Find your PDFs fast.
Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Basic Helix-Loop-Helix Transcription Factors (5):
Recent article
Basic Helix-Loop-Helix Transcription Factors
Abstract
Our simple culture system might offer the potential of a source of mature β cells....
|
PMID: 21926540
PDF is available here.
PDF is available here.
| < More recent | Older article > |
Abstract
Abstract
We selected gelatin as ECM (extracellular matrix) to support differentiation of mES (mouse embryonic stem) cells into TE (trophectoderm), as gelatin was less expensive and widely used. We found that 0.2% and 1.5% gelatin were the suitable concentrations to induce TE differentiation by means of detec...
|
PMID: 21091439
PDF is available here.
PDF is available here.
Abstract
We show that hypoxia induces the expression of Snail via HIF. In silico analysis identified a potential hypoxia-response element (HRE) close to the minimal promoter of the human and mouse genome of the snail gene. Gel shift assays demonstrated that a specific hypoxia-inducible complex is formed with...
|
PMID: 21257819
PDF is available here.
PDF is available here.
BMC Systems Biology (5)Suppl 1 2011
Abstract
Hypoxia-inducible factors (HIFs) are transcription factors that play a crucial role in response to hypoxic stress in living organisms. The HIF pathway is activated by changes in cellular oxygen levels and has significant impacts on the regulation of gene expression patterns in cancer...
|
PMID: 21689478
PDF is available here.
PDF is available here.
Neural Development (6)1 2011
Abstract
We studied the temporal generation and diversity of Neurog2-positive precursor progeny using an inducible genetic fate mapping approach. We show that all subtypes of glutamatergic neurons derive from Neurog2 positive progenitors during development of the OB. Projection neurons, that is, mitral and t...
|
PMID: 21466690
PDF is available here.
PDF is available here.
Development (138)3 2011
Abstract
We have discovered that the Wnt receptor Ryk promotes GABAergic neuron production while repressing oligodendrocyte formation in the ventral telencephalon. We demonstrate that Ryk controls the cell-fate switch by negatively regulating expression of the intrinsic oligodendrogenic factor Olig2 while in...
|
PMID: 21205786
PDF is available here.
PDF is available here.
Abstract
Sertoli cells (SCs) provide an immunoprotective environment to pancreatic islet grafts for treatment of insulin-dependent diabetes. Aim of this work was to verify whether intraperitoneal graft of SCs, enveloped in barium alginate-based microcapsules, would reverse overt spontaneous diabetes in nonob...
|
PMID: 21197711
PDF is available here.
PDF is available here.
Abstract
We investigated the effects of nicotine on the population of cancer stem cells in MCF-7 human breast cancer cells, using flow cytometry with a cancer stem cell marker aldehyde dehydrogenase (ALDH). We found that nicotine increased ALDH-positive cell population in a dose-dependent manner. We further...
|
PMID: 21055391
PDF is available here.
PDF is available here.
Abstract
We investigated the interaction between evodiamine and the aryl hydrocarbon receptor (AhR). Molecular modeling results revealed that evodiamine directly interacted with the AhR. Cytosolic receptor binding assay also provided the evidence that evodiamine could interact with the AhR with the K(i) valu...
|
PMID: 20888792
PDF is available here.
PDF is available here.
Abstract
We focus on a number of genes that have been implicated in the metastatic process, and have been found to be hypoxia-responsive....
|
PMID: 21084801
PDF is available here.
PDF is available here.
Abstract
We report the X-ray structure of a dimeric human Notch1 transcription complex loaded on the paired site from the human HES1 promoter. The small interface between the Notch ankyrin domains could accommodate DNA bending and untwisting to allow a range of spacer lengths between the two sites. Cooperati...
|
PMID: 20972443
PDF is available here.
PDF is available here.
Abstract
We report the X-ray structure of a dimeric human Notch1 transcription complex loaded on the paired site from the human HES1 promoter. The small interface between the Notch ankyrin domains could accommodate DNA bending and untwisting to allow a range of spacer lengths between the two sites. Cooperati...
|
PMID: 20972443
PDF is available here.
PDF is available here.
Abstract
We used pharmacologic, genetic, in vivo, and in vitro experiments to show that activation of the Notch pathway in tubular epithelial cells (TECs) in patients and in mouse models of TIF plays a role in TIF development. Expression of Notch in renal TECs was found to be both necessary and sufficient fo...
|
PMID: 20978353
PDF is available here.
PDF is available here.
Abstract
We used Cre-loxP recombination to ablate Hif-2α in the kidney, whereas Hif-2-mediated hypoxia responses in the liver and other Epo-producing tissues remained intact. We found that the hypoxic induction of renal Epo is completely Hif-2 dependent and that, in the absence of renal Hif-2, hepatic Hif-2...
|
PMID: 20628150
PDF is available here.
PDF is available here.
Abstract
We show that Ldb1 controls gene expression at multiple levels. Ldb1 stabilizes its erythroid complex partners on β-globin chromatin, even though it is not one of the DNA-binding components. In addition, Ldb1 is necessary for enrichment of key transcriptional components in the locus, including P-TEF...
|
PMID: 20570862
PDF is available here.
PDF is available here.
Anticancer Research (30)10 2010
Abstract
We examined the effects of three γ-secretase inhibitors (GSI-IX, GSI-XII and GSI-XXI) that inhibit Notch signaling on the in vitro growth and differentiation of HEL and AA erythroid leukemia cell lines.
GSI treatment induced morphologic erythroid differentiation and promoted hemoglobin production....
|
PMID: 21036721
PDF is available here.
PDF is available here.
Abstract
We investigated the role of Notch signaling in the osteoblastic differentiation of both MC3T3E-1 cells and primary mouse bone marrow stromal cells (BMSCs). P-LPS stimulation activated the Notch1 signaling cascade and increased expression of the Notch target genes HES1 and HEY1. P-LPS can also act as...
|
PMID: 20648628
PDF is available here.
PDF is available here.
Cell Cycle (9)18 2010
Abstract
We studied the effects of hypoxia on PTHrP expression. We found that PTHrP is transcriptionally induced by prolonged (48 h) hypoxia in multiple human cancer and endothelial cell lines. Pharmacological up or downregulation of hypoxia-inducible factor (HIF) resulted in induction or reduction of PTHrP...
|
PMID: 20890122
PDF is available here.
PDF is available here.
Abstract
We show here that Hes1 homozygous null mutant mice exhibit multiple craniofacial malformations including calvaria agenesis, defective anterior cranial base, shortened maxilla and mandible, and abnormal palate and tongue. In the null mutant cranium, the calvarial bones, meninges including the dura ma...
|
PMID: 20818256
PDF is available here.
PDF is available here.
Abstract
Abstract
We analyzed the phenotypic alterations of human articular chondrocytes in this model on the broad molecular level. Freshly isolated chondrocytes were assembled as micromasses and maintained up to 6 weeks in medium containing human serum. Formation of cartilaginous extracellular matrix (ECM) was eval...
|
PMID: 20433912
PDF is available here.
PDF is available here.
Abstract
We used a postnatal day 9 mouse model of hypoxia-ischemia, BrdU labeling of mitotic cells, immunofluorescence and time-lapse multiphoton microscopy to determine whether hypoxia-ischemia increases production of oligodendroglial progenitors within the SVZ with emigration toward injured areas. Although...
|
PMID: 20616554
PDF is available here.
PDF is available here.
Abstract
The relative intensity of brief intermittent exercise is of major importance for the exercise-induced increase of several mRNA, including PGC-1alpha....
|
PMID: 20139785
PDF is available here.
PDF is available here.
Nature Neuroscience (13)8 2010
Abstract
Narrowing down the genetic basis of Down syndrome, in which hundreds of genes are triplicated, has been difficult. A new study finds that the expression of two affected genes, Olig1 and Olig2, is critical for maintaining the balance of inhibitory and excitatory signaling in a mouse model of Down syn...
|
PMID: 20661264
PDF is available here.
PDF is available here.
Abstract
Notch signalling is of fundamental importance to various processes during embryonic development and in adults. The possible role of Hey1, an important Notch signalling component, in odontoblast differentiation was evaluated in this study. Primary cultured dental pulp cells, derived from upper inciso...
|
PMID: 20666749
PDF is available here.
PDF is available here.
Abstract
We used a combination of comparative genomics, locus-wide chromatin immunoprecipitation assays, functional validation in cell lines, and extensive transgenic mouse assays to identify and characterize the complete ensemble of Gfi1 regulatory elements. This concerted effort identified five distinct re...
|
PMID: 20516218
PDF is available here.
PDF is available here.
Abstract
We generated a pancreas-specific ERalpha knockout mouse (PERalpha KO(-/-)) using the Cre-loxP strategy and used a combination of genetic and pharmacologic tools in cultured islets and beta cells. Whereas 17beta-estradiol (E2) treatment up-regulates pancreatic insulin gene and protein content in cont...
|
PMID: 20616010
PDF is available here.
PDF is available here.
Cell Cycle (9)14 2010
Abstract
We propose that these feedback regulators help to flexibly adjust and adapt HIF activated responses to the fluctuating oxygen concentrations within tumors during acute and chronic hypoxia and to curtail the tumor-suppressing components of the HIF pathway. Moreover, feedback regulation of HIF induces...
|
PMID: 20603601
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)29 2010
Abstract
Mu-opioid receptor regulates microRNA-190 (miR-190) in an agonist-dependent manner; fentanyl, but not morphine, decreases the miR-190 level in rat primary hippocampal neuron cultures and in mouse hippocampi. In this study, the correlation between the cellular content of miR-190 and the mRNA level of...
|
PMID: 20457614
PDF is available here.
PDF is available here.
Abstract
An in vivo screen was performed in search of chemicals capable of enhancing neuron formation in the hippocampus of adult mice. Eight of 1000 small molecules tested enhanced neuron formation in the subgranular zone of the dentate gyrus. Among these was an aminopropyl carbazole, designated P7C3, endow...
|
PMID: 20603013
PDF is available here.
PDF is available here.
Abstract
We present the first comparative analysis of serum immunoglobulin G reactivity profiles against the full spectrum of human myelin-associated proteins in multiple sclerosis patients and healthy control subjects. In both groups, serum antibodies display a consistent and prominent reaction to alphaB-cr...
|
PMID: 20535035
PDF is available here.
PDF is available here.
Carcinogenesis (31)7 2010
Abstract
We show that in highly EGFR-expressing HNSCC cells, hypoxic stress triggers the activation of the EGFR and downstream targets, including Akt and phospholipase C (PLC) gamma1. In support of these findings, we also demonstrate that EGFR activation takes place within hypoxic foci in a subset of human H...
|
PMID: 20395290
PDF is available here.
PDF is available here.
Plant Physiology (153)3 2010
Abstract
We present here an updated and comprehensive classification of the bHLHs encoded by the whole sequenced genomes of Arabidopsis (Arabidopsis thaliana), Populus trichocarpa, Oryza sativa, Physcomitrella patens, and five algae species. We define a plant bHLH consensus motif, which allowed the identific...
|
PMID: 20472752
PDF is available here.
PDF is available here.
Abstract
We sequenced 50 exomes of ethnic Tibetans, encompassing coding sequences of 92% of human genes, with an average coverage of 18x per individual. Genes showing population-specific allele frequency changes, which represent strong candidates for altitude adaptation, were identified. The strongest signal...
|
PMID: 20595611
PDF is available here.
PDF is available here.
Abstract
Abstract
Although the fungus Candida albicans is a commensal colonizer of humans, the organism is also an important opportunistic pathogen. Most infections caused by C. albicans arise from organisms that were previously colonizing the host as commensals, and therefore successful establishment of colonization...
|
PMID: 20435697
PDF is available here.
PDF is available here.
Abstract
The kidney is a highly sensitive oxygen sensor and plays a central role in mediating the hypoxic induction of red blood cell production. Efforts to understand the molecular basis of oxygen-regulated erythropoiesis have led to the identification of erythropoietin (EPO), which is essential for normal...
|
PMID: 20444740
PDF is available here.
PDF is available here.
Abstract
We examined the influence of GDNF on the expression of neurogenin3 (Ngn3) and other transcription factors implicated in early beta-cell development, as well as on beta-cell proliferation during embryonic and early postnatal mouse pancreas development. Embryonic day 15.5 (E15.5) mouse pancreatic tiss...
|
PMID: 20448145
PDF is available here.
PDF is available here.
Human Mutation (31)7 2010
Abstract
We found SOHLH1 (spermatogenesis and oogenesis-specific basic helix-loop-helix 1) as the first testis-specific basic helix-loop-helix transcription factor essential for spermatogonial differentiation. SOHLH1 therefore represents an excellent candidate gene for testicular failure such as nonobstructi...
|
PMID: 20506135
PDF is available here.
PDF is available here.
Plant Cell Online (22)7 2010
Abstract
We identified a pericycle-specific iron deficiency response and a bHLH transcription factor, POPEYE (PYE), that may play an important role in this response. Functional analysis of PYE suggests that it positively regulates growth and development under iron-deficient conditions. Chromatin immunoprecip...
|
PMID: 20675571
PDF is available here.
PDF is available here.
Developmental Biology (343)1-2 2010
Abstract
We traced the lineages of the cerebellar neurons. The atoh1(+) progenitors gave rise not only to granule cells but also to neurons of the anteroventral rhombencephalon. The ptf1a(+) progenitors generated Purkinje cells. The olig2(+) eurydendroid cells, which are glutamatergic, were derived mostly fr...
|
PMID: 20388506
PDF is available here.
PDF is available here.
Developmental Biology (343)1-2 2010
Abstract
We have studied the involvement of the proneural gene Ascl1 in the development of the midbrain GABAergic neurons. Analysis of Ascl1 mutant mice demonstrated highly region-specific requirements for Ascl1 for development of different GABAergic neuron subpopulations. Ascl1 is dispensable for the develo...
|
PMID: 20417196
PDF is available here.
PDF is available here.
Abstract
Maintenance of sex-specific germ cells requires balanced activation and repression of genetic hierarchies to ensure gender-appropriate development in mammals. Figla (factor in the germ line, alpha) encodes a germ cell-specific basic helix-loop-helix transcription factor first identified as an activa...
|
PMID: 20479125
PDF is available here.
PDF is available here.
Journal of Neuroscience (30)27 2010
Abstract
We demonstrate that, in addition to activating the expression of astrocyte-specific genes, Nfia also downregulates the activity of the Notch signaling pathway via repression of the key Notch effector Hes1. These data provide a significant conceptual advance in our understanding of neural progenitor...
|
PMID: 20610746
PDF is available here.
PDF is available here.
Development (137)14 2010
Abstract
We used bioinformatic searches and transgenic approaches in medaka fish (Oryzias latipes) to characterise highly conserved regulatory enhancers responsible for Six6 expression. One of the enhancers drove gene expression in the differentiating and adult retina. A search for transcription factor bindi...
|
PMID: 20534668
PDF is available here.
PDF is available here.
Abstract
These results suggest that high glucose increased insulin secretion through a PLD1-related pathway. High glucose induced the binding of Arf6 to PLD1. Pretreatment with brefeldin A (BFA), an Arf inhibitor, decreased the PLD activity as well as the insulin secretion. Furthermore, BFA blocked the gluco...
|
PMID: 20448441
PDF is available here.
PDF is available here.
Circulation Research (106)12 2010
Abstract
We aim to identify the signaling molecules and transcription factors that regulate PE specification.
Here, we present the first genetic evidence that bone morphogenetic protein (Bmp) signaling in conjunction with the T-box transcription factor Tbx5a is essential for PE specification...
|
PMID: 20413782
PDF is available here.
PDF is available here.
Abstract
We still lack fundamental knowledge on the components of this signaling pathway. Here we show that phytochrome-interacting factor 1 (PIF1) and other transcription factors of the phytochrome-interacting factor (PIF) family down-regulate the accumulation of carotenoids by specifically repressing the g...
|
PMID: 20534526
PDF is available here.
PDF is available here.
Abstract
We used genomic and candidate gene approaches to search for evidence of such genetic selection. First, a genome-wide allelic differentiation scan (GWADS) comparing indigenous highlanders of the Tibetan Plateau (3,200-3,500 m) with closely related lowland Han revealed a genome-wide significant diverg...
|
PMID: 20534544
PDF is available here.
PDF is available here.
Abstract
We found that when ngn-3 was inhibited in an E11.5 pancreas, using either morpholino antisense or siRNA, it led to a significant decrease in endocrine differentiation after seven days in culture. Endocrine differentiation was rescued when ngn-3 inhibition was withdrawn after three days of culture, s...
|
PMID: 20471370
PDF is available here.
PDF is available here.
Abstract
We deleted VEGF and its upstream regulators, the hypoxia-inducible transcription factors HIF-1 alpha and HIF-2 alpha, and the negative regulator of HIF alpha, von Hippel-Lindau protein (VHL), in astrocytes. We found that loss of hypoxic response and VEGF production in astrocytes does not impair norm...
|
PMID: 20544853
PDF is available here.
PDF is available here.
Developmental Cell (18)6 2010
Abstract
We transgenically expressed EGFP under the control of the regulatory sequences of the bHLH transcription factor gene hand2. We found that laminin is distributed along the LPM/gut boundary during gut looping, and that it appears to become diminished by the migrating hand2-expressing cells. Laminin di...
|
PMID: 20627079
PDF is available here.
PDF is available here.
Journal of Neuroscience (30)24 2010
Abstract
The cellular level of neurogenic differentiation 1 (NeuroD) is modulated differentially by mu-opioid receptor agonists; fentanyl increases NeuroD level by reducing the amount of microRNA-190 (miR-190), an inhibitor of NeuroD expression, whereas morphine does not alter NeuroD level. In the current st...
|
PMID: 20554861
PDF is available here.
PDF is available here.
Cell Stem Cell (6)6 2010
Abstract
We have used Cre-lox fate mapping in transgenic mice to show that PDGFRA/NG2-expressing glia, a distributed population of stem/progenitor cells in the adult CNS, produce the remyelinating oligodendrocytes and almost all of the Schwann cells in chemically induced demyelinated lesions. In contrast, th...
|
PMID: 20569695
PDF is available here.
PDF is available here.
Brain research (1336) 2010
Abstract
We demonstrated that DDR1 expression is high in human brain and that there is an association between the gene and schizophrenia in a case-control study. However, data regarding expression of DDR1 in the human brain are scarce. Here, we describe the expression pattern of DDR1 in the human adult cereb...
|
PMID: 20380825
PDF is available here.
PDF is available here.
Abstract
We demonstrate that NeuroD2 suppresses REST during differentiation in culture. In the hippocampus of NeuroD2 knockout mice, higher level of REST is detected. Functional significance of NeuroD2-REST interplay is uncovered by showing that forced expression of REST interferes with neuronal differentiat...
|
PMID: 20346398
PDF is available here.
PDF is available here.
Nature Medicine (16)6 2010
Abstract
Schizophrenia Research (119)1-3 2010
Abstract
These results suggest that HAL treatment activates adult OPCs, which divide infrequently under normal conditions but respond to a variety of insulting factors by proliferation and differentiation. However, our further observations showed no changes in the number of mature OLs and the amount of myeli...
|
PMID: 20346631
PDF is available here.
PDF is available here.
Journal of Neuroscience (30)19 2010
Abstract
We selectively deleted Dicer and consequently gene expression regulation by mature miRNAs from Mus musculus SCs. Our results show that in the absence of Dicer, most SCs arrest at the promyelinating stage and fail to start forming myelin. At the molecular level, the promyelinating transcription facto...
|
PMID: 20463238
PDF is available here.
PDF is available here.