M-luc-C6 tumour-bearing mice by microSPECT/CT imaging can further evaluate the potential of (177)Lu-AMBA therapy for PC-3M-luc-C6 tumours....
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PMID: 21036718
PDF is available here.
PDF is available here.
Biochemical Genetics (48)9-10 2010
Abstract
Six polymorphic sites of the bovine prion protein gene (PRNP) were genotyped in 569 animals of Asian native cattle, Japanese breeds, purebred mythun (Bos frontalis), and mythun x cattle composite animals. At the 23-bp indel site, a deletion (23-) allele was a major allele in all populations except m...
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PMID: 20623331
PDF is available here.
PDF is available here.
Lab On a Chip (10)18 2010
Abstract
We demonstrate how such dynamic changes can provide a basis for the identification of three distinct phenotypes of endothelial cells: human umbilical vein endothelial cells (HUVECs), human microvascular endothelial cells (HMVECs), and endothelial colony forming cells (ECFCs). This distinction is acc...
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PMID: 20714500
PDF is available here.
PDF is available here.
Pediatric Research (68)3 2010
Abstract
We hypothesized that fetal pancreatic digestive enzymes play a role in the lung damage after meconium aspiration. We studied the effect of meconium on the A549 alveolar epithelial cell line. The exposure of the cells to 0.5 to 5% meconium resulted in significant disruption of connections between A54...
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PMID: 20551860
PDF is available here.
PDF is available here.
Abstract
We constructed the cell adhesive, fp-151-RGD, by fusion of the hybrid mussel adhesive protein, fp-151, and GRGDSP peptide, one of the major cell adhesion recognition motifs; fp-151-RGD efficiently immobilized cells on coated culture surfaces with no protein and surface modifications, and apparently...
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PMID: 20336754
PDF is available here.
PDF is available here.
Thrombosis and Haemostasis (104)3 2010
Abstract
I was 13 +/- 2 microM. k cat was seven fold decreased whereas K M was unaffected in the presence of 10 microM Zn2+. The inhibitory effect of Zn2+ on APC activity was also observed when factor Va was used as a substrate in an assay coupled to a prothrombinase assay. The interaction of Zn2+ with APC w...
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PMID: 20664913
PDF is available here.
PDF is available here.
Abstract
We developed a medium-throughput assay to address this question in a wholly endogenous context using RNA interference. We performed medium-throughput calcium mobilization assays of agonist-stimulated muscarinic acetylcholine and protease-activated receptors in human embryonic kidney 293 (HEK293) cel...
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PMID: 20573995
PDF is available here.
PDF is available here.
Chemical Communications (46)31 2010
Abstract
A unique method has been developed for the formation of multivalent cyclic peptides. This procedure exploits on-resin peptide cyclization using a photoinitiated thiol-ene click reaction and subsequent clustering using thiol-yne photochemistry. Both reactions utilize the sulfhydryl group on natural c...
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PMID: 20552127
PDF is available here.
PDF is available here.
Chemical Communications (46)31 2010
Abstract
A water-soluble doubly N-confused hexaphyrin (N(2)CH) having two octa-arginine peptide arms displays an enhanced near-infrared (NIR) emission around 1050 nm in the presence of Zn(2+) in aqueous solution.
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PMID: 20593089
PDF is available here.
PDF is available here.
Bioconjugate Chemistry (21)8 2010
Abstract
We summarize various attempts of the interaction of MGBLs with ps-DNA and DNA triplexes....
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PMID: 20509695
PDF is available here.
PDF is available here.
Abstract
We describe a scanning approach using a library of pyranose-based peptidomimetics that is structurally diverse in a systematic manner, designed to cover all possible conformations of tripeptide motifs containing two aromatic groups and one positive charge. Structural diversity was achieved by effici...
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PMID: 20684600
PDF is available here.
PDF is available here.
Biomacromolecules (11)8 2010
Abstract
In this work, human mesenchymal stem cells (hMSC) immobilized in RGD-coupled alginate microspheres, with a binary composition of high and low molecular weight alginate, were investigated. Cells immobilized within RGD-alginate microspheres (during 21 days) showed metabolic activity, w...
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PMID: 20690708
PDF is available here.
PDF is available here.
Abstract
Our results indicate that the OpdA Tyr(607) residue plays an important role in the enzyme-substrate interaction and in the hydrolytic activity.
2010 Elsevier Inc. All rights reserved....
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PMID: 20513640
PDF is available here.
PDF is available here.
Abstract
We investigated the immunopharmacological aspects of innate immune responses via Toll-like receptors (TLRs), NOD1 and NOD2, in terms of induction of the histamine-forming enzyme, histidine decarboxylase (HDC), activity in mice. Intravenous injection of TLR4-agonistic synthetic lipid A definitely ind...
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PMID: 19710098
PDF is available here.
PDF is available here.
Abstract
The effect of selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro), which is a synthetic derivative of the endogenous tetrapeptide tuftsin (stable with respect to tissue peptidases), on the learning and memory processes and metabolism of serotonin (5-HT) have been experimentally studied on Wistar rats. The animals...
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PMID: 20919548
PDF is available here.
PDF is available here.
Abstract
An efficient HPLC method for the determination of atazanavir in human plasma has been developed and validated. A relatively simple mobile phase consisting of acetonitrile-ammonium formate buffer (pH 3; 10 mM) (45:55, v/v) was pumped at a low flow rate of 0.3 ml/min through a reverse phase Phenomenex...
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PMID: 20395105
PDF is available here.
PDF is available here.
Abstract
We developed peptides as potential estrogen mimetic compounds and now we evaluated the effects of the most efficacious peptide; hexapeptide estrogen-mimetic peptide 1 (EMP-1) (VSWFFE) in comparison to estrogen (E(2)) and peptides with weak activity A44 (KAWFFE) and A45 (KRAFFE) on modulation of cell...
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PMID: 20564210
PDF is available here.
PDF is available here.
Abstract
The two codon-specific eubacterial release factors (RF1: UAA/UAG and RF2: UAA/UGA) have specific tripeptide motifs (PXT/SPF) within an exposed recognition loop shown in recent structures to interact with stop codons during protein synthesis termination. The motifs have been inferred to be critical f...
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PMID: 20584893
PDF is available here.
PDF is available here.
Nutrition and Cancer (62)6 2010
Abstract
We demonstrate that combinations of the dietary plant polyphenols--curcumin and carnosic acid--at noncytotoxic concentrations of each agent, produced a synergistic antiproliferative effect and a massive apoptotic cell death in HL-60 and KG-1a human AML cells. In contrast, combinations of curcumin an...
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PMID: 20661831
PDF is available here.
PDF is available here.
Abstract
We developed a time-resolved FRET strategy that is based on receptor labeling with selective fluorescent ligands. Specific FRET signals were observed with four different receptors expressed in cell lines, consistent with their dimeric or oligomeric nature in these transfected cells. More notably, th...
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PMID: 20622858
PDF is available here.
PDF is available here.
Abstract
The cationic, alpha-helical frog skin antimicrobial peptide B2RP (brevinin-2-related peptide) shows sequence similarity to antimicrobial peptides belonging to the brevinin-2 family, but lacks the C-terminal cyclic heptapeptide domain (Cys-Lys-Xaa (4)-Cys). Synthetic B2RP produced a significant (p<0....
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PMID: 20496306
PDF is available here.
PDF is available here.
Infection and Immunity (78)8 2010
Abstract
We provide new insight into the structure-function relationship of the SPATEs and the functional roles of their conserved residues....
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PMID: 20479079
PDF is available here.
PDF is available here.