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Antibodies (32):
- Immune Sera
- Autoantibodies
- Antibodies, Phospho-Specific
- Immunoglobulin Allotypes
- Antibodies, Viral
- Antibodies, Heterophile
- Antibodies, Archaeal
- Antibodies, Anti-Idiotypic
- Opsonin Proteins
- Immunoglobulins, Thyroid-Stimulating
- Antibodies, Protozoan
- Antibodies, Immobilized
- Insulin Antibodies
- Immunoconjugates
- Antibodies, Neoplasm
- Antibodies, Monoclonal
- Antibodies, Helminth
- Antibodies, Fungal
- Antibodies, Catalytic
- Oligoclonal Bands
- Immunoglobulin Isotypes
- Binding Sites, Antibody
- Plantibodies
- Isoantibodies
- Reagins
- Precipitins
- Antitoxins
- Antibodies, Blocking
- Antigen-Antibody Complex
- Immunoglobulins, Intravenous
- Antibodies, Bacterial
- Antibodies, Bispecific
Recent article
Antibodies
Poultry Science (90)9 2011
Abstract
Natural antibodies (NA) create a crucial barrier at the initial steps of the innate humoral immune response. The main role of NA in the defense system is to bind the pathogens at early stages of infection. Different pathogens are recognized by the presence of highly conserved antigen determinant [e.g...
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PMID: 21844254
PDF is available here.
PDF is available here.
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Abstract
We estimated the effective propagation number, which reflects the relative importance of contrasting within-host control mechanisms through time and is sensitive to the inoculating parasite dose. Our analysis showed that the capacity of innate responses to restrict initial parasite growth saturates...
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PMID: 21852493
PDF is available here.
PDF is available here.
Abstract
The authors reported 2 cases of Hashimoto's ophthalmopathy. These cases presented with no preceding illness; euthyroid state; acute presentation of painful or painless ophthalmoplegia, preferentially affecting the lateral rectus muscles; positive antithyroglobulin/antithyroid peroxid...
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PMID: 21701269
PDF is available here.
PDF is available here.
Abstract
These results suggested that both CXCR7 and CXCR4 are important for EPCs in response to SDF-1, indicating that CXCR7 may be another potential target molecule for angiogenesis-dependent diseases.
2011....
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PMID: 21418513
PDF is available here.
PDF is available here.
Abstract
Since the discovery of endothelial progenitor cells in 1997, the scientific world has seen their ups and downs. There has been much discussion about the detection methods of endothelial progenitor cells and their diagnostic and predictive value. A lack of standardized methods to define endothelial pr...
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PMID: 21605723
PDF is available here.
PDF is available here.
Abstract
We used single-cell "mass cytometry" to examine healthy human bone marrow, measuring 34 parameters simultaneously in single cells (binding of 31 antibodies, viability, DNA content, and relative cell size). The signaling behavior of cell subsets spanning a defined hematopoietic hierarchy was monitore...
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PMID: 21551058
PDF is available here.
PDF is available here.
Abstract
The present research focused on the development of an immunoassay and an immunochemical sol-gel-based immunoaffinity purification (IAP) method for purification and detection of the non-steroid anti-inflammatory drug (NSAID) indomethacin (IMT). A polyclonal antibody (Ab) for IMT was g...
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PMID: 21537913
PDF is available here.
PDF is available here.
Xenobiotica (41)5 2011
Abstract
We describe a targeted approach for affinity improvement of therapeutic antibodies. Sets of CDR residues that are solvent accessible and relatively diverse in natural antibodies are targeted for diversification. Degenerate oligonucleotides are used to generate combinatorial phage-displayed antibody...
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PMID: 19252851
PDF is available here.
PDF is available here.
Xenobiotica (41)5 2011
Abstract
Immunoprecipitation (IP) uses the specificity of antibodies to isolate target proteins (antigens) out of complex sample mixtures. Three different approaches for performing IP will be discussed; traditional (classical) method, oriented affinity method and direct affinity method. The traditional metho...
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PMID: 18369874
PDF is available here.
PDF is available here.
Xenobiotica (41)5 2011
Abstract
Conjugates of antibodies with cytotoxic agents offer a targeted therapeutic strategy against cancer cells expressing target antigens. Several antibodies against various cancer cell-surface antigens have been conjugated with different cytotoxic agents that inhibit essential cellular targets such as m...
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PMID: 19252846
PDF is available here.
PDF is available here.
Xenobiotica (41)5 2011
Abstract
We describe a detailed method for establishing synergy between two treatments in vivo. We utilized this method to establish that antibodies targeting the epidermal growth factor receptor and vascular endothelial growth factor receptor-2 are synergistic with regard to antitumor effects, in a BxPC-3 s...
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PMID: 19252838
PDF is available here.
PDF is available here.
Xenobiotica (41)5 2011
Abstract
We have adapted the commercially available enzyme fragment complementation technology to provide a rapid protein detection method for protein blots based on significantly reducing the number of incubation and washing steps used in traditional approaches, and eliminating the requirement for antibodie...
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PMID: 19378077
PDF is available here.
PDF is available here.
Xenobiotica (41)5 2011
Abstract
Immunoglobulins are a heterogeneous group of proteins. It naturally follows that the strategies for purifying them are diverse and numerous. A good knowledge of their respective physiochemical properties will obviously make the task easier. The choice between using polyclonal and/or monoclonal antib...
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PMID: 18612609
PDF is available here.
PDF is available here.
Transplantation (91)8 2011
Abstract
We studied early transcriptional changes of inflammatory mediators in the grafts during combined auxiliary liver-kidney transplantation using microarrays and real-time polymerase chain reaction. The results were correlated to clinical data.
Liver and kidney grafts both exhibited an u...
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PMID: 21494202
PDF is available here.
PDF is available here.
Abstract
More than 90% of venous malformations (VM) are associated with pain, which is presumed related to phlebolith formation and subsequent nociceptive mediator release. Increasing evidence supports a link between angiogenesis and nerve patterning. Since vascular malformations are aberrati...
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PMID: 20705529
PDF is available here.
PDF is available here.
Abstract
The effect of Helicobacter pylori treatment on the potential reversal of atrophic body gastritis (ABG) is controversial. Body atrophy reversal was evaluated in a cohort of H. pylori-negative and treated H. pylori-positive ABG patients.
Observational long-term follow-u...
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PMID: 21112822
PDF is available here.
PDF is available here.
Journal of Immunotherapy (34)3 2011
Abstract
We investigated the effects of murine Trop2 (mTrop2) VLP immunization in a pancreatic cancer syngeneic murine model. VLPs incorporating mTrop2 were used to immunize C57BL/6 tumor-bearing mice. Immunization with mTrop2 VLPs led to a significant reduction in tumor growth accompanied by a broad activat...
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PMID: 21389873
PDF is available here.
PDF is available here.
Abstract
We will focus on the system level or global analysis of biological systems using protein microarrays. Four major types of protein microarrays will be discussed: proteome microarrays, antibody microarrays, reverse-phase protein arrays, and lectin microarrays. We will also discuss the challenges and f...
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PMID: 21257623
PDF is available here.
PDF is available here.
Immunotherapy (3)2 2011
Abstract
Advances in biomolecular technology have allowed the development of genetically fused antibody-enzymes. Antibody-enzyme fusion proteins have been used to target tumors for cancer therapy in two ways. In one system, an antibody-enzyme is pretargeted to the tumor followed by administra...
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PMID: 21322759
PDF is available here.
PDF is available here.
Epigenetics (6)1 2011
Abstract
We compared two commonly used approaches to enrich for methylated DNA regions of the genome, namely methyl-DNA immunoprecipitation (MeDIP) that is based on enrichment with antibodies specific for 5'-methylcytosine (5MeC), and capture of methylated DNA using a methyl-CpG binding domain-based (MBD) pr...
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PMID: 20818161
PDF is available here.
PDF is available here.
Epigenetics (6)1 2011
Abstract
We compared two commonly used approaches to enrich for methylated DNA regions of the genome, namely methyl-DNA immunoprecipitation (MeDIP) that is based on enrichment with antibodies specific for 5'-methylcytosine (5MeC), and capture of methylated DNA using a methyl-CpG binding domain-based (MBD) pr...
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PMID: 20818161
PDF is available here.
PDF is available here.
Abstract
We continue to characterize the AmOA1 receptor by investigating its distribution in the honey bee brain. We used two independent antibodies produced against two distinct peptides in the carboxyl-terminus to study the distribution of the AmOA1 receptor in the honey bee brain. We found that both anti-...
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PMID: 21267078
PDF is available here.
PDF is available here.
Abstract
We discuss ways whereby we sought to treat myocardial infarctions using extracellular-matrix derived peptides. Using an ischemia/reperfusion myocardial infarction rodent model, we targeted these extracellular matrix-derived peptides to the myocardial infarct site and were able to induce angiogenesis...
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PMID: 21048428
PDF is available here.
PDF is available here.
Abstract
The 21st Annual Antibody Engineering and 8th Annual Antibody Therapeutics international conferences, and the 2010 Annual Meeting of The Antibody Society, organized by IBC Life Sciences with contributions from The Antibody Society and two Scientific Advisory Boards, were held December...
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PMID: 21304271
PDF is available here.
PDF is available here.
Abstract
We present the method for developing a custom CHO-HCP AMMP assay for bioprocess development. Developing AMMP assays or modifying existing assays into AMMP assays can provide better performance (reproducibility, sensitivity) in complex samples and reduced operator time. The protocol shows the steps f...
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PMID: 21339717
PDF is available here.
PDF is available here.
Cytometry Part B (80)4 2011
Abstract
We set to analyze more leukemia cases and establish an algorithm for the efficient diagnosis of acute leukemia.
We retrospectively analyzed 127 consecutive cases of acute leukemia within the last 2 years and correlated the blast distribution patterns in the CD45/SSC panel, with the m...
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PMID: 21298777
PDF is available here.
PDF is available here.
Abstract
A growing number of research consortia are now focused on generating antibodies and recombinant antibody fragments that target the human proteome. A particularly valuable application for these binding molecules would be their use inside a living cell, e.g., for imaging or functional...
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PMID: 21099369
PDF is available here.
PDF is available here.
Abstract
Ginkgo biloba leaf extract (Gb) has been known to improve blood flow and preclude the tissue from free radical damage. Effects of Gb were examined by using Ki67, a specific proliferative marker for cellular proliferation, and doublecortin (DCX), a marker for immature neurons, indicating degree of neu...
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PMID: 20814173
PDF is available here.
PDF is available here.
Abstract
Affinity chromatography permits the isolation of a target analyte from a complex mixture and can be utilised to purify proteins, carbohydrates, drugs, haptens, or any analyte of interest once an affinity pair is available. It involves the exploitation of specific interactions between a binding affin...
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PMID: 20978976
PDF is available here.
PDF is available here.
Abstract
Immunohistochemical techniques detect antigens in tissue sections by means of immunological and chemical reactions. This technique is highly sensitive and specific and can detect a wide variety of antigens in multiple animal species. This chapter reviews common immunohistochemical methods used in th...
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PMID: 20972748
PDF is available here.
PDF is available here.
Abstract
Redox-dependent thylakoid protein phosphorylation regulates both the short- and long-term acclimation of the photosynthetic apparatus to changes in environmental conditions. The major thylakoid phosphoproteins belong to photosystem II (D1, D2, CP43, PsbH) and its light-harvesting antenna (Lhcb1, Lhc...
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PMID: 20960130
PDF is available here.
PDF is available here.
Abstract
We discuss the inherent limitations of classical polyclonal and monoclonal antibody generation and highlight an attractive alternative: generating high specificity, high affinity recombinant antibodies from alternative immune sources such as chickens, via phage display....
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PMID: 20978962
PDF is available here.
PDF is available here.
Molecular BioSystems (6)12 2010
Abstract
We approached this subject in a syngeneic mouse model of ovarian cancer. Antibody microarrays were applied to obtain the proteomic profiles of IF5 and IG10, two spontaneously transformed mouse ovarian surface epithelial (MOSE) cell lines of cognate clonal origin but different tumorigenic behavior in...
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PMID: 20938528
PDF is available here.
PDF is available here.
Abstract
We established in the present study a novel mouse model of passive IgG-mediated systemic anaphylaxis to a native protein antigen, ovalbumin (OVA), rather than artificially haptenated protein antigens used in previous studies. Passive sensitization of mice with a cocktail of but not individual IgG1 m...
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PMID: 21029722
PDF is available here.
PDF is available here.
Abstract
This paper describes some of the early work on pyrethroid insecticides in the Casida laboratory and briefly reviews the development and application of immunochemical approaches for the detection of pyrethroid insecticides and their metabolites for monitoring environmental and human exposure. Multiple...
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PMID: 21105656
PDF is available here.
PDF is available here.
Abstract
We have previously reported that gicerin plays an important role in the development and regeneration as well as in the metastasis of tumors through its adhesive activities, mediating cell-cell and/or cell-extracellular matrix interactions. In this study, we investigated the involvement of gicerin in...
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PMID: 20878087
PDF is available here.
PDF is available here.
Abstract
We are developing a specific antibody filter (SAF) device to selectively remove ABO blood group antibodies from the whole blood by utilizing immunoaffinity adsorption. The device consists of ultrafiltration hollow fiber membranes with synthetic antigens specific to bind blood group antibodies immobi...
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PMID: 20878917
PDF is available here.
PDF is available here.
Proteomics (10)22 2010
Abstract
We discuss methodologies for systematic subcellular profiling with emphasis on the antibody-based approach performed as a part of the Human Protein Atlas project. The considerations made when creating the subcellular protein atlas and critical parameters of this approach are discussed....
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PMID: 20648481
PDF is available here.
PDF is available here.
Nature Biotechnology (28)11 2010
Abstract
We apply the latter strategy to antibody discovery, using a library of ∼10,000 human germline antibody Fabs created by de novo DNA synthesis and automated protein expression and purification. In multiplexed screening assays, we obtained specific hits against seven of nine antigens. Using sequence-...
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PMID: 20972421
PDF is available here.
PDF is available here.
Abstract
As human leukocyte (HLA) antigen and antibody testing has evolved, typing, screening, and crossmatching assays have become exquisitely specific and sensitive. How best to use this information is a focal point of the transplant community and of this review.
Driven by advances in technology, two major...
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PMID: 20720491
PDF is available here.
PDF is available here.
Abstract
To study the protective effect of bone marrow stromal cells (BMSCs) upon childhood leukemia cells and the influence of VLA-4 antibody in vitro on leukemia cell apoptosis.
BMSCs from children with acute leukemia-were isolated by human lymphocyte separation medium. BMSCs (adherent) and leukemia cells...
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PMID: 21083987
PDF is available here.
PDF is available here.
Abstract
Arerugi = [Allergy] (59)11 2010
Abstract
We have evaluated the prognosis of milk allergy and the related factors.
Patients with milk allergy (n=60) who had initially visited our hospital before 2 years old were recruited for the chart review. The ability of milk intake (> 30 ml) at the age of 5 years and the related clinical factors were e...
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PMID: 21119302
PDF is available here.
PDF is available here.
Biochemical Journal (432)1 2010
Abstract
Of the four human IgG antibody subclasses IgG1-IgG4, IgG4 is of interest in that it does not activate complement and exhibits atypical self-association, including the formation of bispecific antibodies. The solution structures of antibodies are critical to understand function and therapeutic applica...
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PMID: 20722630
PDF is available here.
PDF is available here.
Abstract
We examined whether the nonobese diabetic/severe combined immunodeficient (NOD/scid) mouse, which lacks xenoantibodies and therefore allows infused human platelets to circulate, can be used to study drug-dependent clearance of platelets by DDAbs in vivo. In this report, we show that the NOD/scid mod...
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PMID: 20587782
PDF is available here.
PDF is available here.
New England Journal of Medicine (363)15 2010
Abstract
Clinical Immunology (137)1 2010
Abstract
Abstract
We evaluated the effects of top 7/top 14 immunodepletion on the shotgun proteomic analysis of human plasma. Our goal was to evaluate the impact of immunodepletion on detection of proteins across detectable ranges of abundance. The depletion columns afforded highly repeatable and efficient plasma pro...
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PMID: 20677825
PDF is available here.
PDF is available here.
Oligonucleotides (20)5 2010
Abstract
Abstract
We discuss some of the great opportunities that molecular diagnostic tools have to offer both basic scientists and translational researchers for bench-to-bedside clinical application in transplantation medicine, with special focus on genomics and genome-wide association studies, epigenetics (DNA met...
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PMID: 20736923
PDF is available here.
PDF is available here.
Abstract
We investigated the efficacy and safety of AIN457, a human antibody to IL-17A, in patients with psoriasis, rheumatoid arthritis, and chronic noninfectious uveitis. Patients with chronic plaque-type psoriasis (n = 36), rheumatoid arthritis (n = 52), or chronic noninfectious uveitis (n = 16) were enro...
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PMID: 20926833
PDF is available here.
PDF is available here.
Annals of Medicine (42)7 2010
Abstract
We analyzed 3,511 subjects with matched samples from 1974 (CLUE I) and 1989 (CLUE II). To avoid a selection bias regarding survival, we also screened 840 CLUE I participants who deceased after the 1974 survey. Outcome measure. CD autoimmunity (positivity to auto-antibodies) over time.
CD autoimmunit...
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PMID: 20868314
PDF is available here.
PDF is available here.
Journal of Gastroenterology (45)10 2010
Abstract
We investigated the associations between the stage of PBC and the immune reaction triggered by oxidative stress; the presence of obesity, steatosis,steatohepatitis; and other toxic, metabolic, or steatogenic factors.
We studied clinical, laboratory, and histological data for 274 untreated patients w...
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PMID: 20393861
PDF is available here.
PDF is available here.
Abstract
Abstract
The DSA strength correlates well with crossmatch results. An MFI of 6540 predicted a positive antihuman globulin T-cell crossmatch....
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PMID: 20923311
PDF is available here.
PDF is available here.
Abstract
This paper reports on an inkjet printing method for the fabrication of lateral flow immunochromatographic devices made from a single piece of filter paper by patterning microfluidic channels and dispensing immunosensing inks, requiring only a single printing apparatus. This "paperfluidic" immunosens...
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PMID: 20652543
PDF is available here.
PDF is available here.
Abstract
A new detection format for multiplexed analysis based on fluorescent encoded magnetic composite nanoparticles is presented. Two kinds of virus were analyzed by this new method: equine influenza virus (EIV) and equine infectious anemia virus (EIAV). Firstly, EIV antigen and EIAV antigen were conjugat...
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PMID: 20652548
PDF is available here.
PDF is available here.
Abstract
We describe the combined use of new agents (bortezomib and eculizumab) and modalities (nontraditional vascular access, splanchnic drainage of graft and domino paired donation) in a patient who would have died without transplantation.
© 2010 The Authors Journal compilation © 2010 The American Socie...
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PMID: 20636451
PDF is available here.
PDF is available here.
Abstract
We have now examined the role of GPx1 in the activation, differentiation, and functions of CD4(+) T helper (Th) cells. TCR stimulation increased the intracellular ROS concentration in Th cells in a time-dependent manner, and such TCR-induced ROS generation was found to promote cell proliferation. GP...
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PMID: 20367278
PDF is available here.
PDF is available here.
Thrombosis and Haemostasis (104)3 2010
Abstract
Our study shows that integrins are dispensable for migration on 2D and in 3D fibrin matrices, both when neutrophils enter into the fibrin matrix and when captured in the matrix....
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PMID: 20589324
PDF is available here.
PDF is available here.