Find your PDFs fast.
Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Membrane Proteins (28):
- Membrane Fusion Proteins
- Cornified Envelope Proline-Rich Proteins
- Vesicular Transport Proteins
- Presenilins
- Myelin Proteins
- Ankyrins
- Bacterial Outer Membrane Proteins
- Pore Forming Cytotoxic Proteins
- Ephrins
- Matrix Metalloproteinases, Membrane-Associated
- Dystrophin
- Receptors, Cell Surface
- Chemokine CX3CL1
- Calnexin
- Spectrin
- Receptor-Like Protein Tyrosine Phosphatases
- Dystrophin-Associated Proteins
- Phospholipid Transfer Proteins
- Membrane Glycoproteins
- Heterotrimeric GTP-Binding Proteins
- Arrestins
- Utrophin
- Protoporphyrinogen Oxidase
- Membrane Transport Proteins
- LDL-Receptor Related Protein-Associated Protein
- Pulmonary Surfactant-Associated Protein C
- Pulmonary Surfactant-Associated Protein B
- Neurofibromin 2
Recent article
Membrane Proteins
Abstract
| < More recent | Older article > |
Developmental Cell (21)4 2011
Abstract
We show that Fgf8 and Sema3f, produced by early dental epithelium, respectively, attract and repulse mesenchymal cells, which cause them to pack tightly together during mouse tooth development. Resulting mechanical compaction-induced changes in cell shape induce odontogenic transcription factors (Pa...
|
PMID: 21924961
PDF is available here.
PDF is available here.
Circulation (124)11 Suppl 2011
Abstract
We investigated the effect of epidermal growth factor-like domain 7 (Egfl7) on nuclear factor-κB activation, intercellular adhesion molecule-1 expression, and neutrophil adhesion to human coronary artery endothelial cells after calcineurin-inhibition-induced injury.
Human coronary e...
|
PMID: 21911813
PDF is available here.
PDF is available here.
Abstract
We show an innovative procedure of perfusion and fixation of brain tissue, that allows, by applying Golgi-Cox impregnation and immunofluorescence in the same histological section, to obtain high-quality histological material, with a very simple and inexpensive method. This procedure is based on thre...
|
PMID: 21461741
PDF is available here.
PDF is available here.
Abstract
We studied albuminuria, renal function, expression of podocyte proteins (nephrin and zonula occludens-1), and markers of both fibrosis (fibronectin and transforming growth factor-β1) and inflammation (monocyte chemoattractant protein-1 [MCP-1], CC chemokine receptor 2 [CCR2], and monocyte markers)....
|
PMID: 21810593
PDF is available here.
PDF is available here.
Abstract
We examined the biological activities of quercetin against gastric cancer. Our studies demonstrated that exposure of gastric cancer cells AGS and MKN28 to quercetin resulted in pronounced pro-apoptotic effect through activating the mitochondria pathway. Meanwhile, treatment with quercetin induced ap...
|
PMID: 21610320
PDF is available here.
PDF is available here.
Molecular BioSystems (7)9 2011
Abstract
We resolved cytoplasmic and membrane-associated complexes from hESCs and characterised their composition, stoichiometry, and dynamics by denaturing SDS-PAGE. The reliability of the fractionation was examined by western blot analysis of membrane and cytosolic markers. MALDI TOF/TOF mass spectrometry...
|
PMID: 21727978
PDF is available here.
PDF is available here.
Proteomics (11)18 2011
Abstract
We present a simple, time- and cost-efficient approach to tackle the proteome of prokaryotic organisms. To obtain large data sets of complex biological experiments high-throughput and time- and cost-efficient methods still have to be developed and refined. In this study, we combined well-approved te...
|
PMID: 21751368
PDF is available here.
PDF is available here.
Abstract
We compared the efficiency of three different feeder-free cultures for differentiating mouse iPS cells into ckit+sca1+ hematopoietic progenitor cells (HPCs) and compared how differentiation and functionality varies between ES and iPS cells. Our results indicated that both iPS and ES cells can be eff...
|
PMID: 21188655
PDF is available here.
PDF is available here.
FEBS Journal (278)18 2011
Abstract
We report data showing that TGF-β1 signals via IRS2 in kidney epithelial cells. Small interfering RNA (siRNA)-mediated targeting of IRS2 increased E-cadherin expression, although it did not alter TGF-β1-mediated E-cadherin repression. Phosphorylation of the downstream target of IRS2/Akt signalling...
|
PMID: 21777391
PDF is available here.
PDF is available here.
FEBS Journal (278)18 2011
Abstract
We report data showing that TGF-β1 signals via IRS2 in kidney epithelial cells. Small interfering RNA (siRNA)-mediated targeting of IRS2 increased E-cadherin expression, although it did not alter TGF-β1-mediated E-cadherin repression. Phosphorylation of the downstream target of IRS2/Akt signalling...
|
PMID: 21777391
PDF is available here.
PDF is available here.
Abstract
We show that in vivo in mice, TIM-1 is predominantly expressed on B rather than T cells. Importantly, TIM-1 was expressed by a large majority of IL-10-expressing regulatory B cells in all major B cell subpopulations, including transitional, marginal zone, and follicular B cells, as well as the B cel...
|
PMID: 21821911
PDF is available here.
PDF is available here.
Abstract
Journal of Proteomics (74)8 2011
Abstract
The workhorse for proteomics in non-model plants is classical two-dimensional electrophoresis, a combination of iso-electric focusing and SDS-PAGE. However, membrane proteins with multiple membrane spanning domains are hardly detected on classical 2-DE gels because of their low abund...
|
PMID: 21354347
PDF is available here.
PDF is available here.
Journal of Proteomics (74)8 2011
Abstract
Membrane proteins are an interesting class of proteins because of their functional importance. Unfortunately their analysis is hampered by low abundance and poor solubility in aqueous media. Since shotgun methods are high-throughput and partly overcome these problems, they are prefer...
|
PMID: 21334471
PDF is available here.
PDF is available here.
Journal of Cell Science (124)Pt 16 2011
Abstract
We provide novel insights into the roles of the CB2 splice variants, CB2(SH3+) and CB2(SH3-), and their substrate, Cdc42, in regulating gephyrin clustering at GABAergic synapses. Transfection of Myc-tagged CB2(SH3+) and CB2(SH3-) into cultured neurons revealed strong, but distinct, effects promoting...
|
PMID: 21807943
PDF is available here.
PDF is available here.
Journal of Cell Biology (194)3 2011
Abstract
We report that mitochondria lacking the mitochondrial import protein 1 (Mim1) are impaired in the biogenesis of multispanning outer membrane proteins, whereas overexpression of Mim1 stimulates their import. The Mim1 complex cooperates with the receptor Tom70 in binding of precursor proteins and prom...
|
PMID: 21825073
PDF is available here.
PDF is available here.
Journal of Cell Biology (194)3 2011
Abstract
We address this issue using yeast mitochondria and the multispan protein Ugo1. Using a specific insertion assay and analysis by native gel electrophoresis, we show that the import receptor Tom70, but not its partner Tom20, is involved in the initial recognition of the Ugo1 precursor. Surprisingly, t...
|
PMID: 21825074
PDF is available here.
PDF is available here.
Abstract
We show that a previously uncharacterized member of the I-BAR subfamily, Pinkbar, is specifically expressed in intestinal epithelial cells, where it localizes to Rab13-positive vesicles and to the plasma membrane at intercellular junctions. Notably, the BAR domain of Pinkbar does not induce membrane...
|
PMID: 21743456
PDF is available here.
PDF is available here.
Reproductive Sciences (18)8 2011
Abstract
We examined expressions and distributions of nephrin, podoplanin, polarity protein partitioning defective-3 (PARD-3), and PARD-6 in podocytes from PE. Podocyte cell line (AB 8/13 cells) was used as control. Podocytes were found in all severe PE cases. In contrast, no podocyte was found in the sample...
|
PMID: 21422051
PDF is available here.
PDF is available here.
Rinsho Ketsueki (52)7 2011
Abstract
Rinsho Ketsueki (52)7 2011
Abstract
Abstract
We have produced human CFTR in the prokaryotic expression host Lactococcus lactis. The full-length protein was detected in the membrane of the bacterium, but the yields were too low (< 0.1% of membrane proteins) for in vitro functional and structural characterization, and induction of the expression...
|
PMID: 21742800
PDF is available here.
PDF is available here.
Abstract
Heritable causes of proteinuria are rare and account for a relatively small proportion of all cases of proteinuria affecting children and adults. Yet, significant contributions to understanding the mechanistic basis for proteinuria have been made through genetic and molecular analyse...
|
PMID: 21782134
PDF is available here.
PDF is available here.
Developmental Cell (20)6 2011
Abstract
We report here a role for Cohibin at telomeres and show that functions of the complex at chromosome ends and rDNA maintain replicative life span. Cohibin binds LEM/SUN domain-containing nuclear envelope proteins and telomere-associated factors. Disruption of Cohibin or the envelope proteins abrogate...
|
PMID: 21664583
PDF is available here.
PDF is available here.
Abstract
We investigated whether variants in major candidate genes for food intake and body weight regulation contribute to obesity-related traits under a multilocus perspective. We studied 375 Brazilian subjects from partially isolated African-derived populations (quilombos). Seven variants displaying confl...
|
PMID: 21233811
PDF is available here.
PDF is available here.
Abstract
We will use the most common primary brain tumor, glioblastoma multiforme, as an example to illustrate why studying cancer stem cells holds great promise for more effective therapies to highly lethal tumors. In addition, we will discuss why the abilities of self-renewal and tumor propagation are the...
|
PMID: 20957452
PDF is available here.
PDF is available here.
Abstract
We show that the endocytic adaptor protein Numb, previously characterized for its role in cell proliferation, subsequently plays an important role in cell migration. In neural precursors stimulated with the chemotactic factor BDNF, Numb binds to activated TrkB, the BDNF receptor, and functions both...
|
PMID: 21571219
PDF is available here.
PDF is available here.
Cancer Biology & Therapy (11)10 2011
Abstract
We developed a new tumor vaccine, FAPτ-MT, which was produced by conjugating 1-MT to a tumor associated antigen, fibroblast activation protein α (FAPα). The results in vitro confirmed that 1-MT could be dissociated from the FAPτ-MT vaccine and inhibit intracellular IDO activity. In an FAPα-posi...
|
PMID: 21372637
PDF is available here.
PDF is available here.
Xenobiotica (41)5 2011
Abstract
The discovery of novel target antigens for antibody-based immunotherapy is still a major challenge. Antibody phage display is one of the technologies that is widely applied for the identification of novel cell surface molecules on intact eukaryotic cells and many reports describe the isolation of ph...
|
PMID: 19153691
PDF is available here.
PDF is available here.
Xenobiotica (41)5 2011
Abstract
We describe a protocol for native fractionation of membrane-bound protein complexes from isolated porcine rod outer segments (ROSs). Protein complexes from isolated ROS membranes were solubilized using the nonionic detergent beta-dodecylmaltoside and fractionated by isopycnic sucrose density gradien...
|
PMID: 18592179
PDF is available here.
PDF is available here.
Xenobiotica (41)5 2011
Abstract
Key enzymes that assemble the bacterial cell wall are also the target of the Beta-lactam class of antibiotics. The covalent binding of labeled penicillin to these proteins has been used in numerous studies in drug discovery, antibiotic mechanisms of action and resistance, and cell wall physiology. M...
|
PMID: 18437311
PDF is available here.
PDF is available here.
Abstract
Abstract
We have identified 6 different mutations in coenzyme Q10 biosynthesis monooxygenase 6 (COQ6) in 13 individuals from 7 families by homozygosity mapping. Each mutation was linked to early-onset SRNS with sensorineural deafness. The deleterious effects of these human COQ6 mutations were validated by th...
|
PMID: 21540551
PDF is available here.
PDF is available here.
Abstract
Our aim was to test whether the UPR is activated during metabolic stress and mediates a tubular inflammatory response. Glucose deprivation, not hypoxia and amino acids deprivation, activated the UPR in human renal cortical tubular cells in culture. This stress activated NF-κB and promoted the trans...
|
PMID: 21490675
PDF is available here.
PDF is available here.
Abstract
We present a comprehensive, gel-free, and GeLC-MS/MS-based quantitative proteome profiling of S. aureus under this infection-relevant situation. (14)N(15)N metabolic labeling and three complementing approaches were combined for relative quantitative analyses of surface-associated proteins. The surfa...
|
PMID: 21323324
PDF is available here.
PDF is available here.
Abstract
Autism is a developmental disorder of the central nervous system characterized by impairments in social interaction, communication and restricted repetitive and stereotyped behavior. It is generally assumed that in most cases autism has a polygenic cause, but the pathogenesis is stil...
|
PMID: 21375492
PDF is available here.
PDF is available here.
Proteomics (11)7 2011
Abstract
We report the subproteome reference maps of E. coli B REL606 by analyzing cytoplasmic, periplasmic, inner and outer membrane, and extracellular proteomes based on the genome information using experimental and computational approaches. Among the total of 3487 spots, 651 proteins including 410 non-red...
|
PMID: 21337514
PDF is available here.
PDF is available here.
Cellular Microbiology (13)4 2011
Abstract
I investigated the regulation of host cell actin dynamics in T. annulata-transformed macrophages and how this affects host cell morphology and motility. T. annulata was found to promote the formation of filamentous-actin-rich podosome-type adhesions (PTAs) and lamellipodia, and to establish a polari...
|
PMID: 21091599
PDF is available here.
PDF is available here.
Abstract
We show in mice that repression of TCR-induced death pathways is critical for proper interpretation of positive selecting signals in vivo, and identify schnurri-2 (Shn2; also known as Hivep2) as a crucial death dampener. Our results indicate that Shn2(-/-) double-positive thymocytes inappropriately...
|
PMID: 21475200
PDF is available here.
PDF is available here.
Abstract
We have examined the relationship between host resistance and pathogen virulence using mice with a functional allele of the nramp-1 gene and lacking combinations of TLRs. Mice deficient in both TLR2 and TLR4 were highly susceptible to the intracellular bacterial pathogen Salmonella typhimurium, cons...
|
PMID: 21376231
PDF is available here.
PDF is available here.
Abstract
We show here that Mpk1 additionally serves a function in transcription elongation that is also independent of its catalytic activity. This function is mediated by an interaction between Mpk1 and the Paf1 subunit of the Paf1C elongation complex. A mutation in Paf1 that blocks this interaction causes...
|
PMID: 21376235
PDF is available here.
PDF is available here.
Abstract
We will focus on the system level or global analysis of biological systems using protein microarrays. Four major types of protein microarrays will be discussed: proteome microarrays, antibody microarrays, reverse-phase protein arrays, and lectin microarrays. We will also discuss the challenges and f...
|
PMID: 21257623
PDF is available here.
PDF is available here.
Abstract
We sought to determine whether loss of JPH2 expression is noted among patients with HCM and whether expression silencing might perturb Ca(2+) handling in a prohypertrophic manner.
JPH2 expression was reduced in flash-frozen human cardiac tissue procured from patients with HCM compare...
|
PMID: 21216834
PDF is available here.
PDF is available here.
Abstract
We sought to determine whether loss of JPH2 expression is noted among patients with HCM and whether expression silencing might perturb Ca(2+) handling in a prohypertrophic manner.
JPH2 expression was reduced in flash-frozen human cardiac tissue procured from patients with HCM compare...
|
PMID: 21216834
PDF is available here.
PDF is available here.
Abstract
We summarize all the inhibitors of uPAR that have been created so far. Finally, we discuss the functions of uPAR in the development, functioning, and pathology of the central nervous system....
|
PMID: 20874700
PDF is available here.
PDF is available here.
Abstract
We also investigated the multi-differentiation potentials of the dedifferentiated cells. TGF-β(1) pre-treated C2C12 myoblasts were implanted into mice to repair dystrophic skeletal muscle or injured bone. In addition to the C2C12 myoblasts, similar effects of TGF-β(1) were also observed in the pri...
|
PMID: 20184662
PDF is available here.
PDF is available here.
Molecular Plant (4)2 2011
Abstract
We report the ability of Toc90 to support the import of Toc159 client proteins. We show that the overexpression of Toc90 partially complements the albino knockout of Toc159 and restores photoautotrophic growth. Several lines of evidence including proteome profiling demonstrate the import and accumul...
|
PMID: 21220583
PDF is available here.
PDF is available here.
Journal of Proteomics (74)3 2011
Abstract
Milk fat globule membranes (MFGM) are three-layered structures that enclose fat droplets, and are composed by an internal monolayer of endoplasmic reticulum origin, surrounded by a bilayer derived from the apical membrane of the lactating cell. In this work, an optimized protein extr...
|
PMID: 21147282
PDF is available here.
PDF is available here.
Autoimmunity Reviews (10)5 2011
Abstract
We are currently reaching a period of rapid data production. Several themes are already rising from the first wave of results. First, some genetic variants clearly predispose to multiple autoimmune diseases, thus providing evidence for a shared autoimmune genetic background. Second, multiple genes a...
|
PMID: 20863905
PDF is available here.
PDF is available here.
BMC Genomics (12) 2011
Abstract
We have manually curated the rif and stevor gene repertoires of two Plasmodium falciparum genomes, isolates DD2 and HB3. We have identified 25% of mis-annotated and ~30 missing rif and stevor genes. Using these data sets, as well as sequences from the well curated reference genome (isolate 3D7) and...
|
PMID: 21332983
PDF is available here.
PDF is available here.
Cancer Cell (19)2 2011
Abstract
We report that the Notch ligand Jagged1 is a clinically and functionally important mediator of bone metastasis by activating the Notch pathway in bone cells. Jagged1 promotes tumor growth by stimulating IL-6 release from osteoblasts and directly activates osteoclast differentiation. Furthermore, Jag...
|
PMID: 21295524
PDF is available here.
PDF is available here.
Cancer Cell (19)2 2011
Abstract
We report that the Notch ligand Jagged1 is a clinically and functionally important mediator of bone metastasis by activating the Notch pathway in bone cells. Jagged1 promotes tumor growth by stimulating IL-6 release from osteoblasts and directly activates osteoclast differentiation. Furthermore, Jag...
|
PMID: 21295524
PDF is available here.
PDF is available here.
Journal of Cell Science (124)Pt 6 2011
Abstract
We report here that kindlin-2 interacts with multiple phosphoinositides, preferentially with phosphatidylinositol 3,4,5-trisphosphate. Although integrin-binding is essential for focal adhesion localization of kindlin-2, phosphoinositide-binding is not required for this process. Using biologically an...
|
PMID: 21325030
PDF is available here.
PDF is available here.
Abstract
We show that Notch is activated in select olfactory receptor neurons (ORNs) in an odorant-specific fashion. This response requires olfactory receptor activity and the Notch ligand Delta. We present evidence that Notch activation depends on synaptic transmission by the ORNs in which the receptors are...
|
PMID: 21315258
PDF is available here.
PDF is available here.
Abstract
We have established a tethering system, in which the Gal4 DNA binding domain (DBD) of the Flag:Gal4 DBD:Ote▵LEM fusion protein physically interacts with the Gal4 binding sites upstream of bamP-gfp to artificially recruit the reporter gene gfp to the nuclear membrane. Our data demonstrated that the...
|
PMID: 21356524
PDF is available here.
PDF is available here.
Abstract
We mapped 2 differential transcriptome data of MSCs compared, one to mononuclear cells and the other to fibroblasts, onto the membrane proteome data, the analysis of which led to an identification of transmembrane 4 L6 family member 1 (TM4SF1) as a surface protein marker candidate that could discrim...
|
PMID: 20486778
PDF is available here.
PDF is available here.
Proteomics (11)3 2011
Abstract
We mapped the surface-attached proteome of S. Typhimurium SL1344 grown in vitro under SPI-2-inducing conditions and identified 108 proteins; using secretion signal prediction software, 43% of proteins identified contained a signal sequence. Of these proteins, 13 were known secreted effector proteins...
|
PMID: 21268266
PDF is available here.
PDF is available here.
Proteomics (11)3 2011
Abstract
Cell surface physicochemical characterization techniques were combined with quantitative changes in protein expression, to investigate the biological and biophysical changes of Escherichia coli MG1655 cells when grown as a biofilm (BIO). The overall surface charge of BIO cells was fo...
|
PMID: 21268264
PDF is available here.
PDF is available here.