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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Carrier Proteins (33):
- Ceruloplasmin
- Phosphatidylethanolamine Binding Protein
- Periplasmic Binding Proteins
- Fatty Acid-Binding Proteins
- RNA-Binding Proteins
- Phosphate-Binding Proteins
- Lymphocyte Antigen 96
- Phospholipid Transfer Proteins
- Latent TGF-beta Binding Proteins
- Iron-Binding Proteins
- Neurophysins
- Transcobalamins
- Retinol-Binding Proteins
- Vitamin D-Binding Protein
- Membrane Transport Proteins
- Follistatin
- Cholesterol Ester Transfer Proteins
- Calmodulin-Binding Proteins
- Transferrin-Binding Proteins
- S-Phase Kinase-Associated Proteins
- Light-Harvesting Protein Complexes
- Follistatin-Related Proteins
- Androgen-Binding Protein
- Transcortin
- Thyroxine-Binding Proteins
- Calcium-Binding Proteins
- Acyl Carrier Protein
- Sex Hormone-Binding Globulin
- F-Box Proteins
- Lipocalins
- Insulin-Like Growth Factor Binding Proteins
- GTP-Binding Proteins
- Adaptor Proteins, Signal Transducing
Recent article
Carrier Proteins
Abstract
To evaluate the effect of human amniotic fluid (HAF) on retinal pigmented epithelial cells growth and trans-differentiation into retinal neurons, retinal pigmented epithelium (RPE) cells were isolated from neonatal human cadaver eye globes and cultured in Dulbecco's modified Eagle's...
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PMID: 21142973
PDF is available here.
PDF is available here.
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Molecular features of colorectal hyperplastic polyps and sessile serrated adenoma/polyps from Korea.
Abstract
We conclude that HPs and SSA/Ps in Korean patients share some, but not all, clinical and molecular characteristics to those that occur in Americans. The data support the theory that the right and left colon are biologically different with regard to susceptibility to serrated cancer, and that anatomi...
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PMID: 21836485
PDF is available here.
PDF is available here.
Abstract
We show that the proliferating cell nuclear antigen-associated factor (Paf) is highly expressed in cycling bone marrow HSCs and plays a critical role in hematopoiesis. Mice lacking Paf exhibited reduced bone marrow cellularity; reduced numbers of HSCs and committed progenitors; and leukopenia. These...
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PMID: 21844206
PDF is available here.
PDF is available here.
Journal of Neuroscience (31)33 2011
Abstract
We use the mouse olfactory system as an in vivo model to demonstrate that by modulating Fas-associated factor 1 (FAF1), an apoptosis regulatory molecule, we can rewire axonal projections. Interestingly, FAF1 is highly expressed in the developing mouse olfactory system, but its expression is downregu...
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PMID: 21849551
PDF is available here.
PDF is available here.
Journal of Cell Science (124)Pt 16 2011
Abstract
We provide novel insights into the roles of the CB2 splice variants, CB2(SH3+) and CB2(SH3-), and their substrate, Cdc42, in regulating gephyrin clustering at GABAergic synapses. Transfection of Myc-tagged CB2(SH3+) and CB2(SH3-) into cultured neurons revealed strong, but distinct, effects promoting...
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PMID: 21807943
PDF is available here.
PDF is available here.
Journal of Cell Biology (194)3 2011
Abstract
We report that mitochondria lacking the mitochondrial import protein 1 (Mim1) are impaired in the biogenesis of multispanning outer membrane proteins, whereas overexpression of Mim1 stimulates their import. The Mim1 complex cooperates with the receptor Tom70 in binding of precursor proteins and prom...
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PMID: 21825073
PDF is available here.
PDF is available here.
Journal of Cell Biology (194)3 2011
Abstract
We address this issue using yeast mitochondria and the multispan protein Ugo1. Using a specific insertion assay and analysis by native gel electrophoresis, we show that the import receptor Tom70, but not its partner Tom20, is involved in the initial recognition of the Ugo1 precursor. Surprisingly, t...
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PMID: 21825074
PDF is available here.
PDF is available here.
Abstract
Yeast tRNA-thiouridine modification protein 1 (Tum1p), a crucial component of the Urm1 system, is believed to play important roles in protein urmylation and tRNA-thiouridine modification. Previous studies have demonstrated that the conserved residue Cys259 in the C-terminal rhodanese...
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PMID: 21821903
PDF is available here.
PDF is available here.
Abstract
We selected gelatin as ECM (extracellular matrix) to support differentiation of mES (mouse embryonic stem) cells into TE (trophectoderm), as gelatin was less expensive and widely used. We found that 0.2% and 1.5% gelatin were the suitable concentrations to induce TE differentiation by means of detec...
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PMID: 21091439
PDF is available here.
PDF is available here.
Cancer Cell (19)5 2011
Abstract
We show that mice lacking the ATM cofactor ATMIN in B cells (ATMIN(ΔB/ΔB)) have impaired ATM signaling and develop B cell lymphomas. Notably, ATMIN(ΔB/ΔB) cells exhibited defective peripheral V(D)J rearrangement and CSR, resulting in translocations involving the Igh and Igl loci, indicating that...
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PMID: 21575860
PDF is available here.
PDF is available here.
Nature Immunology (12)5 2011
Abstract
We show that the saturated fatty acid palmitate, but not unsaturated oleate, induces the activation of the NLRP3-ASC inflammasome, causing caspase-1, IL-1β and IL-18 production. This pathway involves mitochondrial reactive oxygen species and the AMP-activated protein kinase and unc-51-like kinase-1...
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PMID: 21478880
PDF is available here.
PDF is available here.
Cell Host & Microbe (9)4 2011
Abstract
We show that the Leishmania protease GP63 cleaves the mammalian/mechanistic target of rapamycin (mTOR), a serine/threonine kinase that regulates the translational repressor 4E-BP1. mTOR cleavage results in the inhibition of mTOR complex 1 (mTORC1) and concomitant activation of 4E-BP1 to promote Leis...
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PMID: 21501832
PDF is available here.
PDF is available here.
Cell Cycle (10)8 2011
Abstract
The ATM substrate Chk2-interacting Zn(2+)-finger protein (ASCIZ, also known as ATMIN and ZNF822) has previously been reported to be important for the repair of methylating and oxidative DNA damage, and it has also been proposed to regulate the stability and DNA damage-independent act...
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PMID: 21415597
PDF is available here.
PDF is available here.
Abstract
Abstract
Autism is a developmental disorder of the central nervous system characterized by impairments in social interaction, communication and restricted repetitive and stereotyped behavior. It is generally assumed that in most cases autism has a polygenic cause, but the pathogenesis is stil...
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PMID: 21375492
PDF is available here.
PDF is available here.
Abstract
We decided to study the expression of the translocator protein (TSPO) 18-kDa, peroxisome proliferator-activated receptor-γ (PPAR-γ), mitochondrial uncoupling protein-1 (UCP-1), and adipocyte morphology in the adipose tissue of rats subjected to stress conditions. In our model of stress, rats faste...
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PMID: 20948513
PDF is available here.
PDF is available here.
Nature Immunology (12)4 2011
Abstract
We demonstrate that differentiation into the T(H)1 and T(H)17 subsets of helper T cells was selectively regulated by signaling from mTOR complex 1 (mTORC1) that was dependent on the small GTPase Rheb. Rheb-deficient T cells failed to generate T(H)1 and T(H)17 responses in vitro and in vivo and did n...
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PMID: 21358638
PDF is available here.
PDF is available here.
Nature Medicine (17)4 2011
Abstract
Abstract
We investigated the upstream regulation of mTORC2. A genetic screen in yeast and subsequent studies in mammalian cells revealed that ribosomes, but not protein synthesis, are required for mTORC2 signaling. Active mTORC2 was physically associated with the ribosome, and insulin-stimulated PI3K signali...
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PMID: 21376236
PDF is available here.
PDF is available here.
Current Biology (21)5 2011
Abstract
Dynamic signaling networks are required to perform complex cellular processes. Structural and functional data now indicate the intriguing possibility that extracellular bacterial pathogens use catalytic scaffolds to assemble unique supramolecular signaling networks that effectively s...
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PMID: 21377097
PDF is available here.
PDF is available here.
Abstract
Abstract
We investigated the possible role of microRNAs in regulating drug sensitivity of colorectal adenocarcinoma cells SW620 and SW480. Using microRNA expression arrays and quantitative reverse transcriptase (RT)-PCR, we found that SW620 cells exhibited elevated miR-20a expression compared with SW480 cell...
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PMID: 21242194
PDF is available here.
PDF is available here.
Cell Host & Microbe (9)2 2011
Abstract
We show that RIN4 phosphorylation activates RPM1. RIN4(142-176) is necessary and, with appropriate localization sequences, sufficient to support effector-triggered RPM1 activation, with the threonine residue at position 166 being critical. Phosphomimic substitutions at T166 cause effector-independen...
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PMID: 21320695
PDF is available here.
PDF is available here.
Abstract
We focus on developing mouse skin, where progenitor cells execute a switch from symmetric to predominantly asymmetric divisions concomitant with stratification. Using in vivo skin-specific lentiviral RNA interference, we investigate spindle orientation regulation and provide direct evidence that LGN...
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PMID: 21331036
PDF is available here.
PDF is available here.
Cell Cycle (10)3 2011
Abstract
We show that CtIP, which is recruited to DSB-containing chromatin, interacts with both TopBP1 and Nbs1 in a damage-dependent manner. An N-terminal region containing the first two BRCT repeats of TopBP1 is essential for the interaction with CtIP. Furthermore, two distinct regions in the N-terminus of...
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PMID: 21263215
PDF is available here.
PDF is available here.
Molecular Cell (41)2 2011
Abstract
We asked if, during B cell activation, AID also induces DNA breaks at genes other than IgH genes. Using a nonbiased genome-wide approach, we have identified hundreds of reproducible, AID-dependent DSBs in mouse splenic B cells shortly after induction of CSR in culture. Most interestingly, AID induce...
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PMID: 21255732
PDF is available here.
PDF is available here.
Abstract
Abstract
We developed a Galleria mellonella larvae (wax worm) model of invasive GAS infection and used it to compare the virulence of serotype M3 GAS strains. We found that GAS causes severe tissue damage and kills wax worms in a dose-dependent manner. The virulence of genetically distinct GAS strains wa...
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PMID: 21258213
PDF is available here.
PDF is available here.
Abstract
We show that HIF-1α protects against drug-induced apoptosis by antagonizing the function of the tumor suppressor p53. HIF-1α upregulation induced proteasomal degradation of homeodomain-interacting protein kinase-2 (HIPK2), the p53 apoptotic activator. Inhibition of HIF-1α by siRNA, HIF-1α-domina...
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PMID: 21248371
PDF is available here.
PDF is available here.
Abstract
We have demonstrated a significant interaction between the GCKR rs1260326-P446L polymorphism and plasma n-3 PUFA levels modulating insulin resistance and inflammatory markers in MetS subjects. Further studies are needed to confirm this gene-diet interaction in the general population and whether targ...
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PMID: 21674002
PDF is available here.
PDF is available here.
Abstract
We show that porcine sialoadhesin-specific antibodies and F(ab')₂ fragments trigger sialoadhesin internalization, both in primary porcine macrophages and in cells expressing recombinant porcine sialoadhesin. Using chemical inhibitors, double immunofluorescence stainings and dominant-negative const...
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PMID: 21359217
PDF is available here.
PDF is available here.
Metallomics (3)1 2011
Abstract
We treat the changes in copper proteins in historically the same increasingly oxidising environmental conditions. The study is a bioinformatic analysis of the types and the numbers of copper domains of proteins from 435 DNA sequences of a wide range of organisms available in NCBI, using the method d...
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PMID: 21085721
PDF is available here.
PDF is available here.
Cellular Immunology (271)2 2011
Abstract
We observed that the phytol-derived immunostimulant, PHIS-01 (phytanol), is a nontoxic oil-in-water adjuvant which is superior to most commercial adjuvants. In contrast, the parent diterpene alcohol phytol, though highly effective as an adjuvant, is relatively toxic. To assess the importance of the...
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PMID: 21813116
PDF is available here.
PDF is available here.
Abstract
We report that chromatin regulator tripartite motif-containing 24 (TRIM24) functions in humans as a reader of dual histone marks by means of tandem plant homeodomain (PHD) and bromodomain (Bromo) regions. The three-dimensional structure of the PHD-Bromo region of TRIM24 revealed a single functional...
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PMID: 21164480
PDF is available here.
PDF is available here.
Abstract
We examined the effects of constitutively active mutants of RhoA effectors, which have not been reported before, on cortical stiffness of living cells by using scanning probe microscopy, fluorescence microscopy, and truncated mutants of RhoA effectors labeled with a fluorescent protein. Our data ind...
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PMID: 21078298
PDF is available here.
PDF is available here.
Abstract
We have previously reported that the two components of R2TP complex, RNA polymerase II-associated protein 3 (RPAP3), and Reptin, regulate apoptosis. Here we characterize another component of the complex, PIH1 domain containing protein 1 (PIH1D1). PIH1D1 interacts with both RPAP3 and Monad in HEK293...
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PMID: 21078300
PDF is available here.
PDF is available here.
Abstract
We recently showed that bone morphogenetic protein 4 (BMP4) signalling involves the effect of cholesterol myristate on the proliferation of MSCs. The present study evaluated the effects of cholesterol myristate on the apoptosis of MSCs and the inhibitor of differentiation (Id1), target gene of BMP4...
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PMID: 20674581
PDF is available here.
PDF is available here.
EMBO Journal (29)24 2010
Abstract
We report the identification of MTM-6 and MTM-9 as novel regulators of MIG-14/Wls trafficking in Caenorhabditis elegans. MTM-6 and MTM-9 are myotubularin lipid phosphatases that function as a complex to dephosphorylate phosphatidylinositol-3-phosphate, a central regulator of endosomal trafficking. W...
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PMID: 21076391
PDF is available here.
PDF is available here.
Abstract
We established a series of stable transfectants expressing wild-type and three mutant LANA; amino terminus, carboxyl terminus and amino terminus plus DNA binding domain, as a new strategy to assess systematically the interactions and binding domains with cellular proteins. Using the system, we repor...
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PMID: 21056547
PDF is available here.
PDF is available here.
Abstract
We generated Vps26b knockout mice and studied their molecular, histological, and behavioral phenotypes. We found that the loss of Vps26b results in no significant defects in the behavior, body size, and health of the mice. Vps26b-deficient mice showed a severe reduction of Vps35 protein at cellular...
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PMID: 21040701
PDF is available here.
PDF is available here.
Pediatric Annals (39)12 2010
Abstract
Critical Care Medicine (38)12 2010
Abstract
Endotoxin triggers a reorganization of the energy metabolic pathway, including the promotion of fatty acid utilization to adapt to a high energy demand during endotoxemia. However, the factors responsible for the metabolic adaptation and characteristic pathologies resulting from defective utilizatio...
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PMID: 20838331
PDF is available here.
PDF is available here.
Abstract
We examined neuropathologic alterations in the central nervous system of Clcn6(-/-), Clcn7(-/-), andgl mice. gl mice bear a mutation in Ostm1, the β-subunit critical for Clcn7 function. Severely affected Clcn7(-/-) and gl mice have remarkably similar neuropathologic phenotypes, with pronounced reac...
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PMID: 21107136
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)48 2010
Abstract
These results indicate that the cysteine-containing sensor II plays a critical role in redox sensing and the nucleotide and partner binding functions of torsinA and suggest that loss of this function of torsinA contributes to the development of DYT1 dystonia....
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PMID: 20861018
PDF is available here.
PDF is available here.
Abstract
We show that a West Nile virus (WNV) mutant (E218A) that lacks 2'-O MTase activity was attenuated in wild-type primary cells and mice but was pathogenic in the absence of type I interferon (IFN) signalling. 2'-O methylation of viral RNA did not affect IFN induction in WNV-infected fibroblasts but in...
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PMID: 21085181
PDF is available here.
PDF is available here.
Abstract
We screened pools of P element-mediated mutants and tested locomotor activity of homozygous flies. Of 1014 P element-mutagenized lines, 638 were homozygous viable. These lines were tested for climbing ability and lifespan. We isolated dGIPC, a Drosophila homolog of GIPC, that produced a 50% prematur...
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PMID: 21029723
PDF is available here.
PDF is available here.
Brain research (1360) 2010
Abstract
We have shown for the first time the neuroprotective efficacy of full-length and truncated AP-1 inhibitory peptides in kainic acid and glutamate neuronal excitotoxicity models. The identification of therapeutic targets, such as the AP-1 complex, is an important step for the development of pharmaceut...
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PMID: 20833150
PDF is available here.
PDF is available here.
Abstract
We report the identification of novel interconnections in the interaction network of this endocytic adaptor. We show that the membrane-deforming protein SGIP1 (Src homology 3-domain growth factor receptor-bound 2-like (endophilin) interacting protein 1) and the signaling adaptor Reps1 (RalBP associa...
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PMID: 20946875
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)45 2010
Abstract
We show that a third GCK, Ppk11, is also required for efficient cell separation particularly, at a high temperature. Although Ppk11 is not essential for cell division, this kinase plays an auxiliary role in concert with MOR in cell morphogenesis. Ppk11 physically interacts with the MOR component Pmo...
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PMID: 20826805
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)45 2010
Abstract
These results demonstrate a new hierarchical phosphorylation for 4E-BP1 regulation in which Thr(69) is phosphorylated first followed by Thr(36)/Thr(45) phosphorylation, and Ser(64) is phosphorylated last. Thr(69) phosphorylation alone allows binding to eIF4E, and subsequent Thr(36)/Thr(45) phosphory...
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PMID: 20736160
PDF is available here.
PDF is available here.
Abstract
In vitro and in vivo evaluation of BBP interactions with BMP.
To explore bone morphogenetic protein-binding peptide (BBP)'s mechanism of action, investigate an extended repertoire for BBP applications, and evaluate the usefulness of BBP as a surgical adjuvant when used with recombinant human osteoge...
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PMID: 20581758
PDF is available here.
PDF is available here.
EMBO Reports (11)11 2010
Abstract
We report that TpMs regulates the tethering between mitochondria and endoplasmic reticulum (ER) in a Mitofusin 2 (Mfn2)-dependent manner. Subcellular fractionation and immunostaining show that TpMs is present at the interface between mitochondria and ER. The expression of TpMs leads to mitochondrial...
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PMID: 20930847
PDF is available here.
PDF is available here.
Nippon Ganka Gakkai zasshi (114)11 2010
Abstract
We identified the novel retinal extracellular matrix protein pikachurin, and observed that it is localized in the synaptic cleft of the photoreceptor ribbon synapse. In order to investigate the biological functions of pikachurin, we generated a pikachurin knock-out mouse. These mice showed improper...
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PMID: 21141075
PDF is available here.
PDF is available here.
Gastroenterology (139)5 2010
Abstract
We aim to select and validate an affinity peptide that binds to esophageal dysplasia for future clinical studies.
Peptide selection was performed using phage display by removing nonspecific binders using Q-hTERT (intestinal metaplasia) cells and achieving specific binding against OE33 (esophageal ad...
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PMID: 20637198
PDF is available here.
PDF is available here.
Anti-Cancer Drugs (21)10 2010
Abstract
We sought to investigate their impact on normal cells by using Drosophila as a model. We investigated the possible involvement of Drosophila homologue of p53 (Dmp53) and a member of the retinoblastoma binding protein 6 family, known as Snama. On account of its molecular features and experimental evi...
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PMID: 20717003
PDF is available here.
PDF is available here.
EMBO Journal (29)21 2010
Abstract
We show that TopBP1 also colocalizes with 53BP1 at sites of DNA double-strand breaks (DSBs), but only in the G1-phase of the cell cycle. Recruitment of TopBP1 to sites of DNA replication stress was dependent on BRCT domains 1-2 and 7-8, whereas recruitment to sites of DNA DSBs was dependent on BRCT...
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PMID: 20871591
PDF is available here.
PDF is available here.
Hepatology (52)5 2010
Abstract
We therefore analyzed the relationship between NS3/4A and TNFα. Wild-type and NS3/4A-transgenic (Tg) mice were treated with TNFα/D-galactosamine (D-galN), acting through the TNF receptor 1 on hepatocytes and macrophages, or lipopolysaccharide (LPS)/D-galN, acting through Toll-like receptor 4 on si...
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PMID: 20886569
PDF is available here.
PDF is available here.
Abstract
We examined the kinetics and molecular mechanisms of neutrophil recruitment to sites of focal hepatic necrosis in vivo. Adenosine triphosphate released from necrotic cells activated the Nlrp3 inflammasome to generate an inflammatory microenvironment that alerted circulating neutrophils to adhere wit...
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PMID: 20947763
PDF is available here.
PDF is available here.
EMBO Journal (29)20 2010
Abstract
We report that our budding yeast two-hybrid assay identified hsSsu72 phosphatase as a Rad21-binding protein. Additional experiments revealed that Ssu72 directly interacts with Rad21 and SA2 in vitro and in vivo, and associates with sister chromatids in human cells. Interestingly, depletion or mutati...
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PMID: 20818333
PDF is available here.
PDF is available here.
Abstract
We report the crystal structure at 2.4 Å resolution of the amino-terminal domain (residues 30-340) of human symplekin in a ternary complex with the Pol II carboxy-terminal domain (CTD) Ser 5 phosphatase Ssu72 (refs 7, 10-17) and a CTD Ser 5 phosphopeptide. The N-terminal domain of symplekin...
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PMID: 20861839
PDF is available here.
PDF is available here.