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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Kruppel-Like Transcription Factors (2):
Recent article
Kruppel-Like Transcription Factors
Abstract
We have generated and characterized nonhuman primate iPS cells with the goal of evaluating iPS cell transplantation in a clinically relevant large animal model. We developed stable Phoenix-RD114-based packaging cell lines that produce OCT4, SOX2, c-MYC, and KLF4 (OSCK) expressing gammaretroviral vec...
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PMID: 21058905
PDF is available here.
PDF is available here.
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New England Journal of Medicine (364)10 2011
Abstract
Cell Metabolism (13)2 2011
Abstract
In mammals, most metabolic processes are influenced by biological clocks and feeding rhythms. The mechanisms that couple metabolism to circadian oscillators are just emerging. NAD-dependent enzymes (e.g., Sirtuins and poly[ADP-ribose] polymerases), redox- and/or temperature-dependent...
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PMID: 21284980
PDF is available here.
PDF is available here.
Science Signaling (4)157 2011
Abstract
We established previously unknown associations between these signaling pathways and genes linked to developmental malformations, diseases of premature tissue degeneration, and cancer. We identified functions in both pathways for the multitasking kinase Stk11 (also known as Lkb1), a tumor suppressor...
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PMID: 21266715
PDF is available here.
PDF is available here.
Science Signaling (4)157 2011
Abstract
We established previously unknown associations between these signaling pathways and genes linked to developmental malformations, diseases of premature tissue degeneration, and cancer. We identified functions in both pathways for the multitasking kinase Stk11 (also known as Lkb1), a tumor suppressor...
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PMID: 21266715
PDF is available here.
PDF is available here.
Abstract
We have shown that key factors supporting pluripotency-Nanog, Oct4 and Sox2-bind within Xist intron 1 in undifferentiated embryonic stem cells (ESC) to repress Xist transcription. However, the relationship between transcription factors of the pluripotency network and Tsix regulation has remained unc...
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PMID: 21085182
PDF is available here.
PDF is available here.
Arthritis & Rheumatism (62)11 2010
Abstract
Our findings extend the role of miRNA in the pathogenesis of lupus and provide potential strategies for therapeutic intervention.
Copyright © 2010 by the American College of Rheumatology....
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PMID: 20589685
PDF is available here.
PDF is available here.
Histology and histopathology (25)10 2010
Abstract
We investigated the expression of Gli2 and FoxM1 (forkhead-box transcription factor M1) which is one of the Gli downstream target genes modulating cell cycle progression in 91 specimens of human HCCs with immunohistochemistry. These immunostaining results were compared with various clinicopathologic...
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PMID: 20712011
PDF is available here.
PDF is available here.
Abstract
We also demonstrated the upregulation of endogenous Oct4 and Sox2 after successful reprogramming to pluripotency in rHD-iPSCs, which was not expressed in skin fibroblasts. rHD-iPSCs also developed cellular features comparable to Huntington's disease (HD), including the accumulation of mutant hunting...
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PMID: 20936902
PDF is available here.
PDF is available here.
Abstract
We noted chromosomal amplification of Gli2, a downstream effector of Hh signaling, and, more rarely, point mutations in Smo that led to reactivated Hh signaling and restored tumor growth. Analysis of pathway gene expression signatures also, unexpectedly, identified up-regulation of phosphatidylinosi...
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PMID: 20881279
PDF is available here.
PDF is available here.
Abstract
We now report that B cell sequestration requires lineage-specific regulation of migratory receptors by the transcription factor Klf2. Moreover, using gene-targeted mice we show that altered splenic B cell migration confers a significant in vivo gain-of-function phenotype to FO B cells, including the...
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PMID: 20691614
PDF is available here.
PDF is available here.
Nature Genetics (42)9 2010
Abstract
The transition from fetal to adult beta-like globin expression is a key step in the maturation of the red blood cell lineage. Two new studies show that the KLF1 zinc finger protein uses direct and indirect means to regulate the final switch from fetal to adult globin expression and t...
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PMID: 20802474
PDF is available here.
PDF is available here.
Abstract
We show that mTORC1 impairs stem cell maintenance by a negative feedback from mTORC1 to receptors required to transduce niche-derived signals. We find that SPCs lacking Plzf, a transcription factor essential for SPC maintenance, have enhanced mTORC1 activity. Aberrant mTORC1 activation in Plzf(-/-)...
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PMID: 20691905
PDF is available here.
PDF is available here.
Experimental Cell Research (316)14 2010
Transcription factor KLF7 regulates differentiation of neuroectodermal and mesodermal cell lineages.
Abstract
We demonstrate that murine Klf7 gene expression is required for in vitro differentiation of neuroectodermal and mesodermal cells. Specifically, we show a correlation of Klf7 silencing with down-regulation of the neuronal marker microtubule-associated protein 2 (Map2) and the nerve growth factor (NGF...
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PMID: 20580711
PDF is available here.
PDF is available here.
Early progenitor cell marker expression distinguishes type II from type I focal cortical dysplasias.
Abstract
We hypothesized that c-Myc, SOX2, and Oct-4 expression would distinguish type II from type I FCDs. In addition, we assayed the expression of progenitor cell proteins forkhead box G1 (FOXG1), Kruppel-like factor 4 (KLF4), Nanog, and SOX3. Differential expression of 7 stem cellproteins and aberrant ph...
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PMID: 20613634
PDF is available here.
PDF is available here.
Developmental Biology (344)1 2010
Abstract
We utilized zebrafish and mouse ES cells to investigate the role of copeb in endoderm specification and hepatogenesis separate from its function in angiogenesis. During zebrafish development, copeb expression is enriched in digestive organs. Morpholino knockdown of copeb blocks expansion of the live...
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PMID: 20430021
PDF is available here.
PDF is available here.
Cancer Letters (294)1 2010
Abstract
We showed that PLZF inhibits endothelial cell angiogenesis using a human umbilical vein endothelial cell system. We also focused on characterizing the specific function of the BTB domain of PLZF as a novel apoptotic and anti-angiogenic protein via deletion mapping analysis. The BTB domain directly i...
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PMID: 20236758
PDF is available here.
PDF is available here.
Life Sciences (87)3-4 2010
Abstract
As expected, simvastatin and LSS separately enhanced KLF2, eNOS, and TM mRNA expressions. The combination of simvastatin and LSS resulted in significantly higher mRNA levels of all three genes compared to cells treated with LSS only. The highest KLF2, eNOS, and TM mRNA levels were detected at 10 mic...
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PMID: 20493886
PDF is available here.
PDF is available here.
Abstract
These results provide evidence of a molecular mechanism linking cell-cell contact to cell proliferation and dedifferentiation in RPE cells....
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PMID: 20207963
PDF is available here.
PDF is available here.
Abstract
We report here the molecular characterization of porcine chemerin and its receptors ChemR23 and GPR1, as well as their transcriptional regulation during lipogenesis. Chemerin was mainly expressed in liver, intestine, kidney and adipose tissue, consistent with the expression pattern of GPR1, but not...
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PMID: 20663411
PDF is available here.
PDF is available here.
Abstract
Weak growth suppression by cyclopamine suggests that hedgehog signaling is not involved in bladder cancer cell proliferation but Gli2 expression strongly correlated with invasive behavior. Increased Gli2 expression increased low Gli2 cell invasiveness while Gli inhibition by GANT61 decreased high Gl...
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PMID: 20488474
PDF is available here.
PDF is available here.
Gastroenterology (139)1 2010
Abstract
Klf4 is essential for squamous epithelial differentiation in vivo and interacts with Klf5 to maintain normal epithelial homeostasis.
Copyright 2010 AGA Institute. Published by Elsevier Inc. All rights reserved....
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PMID: 20347813
PDF is available here.
PDF is available here.
Endocrinology (151)7 2010
Abstract
We previously showed that mice null for the progesterone receptor (PGR)-interacting protein Krüppel-like factor (KLF) 9 are subfertile and exhibit reduced uterine progesterone sensitivity. KLF9 expression is high in predecidual stroma, undetectable in decidua, and enhanced in uteri of mice with con...
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PMID: 20410205
PDF is available here.
PDF is available here.
Abstract
Abstract
Together, these results suggest that Vezf1 is involved in early differentiation processes of the vasculature by regulating cell differentiation, proliferation, and ECM distribution and deposition....
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PMID: 20431070
PDF is available here.
PDF is available here.
Abstract
We investigated whether the transcription factor KLF15 has a role in the regulation of gluconeogenesis and whether KLF15 participates in the antidiabetes effect of metformin.
Here we show that KLF15 regulates the expression of genes for gluconeogenic or amino acid-degrading enzymes i...
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PMID: 20393151
PDF is available here.
PDF is available here.
Cell Stem Cell (7)1 2010
Abstract
We show that the generation of iPSCs from mouse fibroblasts requires a mesenchymal-to-epithelial transition (MET) orchestrated by suppressing pro-EMT signals from the culture medium and activating an epithelial program inside the cells. At the transcriptional level, Sox2/Oct4 suppress the EMT mediat...
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PMID: 20621050
PDF is available here.
PDF is available here.
Abstract
Our results provide the first evidence of a role for KLF3 in muscle gene regulation and reveal an alternate mechanism for transcriptional regulation by SRF via its recruitment to KLF binding sites. Since both factors are expressed in all muscle lineages, SRF may regulate many striated- and smooth-mu...
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PMID: 20404088
PDF is available here.
PDF is available here.
Abstract
The zinc finger transcription factor ZNF24 is a relatively uncharacterized Krüppel-like transcription factor, displaying a suppressive effect on the transcription. ZNF24 is involved in negative regulation of vascular endothelial growth factor (VEGF) and may represent a novel repressor of VEGF trans...
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PMID: 20510677
PDF is available here.
PDF is available here.
Abstract
We employed a transgenic mouse model in which an activated version of GLI2, a transcriptional mediator of the pathway, is overexpressed specifically in the pancreatic epithelium. Surprisingly, efficient Hh activation was not observed in these transgenic mice, indicating the presence of physiological...
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PMID: 20479231
PDF is available here.
PDF is available here.
Abstract
We show that KLF13 and FGFR3 are overexpressed in oral cancer cells. We also show that artificially reducing cellular levels of KLF13 and FGFR3 decreases cell proliferation and increases sensitivity to ionizing radiation. These data suggest that KLF13 and FGFR3 contribute to malignancy in oral cance...
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PMID: 20539070
PDF is available here.
PDF is available here.
Hereditas (Beijing) (32)6 2010
Abstract
We reviewed the structure, molecular mechanisms and biological functions of Sp1/KLFs....
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PMID: 20566455
PDF is available here.
PDF is available here.
Abstract
We previously defined a list of GC-regulated genes by expression profiling in children with acute lymphoblastic leukemia (ALL) during systemic GC monotherapy and in experimental systems of GC-induced apoptosis. PLZF/ZBTB16, a transcriptional repressor, was one of the most promising candidates derive...
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PMID: 20435142
PDF is available here.
PDF is available here.
Abstract
We find dramatic differences in the gene networks that are directly driven by the Gli1 transcription factor in GNPs and medulloblastoma. Gli1 binding location analysis revealed hundreds of genomic loci bound by Gli1 in normal and cancer cells. Only one third of the genes bound by Gli1 in GNPs were a...
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PMID: 20460306
PDF is available here.
PDF is available here.
Abstract
We rewire the identity of conventional human ESCs into a more immature state that extensively shares defining features with pluripotent mouse ESCs. This was achieved by ectopic induction of Oct4, Klf4, and Klf2 factors combined with LIF and inhibitors of glycogen synthase kinase 3beta (GSK3beta) and...
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PMID: 20442331
PDF is available here.
PDF is available here.
Abstract
We establish a mammalian affinity purification and lentiviral expression (MAPLE) system for characterizing the subunit compositions of protein complexes. The system is flexible (i.e. multiple N- and C-terminal tags and multiple promoters), is compatible with Gateway cloning, and incorporates a refer...
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PMID: 20305087
PDF is available here.
PDF is available here.
Journal of Urology (183)5 2010
Abstract
Data suggest that prostate tumor cells expressing pluripotent stem cell transcription factors are highly tumorigenic. Identifying such cells and their importance in prostate cancer growth could provide opportunities for novel targeting strategies for prostate cancer therapy.
2010 American Urological...
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PMID: 20303530
PDF is available here.
PDF is available here.
Reproduction (139)5 2010
Abstract
The undifferentiated spermatogonial population consists of stem and progenitor germ cells which function to provide the foundation for spermatogenesis. The stem cell component, termed spermatogonial stem cells (SSCs), is capable of self-renewal and differentiation. These unique attri...
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PMID: 20154176
PDF is available here.
PDF is available here.
Abstract
We show that HIC1 is a direct transcriptional repressor of the gene encoding ephrin-A1, a cell surface ligand implicated in the pathogenesis of epithelial cancers. We also show that mouse embryos lacking both Hic1 alleles manifest developmental defects spatially associated with the misexpression of...
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PMID: 20154726
PDF is available here.
PDF is available here.
Abstract
We focused on the aortic arch (AA) blood vessels, which are known to remodel in response to blood flow. By using two-photon imaging of live zebrafish embryos, we observe that flow is essential for angiogenesis during AA development. We further find that angiogenic sprouting of AA vessels requires a...
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PMID: 20364122
PDF is available here.
PDF is available here.
Abstract
Abstract
We evaluated this model with the use of lineage analysis and live imaging, and found that this putative stem cell population is not homogeneous. Instead, the stem cell pool that supports steady-state spermatogenesis is contained within a subpopulation of single spermatogonia. We also found that cyst...
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PMID: 20299552
PDF is available here.
PDF is available here.
Abstract
We asked whether stem/progenitor cells from discarded dental tissues can be reprogrammed into iPS cells. The 4 factors Lin28/Nanog/Oct4/Sox2 or c-Myc/Klf4/Oct4/Sox2 carried by viral vectors were used to reprogram 3 different dental stem/progenitor cells: stem cells from exfoliated deciduous teeth (S...
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PMID: 19795982
PDF is available here.
PDF is available here.
Reproduction (139)4 2010
Abstract
We analyzed Klf4 expression in different mouse tissues using northern blot analysis and immunohistochemistry. Focusing on the male and female reproductive tract, we showed for the first time that KLF4 is expressed in the epithelia of the murine uterus and the vagina. In the male reproductive tract,...
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PMID: 20051481
PDF is available here.
PDF is available here.
Abstract
We therefore produced recombinant transcription factor proteins in E. coli (OCT4, SOX2, c-MYC and KLF4) carrying the cell penetrating TAT domain from HIV1. The purified proteins were able to enter into mammalian cells when added to tissue culture medium but appeared not to translocate to the nucleus...
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PMID: 19669668
PDF is available here.
PDF is available here.
Abstract
Natural killer T cells (NKT cells) are CD1d-restricted, lipid antigen-reactive, immunoregulatory T lymphocytes that can promote cell-mediated immunity to tumors and infectious organisms, including bacteria and viruses, yet paradoxically they can also suppress the cell-mediated immuni...
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PMID: 20139988
PDF is available here.
PDF is available here.
Abstract
We term OSK) constitutes the minimal requirement for generating iPS cells from mouse embryonic fibroblasts. These cells are thought to resemble embryonic stem cells (ESCs) on the basis of global gene expression analyses; however, few studies have tested the ability and efficiency of iPS cells to con...
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PMID: 20139965
PDF is available here.
PDF is available here.
Cell Stem Cell (6)2 2010
Abstract
We show that the orphan nuclear receptor Nr5a2 (also known as Lrh-1) can replace Oct4 in the derivation of iPSCs from mouse somatic cells, and it can also enhance reprogramming efficiency. Sumoylation mutants of Nr5a2 with enhanced transcriptional activity can further increase reprogramming efficien...
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PMID: 20096661
PDF is available here.
PDF is available here.
Nature Cell Biology (12)2 2010
Abstract
We show here that Gli1 and Gli2 are acetylated proteins and that their HDAC-mediated deacetylation promotes transcriptional activation and sustains a positive autoregulatory loop through Hedgehog-induced upregulation of HDAC1. This mechanism is turned off by HDAC1 degradation through an E3 ubiquitin...
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PMID: 20081843
PDF is available here.
PDF is available here.
Abstract
We reprogrammed fibroblasts in the presence or absence of c-MYC to determine if the acquired cardiogenicity is sensitive to the method of nuclear reprogramming. Using lentiviral constructs that expressed stemness factors SOX2, OCT4, and KLF4 with or without c-MYC, iPS clones generated through fibrob...
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PMID: 20221419
PDF is available here.
PDF is available here.
Development (137)3 2010
Abstract
We examined the ability of Foxg1(-/-) telencephalic cells to respond to Shh and Fgf8 by examining the expression of genes whose activation requires Shh or Fgf8 in vivo and by testing their responses to Shh and Fgf8 in culture. We found that many elements of the Shh and Fgf8 signalling pathways conti...
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PMID: 20081193
PDF is available here.
PDF is available here.
Abstract
The limb has long been considered a paradigm for organogenesis because of its simplicity and ease of manipulation. However, it has become increasingly clear that the processes required to produce a perfectly formed limb involve complex molecular interactions across all three axes of limb development...
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PMID: 20691854
PDF is available here.
PDF is available here.
Abstract
We found that Klf4 can potentially interact with pNF-κB and is important for iNOS and Cox-2 promoter activity in vitro.
These studies demonstrate the role of Klf4 in microglia in mediating neuroinflammation in response to the bacterial endotoxin LPS....
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PMID: 20946687
PDF is available here.
PDF is available here.
Abstract
We report a pluripotency monitoring system in which the expression of green fluorescent protein (GFP) is under the control of the promoter of a pluripotency gene (Rex-1). The reporter system can be permanently integrated into the genome of live cells via lentiviral vectors. This pluripotency reporte...
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PMID: 19473101
PDF is available here.
PDF is available here.
Abstract
In this study we analyzed KLF6 expression and sub-cellular distribution by immunohistochemistry in several normal and tumor tissues in a microarray format representing fifteen human organs. Results indicate that while both nuclear and cytoplasmic distribution of KLF6 is detected in normal breast tis...
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PMID: 20126619
PDF is available here.
PDF is available here.
Abstract
The structure of gene pool of the Siberian aboriginal population has been described based on the data on polymorphism of ZFX gene located on X-chromosome. In ten populations under study 49 haplotypes have been determined, three of which are presented with high frequency. Comparing the obtained resul...
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PMID: 21090236
PDF is available here.
PDF is available here.
Molecular Psychiatry (15)1 2010
Abstract
We attempted to replicate these findings in our Irish Case-Control Study of Schizophrenia (ICCSS) sample (N=1021 cases, 626 controls). Following consultation with the original investigators, we genotyped three of the most promising single-nucleotide polymorphisms (SNPs) from the Cardiff study. We re...
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PMID: 19844207
PDF is available here.
PDF is available here.
Molecular Cancer (9)1 2010
Abstract
Results of the current study confirm the cumulative effect of Apc loss and oncogenic KRAS activation on intestinal tumorigenesis. The drastic reduction in tumor number and size due to Klf5 heterozygosity in ApcMin/KRASV12 mice indicate a critical function of KLF5 in modulating intestinal tumor initi...
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PMID: 20298593
PDF is available here.
PDF is available here.
BMC Medical Genetics (11) 2010
Abstract
We have conducted a genome-wide scan to map the linkage region in this family.
Genome-wide linkage analysis using Single Nucleotide Polymorphism (SNP) markers on the Affymetrix 10K SNP array was conducted and analysed using MERLIN. Three positional candidate genes (ZBTB17, EPHA2 and EPHB2) were sequ...
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PMID: 21092079
PDF is available here.
PDF is available here.
Abstract
We identified three additional targets, Sostdc1, Penk1 and Igfbp5, which were also severely affected. Penk1 and Igfbp5 were confirmed to be regulated by GLI1, while the induction of Sostdc1 by IHH is independent of GLI1. SOSTDC1 is a BMP antagonist, and altered BMP signaling is known to affect digit...
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PMID: 20024692
PDF is available here.
PDF is available here.