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DNA-Binding Proteins (60):
- Winged-Helix Transcription Factors
- Oncogene Protein p55(v-myc)
- Nuclear Respiratory Factors
- Matrix Attachment Region Binding Proteins
- Smad Proteins
- Retinoblastoma Protein
- Proto-Oncogene Proteins c-sis
- Origin Recognition Complex
- Leucine-Responsive Regulatory Protein
- Immunoglobulin J Recombination Signal Sequence-Binding Protein
- Erythroid-Specific DNA-Binding Factors
- Centromere Protein B
- Trans-Activators
- Proto-Oncogene Proteins c-bcl-6
- NFI Transcription Factors
- Adenovirus E2 Proteins
- Rad52 DNA Repair and Recombination Protein
- Kruppel-Like Transcription Factors
- Integration Host Factors
- Heterogeneous-Nuclear Ribonucleoprotein K
- Telomere-Binding Proteins
- POU Domain Factors
- COUP Transcription Factors
- Tumor Suppressor Protein p53
- TCF Transcription Factors
- SOX Transcription Factors
- Proto-Oncogene Proteins c-ets
- HMGB Proteins
- G-Box Binding Factors
- Factor For Inversion Stimulation Protein
- T-Box Domain Proteins
- Replication Protein C
- Replication Protein A
- Proto-Oncogene Proteins c-rel
- MutS DNA Mismatch-Binding Protein
- Interferon-Stimulated Gene Factor 3
- Interferon Regulatory Factors
- Butyrate Response Factor 1
- Methyl-CpG-Binding Protein 2
- Homeodomain Proteins
- Xeroderma Pigmentosum Group A Protein
- HMGA Proteins
- GATA Transcription Factors
- Basic Helix-Loop-Helix Transcription Factors
- Transcription Factors, General
- Transcription Factor AP-2
- Toll-Like Receptor 9
- Rad51 Recombinase
- Proto-Oncogene Proteins c-myc
- Proto-Oncogene Proteins c-myb
- Myeloid-Lymphoid Leukemia Protein
- I-kappa B Proteins
- Hepatocyte Nuclear Factors
- Early Growth Response Transcription Factors
- Tristetraprolin
- Paired Box Transcription Factors
- NF-kappa B
- MutS Homolog 2 Protein
- Basic-Leucine Zipper Transcription Factors
- AraC Transcription Factor
Recent article
DNA-Binding Proteins
Abstract
We constructed rad50 alleles encoding truncations of the coiled-coil domain to determine which Mre11 complex functions required the full length of the coils. These mutations abolished telomere maintenance and meiotic double-strand break (DSB) formation, and severely impaired homologous recombination...
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PMID: 21892167
PDF is available here.
PDF is available here.
| < More recent | Older article > |
Abstract
We show that the combined action of Isw1 and Chd1 nucleosome-spacing enzymes is required to maintain this organization. In the absence of these enzymes, regular positioning of the majority of nucleosomes is lost. Exceptions include the region upstream of the promoter, the +1 nucleosome, and a subset...
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PMID: 21940898
PDF is available here.
PDF is available here.
Abstract
We show that in vivo in mice, TIM-1 is predominantly expressed on B rather than T cells. Importantly, TIM-1 was expressed by a large majority of IL-10-expressing regulatory B cells in all major B cell subpopulations, including transitional, marginal zone, and follicular B cells, as well as the B cel...
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PMID: 21821911
PDF is available here.
PDF is available here.
Molecular Cell (43)3 2011
Abstract
We have biochemically reconstituted two distinct populations of nucleosomes containing Saccharomyces cerevisiae CenH3 (Cse4). Reconstitution of octameric nucleosomes containing histones Cse4/H4/H2A/H2B is robust on noncentromere DNA, but inefficient on AT-rich centromere DNA. However, nonhistone Scm...
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PMID: 21816344
PDF is available here.
PDF is available here.
Abstract
Abstract
Alcohol abuse is the leading etiologic factor of pancreatitis, although many heavy drinkers do not develop pancreatic damage. Alcohol promotes pancreatitis through a combination of remote (e.g., increased gut permeability to bacterial products such as lipopolysaccharide) and more pro...
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PMID: 21460613
PDF is available here.
PDF is available here.
Developmental Cell (20)6 2011
Abstract
We report here a role for Cohibin at telomeres and show that functions of the complex at chromosome ends and rDNA maintain replicative life span. Cohibin binds LEM/SUN domain-containing nuclear envelope proteins and telomere-associated factors. Disruption of Cohibin or the envelope proteins abrogate...
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PMID: 21664583
PDF is available here.
PDF is available here.
Abstract
Providing accurate estimates of cancer risks is a major challenge in the clinical management of Lynch syndrome.
To estimate the age-specific cumulative risks of developing various tumors using a large series of families with mutations of the MLH1, MSH2, and MSH6 genes...
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PMID: 21642682
PDF is available here.
PDF is available here.
Targeted Oncology (6)2 2011
Abstract
Integration of cellular and extracellular signals maintains tissue homeostasis under conditions of normal proliferation and stress. A central player in regulating responses to stress is the serine/threonine kinase mammalian target of rapamycin (mTOR). In many cancers, mTOR complex 1...
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PMID: 21499767
PDF is available here.
PDF is available here.
Abstract
We previously showed that microRNA-155 (miR-155) is down-regulated in melanoma cells as compared with normal melanocytes and that its ectopic expression impairs proliferation and induces apoptosis. Here, we investigated whether miR-155 could mediate melanoma growth inhibition via SKI gene silencing....
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PMID: 21466664
PDF is available here.
PDF is available here.
Cancer Cell (19)5 2011
Abstract
We show that mice lacking the ATM cofactor ATMIN in B cells (ATMIN(ΔB/ΔB)) have impaired ATM signaling and develop B cell lymphomas. Notably, ATMIN(ΔB/ΔB) cells exhibited defective peripheral V(D)J rearrangement and CSR, resulting in translocations involving the Igh and Igl loci, indicating that...
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PMID: 21575860
PDF is available here.
PDF is available here.
Transplantation (91)9 2011
Abstract
Abstract
We have recently demonstrated that Tet1 is specifically expressed in murine embryonic stem (ES) cells and is required for ES cell maintenance. Using chromatin immunoprecipitation coupled with high-throughput DNA sequencing, here we show in mouse ES cells that Tet1 is preferentially bound to CpG-rich...
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PMID: 21451524
PDF is available here.
PDF is available here.
Abstract
The primary progressive aphasias (PPA) are a group of clinically, genetically and pathologically heterogeneous neurodegenerative disorders caused by FTLD-tau, FTLD-TDP or Alzheimer's disease pathology. Clinically, three subtypes are recognized, the semantic, logopenic and nonfluent v...
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PMID: 21222598
PDF is available here.
PDF is available here.
DNA Repair (10)5 2011
Abstract
We show that FANCD2 deficient cells have a defective S-phase checkpoint after Hydrogen Peroxide (H(2)O(2)) induced oxidative damage. ATM dependent phosphorylation of FANCD2 at the S222 residue is necessary for normal S-phase checkpoint activation after oxidative stress, while FANCD2 monoubiquitinati...
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PMID: 21466974
PDF is available here.
PDF is available here.
Abstract
We aim to provide an updated review of ways by which TDP-43 and FUS/TLS influence gene expression. In particular, we will focus on the characterized properties of both proteins that involve gene transcription and also RNA splicing, transport and stability processes....
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PMID: 21222602
PDF is available here.
PDF is available here.
Abstract
We conducted a phase II study to assess the efficacy and feasibility of integrating pemetrexed in a concurrent therapy plan for patients with stage III NSCLC.
Patients with stage III NSCLC with performance status 0 to 1, adequate organ function including pulmonary function, and V20 l...
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PMID: 21415776
PDF is available here.
PDF is available here.
Cell Cycle (10)8 2011
Abstract
The ATM substrate Chk2-interacting Zn(2+)-finger protein (ASCIZ, also known as ATMIN and ZNF822) has previously been reported to be important for the repair of methylating and oxidative DNA damage, and it has also been proposed to regulate the stability and DNA damage-independent act...
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PMID: 21415597
PDF is available here.
PDF is available here.
Cell Cycle (10)8 2011
Abstract
We show that RNF8 and RNF168 are recruited to DNA damage foci in late mitosis, presumably to prime sites for 53BP1 recruitment in early G1. Interestingly, we show that, although RNF8, RNF168 and 53BP1 are excluded from DSB sites during most of mitosis, they associate with mitotic structures such as...
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PMID: 21412056
PDF is available here.
PDF is available here.
Abstract
We show in mice that repression of TCR-induced death pathways is critical for proper interpretation of positive selecting signals in vivo, and identify schnurri-2 (Shn2; also known as Hivep2) as a crucial death dampener. Our results indicate that Shn2(-/-) double-positive thymocytes inappropriately...
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PMID: 21475200
PDF is available here.
PDF is available here.
Abstract
We report here that the two most common types--follicular lymphoma and diffuse large B-cell lymphoma--harbour frequent structural alterations inactivating CREBBP and, more rarely, EP300, two highly related histone and non-histone acetyltransferases (HATs) that act as transcriptional co-activators in...
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PMID: 21390126
PDF is available here.
PDF is available here.
Abstract
We demonstrate that FFAs can activate endoplasmic reticulum (ER) stress pathway by examination of ER stress sensor activation and marker gene expression. Chemical chaperone tauroursodeoxycholic acid (TUDCA) can reduce FFA-induced adipocyte inflammation and improve insulin signaling whereas overexpre...
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PMID: 20829802
PDF is available here.
PDF is available here.
Abstract
We investigated the clinical significance of excision repair cross-complementation group 1 (ERCC1), breast cancer susceptibility 1 (BRCA1), and class III β-tubulin (TUBB3) expression in thymic epithelial tumors.
Fifty-six patients with thymic epithelial tumors were included in this...
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PMID: 21289518
PDF is available here.
PDF is available here.
Cell Cycle (10)4 2011
Abstract
We perform an extensive analysis of the developing central nervous system in global p63-/- mice and their wildtype littermates. Brain and spinal cord of embryos and newborn mice were assessed in vivo for neuroanatomy, histology, apoptosis, proliferation, stemness and differentiation, and in vitro fo...
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PMID: 21293190
PDF is available here.
PDF is available here.
Cell Cycle (10)4 2011
Abstract
Abstract
Oligonucleotides (21)1 2011
Abstract
Recently, it has been reported that, in several tumor cell lines, short double-stranded RNAs tailored for promoter regions of specific genes are able to activate their transcription. Such molecules (named RNA activators) act opposite to other double-stranded RNA molecules (named RNA...
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PMID: 21241187
PDF is available here.
PDF is available here.
Abstract
We have established a tethering system, in which the Gal4 DNA binding domain (DBD) of the Flag:Gal4 DBD:Ote▵LEM fusion protein physically interacts with the Gal4 binding sites upstream of bamP-gfp to artificially recruit the reporter gene gfp to the nuclear membrane. Our data demonstrated that the...
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PMID: 21356524
PDF is available here.
PDF is available here.
Cell Cycle (10)3 2011
Abstract
We show that CtIP, which is recruited to DSB-containing chromatin, interacts with both TopBP1 and Nbs1 in a damage-dependent manner. An N-terminal region containing the first two BRCT repeats of TopBP1 is essential for the interaction with CtIP. Furthermore, two distinct regions in the N-terminus of...
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PMID: 21263215
PDF is available here.
PDF is available here.
Abstract
We identify a mechanism in which EZH2 expression-mediated downregulation of DNA damage repair leads to accumulation of recurrent RAF1 gene amplification in BTICs, which activates p-ERK-β-catenin signaling to promote BTIC expansion. We further reveal that AZD6244, a clinical trial drug that inhibits...
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PMID: 21215703
PDF is available here.
PDF is available here.
Abstract
We present a protocol for propagating human retinoblastoma tumors in vivo using Rag2(-/-) immune deficient mice. Cultured human retinoblastoma tumorspheres of low passage or cells obtained from freshly harvested human retinoblastoma tumors injected directly into the vitreous cavity of murine eyes fo...
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PMID: 21847079
PDF is available here.
PDF is available here.
Abstract
The availability of targeted therapies has created a need for precise subtyping of non-small cell lung carcinomas (NSCLCs). The aim of this study was to assess the utility of immunohistochemical markers in subtyping poorly differentiated NSCLC and to compare the results of immunohistochemical staini...
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PMID: 21164283
PDF is available here.
PDF is available here.
Epigenetics (6)1 2011
Abstract
We compared two commonly used approaches to enrich for methylated DNA regions of the genome, namely methyl-DNA immunoprecipitation (MeDIP) that is based on enrichment with antibodies specific for 5'-methylcytosine (5MeC), and capture of methylated DNA using a methyl-CpG binding domain-based (MBD) pr...
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PMID: 20818161
PDF is available here.
PDF is available here.
Epigenetics (6)1 2011
Abstract
We compared two commonly used approaches to enrich for methylated DNA regions of the genome, namely methyl-DNA immunoprecipitation (MeDIP) that is based on enrichment with antibodies specific for 5'-methylcytosine (5MeC), and capture of methylated DNA using a methyl-CpG binding domain-based (MBD) pr...
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PMID: 20818161
PDF is available here.
PDF is available here.
DNA Repair (10)1 2011
Abstract
We found that uniform or localized UV treatment induced phosphorylation of the DNA damage related (DDR) proteins H2AX, ATM and NBS1 and co-localization of γ-H2AX with the DDR proteins p-ATM, p-NBS1, Rad51 and FANCD2 that persisted for about 6h in normal human fibroblasts. This post-UV phosphorylati...
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PMID: 20947453
PDF is available here.
PDF is available here.
DNA Repair (10)1 2011
Abstract
We found that uniform or localized UV treatment induced phosphorylation of the DNA damage related (DDR) proteins H2AX, ATM and NBS1 and co-localization of γ-H2AX with the DDR proteins p-ATM, p-NBS1, Rad51 and FANCD2 that persisted for about 6h in normal human fibroblasts. This post-UV phosphorylati...
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PMID: 20947453
PDF is available here.
PDF is available here.
DNA Repair (10)1 2011
Abstract
We found that uniform or localized UV treatment induced phosphorylation of the DNA damage related (DDR) proteins H2AX, ATM and NBS1 and co-localization of γ-H2AX with the DDR proteins p-ATM, p-NBS1, Rad51 and FANCD2 that persisted for about 6h in normal human fibroblasts. This post-UV phosphorylati...
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PMID: 20947453
PDF is available here.
PDF is available here.
Oligonucleotides (21)2 2011
Abstract
We focused on the function of special AT-rich sequence binding protein 1 (SATB1) as a target molecule for the treatment of TN breast cancers. By recruiting chromatin remodeling enzymes and transcriptional factors, SATB1 regulates the expression of >1,000 genes related to cell growth and translocatio...
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PMID: 21500976
PDF is available here.
PDF is available here.
Neural Development (6)1 2011
Abstract
We studied the temporal generation and diversity of Neurog2-positive precursor progeny using an inducible genetic fate mapping approach. We show that all subtypes of glutamatergic neurons derive from Neurog2 positive progenitors during development of the OB. Projection neurons, that is, mitral and t...
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PMID: 21466690
PDF is available here.
PDF is available here.
Abstract
Copy number variations (CNV) within the genome are extremely abundant. In this closeup, Canales and Walz discuss how CNV are associated with normal variation, genomic disorders, genome evolution, adaptive traits and how the use of a novel screen described by Ermakova et al in this is...
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PMID: 21204264
PDF is available here.
PDF is available here.
Abstract
We found a 2.27-fold (p<0.001) enhanced expression of PINCH, 4 fold for α-parvin, and 10.5 fold (p<0.001) for ILK as compared to non-failing (NF) counterparts. No significant enhancements were found for the PINCH isoform PINCH-2 and parvin isoform β-parvin. Using a co-immunoprecipitation method, w...
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PMID: 21625516
PDF is available here.
PDF is available here.
Abstract
We found that expression of MAGE I proteins, MAGE-A3 or MAGE-C2, relieved repression of a reporter gene by ZNF382, a KZNF with tumor suppressor activity. ChIP of MAGE I (-) HEK293T cells showed KAP1 and H3me3K9 are normally bound to the ID1 gene, a target of ZNF382, but that binding is greatly reduc...
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PMID: 21876767
PDF is available here.
PDF is available here.
Abstract
Our previous studies showed a down-regulation of GRIM-19 in primary human cervical cancers, and restoration of GRIM-19 induced tumor regression. The induction of tumor suppressor protein p53 ubiquitination and degradation by E6 oncoportein of high risk-HPV through forming a stable complex with E6AP...
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PMID: 21765936
PDF is available here.
PDF is available here.
Abstract
Our recent study shows that p53, a downstream effector of the telomere damage signaling, also functions upstream of the telomere‐capping protein complex by inhibiting one of its components, TRF2 (telomeric repeat binding factor 2). Since TRF2 inhibition leads to ATM activation, a novel positive fe...
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PMID: 21266744
PDF is available here.
PDF is available here.
Science Signaling (4)156 2011
Abstract
In response to genotoxic stress induced by DNA double-stranded breaks (DSBs), the inhibitor of κB kinase (IKK) to nuclear factor κB (NF-κB) pathway is activated, which can promote cancer progression and increase the resistance of cancer cells to ionizing radiation or chemotherapeu...
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PMID: 21245467
PDF is available here.
PDF is available here.
Abstract
We have assessed by real-time in vivo imaging the dynamic and temporal contribution of different immune factors in infected red blood cell (IRBC) accumulation and distribution in different organs during PbA infection. Using deficient mice or depleting antibodies, we observed that CD8(+) T cells and...
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PMID: 21494565
PDF is available here.
PDF is available here.
Abstract
We manipulated levels of Ena, the Drosophila homologue of Mena, in migrating embryonic macrophages (haemocytes). Consistent with data from fibroblasts in vitro, Ena localises to regions of actin dynamics within migrating haemocytes, stimulates lamellipodial dynamics and positively regulates the numb...
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PMID: 21045209
PDF is available here.
PDF is available here.
Abstract
We identify suppressor of cytokine signalling 1 (SOCS1) as an essential mediator of immune tolerance in the intestine. Socs1(-/-)Rag2(-/-) mice develop severe colitis, which can be prevented by the reduction of microbiota and the transfer of IL-10-sufficient Tregs. Additionally, we find an essential...
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PMID: 21304519
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)52 2010
Abstract
We recently identified Grainyhead-like 2 (GRHL2) as a novel transcription factor that binds to and regulates the activity of the human telomerase reverse transcriptase (hTERT) gene promoter. In this study, we investigated the biological functions of GRHL2 and the molecular mechanism underlying hTERT...
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PMID: 20938050
PDF is available here.
PDF is available here.
Abstract
We found that MDM2 indirectly induces the degradation of p73 through the interaction with Itch in HeLa cells. During adriamycin (ADR)-mediated apoptosis, p53 and p73 were induced to stabilize in association with a significant reduction of MDM2 and Itch, suggesting that, in addition to Itch, MDM2 cou...
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PMID: 21093410
PDF is available here.
PDF is available here.
Cancer Cell (18)6 2010
Abstract
Cancer-associated IDH mutations are characterized by neomorphic enzyme activity and resultant 2-hydroxyglutarate (2HG) production. Mutational and epigenetic profiling of a large acute myeloid leukemia (AML) patient cohort revealed that IDH1/2-mutant AMLs display global DNA hypermethy...
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PMID: 21130701
PDF is available here.
PDF is available here.
Abstract
We have shown previously that immunoglobulin fragment-fused GLP-1 (GLP-1/Fc) is a structurally stable GLP-1 analog. Here, we report a non-viral GLP-1/Fc gene therapy strategy utilizing a REP78-in-trans and REB-in-cis element system to achieve a site-specific genomic integration. For this purpose, th...
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PMID: 21070745
PDF is available here.
PDF is available here.
EMBO Journal (29)24 2010
Abstract
We analysed the function of DCAFs and Cul4-linked proteins, and identified specific subsets required for progression through G1 and S phase. We discovered C6orf167/Mms22-like protein (Mms22L) as a putative human orthologue of budding yeast Mms22, which, together with cullin Rtt101, regulates genome...
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PMID: 21113133
PDF is available here.
PDF is available here.
Abstract
We show that TAp73 is expressed in neural stem cells (NSC) and its expression increases following their differentiation. NSC from p73 null mice have a reduced proliferative potential, together with reduced expression of members of the Sox-2 and Notch gene families known to be important for NSC proli...
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PMID: 20977890
PDF is available here.
PDF is available here.
Abstract
We have noted that some neoadjuvantly treated colorectal carcinomas display loss of MMR protein immunoexpression, despite a lack of underlying MSI and preserved staining in pretreatment tumor samples. The purpose of this study was to determine the frequency of this finding. We identified 51 neoadjuv...
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PMID: 21107085
PDF is available here.
PDF is available here.
European Journal of Pharmacology (647)1-3 2010
Abstract
The expression of the bradykinin B(1) receptor is strongly regulated in vascular tissue following injury, with little or no expression in healthy tissues. The present work aimed to verify whether primary human vascular cells (umbilical vein endothelial cells, umbilical artery smooth...
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PMID: 20813106
PDF is available here.
PDF is available here.
Abstract
We show that BRCA1 expression is controlled by a dynamic equilibrium between transcriptional coactivators and co-repressors that govern histone acetylation and DNA accessibility at the BRCA1 promoter. Eviction of the transcriptional co-repressor and metabolic sensor, C terminal-binding protein (CtBP...
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PMID: 21102443
PDF is available here.
PDF is available here.
Cold Spring Harbor Protocols (2010)12 2010
Abstract
Homologous recombination is the most precise way to manipulate the genome. It has been used extensively in bacteria, yeast, murine embryonic stem cells, and a few other specialized cell lines, but it has not been available in other genetic systems such as mammalian somatic cells. How...
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PMID: 21123434
PDF is available here.
PDF is available here.
Journal of Neurosurgery (113 Suppl) 2010
Abstract
Our data support the potential for downregulation of Ku70 expression in enhancing the radiosensitivity of gliomas. The findings of our study indicate that targeted gene therapy-mediated inactivation of Ku70 may represent a promising strategy in improving the radioresponsiveness of gliomas to GKT....
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PMID: 21121806
PDF is available here.
PDF is available here.
Nature Medicine (16)12 2010
Abstract
We searched for GLI1-interacting proteins. We report that the chromatin remodeling protein SNF5 (encoded by SMARCB1, hereafter called SNF5), which is inactivated in human malignant rhabdoid tumors (MRTs), interacts with GLI1. We show that Snf5 localizes to Gli1-regulated promoters and that loss of S...
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PMID: 21076395
PDF is available here.
PDF is available here.