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Tumor Suppressor Protein p53 (0):
Recent article
Tumor Suppressor Protein p53
Abstract
We show that the proliferating cell nuclear antigen-associated factor (Paf) is highly expressed in cycling bone marrow HSCs and plays a critical role in hematopoiesis. Mice lacking Paf exhibited reduced bone marrow cellularity; reduced numbers of HSCs and committed progenitors; and leukopenia. These...
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PMID: 21844206
PDF is available here.
PDF is available here.
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Abstract
We also discuss how these mechanisms can be translated into usable biomarkers. Although progress has been made in the understanding of inflammation-driven carcinogenesis, markers based on these findings possess insufficient sensitivity or specificity to be usable as reliable biomarkers for risk of c...
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PMID: 21647200
PDF is available here.
PDF is available here.
Abstract
The identification of patients with inherited cancer susceptibility syndromes facilitates early diagnosis, prevention, and treatment. However, in many cases of suspected cancer susceptibility, the family history is unclear and genetic testing of common cancer susceptibility genes is...
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PMID: 21505135
PDF is available here.
PDF is available here.
Cancer Biology & Therapy (11)8 2011
Abstract
Abstract
We have established an RNA interference (RNAi) screen to identify genes whose depletion selectively inhibits the growth of cells lacking BRCA2, and then studied the effects of the genetic depletion or pharmacologic inhibition of 1 candidate, the checkpoint kinase 1 (CHK1), in the context of pancreat...
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PMID: 21289082
PDF is available here.
PDF is available here.
Abstract
We found an association between sensitivity to CD40 stimulation and mutation of the tumor suppressor p53 in a panel of non-Hodgkin's lymphoma cell lines. Consistent with p53's tumor suppressor role, we found that higher levels of intrinsic DNA damage and increased proliferation rates, as well as hig...
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PMID: 21411738
PDF is available here.
PDF is available here.
Abstract
We report here that the two most common types--follicular lymphoma and diffuse large B-cell lymphoma--harbour frequent structural alterations inactivating CREBBP and, more rarely, EP300, two highly related histone and non-histone acetyltransferases (HATs) that act as transcriptional co-activators in...
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PMID: 21390126
PDF is available here.
PDF is available here.
Gastroenterology (140)3 2011
Abstract
Mutations in TP53, a tumor suppressor gene, are associated with prognosis of many cancers. However, the prognostic values of TP53 mutation sites are not known for patients with hepatocellular carcinoma (HCC) because of heterogeneity in their geographic and etiologic backgrounds....
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PMID: 21094160
PDF is available here.
PDF is available here.
Journal of Proteomics (74)3 2011
Abstract
We here proposes a Partial Least Squares Regression (PLSR)-based data integration strategy, which allows simultaneous analysis of proteomic data, gene expression data and classical clinical parameters. PLSR collapses multidimensional data into fewer relevant dimensions for data interpretation. PLSR...
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PMID: 21075225
PDF is available here.
PDF is available here.
Abstract
We have shown here that UVC upregulates p16(INK4A) and the phosphorylated form of the protein at the 4 serine sites; Ser-7, Ser-8, Ser-140, and Ser-152. This accumulation of p16(INK4A) occurred through increasing the stability of both forms of the protein. Importantly, phospho-p16(INK4A) showed much...
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PMID: 21270107
PDF is available here.
PDF is available here.
Abstract
We investigated the clinical significance of excision repair cross-complementation group 1 (ERCC1), breast cancer susceptibility 1 (BRCA1), and class III β-tubulin (TUBB3) expression in thymic epithelial tumors.
Fifty-six patients with thymic epithelial tumors were included in this...
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PMID: 21289518
PDF is available here.
PDF is available here.
Abstract
We show that TAp63α is kept in an inactive dimeric state. We reveal that relief of inhibition leads to tetramer formation with ∼20-fold higher DNA affinity. In vivo, phosphorylation-triggered tetramerization of TAp63α is not reversible by dephosphorylation. Furthermore, we show that a helix in t...
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PMID: 21335238
PDF is available here.
PDF is available here.
Oligonucleotides (21)1 2011
Abstract
Recently, it has been reported that, in several tumor cell lines, short double-stranded RNAs tailored for promoter regions of specific genes are able to activate their transcription. Such molecules (named RNA activators) act opposite to other double-stranded RNA molecules (named RNA...
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PMID: 21241187
PDF is available here.
PDF is available here.
Cell Cycle (10)2 2011
Abstract
Abstract
We investigated whether USP7 itself regulates PML-NBs. Silencing of USP7 was found to increase the number of PML-NBs, to increase the levels of PML protein and to inhibit PML polyubiquitylation in nasopharyngeal carcinoma cells. This effect of USP7 was independent of p53 as PML loss was observed in...
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PMID: 21305000
PDF is available here.
PDF is available here.
Abstract
We introduce the concept of contagion in order to infer directionality at the edges, i.e., asymmetries in gene expression dependences of regulatory networks. Moreover, we present a bootstrap algorithm in order to test the contagion concept. This technique was applied in simulated data and, also, in...
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PMID: 20479499
PDF is available here.
PDF is available here.
Abstract
Establishing a diagnosis of ovarian clear cell carcinoma (O-CCC) can be subject to significant interobserver variation. Accurately diagnosing this tumor is important because of its chemoresistance and reported association with Lynch syndrome. The spectrum of the morphologic features of O-CCC has not...
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PMID: 21164285
PDF is available here.
PDF is available here.
Abstract
Chromosomal abnormalities (namely 13q, 17p, and 11q deletions) have prognostic implications and are recurrent in chronic lymphocytic leukemia (CLL), suggesting that they are involved in a common pathogenetic pathway; however, the molecular mechanism through which chromosomal abnormal...
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PMID: 21205967
PDF is available here.
PDF is available here.
Abstract
We show that HIF-1α protects against drug-induced apoptosis by antagonizing the function of the tumor suppressor p53. HIF-1α upregulation induced proteasomal degradation of homeodomain-interacting protein kinase-2 (HIPK2), the p53 apoptotic activator. Inhibition of HIF-1α by siRNA, HIF-1α-domina...
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PMID: 21248371
PDF is available here.
PDF is available here.
Abstract
We proposed that the remarkable efficacy and broad spectrum of RLIP76-targeted therapy is because its glutathione-conjugate (GS-E) transport activity is required for clathrin-dependent endocytosis (CDE), which regulates all ligand-receptor signaling, and that RLIP76 is required not only for survival...
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PMID: 21220488
PDF is available here.
PDF is available here.
Abstract
Our previous studies showed a down-regulation of GRIM-19 in primary human cervical cancers, and restoration of GRIM-19 induced tumor regression. The induction of tumor suppressor protein p53 ubiquitination and degradation by E6 oncoportein of high risk-HPV through forming a stable complex with E6AP...
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PMID: 21765936
PDF is available here.
PDF is available here.
Abstract
Our recent study shows that p53, a downstream effector of the telomere damage signaling, also functions upstream of the telomere‐capping protein complex by inhibiting one of its components, TRF2 (telomeric repeat binding factor 2). Since TRF2 inhibition leads to ATM activation, a novel positive fe...
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PMID: 21266744
PDF is available here.
PDF is available here.
Abstract
We have recently shown that HBXIP promotes the growth of both normal liver cells and hepatoma cells in vitro, but the molecular mechanisms of this have not been documented. In this study, we investigated the potential effects of HBXIP on the proliferation of HepG2 cells and the intracellular signali...
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PMID: 21239735
PDF is available here.
PDF is available here.
Molecular Carcinogenesis (50)1 2011
Abstract
We find that berberine, when administered orally through the diet, inhibits in vivo tumorigenesis of both p53 expressing and p53 null lung tumor xenografts equally whether administered in its pure form or as a part of P. amurense extract. We also show that berberine induces G1 cell cycle arrest, inh...
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PMID: 21061266
PDF is available here.
PDF is available here.
Molecular Carcinogenesis (50)1 2011
Abstract
We demonstrate for the first time that curcumin treatment suppresses cervical cancer cell growth in a three-dimensional raft culture system. Curcumin also inhibits tumorigenic characteristics as shown by decreases in both clonogenic potential and cell motility. Additionally, our findings show that c...
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PMID: 21061268
PDF is available here.
PDF is available here.
Abstract
Our results suggest that TAp63 may play a compensatory role in cell cycle regulation and DNA damage repair in p53-deficient cancer cells.
Copyright © 2010 Elsevier Inc. All rights reserved....
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PMID: 21075072
PDF is available here.
PDF is available here.
Abstract
We established a series of stable transfectants expressing wild-type and three mutant LANA; amino terminus, carboxyl terminus and amino terminus plus DNA binding domain, as a new strategy to assess systematically the interactions and binding domains with cellular proteins. Using the system, we repor...
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PMID: 21056547
PDF is available here.
PDF is available here.
Abstract
We show that restoration of p53 in established murine lung tumours leads to significant but incomplete tumour cell loss specifically in malignant adenocarcinomas, but not in adenomas. We define amplification of MAPK signalling as a critical determinant of malignant progression and also a stimulator...
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PMID: 21107428
PDF is available here.
PDF is available here.
Abstract
We model the probable therapeutic impact of p53 restoration in a spontaneously evolving mouse model of NSCLC initiated by sporadic oncogenic activation of endogenous Kras. Surprisingly, p53 restoration failed to induce significant regression of established tumours, although it did result in a signif...
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PMID: 21107427
PDF is available here.
PDF is available here.
Abstract
Activation of the KEAP1-NRF2 signaling pathway is an adaptive response to environmental and endogenous stresses and serves to render animals resistant to chemical carcinogenesis and other forms of toxicity, whereas disruption of the pathway exacerbates these outcomes. This pathway, w...
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PMID: 20367496
PDF is available here.
PDF is available here.
Abstract
We found in this study that blockade of the interaction of p53 and MDM2 by the MDM2 antagonist nutlin-3 in melanoma cells did not induce apoptosis, even though it upregulated p53 and its proapoptotic targets. Nevertheless, nutlin-3 enhanced TRAIL-induced apoptosis as a result of p53-mediated upregul...
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PMID: 21159614
PDF is available here.
PDF is available here.
Abstract
We provide a brief overview of simple deterministic models of oscillations. In particular, we explain the mechanism of saturated degradation that has been used to model oscillations in the NF-κB, p53 and Wnt systems. The second part deals with the potential physiological role of oscillations. We us...
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PMID: 20934871
PDF is available here.
PDF is available here.
Abstract
The present study demonstrates that population-dependent differences in allele frequencies associated with health disparities provide a valuable framework for the interrogation of complex diseases in all populations.
© 2010 Wiley-Liss, Inc....
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PMID: 20593380
PDF is available here.
PDF is available here.
Abstract
We specifically investigated the influence of PRIMA-1 on cellular localization of mutated p53-R280K endogenously expressed in tumour cells. By using immunofluorescence staining, we found a strong nucleolar redistribution of mutant p53 following PRIMA-1 treatment. This subcellular localization was as...
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PMID: 20946886
PDF is available here.
PDF is available here.
Chemical Communications (46)42 2010
Abstract
We validate a practical methodology for the rapid profiling of small molecule inhibitors of protein-protein interactions. We find that a well known BH3 family inhibitor can potently inhibit the p53/hDM2 interaction.
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PMID: 20856941
PDF is available here.
PDF is available here.
DNA Repair (9)11 2010
Abstract
We have previously shown that whereas T-cells from normal individuals undergo accumulation of p53 and apoptosis when treated with the genotoxic agent Actinomycin D (ActD), those from Ataxia Telangiectasia (AT) and Nijmegen Breakage Syndrome (NBS) patients resist ActD-induced apoptosis [1]. We have n...
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PMID: 20947454
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)45 2010
Abstract
We investigated a combinatorial approach using two natural dietary polyphenols, luteolin and EGCG, and found that their combination at low doses (at which single agents induce minimal apoptosis) synergistically increased apoptosis (3-5-fold more than the additive level of apoptosis) in both head and...
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PMID: 20826787
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)45 2010
Abstract
We report novel functions of B56ε in regulating apoptosis. We provide evidence that B56ε has both anti- and pro-apoptotic functions. B56ε suppresses p53-independent apoptosis during neural development, but triggers p53-dependent apoptosis. Mechanistically, B56ε regulates the p53-dependent apopto...
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PMID: 20807766
PDF is available here.
PDF is available here.
Radiation Research (174)5 2010
Abstract
We investigated the influence of oxidative stress and the cell-protective effects of α(1)-microglobulin during α-particle irradiation. The results showed an increase in cell death in both irradiated cells and bystander cells. A significant increase in apoptosis, oxidation markers and expression of...
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PMID: 20954860
PDF is available here.
PDF is available here.
Radiation Research (174)5 2010
Abstract
We tested this concept for radiotherapy of p53-deficient and -proficient glioma. We observed significant interaction of PFT-α with radiation-induced G(1) checkpoint activation and plating efficiency only in glioma cells expressing at least one wild-type allele of p53. This interaction was correlate...
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PMID: 20718603
PDF is available here.
PDF is available here.
Cancer Science (101)11 2010
Abstract
We aim to investigate its inhibitory effect on both MCF-7 and MDA-MB-231 cells, and explore the possible mechanisms of its anticancer effect. Cell viability and motility were measured by MTT and invasive assays, migration and scratch assays in vitro, respectively. The distribution of cell cycle, PI-...
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PMID: 20718753
PDF is available here.
PDF is available here.
EMBO Reports (11)11 2010
Abstract
Cancer Research (70)22 2010
Abstract
We describe the mechanism of action of WP1130, a small molecule derived from a compound with Janus-activated kinase 2 (JAK2) kinase inhibitory activity. WP1130 induces rapid accumulation of polyubiquitinated (K48/K63-linked) proteins into juxtanuclear aggresomes, without affecting 20S proteasome act...
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PMID: 21045142
PDF is available here.
PDF is available here.
Abstract
We show that liver-specific ablation of Cul3 in mice results in the persistence and massive expansion of hepatic progenitor cells. Upon induction of differentiation, Cul3-deficient progenitor cells underwent substantial DNA damage in vivo and in vitro, thereby triggering the activation of a cellular...
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PMID: 20978349
PDF is available here.
PDF is available here.
Abstract
To identify the gene expression profiles associated with the apoptosis of pulmonary arterial smooth muscle cells stimulated by carbon monoxide (CO).
Primary cultured Sprague-Dawley rat pulmonary arterial smooth muscle cells (PASMC) were stimulated by platelet-derived growth factor (PDGF, 20 ng/mL) a...
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PMID: 21083984
PDF is available here.
PDF is available here.
Anti-Cancer Drugs (21)10 2010
Abstract
We sought to investigate their impact on normal cells by using Drosophila as a model. We investigated the possible involvement of Drosophila homologue of p53 (Dmp53) and a member of the retinoblastoma binding protein 6 family, known as Snama. On account of its molecular features and experimental evi...
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PMID: 20717003
PDF is available here.
PDF is available here.
Abstract
We show that, in many cell types, p53 confers increased survival in the face of chronic starvation. We implicate regulation of autophagy in this effect. In HCT116 human colorectal cancer cells exposed to prolonged nutrient deprivation, the endogenous wt p53 posttranscriptionally down-regulates LC3,...
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PMID: 20937856
PDF is available here.
PDF is available here.
Abstract
To investigate the expression of p53 and p21 and associations with possible risk factors, such as cigarette smoking, in esophageal squamous cell carcinoma (ESCC) in northeastern Iran, a region with a high incidence of ESCC.
The expression of p53 and p21 proteins was investigated immunohistochemicall...
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PMID: 20954283
PDF is available here.
PDF is available here.
Cell Cycle (9)20 2010
Abstract
We demonstrate that part of this regulation occurs at the level of DNA binding. We show that the killer function of p53 requires the four DNA binding domains within the p53 tetramer to interact with one another. These intermolecular interactions enable cooperative binding of p53 to less perfect resp...
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PMID: 20948308
PDF is available here.
PDF is available here.
Abstract
We show here that depleting cyclin B1 stabilizes and reactivates p53 in papillomavirus-infected cervical cancer cell lines HeLa and CaSki. HeLa cells depleted of cyclin B1 exhibit mitotic defects in spindle formation and chromosome alignment. Downregulation of cyclin B1 increases p14 alternative rea...
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PMID: 20661218
PDF is available here.
PDF is available here.
Abstract
Nutrition and Cancer (62)7 2010
Abstract
Head and neck squamous cell carcinoma (HNSCC) is one of the most fatal cancers worldwide. Despite advances in the management of HNSCC, the overall survival for patients has not improved significantly due to advanced stages at diagnosis, high recurrence rate after surgical removal, and second primary...
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PMID: 20924973
PDF is available here.
PDF is available here.
Human Pathology (41)10 2010
Abstract
We observed a strong correlation between high p53 expression and DNA aneuploidy. This relation was also present at the level of a single nucleus, measured by sequential image cytometry of p53 immunohistochemistry followed by DNA image cytometry on formalin-fixed tissue sections. Similarly, we found...
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PMID: 20656324
PDF is available here.
PDF is available here.
Laboratory Investigation (90)10 2010
Abstract
Our earlier report has shown that Helicobacter pylori promoted hepatic fibrosis in a murine model. Herein, in order to elucidate the mechanism by which H. pylori accelerate liver fibrosis, the authors investigated the changes in expression levels of mitogen-activated protein kinases (MAPKs), p53-rel...
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PMID: 20531291
PDF is available here.
PDF is available here.
Abstract
We sought to determine which wt p53(65-73) peptide should be used in wt p53-based cancer vaccines. Despite similar predicted HLA-A2-binding affinities, the p53(72P) peptide was more efficient than the p53(72R) peptide in HLA-A2 stabilization assays. In vitro stimulation (IVS) of CD8+ T cells obtaine...
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PMID: 20577877
PDF is available here.
PDF is available here.
Clinical Breast Cancer (10)5 2010
Abstract
We scrutinized the 2 genetic polymorphisms in exons of DNMT1 that may influence the activity of DNMT1. Our research subjects consisted of 305 patients with IDC and 314 age-matched healthy controls. Genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism. Data...
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PMID: 20920981
PDF is available here.
PDF is available here.
Cell Cycle (9)19 2010
Abstract
We report that depletion of L37 leads to cell cycle arrest in a L11- and p53-dependent manner. DNA damage can initiate ribosomal stress, although little is known about the mechanisms involved. We have found that some genotoxic insults, namely, UV light and cisplatin, lead to proteasomal degradation...
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PMID: 20935493
PDF is available here.
PDF is available here.
Abstract
We describe recent observations that link these important cellular processes....
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PMID: 20975209
PDF is available here.
PDF is available here.
PLoS Genetics (6)10 2010
Abstract
We investigate the consequences of desmosome loss for carcinogenesis by analyzing conditional knockout mice lacking Perp, a p53/p63 regulated gene that encodes an important component of desmosomes. Analysis of Perp-deficient mice in a UVB-induced squamous cell skin carcinoma model reveals that Perp...
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PMID: 20975948
PDF is available here.
PDF is available here.