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Immunoglobulin Isotypes (5):
Recent article
Immunoglobulin Isotypes
Abstract
We have evaluated the immunostimulatory role of the highly-conserved outer membrane lipoprotein P6 from non-typeable Haemophilus influenzae (NTHI) to determine whether the presence of the lipid motif plays a critical role on its immunogenicity. We undertook a systematic analysis of the role that the...
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PMID: 21611194
PDF is available here.
PDF is available here.
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Abstract
This study characterizes three monoclonal antibodies (mAbs) developed against the constant (C) region of the immunoglobulin light (IgL) sigma chain isotype of the channel catfish, Ictalurus punctatus. Microsphere bead assays and Western blot analyses utilizing different recombinant (r) proteins show...
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PMID: 20149930
PDF is available here.
PDF is available here.
Abstract
The magnitude of the ACPA isotype profile at baseline reflects the risk of future radiographic damage. These results indicate that the presence and the constitution of the ACPA response are relevant to the disease course of RA....
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PMID: 20439289
PDF is available here.
PDF is available here.
Abstract
The occurrence of OB could be a potential favorable prognostic marker after transplantation due to the prolonged survival observed. Close follow-up of anomalous protein bands, either in serum or urine, is essential due to the additional difficulty in interpretation when the therapeutic response and...
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PMID: 20450334
PDF is available here.
PDF is available here.
Abstract
I backbone, a pectin domain, using Arabidopsis thaliana seed mucilage-derived rhamnogalacturonan I oligosaccharides--BSA conjugates. Two monoclonal antibodies, designated INRA-RU1 and INRA-RU2, selected for further characterization, were specific for the backbone of rhamnogalacturonan I, displaying...
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PMID: 20309579
PDF is available here.
PDF is available here.
Abstract
Drug development from early discovery to late stage commercialization is a long arduous process where a number of factors are taken into consideration when deciding on a particular immunoglobulin isotype for a therapeutic purpose. There are no general rules for which isotype is selected; however, pr...
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PMID: 20404539
PDF is available here.
PDF is available here.
Abstract
We present novel insights into the antibody responses following S. aureus bacteremia. Fifteen bacteremic patients were followed extensively from diagnosis onwards (median 29 days, range 9-74). S. aureus strains (median 3, range 1-6) and serial serum samples (median 16, range 6-27) were collected. St...
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PMID: 20186449
PDF is available here.
PDF is available here.
Abstract
Host cell-derived protein impurities may be present at low levels in biopharmaceutical products. Antibodies to host cell proteins are present in individuals with no known exposure to these products. In this study, antibodies to drug process-specific Chinese hamster ovary host cell-de...
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PMID: 20013082
PDF is available here.
PDF is available here.
Abstract
We investigated the level of meningococcal-specific IgG, IgA, and IgM in serum using dot-ELISA with outer membrane antigens prepared from Neisseria meningitidis serotype B:4.19:P1.15,3,7,9 (a strain isolated from a Brazilian epidemic). The dot-ELISA is based on the same principles as the standard EL...
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PMID: 20428652
PDF is available here.
PDF is available here.
Abstract
We describe two modular protocols for immunostaining and multiparameter flow cytometric analysis of major human antigen-presenting cells (APCs; e.g., dendritic cells, monocytes and B lymphocytes) in minimally manipulated whole blood samples. Simultaneous detection of up to eight colors is enabled by...
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PMID: 20134434
PDF is available here.
PDF is available here.
Abstract
We propose that an exacerbated TH1 immune response is a likely cause of pathological damage observed in cardiac tissue and the primary cause of death in Qro-infected mice....
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PMID: 20396398
PDF is available here.
PDF is available here.
Abstract
Humoral immunity is the branch of the immune system maintained by B cells and mediated through the secretion of antibodies. Upon B cell activation, the immunoglobulin locus undergoes a series of genetic modifications to alter the binding capacity and effector function of secreted antibodies. This pr...
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PMID: 20736917
PDF is available here.
PDF is available here.
Molecular Vision (16) 2010
Abstract
These results suggest that the absence of T(H)1 cytokine responses did alter protection against viral replication and IgG isotypes but not eye disease or survival....
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PMID: 20104254
PDF is available here.
PDF is available here.
Abstract
We examined whether monoclonal gammopathy of undetermined significance (MGUS) is increased in first-degree relatives of multiple myeloma (MM) or MGUS patients. Probands were recruited from a population-based prevalence study (MGUS) and the Mayo Clinic (MM). Serum samples were collected from first-de...
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PMID: 19179466
PDF is available here.
PDF is available here.
Mikrobiyoloji bulteni (43)3 2009
Abstract
The relation between the duration of human fasciolosis and development of humoral immune response has not yet been clarified. This study was conducted to investigate the relation between different immunoglobulin isotypes and the period of disease in fasciolosis patients and also to evaluate the diag...
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PMID: 19795623
PDF is available here.
PDF is available here.
Abstract
We detail our immunization protocol in order to raise a humoral IgNAR response in the nurse shark (Ginglymostoma cirratum) and the subsequent cloning of the single-domain V regions from this isotype in order to select antigen-specific binders by phage display....
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PMID: 19554288
PDF is available here.
PDF is available here.
Abstract
We assessed the activity of IL-21 along with TGF-beta1 in Ig synthesis by murine spleen B cells. IL-21 showed antiproliferative activity on LPS-activated splenic B cells, comparable with that of TGF-beta1. IL-21 alone had little effect on IgA secretion and decreased other isotypes. Likewise, IL-21 a...
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PMID: 19168593
PDF is available here.
PDF is available here.
Abstract
Peyer's patches (PP) are lymphoid follicles of the small intestine containing predominantly IgA(+) B cells. In this JLB issue, IL-21 is reported to dampen TGF-beta1-induced IgG2b but not IgA production by mouse B cells, possibly explaining why IgA(+) B cells predominate in PP.
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PMID: 19406834
PDF is available here.
PDF is available here.
Abstract
Autoimmunity (42)3 2009
Abstract
Anti nuclear (ANA) immunomorphological patterns such as multiple nuclear dots (MND) and rim-like/membranous (RL/M) are considered highly specific but little sensitive for primary biliary cirrhosis (PBC) diagnosis. To evaluate frequency and clinical significance of MND and RL/M in PBC patients when i...
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PMID: 19301204
PDF is available here.
PDF is available here.
Autoimmunity (42)3 2009
Abstract
We explored the role of interleukin-6 (IL-6) in the development of autoimmune thyroiditis in nonobese diabetic (NOD) mice, an animal model of Hashimoto's thyroiditis, using anti-mouse IL-6 receptor antibody (MR16-1). Thyroiditis was induced by iodide ingestion or mouse thyroglobulin (Tg) immunizatio...
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PMID: 19301205
PDF is available here.
PDF is available here.
Medicina: Buenos Aires (69)5 2009
Abstract
We examined the sera of 100 patients with different CTD by IIF-HEp2 and detected a prevalence of 38% IgA-ANA (titles > or = 1:80) and 12% IgM-ANA (titles < or = 1:160). In twenty nine cases we detected IgA-ANA in absence of IgM-ANA, and in 3 cases IgM-ANA in absence of IgA-ANA. In all the cases IgG-...
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PMID: 19897433
PDF is available here.
PDF is available here.
Journal of Immunology (182)1 2009
Abstract
We inactivated murine Blm specifically in B lymphocytes in vivo. Numbers of developing B lymphoid cells in the bone marrow and mature B cells in the periphery were drastically reduced upon Blm inactivation. Of the major peripheral B cell subsets, B1a cells were most prominently affected. In the sera...
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PMID: 19109166
PDF is available here.
PDF is available here.
Clinical Immunology (129)3 2008
Abstract
We present here clinical, immunological, and molecular findings of four patients with CD40 ligand deficiency associated with neuroendocrine carcinoma (NEC). NEC developed as a rapidly disseminated solid cancer leading to death in three patients. Data presented here and published previously suggest t...
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PMID: 18805740
PDF is available here.
PDF is available here.
International Immunology (20)11 2008
Abstract
We examine single-strand breaks (SSBs) using LMPCR and report, surprisingly, that CSR-related anti-sense strand breaks in Sgamma regions are dependent only on UNG, and not AID, suggesting participation of a cytosine deaminase other than AID. This conclusion is supported by the sequences at these DNA...
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PMID: 18794203
PDF is available here.
PDF is available here.
Abstract
We present mouse strain KN1 that expresses a chimeric epsilon-gamma1 BCR, consisting of the extracellular domains of the epsilon gene and the transmembrane and cytoplasmic domains of the gamma1 gene. Thus, differences in the IgE immune response of KN1 mice reflect the influence of the "gamma1-mediat...
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PMID: 18925577
PDF is available here.
PDF is available here.
Abstract
We targeted ovalbumin (OVA) to B cells via CD19 and found that a single low dose of anti-CD19-OVA conjugates, but not isotype mAb-OVA, stimulated augmented CD4 and CD8 T-cell proliferation and expansion. Administration of TLR9 agonist CpG could significantly enhance long-term T-cell survival. Simila...
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PMID: 18669871
PDF is available here.
PDF is available here.
Abstract
We demonstrate that IL-6 impaired in vitro the antigenic- but not the mitogenic-induced proliferation of lymphocytes from control pigs vaccinated with ovalbumin. These results indicate that AFB1 dietary exposure decreases cell-mediated immunity while inducing an inflammatory response. These impairme...
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PMID: 18501398
PDF is available here.
PDF is available here.
Abstract
Abstract
The intercellular adhesion molecule is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. Serum and cerebrospinal fluid (CSF) soluble intercellular adhesion molecule 1 (sICAM-1) from normal control children as well as from children with Guillain-Barré syndrome (GBS), with C...
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PMID: 18813709
PDF is available here.
PDF is available here.
Viral Immunology (21)3 2008
Abstract
We previously reported that the majority of patients infected with HCV have significant levels of IgG specific to an HCV-derived peptide at positions 35-44 of core protein (C35-44), a major epitope recognized by cellular immunity. This study addresses whether or not the other subclasses of immunoglo...
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PMID: 18788944
PDF is available here.
PDF is available here.
Zhonghua Yixue Zazhi (88)30 2008
Abstract
The proportions of each kind of MM including IgG, IgA, light chain, IgD, IgM and biclonal MM were 48.0%, 20.6%, 25.6%, 4.0%, 0.9% and 0.9% respectively. No IgE and nonsecretory myeloma was found. The median age of onset was 58 years, of which that of the IgA type was the oldest one and the light cha...
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PMID: 19080477
PDF is available here.
PDF is available here.
Zhen ci yan jiu = Acupuncture research / [Zhongguo yi xue ke xue yuan Yi xue qing bao yan jiu suo bian ji] (33)4 2008
Abstract
In comparison with normal control group, serum IgG, IgM, IgA, C3, C4 and CD8+ contents, and CD4+/CD8+ in model group decreased significantly (P < 0.05, 0.01); while CD8+ content in model group increased remarkably (P < 0.01). Compared with model group, serum IgG, IgM, IgA, C3, C4, CD4+, CD8+ and CD4...
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PMID: 18928116
PDF is available here.
PDF is available here.
Abstract
The European Common Variable Immunodeficiency Disorders registry was started in 1996 to define distinct clinical phenotypes and determine overlap within individual patients. A total of 7 centers contributed patient data, resulting in the largest cohort yet reported. Patients (334), validated for the...
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PMID: 18319398
PDF is available here.
PDF is available here.
Abstract
Infection and Immunity (76)7 2008
Abstract
We constructed a series of plasmid expression vectors, each containing a different type II signal sequence. We evaluated the utilities of these vectors by fusing two different antigens, the alpha-helix domains of pneumococcal surface protein A (PspA) and pneumococcal surface protein C (PspC), to the...
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PMID: 18458067
PDF is available here.
PDF is available here.
Laboratory Animals (42)3 2008
Abstract
We characterized the time course of MN in a murine MN model induced by cationic bovine serum albumin (cBSA). Preimmunized mice received cBSA intravenously for six weeks to induce MN and were then sacrificed at different times. Metabolic profiles, renal histopathology, lymphocyte subsets, serum anti-...
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PMID: 18625590
PDF is available here.
PDF is available here.
Journal of Immunology (180)12 2008
Abstract
We addressed the T cell dependency of the TGF-beta1 control of B cells. The analysis of T cell-deficient, TGF-beta1 knockout mice and the production of chimeras in which B but not T cells lacked TGF-beta1 allowed us to show that B cells are controlled in part by cell autonomous production of TGF-bet...
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PMID: 18523280
PDF is available here.
PDF is available here.
Abstract
We concluded that Brazilian individuals chronically infected with hepatitis C virus present a significant production of antiphospholipid antibodies, mainly IgA anti-ss2-glycoprotein I antibodies, which are not associated with clinical manifestations of antiphospholipid syndrome....
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PMID: 18560670
PDF is available here.
PDF is available here.
Abstract
We used a hybridoma technique to develop a TAPIR-like anti-human amyloid-beta (Abeta) mouse monoclonal antibody. The obtained monoclonal antibody, 3.4A10, was an IgG2b isotype and recognized N-terminal portion of Abeta1-42 without binding denatured or native amyloid-beta protein precursor. It had hi...
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PMID: 18560128
PDF is available here.
PDF is available here.
Abstract
We are to take optimal advantage of the current mAbs and develop more effective mAbs in the future....
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PMID: 18476787
PDF is available here.
PDF is available here.
Abstract
Molecular Immunology (45)11 2008
Abstract
Three immunoglobulin light chain (IgL) isotypes TrbeL1, TrbeL2, and TrbeL3 were identified in the Antarctic teleost Trematomus bernacchii by immunoscreening a cDNA expression library, and using RT-PCR, and 5' RACE. One of them was distinguished in two subisotypes TrbeL1A and TrbeL1B. Real-time PCR e...
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PMID: 18455799
PDF is available here.
PDF is available here.
Cancer Research (68)10 2008
Abstract
We have previously reported that fucose removal from Fc-linked oligosaccharides greatly enhances antibody-dependent cellular cytotoxicity (ADCC) of therapeutic antibodies. Here, we report a unique approach to enhance complement-dependent cytotoxicity (CDC), another important effector function of ant...
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PMID: 18483271
PDF is available here.
PDF is available here.
International Immunology (20)5 2008
Abstract
Alum is used as a vaccine adjuvant and induces T(h)2 responses and T(h)2-driven antibody isotype production against co-injected antigens. Alum also promotes the appearance in the spleen of Gr1+IL-4+ innate cells that, via IL-4 production, induce MHC II-mediated signaling in B cells. To investigate w...
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PMID: 18343889
PDF is available here.
PDF is available here.
Journal of Immunology (180)8 2008
Abstract
We investigated this notion in mice that possess genetics permissible for the development of autoimmunity. To this end, Mrl-MpJ Fcgr2b-/- mice were monitored for the development of autoreactivity. We found that FcgammaRIIB deficiency led to chronic B cell activation associated with increased germina...
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PMID: 18390752
PDF is available here.
PDF is available here.
Abstract
Environmental impacts on autoimmunity have significant public health implications. Epidemiological studies have shown associations between exposure to airborne silicates, such as crystalline silica or asbestos, and autoimmunity, but the etiology remains unclear. The purpose of this study was to test...
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PMID: 18569382
PDF is available here.
PDF is available here.
Abstract
After 5.5 months, rBet v1 and rMal dl specific IgA levels had increased from baseline in the LGG compared with the placebo group (delta rBet v1 IgA, 0.319 vs. -0.136 relative units; P = .02; delta rMal d1 IgA, 0.097 vs -0.117, P = .02). rBet v1 specific IgE serum levels did not differ between the gr...
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PMID: 18450119
PDF is available here.
PDF is available here.
Abstract
We studied 69 patients with acute myeloid leukemia, chronic myeloid leukemia and myelodysplastic syndrome, including 19 patients who received GM-CSF with peptide antigen and incomplete Freund's adjuvant in a vaccine trial for the presence or induction of anti-GM-CSF antibodies. Anti-GM-CSF IgG were...
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PMID: 18216869
PDF is available here.
PDF is available here.
Journal of Immunology (180)6 2008
Abstract
We have generated a congenic strain that contains the suppressor allele from the BALB/c chromosome 12 centromeric region (sbb2(a)) in an otherwise B6.FcgammaR2B(-/-) background. None of the B6.FcgammaR2B(-/-)sbb2(a/a) mice tested have developed IgG autoantibodies in the serum or autoimmune pathology...
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PMID: 18322187
PDF is available here.
PDF is available here.
Journal of Immunology (180)6 2008
Abstract
We find that B cells with pre-existing autoreactivity are especially subject to L chain inclusion. Specifically, we show that isotypic and allelic inclusion enables autoreactive B cells to bypass central tolerance giving rise to B cells that retain dangerous features. One receptor in dual receptor B...
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PMID: 18322176
PDF is available here.
PDF is available here.
Abstract
FSH is required for spontaneous folliculogenesis and is widely used in ovarian stimulation in IVF. Previously, increased concentrations of antibodies against FSH (anti-FSH) have been demonstrated in infertile women. This study aimed to: (i) assess the possible association of anti-FSH with an adverse...
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PMID: 18339255
PDF is available here.
PDF is available here.
Journal of Immunology (180)5 2008
Abstract
NOD mice deficient for B lymphocytes from birth fail to develop autoimmune or type 1 diabetes. To assess whether B cell depletion influences type 1 diabetes in mice with an intact immune system, NOD female mice representing early and late preclinical stages of disease were treated with mouse anti-mo...
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PMID: 18292508
PDF is available here.
PDF is available here.
Abstract
We also found that the uptake of monomeric hIgA was much more efficient than that of polymeric hIgA. These results suggest that the retention of the monomeric form contributes to the efficient transport of Igs into ovarian follicles. On the other hand, Ig uptakes among monomeric Igs nevertheless dif...
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PMID: 18031828
PDF is available here.
PDF is available here.
Journal of Immunology (180)4 2008
Abstract
We show in this study that B cells with identical hydrophobic HCDR3s are expressed with all major isotypes in PRRSV-infected piglets (PIPs), explaining why PRRSV-induced hypergammaglobulinemia is seen in all major isotypes. Up to one-third of randomly selected VDJ clones from the respiratory tract o...
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PMID: 18250444
PDF is available here.
PDF is available here.
Abstract
There is longstanding evidence that immunoglobulin G (IgG) has a role in protection against clinical malaria, and human antibodies of the cytophilic subclasses are thought to be particularly critical in this respect. In this cohort study, 286 Burkinabè children 6 months to 15 years old were kept un...
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PMID: 18070896
PDF is available here.
PDF is available here.
Trends in Immunology (29)2 2008
Abstract
A central dogma in immunology is that antibody specificity is solely the result of variable (V)-region interactions with an antigen. However, this view is not tenable in light of numerous reports that constant heavy (C(H)) domains can affect binding affinity and specificity and V-region structure. K...
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PMID: 18191616
PDF is available here.
PDF is available here.
Abstract
The objective of this research was to identify maternal and fetal characteristics as prognostic markers of congenital cytomegalovirus (CMV) infection. This is a descriptive study of 13 cases of congenital CMV infection referred to Institute de Puericulture et Perinatologie de Paris (IPP) from Januar...
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PMID: 18553012
PDF is available here.
PDF is available here.
Abstract
Journal of Immunology (180)3 2008
Abstract
We used wild-type (WT) or DM-deficient (DM(-/-)) mice of the H-2(d) MHC haplotype and tested the hypothesis that DM promotes narrowing of the repertoire of class II:peptide complexes displayed by APC, leading to a correspondingly selective CD4 T cell response. Surprisingly, our results indicated tha...
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PMID: 18209058
PDF is available here.
PDF is available here.