Find your PDFs fast.
Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Autoantibodies (7):
Recent article
Autoantibodies
Abstract
We found a very high number of patients who developed antinuclear autoantibodies (16 of 24 (66.6%) at the time of infliximab discontinuation) and anti-ds-DNA autoantibodies (12 of 24 (50%) at the time of infliximab discontinuation). However, in most of these patients they had no clinical significanc...
|
PMID: 21933639
PDF is available here.
PDF is available here.
| < More recent | Older article > |
Abstract
B-cell-directed therapy-the use of agents that eliminate B cells or block cytokines important for B-cell function-is emerging as a promising approach to the treatment of rheumatic disease. Target diseases, including systemic lupus erythematosus (SLE), display diverse patterns of auto...
|
PMID: 21808289
PDF is available here.
PDF is available here.
Autoimmunity Reviews (10)11 2011
Abstract
We included all patients with systemic autoimmune diseases in whom the indication for treatment with TPE was a flare of the disease between 1999 and 2010. The indications for treatment, complications and outcomes were obtained from review of medical records.
A total of 31 patients (1...
|
PMID: 21569864
PDF is available here.
PDF is available here.
Abstract
To develop a preclinical large animal model of autoimmune diabetes to facilitate the translational research of autoimmune diabetes in human.
Nine young rhesus monkeys received multiple-low-dose (MLD) intravenous injections of streptozotocin for five consecutive days,...
|
PMID: 21821007
PDF is available here.
PDF is available here.
Abstract
Atherosclerosis is a chronic inflammatory process. Poly(ADP-ribose) polymerase-1 (PARP), a nuclear enzyme linked to DNA repair, has been shown to be involved in atherogenesis; however, the effects on dendritic cells, T cells and serum auto-antibody levels are not fully understood....
|
PMID: 21813379
PDF is available here.
PDF is available here.
Abstract
Heritable causes of proteinuria are rare and account for a relatively small proportion of all cases of proteinuria affecting children and adults. Yet, significant contributions to understanding the mechanistic basis for proteinuria have been made through genetic and molecular analyse...
|
PMID: 21782134
PDF is available here.
PDF is available here.
Translational Research (157)6 2011
Abstract
Systemic lupus erythematosus (SLE) is a severe multisystem autoimmune disease that results from both genetic predisposition and environmental factors. Many lines of investigation support interferon alpha (IFN-α) as a causal agent in human lupus, and high levels of serum IFN-α are a...
|
PMID: 21575916
PDF is available here.
PDF is available here.
Abstract
I interferon pathway in patients with dermatomyositis or with expression of particular autoantibodies. Decreased release of Ca(2+) from the sarcoplasmic reticulum, as a consequence of release of proinflammatory cytokines and high mobility group protein B1, might contribute to muscle weakness, and no...
|
PMID: 21468145
PDF is available here.
PDF is available here.
Abstract
Inconsistencies in ANCA (anti-neutrophil cytoplasm autoantibodies) and other NSA (neutrophil-specific autoantibodies) terminology frequently cause incorrect indications, choices, applications and interpretations of ANCA diagnostics in routine practice, except for ANCA-associated vasculitis. A review...
|
PMID: 21094701
PDF is available here.
PDF is available here.
Abstract
We show that mature SLE neutrophils are primed in vivo by type I IFN and die upon exposure to SLE-derived anti-ribonucleoprotein antibodies, releasing neutrophil extracellular traps (NETs). SLE NETs contain DNA as well as large amounts of LL37 and HMGB1, neutrophil proteins that facilitate the uptak...
|
PMID: 21389264
PDF is available here.
PDF is available here.
Haemophilia (17)2 2011
Abstract
We were interested in characterizing the spectrum of FVIII antibody formation and the primary and secondary immune responses after FVIII administration in two different exon 16-disrupted haemophilia A mouse strains, Balb/c and C57BL/6. Balb/c and C57BL/6 E16 haemophilia A mice were used in all exper...
|
PMID: 21091850
PDF is available here.
PDF is available here.
Autoimmunity Reviews (10)5 2011
Abstract
Autoimmune and inflammatory phenomena are characteristically present in systemic sclerosis (SSc) and impact on dysregulated fibroblast extracellular matrix deposition, hallmark of the disease in conjunction with fibroproliferative vasculopathy. Oligoclonal T helper 2-like cells are p...
|
PMID: 20863906
PDF is available here.
PDF is available here.
Journal of Neuroimmunology (232)1-2 2011
Abstract
We compared the capacity of a single or multiple antigens to elicit autoantibodies targeting multiple neural autoantigens by ELISA and 2D-immunomics. We induced experimental autoimmune encephalomyelitis (EAE) with MBP peptide(89-104), total MBP or spinal cord homogenate. Both techniques showed anti-...
|
PMID: 21093930
PDF is available here.
PDF is available here.
Abstract
We addressed four major autoimmune-rheumatological diseases investigated through proteomic techniques and provide evidence-based data on the highlights obtained in systemic sclerosis, primary and secondary Sjogren's syndrome, systemic lupus erythematosus and rheumatoid arthritis.
Cop...
|
PMID: 21246742
PDF is available here.
PDF is available here.
Abstract
We report the first case of severe necrotizing myopathy with anti-Hu antibodies complicating MCC....
|
PMID: 21333825
PDF is available here.
PDF is available here.
Journal of Neuroimmunology (231)1-2 2011
Abstract
Although myasthenia gravis (MG) has long been considered a well-established autoimmune disease associated with autoantibodies, which are convincingly pathogenic, accumulating data indicate both clinical and biological heterogeneity similar to many other putative autoimmune disorders....
|
PMID: 21093931
PDF is available here.
PDF is available here.
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova / Ministerstvo zdravookhraneniia i meditsinskoi promyshlennosti Rossiiskoi Federatsii, Vserossiiskoe obshchestvo nevrologov [i] Vserossiiskoe obshchestvo psikhiatrov (111)4 2011
Abstract
An objective of the study was to search for new biologically significant markers of brain damage. Levels of blood serum autoantibodies (aAB) to different fragments of α7-subunit of acetylcholine receptor (ACR) were studied in children with traumatic brain injury of different severit...
|
PMID: 21512503
PDF is available here.
PDF is available here.
Abstract
We investigated the prognostic impact of endogenous Epo in patients with pancreatic ductal adenocarcinoma (PDAC).
The clinico-pathological relevance of hemoglobin (Hb, n = 150), serum Epo (sEpo, n = 87) and tissue expression of Epo/Epo receptor (EpoR, n = 104) was analyzed in patient...
|
PMID: 21829709
PDF is available here.
PDF is available here.
Abstract
Sertoli cells (SCs) provide an immunoprotective environment to pancreatic islet grafts for treatment of insulin-dependent diabetes. Aim of this work was to verify whether intraperitoneal graft of SCs, enveloped in barium alginate-based microcapsules, would reverse overt spontaneous diabetes in nonob...
|
PMID: 21197711
PDF is available here.
PDF is available here.
Autoimmunity Reviews (10)2 2010
Abstract
Immunoglobulins in patients with Graves' disease (GD) that modulate the thyroid stimulating hormone receptor (TSH-R) do so via stimulating cAMP dependent signals (TSI), blocking TSH or inhibition of TSH-receptor activation (TBI) or inducing apoptotic signals. These functional immunog...
|
PMID: 20807591
PDF is available here.
PDF is available here.
Abstract
The pathogenesis of adult-onset Still's disease (AOSD), which is currently thought to be an autoimmune disorder, may share similarities with autoimmune hyperthyroidism. This report describes a middle-aged woman in whom hyperthyroidism and Still's disease developed concurrently. Durin...
|
PMID: 20201625
PDF is available here.
PDF is available here.
Abstract
Epidemiologie, mikrobiologie, imunologie : casopis Spolecnosti pro epidemiologii a mikrobiologii Ceske lekarske spolecnosti J.E. Purkyne (59)4 2010
Abstract
The diagnostic relevance of serum anti-endomysium antibodies (AEA) in patients with celiac disease is discussed. A group of 23 newly diagnosed patients, i.e., seven patients with mild AEA positivity (+), nine patients with intermediate AEA positivity (++) and seven patients with strong AEA positivit...
|
PMID: 21114005
PDF is available here.
PDF is available here.
Abstract
We report the case of a 65-year-old man who had encephalitis with a high titer of voltage-gated potassium channel antibodies (VGKC-Abs). His initial symptoms included memory disturbance, confusion, and seizures. Laboratory tests revealed a low plasma sodium concentration and a strong positive result...
|
PMID: 21068462
PDF is available here.
PDF is available here.
Abstract
We have highlighted their use in celiac disease (CD). The available techniques, which include two-dimensional (2D) gel electrophoresis, mass spectrometry, and antibody and tissue arrays, have been used to identify proteins or changes in protein expression specific to gut tissue from patients with CD...
|
PMID: 20632103
PDF is available here.
PDF is available here.
Abstract
We characterized Dsg-specific mAbs cloned by phage display from 3 patients with pemphigus vulgaris and 2 with pemphigus foliaceus. Variable heavy chain gene usage was restricted, but similar genes were used for both pathogenic and nonpathogenic mAbs. However, the heavy chain complementarity-determin...
|
PMID: 20978359
PDF is available here.
PDF is available here.
Abstract
We have studied lupus AAbs that bind dsDNA and cross-react with the NR2A and NR2B subunits of the NMDA receptor (NMDAR). In adult mouse models, when the blood-brain barrier is compromised, these NMDAR-reactive AAbs access the brain and elicit neuronal death with ensuing cognitive dysfunction and emo...
|
PMID: 20921396
PDF is available here.
PDF is available here.
Abstract
We tested sera from patients with SN-APS with a proteomic approach by analyzing endothelial cell-surface membrane proteins. Sera from SN-APS patients revealed 2 reactive spots corresponding to vimentin, a protein that is shown to bind cardiolipin in vitro. Antivimentin/cardiolipin antibodies were te...
|
PMID: 20634382
PDF is available here.
PDF is available here.
New England Journal of Medicine (363)15 2010
Abstract
We report on delivery of a functional dystrophin transgene to skeletal muscle in six patients with Duchenne's muscular dystrophy. Dystrophin-specific T cells were detected after treatment, providing evidence of transgene expression even when the functional protein was not visualized in skeletal musc...
|
PMID: 20925545
PDF is available here.
PDF is available here.
Abstract
Anti-N-methyl-D-aspartate (NMDA) receptor encephalitis has been reported to be associated with ovarian teratomas. In many patients, surgical excision has resulted in improvement.
A previously healthy 14-year-old girl presented with confusion which later evolved into a comatose state. Imaging reveale...
|
PMID: 20605495
PDF is available here.
PDF is available here.
Annals of Pharmacotherapy (44)10 2010
Abstract
To report a case of cephalosporin-induced factor V inhibitor development, an uncommon but potentially fatal condition characterized by severe hemorrhage.
A 71-year-old Chinese man presented with factor V inhibitors after a 7-day cephradine course for a urinary tract infection, characterized by abnor...
|
PMID: 20807866
PDF is available here.
PDF is available here.
Abstract
The relationships between different autoimmune diseases and among them the connections between systemic lupus erythematosus (SLE) and autoimmune thyroid diseases have been reported for a few years. The aim of this study is the assessment of the laboratory tests findings which are applied in the eval...
|
PMID: 21207638
PDF is available here.
PDF is available here.
Clinical Immunology (137)1 2010
Abstract
Autoimmunity Reviews (9)12 2010
Abstract
The number of 2009 publications in indexed journals dealing with 'autoimmunity' has maintained its increasing trend compared to the previous five years. Numerous developments have been proposed in our understanding of systemic and organ-specific autoimmune diseases (particularly mult...
|
PMID: 20716447
PDF is available here.
PDF is available here.
Abstract
These results showed that normal thyroid recorded by US matches with normal thyroid laboratory assessment to a large degree. These preliminary data need to be confirmed in a prospective study and in a larger series and should suggest the evaluation of thyrotropin and thyroid antibodies in subjects w...
|
PMID: 19998241
PDF is available here.
PDF is available here.
Abstract
High GAD65Ab titers per se are not a major risk factor for disease progression in LADA, while the number of positive autoantibodies and HLA DRB1-DQB1 genotypes at high risk for T1D are significant predictors. Moreover, clinical characteristics such as low BMI and female gender are more likely to ide...
|
PMID: 20603341
PDF is available here.
PDF is available here.
Abstract
Over half (55%) of pregnant women with abnormalities suggestive of autoimmune thyroiditis and/or hypothyroidism would be missed if only those with high-risk criteria were examined. A more extensive screening of thyroid autoimmunity and dysfunction seems warranted....
|
PMID: 20682632
PDF is available here.
PDF is available here.
Dental update (37)8 2010
Abstract
Abstract
We assessed the frequencies of SDF1-3' G801A (rs 1801157) polymorphic variants between systemic lupus erythematosus (SLE) patients (n = 150) and controls (n = 300). There were no significant differences in the prevalence of SDF1-3' G801A polymorphic variants in SLE patients and healthy individuals....
|
PMID: 19826912
PDF is available here.
PDF is available here.
Journal of Immunology (185)7 2010
Abstract
We hypothesized that LMP1-mediated activation signals cooperate with and/or amplify events that predispose individuals to development of autoimmunity. To determine which aspects of autoimmunity may be exacerbated by LMP1, we bred mCD40-LMP1tg mice to two lupus-prone strains, B6.Sle1 and B6.Sle3, and...
|
PMID: 20810985
PDF is available here.
PDF is available here.
Abstract
To determine if pretreatment insulin and C-peptide levels together with antibody status are predictive of HbAlc levels before and during therapy in obese African-American youth with type 2 diabetes.
Records of African-American patients with clinical diagnosis of type 2 diabetes were retrospectively...
|
PMID: 21158213
PDF is available here.
PDF is available here.
Endocrine Pathology (21)3 2010
Features of papillary thyroid microcarcinoma in the presence and absence of lymphocytic thyroiditis.
Abstract
We performed a study to compare the clinical and pathological features of patients with PTMC who did and did not have LT. We collected the 323 consecutive patients following excision of PTMC diagnosed as papillary carcinoma on preoperative needle aspiration cytology. We analyzed the demographic, ser...
|
PMID: 20506003
PDF is available here.
PDF is available here.
Abstract
We report the evaluation of angioedema that was associated with an underlying lymphoproliferative disorder for the purpose of discussing the relationship between C1q and a diagnosis of AAE. A literature review was completed for the purpose of assessing the diagnostic value of C1q when used in the wo...
|
PMID: 20929611
PDF is available here.
PDF is available here.
Abstract
The last few years revealed a molecular distinction between thrombotic thrombocytopenic purpura, a disease characterized by a lack of ADAMTS13 activity, and atypical hemolytic uremic syndrome (aHUS), a disease of complement overactivation. Many different predisposing genetic factors resulting in com...
|
PMID: 20613506
PDF is available here.
PDF is available here.
Abstract
Autoantibodies against thyroxin (T4AA) and triiodothyronine (T3AA) are present in dogs with autoimmune thyroiditis and have been reported to interfere with immunoassays. The objectives of this study were to determine the frequency of autoantibodies and to determine whether interference occurs by T4A...
|
PMID: 20706025
PDF is available here.
PDF is available here.
Autoimmunity Reviews (9)11 2010
Abstract
In clinical practice, it is sometimes difficult to diagnose a relapse in patients suffering from systemic lupus erythematosus (SLE) and lupus nephritis (LN) having potential complications, including renal failure and death. Some immunological markers can help to determine their association with LN a...
|
PMID: 20601199
PDF is available here.
PDF is available here.
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences (35)9 2010
Abstract
To explore the role of IL-21 in the pathogenesis of myasthenia gravis (MG) and its influence on the the class switch of anti-AChR antibodies.
Blood was taken from 26 patients and 18 healthy controls, and the expression of IL-21R mRNA in peripheral blood mononuclear ce...
|
PMID: 20871161
PDF is available here.
PDF is available here.
Autoimmunity Reviews (9)11 2010
Abstract
A novel approach for the selective silencing of targeted autoreactive B lymphocytes is reviewed that mimics the physiological mechanisms for suppressing B cell activity. It is based on the use of bi- or tri-specific chimeric antibodies that cross-link BCRs with a pre-selected antigen...
|
PMID: 20601201
PDF is available here.
PDF is available here.
Immunotherapy (2)5 2010
Abstract
This meeting was dedicated to various autoimmune diseases and their mechanisms, diagnosis and therapies. The autoimmunity-promoting factors included genetic variations and environmental injuries. A broad array of cytokines, including the B-cell activating factor, and autoantibodies,...
|
PMID: 20874644
PDF is available here.
PDF is available here.
Autoimmunity Reviews (9)11 2010
Abstract
I (topo-I, also referred to as Scl-70, ATA) have historically been considered a specific marker for systemic sclerosis (SSc). Although found in approximately 20% of SSc sera, other evidence indicated that ATA also occur in up to 25% of systemic lupus erythematosus (SLE). Given that SLE is approximat...
|
PMID: 20601198
PDF is available here.
PDF is available here.
Abstract
We highlight the importance of revisiting a diagnosis which may have prognostic significance.
Copyright 2010 Elsevier Ltd. All rights reserved....
|
PMID: 20605463
PDF is available here.
PDF is available here.
Abstract
We provide evidence for an important role of actin reorganization in pemphigus pathogenesis. In parallel to loss of cell adhesion and fragmentation of Dsg3 staining along cell borders, PV-IgG treatment resulted in striking changes in actin cytoskeleton organization. Moreover, in experiments using fl...
|
PMID: 20554911
PDF is available here.
PDF is available here.
Abstract
Anti-C1q antibodies were first identified as low-molecular weight C1q precipitins in the sera of patients with systemic lupus erythematosus (SLE) over 30 years ago. Anti-C1q antibodies are strongly associated with the development of proliferative lupus nephritis, so much so that active renal inflamm...
|
PMID: 20421881
PDF is available here.
PDF is available here.
Abstract
We performed a genome-wide haplotype association study and prioritized RA-related genes within 100 kb in either direction of significant haplotypes (P < 0.0001), based on their similarity to known RA susceptibility genes. The results showed that the chemokine CCL3 was associated with susceptibility...
|
PMID: 20518837
PDF is available here.
PDF is available here.
Abstract
Pulmonary arterial hypertension (PAH) is an important complication of connective tissue diseases (CTD) and especially seen in systemic sclerosis, systemic lupus erythematosis (SLE), and mixed connective tissue disease (MCTD). In systemic sclerosis, PAH is isolated or accompanied by interstitial lung...
|
PMID: 20819768
PDF is available here.
PDF is available here.
Abstract
We examine current evidence on the relevance of FcRn in maintaining high autoantibody levels and discuss FcRn-targeted therapeutic approaches. Further investigation of the FcRn-IgG interaction will not only provide mechanistic insights into the receptor function, but should also greatly facilitate t...
|
PMID: 20217455
PDF is available here.
PDF is available here.
Abstract
In Japan,the prevalence of non-herpetic acute limbic encephalitis (NHALE),characterized by a lack of evidence of the herpes simplex virus (HSV) genome or enzyme-linked immunosorbent assay (ELISA) antibody,has shown an upward trend. The causes of NHALE include several anti-neural anti...
|
PMID: 20714033
PDF is available here.
PDF is available here.
Obstetrics & Gynecology (116)2 Pt 1 2010
Abstract
To estimate the prevalence of antithyroid peroxidase antibodies in the general obstetric population and to compare pregnancy outcomes in women who are antithyroid peroxidase-antibody positive with those who are antithyroid peroxidase-antibody negative.
Between November 2000 and April 2003, all women...
|
PMID: 20664399
PDF is available here.
PDF is available here.
Abstract
Antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitides are systemic or more limited conditions characterized by necrotizing destruction of small and medium-sized vessels (eg, capillaries, venules, and arterioles). ANCAs are the most predominant autoantibodies in patients affected by...
|
PMID: 20688245
PDF is available here.
PDF is available here.
Abstract
We noted all patients' reduced LT4 dosage needs, including 7 (47%) who did not require any LT4 through the 9-month follow-up. The LT4 dosage used pre-LLLT (96 +/- 22 microg/day) decreased in the 9th month of follow-up (38 +/- 23 microg/day; P < 0.0001). TPOAb levels also decreased (pre-LLLT = 982 +/...
|
PMID: 20662037
PDF is available here.
PDF is available here.