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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Contractile Proteins (1):
Recent article
Contractile Proteins
Abstract
We performed two-dimensional polyacrylamide gel electrophoresis to determine differentially expressed proteins. Peptides of interest were further analysed by mass spectrometry and Mascot software was employed to identify protein matches.
Our data showed that ATP synthase D chain, ubi...
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PMID: 20859605
PDF is available here.
PDF is available here.
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Macromolecular Bioscience (10)11 2010
Abstract
I collagen (COL1A1) transcription, but is functionally limited as a free molecule. Using a matrix-binding domain (MBD) from microfibril-associated glycoprotein-1, the fusion protein MBD-CTGF was targeted to the ECM and tested for COL1A1 transcriptional activation. MBD-CTGF produced by the ECM-synthe...
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PMID: 20799254
PDF is available here.
PDF is available here.
Abstract
Radiation induced a biphasic stress response in the lung, as shown by the induction of heme oxygenase 1 at 1-3 days and at 6-8 weeks after irradiation. At 6-8 weeks after irradiation, the down-regulation of proteins involved in cytoskeletal architecture (filamin A and talin), antioxidant defense (bi...
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PMID: 20584581
PDF is available here.
PDF is available here.
Anticancer Research (30)10 2010
Abstract
Induction of angiogenic responses by multiple factors, a crucial step in tumor growth and metastasis, is not completely understood. Recently, involvement of the cytoskeletal actin-binding proteins in angiogenesis has been suggested as a target for anti-neovascular cancer therapy in vitro. In this st...
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PMID: 21036706
PDF is available here.
PDF is available here.
Abstract
We examined signaling pathways activated by the CaR, including Ca(2+) oscillations, in individual human colon epithelial cells. Single cell imaging of colon-derived cells expressing the CaR, including SW-480, HT-29, and NCM-460 cells, shows that stimulation of this receptor by addition of aromatic a...
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PMID: 20648625
PDF is available here.
PDF is available here.
Abstract
We introduce myopodin as a novel filamin C binding partner. Corroborative yeast two-hybrid and biochemical analyses indicate that the central part of myopodin that shows high homology to the closely related protein synaptopodin and that is common to all its currently known or predicted variants inte...
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PMID: 20554076
PDF is available here.
PDF is available here.
Brain research (1345) 2010
Abstract
We previously performed a misexpression screening in a Drosophila tauopathy model to identify genetic modifiers of the human Tau-induced neurodegeneration. We identified several components of the actin network as modifiers of Tau V337M-induced neurodegeneration, i.e. Filamin-A, Myosin VI, Paxillin a...
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PMID: 20460118
PDF is available here.
PDF is available here.
Abstract
We investigated the effects of lovastatin on vascular smooth muscle phenotype. We have previously shown that mammalian target of rapamycin complex 1 (mTORC1) inhibition with rapamycin induces vascular smooth muscle cell (VSMC) differentiation. We found that lovastatin also inhibits mTORC1 signaling...
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PMID: 20375271
PDF is available here.
PDF is available here.
Abstract
We studied correlations between changes in expressions of proteins and increases in energy expenditure. This, in proteomic research, innovative application of widely used statistical approaches optimized the information yield in this study. The metabolic responses to cold and overfeeding in 9 lean a...
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PMID: 20143783
PDF is available here.
PDF is available here.
Abstract
Marfan syndrome is a connective-tissue disease inherited in an autosomal dominant manner and caused mainly by mutations in the gene FBN1. This gene encodes fibrillin-1, a glycoprotein that is the main constituent of the microfibrils of the extracellular matrix. Most mutations are uni...
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PMID: 20351703
PDF is available here.
PDF is available here.
Trends in Cell Biology (20)2 2010
Abstract
Filamins are large actin-binding proteins that stabilize delicate three-dimensional actin filament networks and link them to cellular membranes where they integrate cell architectural and signaling functions important for cell locomotion. Filamins have been shown to bind to proteins with diverse fun...
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PMID: 20061151
PDF is available here.
PDF is available here.
Abstract
We describe novel cardiac findings in an 18-month-old girl with PNH associated with a nonsense mutation in FLNA, including a dysplastic pulmonary valve and clefting of the mitral valve. These findings broaden the range of cardiac anomalies associated with filamin A mutations to include abnormality o...
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PMID: 20014127
PDF is available here.
PDF is available here.
Clinical Neuropathology (29)4 2010
Abstract
We compare our findings with previously reported cases and discuss the clinical significance of the inclusions and the pathophysiologic relevance of filamin A and other proteins accumulation in astrocytes....
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PMID: 20569676
PDF is available here.
PDF is available here.
Medycyna pracy (61)1 2010
Abstract
In most cases diagnosis of immediate-type occupational allergy is very complex. Mainly it is caused by diversity of occupational allergens and lack of standardized diagnostic methods. The content of allergic proteins in commercially available skin prick test reagents differs between companies and in...
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PMID: 20437891
PDF is available here.
PDF is available here.
Abstract
I succeeded in recording the ATP-induced individual cross-bridge movement in two different kinds of synthetic thick filaments in 1997 and 2008. In the synthetic bipolar filaments consisting of rabbit skeletal muscle myosin, the amplitude of cross-bridge movement exhibits a peak at 5-7.5 nm, and the...
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PMID: 20824521
PDF is available here.
PDF is available here.
Cancer Cell (16)6 2009
Abstract
We identify and validate a prognostic gene expression signature correlating with survival in a series of microdissected serous ovarian tumors. Independent evaluation confirmed the association of a prognostic gene microfibril-associated glycoprotein 2 (MAGP2) with poor prognosis, whereas in vitro mec...
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PMID: 19962670
PDF is available here.
PDF is available here.
Abstract
Biopsy samples were taken from the vastus lateralis muscle of seven male subjects pre- and post-35 days bed rest (BR). The myosin heavy chain (MHC) isoform distribution of the samples was determined by densitometry of MHC bands separated by sodium dodecyl sulfate polyacrylamide gel e...
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PMID: 19883388
PDF is available here.
PDF is available here.
Biophysical Journal (97)1 2009
Abstract
We investigate both cross-linked and bundled actin/filamin networks and compare their microstructures as well as their viscoelastic properties in the linear and the nonlinear regime....
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PMID: 19580746
PDF is available here.
PDF is available here.
Abstract
We have previously shown that Wnt5A and ROR2, an orphan tyrosine kinase receptor, interact to mediate melanoma cell motility. In other cell types, this can occur through the interaction of ROR2 with the cytoskeletal protein filamin A. Here, we found that filamin A protein levels correlated with Wnt5...
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PMID: 19177143
PDF is available here.
PDF is available here.
Abstract
We provide the first evidence that a novel ASB2 isoform, ASB2beta, is important for muscle differentiation. ASB2beta is expressed in muscle cells during embryogenesis and in adult tissues. ASB2beta is part of an active E3 ubiquitin ligase complex and targets the actin-binding protein filamin B (FLNb...
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PMID: 19300455
PDF is available here.
PDF is available here.
Proteomics (9)10 2009
Abstract
We use proteomic profiling to evaluate protein changes in the larvae elicited by dehydration and rehydration. Larvae were desiccated at 75% relative humidity (RH) for 12 h to achieve a body water loss of 35%, approximately half of the water that can be lost before the larvae succumb to dehydration....
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PMID: 19415656
PDF is available here.
PDF is available here.
Science Signaling (2)66 2009
Abstract
Three studies shed light on the decade-old observation that the actin cytoskeleton is hijacked to facilitate entry of HIV into its target cells. Polymerization of actin is required to assemble high concentrations of CD4 and CXCR4 at the plasma membrane, which promote viral binding an...
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PMID: 19366992
PDF is available here.
PDF is available here.
The Journal of Chemical Physics (130)14 2009
Abstract
We show that unfolding pathways of this protein depend on the pulling speed. The agreement between theoretical and experimental results on the sequencing of unfolding events is achieved at low loading rates. The unfolding free energy landscape is also constructed using dependencies of unfolding forc...
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PMID: 19368475
PDF is available here.
PDF is available here.
Abstract
Ageing induces a progressive morphological change and functional decline in muscles and in nerves. Light and electron microscopy, 2-D DIGE and MS, were applied to profile the qualitative and quantitative differences in the proteome and morphology of rat gastrocnemius muscle and sciatic nerve, in hea...
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PMID: 19333999
PDF is available here.
PDF is available here.
Physical Review E (79)4 Pt 1 2009
Abstract
We propose and test a model of rigid filaments decorated by multiple flexible linkers that is in quantitative agreement with experiment. This allows us to estimate loads on individual cross-links, which we find to be less than 10 pN....
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PMID: 19518277
PDF is available here.
PDF is available here.
EMBO Reports (10)4 2009
Abstract
EMBO Reports (10)4 2009
Abstract
We show that type I IFNs induce the conjugation of filamin B by interferon-stimulated gene 15 (ISG15). ISGylation of filamin B led to the release of RAC1, MEKK1 and MKK4 from the scaffold protein and thus to the prevention of sequential activation of the JNK cascade. By contrast, blockade of filamin...
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PMID: 19270716
PDF is available here.
PDF is available here.
Abstract
We examined 5 cases with neocortical eosinophilic inclusions (3 autopsies, 2 surgical resections) using a standardized immunohistochemical protocol at a single institution. The specimens were immunostained with 32 antibodies to 30 potentially relevant proteins using several antigen retrieval protoco...
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PMID: 19151628
PDF is available here.
PDF is available here.
Prenatal Diagnosis (29)2 2009
Abstract
Abstract
N-acetylaspartic acid (NAA) is converted into aspartate and acetate by aspartoacylase. Abnormal levels of the enzyme leads to accumulation of NAA and these changes have been observed in Canavan disease and type 2 diabetes. How upregulation of NAA affect the gastrointestine protein levels and the fun...
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PMID: 17943458
PDF is available here.
PDF is available here.
Abstract
We report that ASB2 targets the actin-binding proteins filamin A and B for proteasomal degradation. Knockdown of endogenous ASB2 in leukemia cells delays retinoic acid-induced differentiation and filamin degradation; conversely, ASB2 expression in leukemia cells induces filamin degradation. ASB2 exp...
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PMID: 18799729
PDF is available here.
PDF is available here.
Revue Neurologique (164)12 2008
Abstract
Malformations of cortical development (MCD) represent a major cause of developmental disabilities and severe epilepsy. Advances in imaging and genetics have improved the diagnosis and classification of these conditions. Up to now, eight genes have been involved in different types of MCD. Lissencepha...
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PMID: 18808783
PDF is available here.
PDF is available here.
Revue Neurologique (164)12 2008
Abstract
Résumé
Les malformations du développement cortical représentent une cause de retard psychomoteur et d’épilepsie sévère. Les avancées dans les techniques d’imagerie et de génétique ont permis une amélioration dans le diagnostic et la classification de ces pathologies. Les lissencéphali...
PDF is available here.
PDF is available here.
Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology / edited by the Gaetano Conte Academy for the study of striated muscle diseases (27) 2008
Abstract
We selected the following 11 candidate genes: myozenin 1, 2 and 3, gamma-filamin, kinectin-1, enolase-3 beta, ZASP, TRIM 11 and TRIM 17, OZZ and zeta-sarcoglycan. These candidates were chosen for a combination of different reasons: chromosomal position, sequence homology, interaction properties or m...
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PMID: 19472918
PDF is available here.
PDF is available here.
Abstract
Levosimendan increases the sensitivity of the cardiac fibrils to calcium, favorably affects hemodynamics in patients with heart failure. It is a positive inotrope and a peripheral vasodilator. The elimination half-life of the compound is about 1 hour. The drug decreases pulmonary capillary wedge pre...
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PMID: 19087950
PDF is available here.
PDF is available here.
Abstract
The presence of the neonatal MHC isoform in SMA muscles indicates an alteration of the phenotype in these diseased muscles. It is strongly suggested that MHC and troponin T proteins may be good markers for the SMA pathology....
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PMID: 18363640
PDF is available here.
PDF is available here.
Abstract
We assessed the generation of microparticle by flow cytometry, the filamin cleavage and the protein tyrosine phosphorylation by western blotting. Microparticle formation decreased by more than 50% with mAb Ib-23 alone (P < 0.01, n = 23) but filamin cleavage was not inhibited. In contrast, abciximab...
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PMID: 19002047
PDF is available here.
PDF is available here.
Genes & Development (22)22 2008
Abstract
The septation initiation network (SIN) regulates the timing of septum formation in Schizosaccharomyces pombe. However, whether and how the SIN functions in contractile ring formation has remained unclear. In this issue of Genes & Development, Hachet and Simanis (3205-3216) demonstrate that the SIN a...
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PMID: 19056889
PDF is available here.
PDF is available here.
Genes & Development (22)22 2008
Abstract
We reveal an unanticipated, novel role for the SIN in CAR assembly. We demonstrate that CAR assembly involves three, genetically separable steps: establishment of a cortical network of CAR proteins, its lateral condensation, and finally, the formation of a homogeneous CAR. We show that SIN mutants f...
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PMID: 19056897
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (283)46 2008
Abstract
We identified the actin cross-linking molecule filamin B as a novel binding partner for intracellular adhesion molecule-1 (ICAM-1). Immune precipitation as well as laser scanning confocal microscopy confirmed the specific interaction and co-localization of endogenous filamin B with ICAM-1. Important...
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PMID: 18809679
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (283)45 2008
Abstract
We report the characterization of the Drosophila homologue of microfibril-associated protein 1 (dMFAP1), a previously uncharacterized protein found in some human spliceosomal fractions ( Jurica, M. S., and Moore, M. J. (2003) Mol. Cell 12, 5-14 ). We show that dMFAP1 binds directly to the Drosophila...
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PMID: 18765666
PDF is available here.
PDF is available here.
Abstract
High altitude hypoxia is a paraphysiological condition triggering redox status disturbances of cell organization leading, via oxidative stress, to proteins, lipids, and DNA damage. In man, skeletal muscle, after prolonged exposure to hypoxia, undergoes mass reduction and alterations at the cellular...
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PMID: 18937252
PDF is available here.
PDF is available here.
Abstract
I and MHC IIa) originating from different muscles. Vastus lateralis (VL) and soleus biopsies were obtained from 27 recreationally active females (31 +/- 1 yr, 59 +/- 1 kg). A total of 943 single fibers (MHC I = 562; MHC IIa = 301) were isolated and examined for diameter, peak tension (Po), shortenin...
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PMID: 18815206
PDF is available here.
PDF is available here.
Biochemistry (Washington) (47)42 2008
Abstract
We investigate the stability of the Ig-like filamin domains using NMR studies over a range of pH and temperature. We show that the 21st Ig-like module (FLNa21) is partly unfolded even under physiological conditions and when attached to FLNa20. It is, however, appreciably stabilized upon binding to i...
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PMID: 18817417
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (283)41 2008
Abstract
We show by wound-healing assays that Ror2 plays critical roles in Wnt5a-induced cell migration by regulating formation of lamellipodia and reorientation of microtubule-organizing center (MTOC). Wnt5a stimulation induces activation of the c-Jun N-terminal kinase JNK at the wound edge in a Ror2-depend...
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PMID: 18667433
PDF is available here.
PDF is available here.
Abstract
We investigated the effect of stretch on myofilament contractile proteins, Ca(2+) sensitivity, and cross-bridge cycling kinetics (K (tr)) of force in single skinned cardiomyocytes isolated from the sub-endocardial (ENDO) or sub-epicardial (EPI) layer. As observed in other species, ENDO cells were st...
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PMID: 18449562
PDF is available here.
PDF is available here.
Abstract
The most important recent advance in the myofibrillar myopathies has been the discovery that mutations in Z band alternatively spliced PDZ-containing protein and filamin C, as well as in desmin, alphaB-crystallin and myotilin, result in similar pathologic alterations in skeletal muscle that are typi...
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PMID: 18769253
PDF is available here.
PDF is available here.
Biophysical Journal (95)7 2008
Abstract
We plated neonatal rat ventricular myocytes for 7 days on collagen-coated polyacrylamide gels with varying elastic moduli. Cells on 10 kPa substrates developed aligned sarcomeres, whereas cells on stiffer substrates had unaligned sarcomeres and stress fibers, which are not observed in vivo. We found...
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PMID: 18586852
PDF is available here.
PDF is available here.
Experimental Cell Research (314)15 2008
Abstract
We have previously reported that expression of caveolin-1 in stably transfected MCF-7 human breast cancer (MCF-7/Cav1) cells up-regulates phosphorylation of a putative Akt substrate protein, designated pp340 [D. Ravid, S. Maor, H. Werner, M. Liscovitch, Caveolin-1 inhibits cell detachment-induced p5...
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PMID: 18598695
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (283)37 2008
Abstract
Microfibril-associated glycoprotein-1 (MAGP-1) is a small molecular weight component of the fibrillin-rich microfibril. Gene-targeted inactivation of MAGP-1 reveals a complex phenotype that includes increased body weight and size due to excess body fat, an altered wound healing response in bone and...
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PMID: 18625713
PDF is available here.
PDF is available here.
Abstract
This study is the first to characterize a novel cell surface protein ECSM2 that regulates endothelial chemotaxis and tube formation, and interacts with filamin A. These studies implicate a role for ECSM2 in angiogenesis via modulation of the actin cytoskeleton....
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PMID: 18556573
PDF is available here.
PDF is available here.
Abstract
We have identified filamin A (FLNa), an actin-cross-linking protein involved in cell movement, as a bona fide SphK1-interacting protein. Heregulin stimulated SphK1 activity only in FLNa-expressing A7 melanoma cells but not in FLNa-deficient cells and induced its translocation and colocalization with...
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PMID: 18644866
PDF is available here.
PDF is available here.
Abstract
We investigated the binding of filamin, talin, and 14-3-3 proteins to phosphorylated and unphosphorylated beta2 integrins by biochemical methods and x-ray crystallography. 14-3-3 proteins bound only to the phosphorylated integrin cytoplasmic peptide, with a high affinity (K(d), 261 nM), whereas fila...
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PMID: 18550856
PDF is available here.
PDF is available here.
Journal of Cell Science (121)Pt 16 2008
Abstract
We report the identification of a specific isoform of actin depolymerizing factor (ADF)/cofilin as an essential factor for assembly of contractile actin networks in the gonadal myoepithelial sheath. Two ADF/cofilin isoforms, UNC-60A and UNC-60B, are expressed from the unc-60 gene by alternative spli...
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PMID: 18653537
PDF is available here.
PDF is available here.
EMBO Journal (27)15 2008
Abstract
We identified a new CV regulator, Disgorgin, a TBC-domain-containing protein, which translocates to the CV membrane at the late stage of CV charging and regulates CV-plasma membrane fusion and discharging. disgorgin(-) cells produce large CVs due to impaired CV-plasma membrane fusion. Disgorgin is a...
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PMID: 18636095
PDF is available here.
PDF is available here.
Abstract
We present a native-like assay geometry to test the rupture force of a complex formed by an ABP linking two quasiparallel actin filaments. We readily demonstrate the adaptability of this assay by testing it with two different ABPs: filamin and alpha-actinin. For filamin/actin and alpha-actinin/actin...
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PMID: 18591676
PDF is available here.
PDF is available here.
EMBO Journal (27)13 2008
Abstract
We have purified a B-Myb complex containing clathrin and filamin (Myb-Clafi complex). This complex is required for normal localization of clathrin at the mitotic spindle, which was previously reported to stabilize kinetochore fibres. The Myb-Clafi complex is not tightly associated with the mitotic s...
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PMID: 18548008
PDF is available here.
PDF is available here.
Developmental Biology (319)1 2008
Abstract
We previously identified the adaptor protein PACSIN2 as a negative regulator of ADAM13 proteolytic function. In Xenopus embryos, PACSIN2 is ubiquitously expressed, suggesting that PACSIN2 may control other proteins during development. To investigate this possibility, we studied PACSIN2 function duri...
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PMID: 18495106
PDF is available here.
PDF is available here.
Abstract
We report the finding of unique astrocytic inclusions in a series of pediatric epilepsy patients, all of whom presented with seizures in their first year of life and had mild-to-moderate developmental delay. All eventually underwent surgical treatment for refractory epilepsy and, on pathological exa...
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PMID: 18596546
PDF is available here.
PDF is available here.
Abstract
We report on two new patients (a mother and her son) representing the first case of autosomal dominant inheritance. These patients met the clinical and radiological criteria for SCT and did not present any features which could exclude this diagnosis. Molecular analysis failed to identify mutations i...
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PMID: 18470895
PDF is available here.
PDF is available here.