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Tyrothricin (2):
Recent article
Tyrothricin
Abstract
These results validate the BAU-102 assay as an effective tool in antimicrobial drug discovery....
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PMID: 18087073
PDF is available here.
PDF is available here.
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Abstract
Topical pharyngeal anaesthesia with benzocaine/tyrothricin lozenges with conscious sedation has no advantages over conscious sedation alone in patients undergoing upper endoscopy....
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PMID: 16907901
PDF is available here.
PDF is available here.
Journal of Endodontics (32)1 2006
Abstract
The study was aimed at comparing the efficacy of disinfection of root canals with periapical radiolucencies when treated with either antibiotics/steroid medicaments (Ledermix or Septomixine) or a calcium hydroxide paste (Calasept). Microbiological samples were taken before and after two-visit endodo...
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PMID: 16410062
PDF is available here.
PDF is available here.
FEMS Microbiology Letters (66)1-3 2006
Suppression of tyrocidine production by purine nucleotides and related substances in Bacillus brevis
Abstract
We found that adenosine or 5'-AMP suppressed the production of tyrocidine with half-maximum inhibition at 100- 300 03BCM. This inhibition was specific to the production of tyrocidine since neither adenosine nor 5'-AMP showed any effect on bacterial growth. Cyclic nucleotides had no effect. These res...
PDF is available here.
PDF is available here.
Abstract
The treatment groups were comparable at baseline. During randomized treatment, the radius of the lesions was reduced at an average of 0.55 +/- 0.31 mm/day (mean +/- SD) for tyrothricin and 0.47 +/- 0.30 mm/day for placebo (p = 0.016; one-sided; intention-to-treat data set). The wound index decreased...
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PMID: 15587588
PDF is available here.
PDF is available here.
Abstract
Abstract
Abstract
Tyrothricin, a polypeptide antibiotic, is active against yeast cells. Tyrothricin was rapidly fungicidal towards Candida albicans. Concentration of four times the minimum inhibitory (25 mg l-1) reduced the yeast numbers by more than 3 log10 within 1 h. Similar results were obtained in a flow cytomet...
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PMID: 8786757
PDF is available here.
PDF is available here.
Abstract
Methods are reported for the determination of tyrothricin and benzocaine by HPLC and menthol by GC in the analysis of throat lozenges (tablets) containing all three compounds. After optimization of the variables involved in both HPLC and GC the methods have been characterized and validated according...
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PMID: 8634346
PDF is available here.
PDF is available here.
Abstract
A rapid, sensitive, and accurate reversed-phase HPLC method has been developed for the analysis and quantification of pharmaceutical formulations containing tyrothricin (1), an antibiotic used in antiseptic buccal compressed tablets for local application. The assay has been carried out under isocrat...
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PMID: 7983600
PDF is available here.
PDF is available here.
Abstract
Mass spectra of several model oligopeptides (substance P, [Arg8]-vasopressin, tyrothricin, and the B-chain of bovine insulin) have been obtained with a matrix-assisted laser desorption/ionization (MALDI) source and a custom-designed Fourier-transform mass spectrometer (FTMS). The MALDI source is out...
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PMID: 7513214
PDF is available here.
PDF is available here.
Contact Dermatitis (30)2 1994
Abstract
Abstract
Abstract
A solution of formaldehyde and tyrothricin was placed in periodontal pockets of 14 patients. One maxillary quadrant was used as the experimental side, while the contralateral quadrant was employed as the control. A placebo solution was placed in the pockets of the control side. Both the experimental...
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PMID: 1960663
PDF is available here.
PDF is available here.
Abstract
FEMS Microbiology Letters (54)1-3 1990
Abstract
We found that adenosine or 5'-AMP suppressed the production of tyrocidine with half-maximum inhibition at 100-300 microM. This inhibition was specific to the production of tyrocidine since neither adenosine nor 5'-AMP showed any effect on bacterial growth. Cyclic nucleotides had no effect. These res...
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PMID: 2157624
PDF is available here.
PDF is available here.
Abstract
Aqueous solutions of tyrocidine B, iodoacetyltyrocidine B, and diiodotyrocidine B in 40% H2O:60% ethanol (w/w) were investigated by analytical ultracentrifugation, light scattering, and small-angle X-ray scattering techniques. A reasonable hydrodynamic description of the aggregates of molecular weig...
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PMID: 2542523
PDF is available here.
PDF is available here.
L' Information dentaire (70)3 1988
Abstract
Abstract
(1) The interaction of tyrocidine with different lipids is studied in model membranes and the results are compared to the gramicinid-lipid interaction. (2) The tyrocidine-dielaidoylphosphatidylethanolamine interaction gives rise to a population of phospholipids with a lower gel to liquid-crystalline...
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PMID: 2446665
PDF is available here.
PDF is available here.
Abstract
Six preparations (four liquid and two solid) were tested in a double-blind crossover design for their anti-bacterial effect on aerobic and anaerobic bacteria in saliva of 12 volunteers. The four liquid preparations contained either tyrothricin, hexetidine, hydrogen peroxide or ethanol and were teste...
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PMID: 3378662
PDF is available here.
PDF is available here.
Abstract
Three pharmaceutical preparations for the disinfection of the oropharynx were tested with regard to the gramicidin concentration obtained in the saliva after their appropriate application. Peak values followed a dose-concentration relationship and were highest after sucking a lozenge containing 10 m...
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PMID: 2460410
PDF is available here.
PDF is available here.
European Journal of Biochemistry (170)1-2 1987
Abstract
Our results could mean that the peptide antibiotic tyrocidine is active in B. brevis on the DNA level as one regulatory factor controlling DNA functions....
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PMID: 2826154
PDF is available here.
PDF is available here.
Journal of Bacteriology (169)5 1987
Abstract
We identified the promoter for the B. brevis structural gene (tycA) for tyrocidine synthetase I, the enzyme catalyzing the first step in tyrocidine biosynthesis, and studied its regulation in cells of B. brevis and Bacillus subtilis. Transcription from the tycA promoter was induced at the end of the...
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PMID: 3032912
PDF is available here.
PDF is available here.
Abstract
Tyrocidine, a peptide antibiotic produced by Bacillus brevis (ATCC 8185), relaxes superhelical DNA in a biphasic manner and induces 'packaging' of the DNA at higher concentrations. This was concluded from studies using the sensitive 4,5',8-trimethylpsoralen photobinding technique [Sinden, R. R., Car...
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PMID: 2430800
PDF is available here.
PDF is available here.
Abstract
Mutants of Bacillus brevis ATCC 8185 were isolated which were unable to produce detectable amounts of either tyrocidine or linear gramicidin, or both peptide antibiotics. Tyrocidine-negative mutants (BM5, BM21, BM44) sporulated normally. Gramicidin-negative mutants (BM2, BM24) were oligosporogenous,...
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PMID: 6204006
PDF is available here.
PDF is available here.
Abstract
Die Quintessenz (34)5 1983
Abstract
Abstract
Salivary levels and total salivary recovery of gramicidin were determined by high performance liquid chromatography in healthy volunteers after administration of a tyrothricin lozenge and a tyrothricin gargle/mouth-wash. Average peak values of gramicidin after sucking the lozenge were 37.5 mg/l and...
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PMID: 6207119
PDF is available here.
PDF is available here.
Arzneimittel-Forschung (33)12 1983
Abstract
815 recent clinical isolates of different species representing pathogenic or saprophytic constituents of human microbial flora were submitted to agar dilution tests. In concentrations above 64 micrograms/ml tyrothricin is in general equally as gramicidin or slightly more effective whereas below 8 mi...
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PMID: 6199032
PDF is available here.
PDF is available here.
Abstract
This paper presents evidence that the two peptide antibiotics tyrocidine and linear gramicidin, produced by Bacillus brevis ATCC 8185, are required for the induction of sporulation in the producer organism. When tyrocidine synthesis was specifically blocked with 2-amino-3-hydroxy-3-phenylpropanoic a...
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PMID: 6185338
PDF is available here.
PDF is available here.
Abstract
These results provide direct evidence for a role of tyrocidine in sporulation of B. brevis and suggest that the action of the peptide antibiotic may involve the control of transcription. Such a notion is supported by earlier studies on the effects of tyrocidine and linear gramicidin on purified RNA...
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PMID: 6185337
PDF is available here.
PDF is available here.
Abstract
We used one analog of gramicidin S and two of tyrocidine A to study the relationship between peptide structure and antibacterial action as seen in inhibiting active transport and in vitro transcription and in delaying spore outgrowth. The data showed that [Ser2,2']-gramicidin S, in which the two orn...
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PMID: 6185087
PDF is available here.
PDF is available here.
Abstract
The peptide antibiotic tyrocidine which is produced by Bacillus brevis and is probably involved in sporogenesis, unwinds superhelical plasmids in vitro at low peptide: DNA ratios, as found by gel electrophoresis. At higher peptide concentrations, the DNA is packed tightly leading to apparent nucleas...
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PMID: 6181992
PDF is available here.
PDF is available here.
Journal of Bacteriology (151)2 1982
Abstract
We conclude that tyrocidine is not involved in either the sporulation process or the resistance of spores of B. brevis ATCC 10068 to heating at 80 degrees C for up to 3 h....
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PMID: 6284703
PDF is available here.
PDF is available here.
Arzneimittel-Forschung (32)1 1982
Abstract
The combination of fomocaine and diphenhydramine as active constituents of a new burn and wound gel (Herit) guarantees a remarkable antihistaminic effect. The UV-erythema model was a very informative test applied on the dorsal skin of 16 male volunteers.
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PMID: 6120706
PDF is available here.
PDF is available here.
Abstract
Tyrocidine A (TA) is an antibiotic cyclic decapeptide with the sequence of cyclo (-L-Val1-L-Orn2-L-Leu3-D-Phe4-L-Pro5-L-Phe6-D-Phe7-L-Asn8-L-Gln9-L-Tyr10-). Gramicidin S (GS) regarded as a homolog of TA is also a cyclic decapeptide with the sequence of cyclo (-L-Val1-L-Orn2-L-Leu3-D-Phe4-L-Pro5-L-Va...
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PMID: 6273346
PDF is available here.
PDF is available here.
Biophysical Journal (32)2 1980
Abstract
I beta-turn/ type II' beta-turn/ approximately antiparallel beta-pleated sheet conformation of tyrocidine A in solution and the NOEs, cross-relaxation parameters, and interproton distances serve as distinguishing criteria for beta-turn and beta-pleated sheet conformations. It should be borne in mind...
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PMID: 6266536
PDF is available here.
PDF is available here.
Arzneimittel-Forschung (30)4 1980
Abstract
The antibacterial activity of a new jelly for burns and wounds with the components tyrothricin, 8-hydroxyquinoline, fomocaine and diphenhydramine (Herit) is described. The biological availability of tyrothricin and 8-hydroxyquinoline from the gel is in accordance with minimum inhibitor concentration...
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PMID: 6772197
PDF is available here.
PDF is available here.
Biochemistry (Washington) (18)26 1979
Abstract
We report for the decapeptide tyrocidine A: (a) H alpha and H beta chemical shifts and scalar coupling constants for most residues of tyrocidine A in methanol-d4 and dimethyl-d6 sulfoxide (Me2so-d6) and the H alpha and H beta chemical shifts for other residues; (b) scalar coupling constants 3J alpha...
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PMID: 229903
PDF is available here.
PDF is available here.
Journal of Molecular Biology (135)3 1979
Abstract
Biosystems (11)2-3 1979
Abstract
Journal of Biological Chemistry (254)14 1979
Abstract
We report the sequencing and proton magnetic resonance spectral assignments, including those of 4 aromatic residues, of tyrocidine A, an analog of the decapeptide gramicidin S. Two complementary methods, proton-proton nuclear Overhauser enhancements and scalar decoupling, evaluated by two distinct f...
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PMID: 221496
PDF is available here.
PDF is available here.
Abstract
Abstract
Abstract
Arzneimittel-Forschung (29)4 1979
Abstract
The biological availability was investigated of diphenhydramine and fomocaine, two of the active principles of the new formulation "Herit" used as a jelly against burns and small wounds. Fomocaine and diphenhydramine penetrate deeply into stratum corneum. The addition of fomocaine guarantees a quick...
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PMID: 114193
PDF is available here.
PDF is available here.
Arzneimittel-Forschung (29)1 1979
Abstract
Using 12-day old baby mice, strain NMRI, the LD50 of a Herpes simplex virus type 1 was calculated. Intragastric inoculation of the mice was carried out applying a stomach tube. Lethality of the mice was reduced from 67% to 23% by pre-incubation of the virus suspension for 30 min at 37 degrees C in t...
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PMID: 582119
PDF is available here.
PDF is available here.
Abstract
Abstract
The peptide antibiotic tyrocidine affects transcription in vitro by interfering with the initiation process. The complex formed between tyrocidine and native DNA is stable against nucleolytic enzymes. It is sensitive to variations in the salt concentration. Protection of DNA as a function of the tyr...
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PMID: 81775
PDF is available here.
PDF is available here.
Zentralblatt fur Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene. Erste Abteilung Originale. Reihe B: Hygiene, praventive Medizin (166)4-5 1978
Abstract
We suppose a virustatic effect of tyrothricin also in the case of other lipophilic viruses....
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PMID: 207052
PDF is available here.
PDF is available here.
Naturwissenschaften (64)10 1977
Abstract
Laryngoscope (87)9 Pt 1 1977
Abstract
Chronic otitis media and hearing loss is a major health problem today in the Canadian Eskimo. The subject is reviewed and the findings of projects and a survey that have been carried out recently are discussed. A modality of treatment is proposed which is based upon the findings of the projects, the...
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PMID: 197359
PDF is available here.
PDF is available here.
Analytica Chimica Acta (92)2 1977
Abstract
Abstract
The sporulating bacterial strain Bacillus brevis (ATCC 8185) produces two types of peptide antibiotics, the linear gramicidins and the cyclic tyrocidines. Their effects on transcription in vitro were studied: 1. RNA synthesis catalized by RNA polymerase and DNA as template, both from B. brevis cells...
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PMID: 69443
PDF is available here.
PDF is available here.
Abstract
Dissociation of the multienzymes of tyrocidine synthesis by prolonged incubation of crude extracts of Bacillus brevis (Dubos strain, ATCC 8185) has yielded, on Sephadex G-100 chromatography, two fractions of amino acid activating subunits, a larger one of 70,000 daltons and a smaller one of 90,000 d...
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PMID: 196286
PDF is available here.
PDF is available here.
Vojnosanitetski pregled (34)4 1977
Abstract
Abstract
Abstract
The adenine nucleotide levels and derived energy charge value of a tyrothricin-producing strain of Bacillus brevis under aerobic conditions were in good agreement with published values for other bacteria. When growing cultures of B. brevis underwent a transition from aerobic to anaerobic conditions,...
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PMID: 932690
PDF is available here.
PDF is available here.
Abstract
A double-blind comparative study of Otoseptil Ear Drops and Otosporin Ear Drops in otitis externa in fifty-eight patients revealed them both to be equally effective in a series with very few fungal infections. In view of the normally high proportion of infections including fungi, there are obvious a...
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PMID: 193743
PDF is available here.
PDF is available here.
Le Chirurgien-dentiste de France (45)284 1975
Abstract