Find your PDFs fast.
Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Neoplasm Proteins (5):
Recent article
Neoplasm Proteins
Abstract
| < More recent | Older article > |
Cell Metabolism (13)6 2011
Abstract
We show that heat shock protein beta-1 (HSPB1 or HSP27) is the downstream mediator of this effect. Disruption of the HSPB1 gene in embryonic fibroblasts with wild-type HMGB1 recapitulates the mitochondrial fragmentation, deficits in mitochondrial respiration, and adenosine triphosphate (ATP) synthes...
|
PMID: 21641551
PDF is available here.
PDF is available here.
Abstract
I and II trials in lung cancer that have been performed or are currently ongoing are also discussed....
|
PMID: 21623278
PDF is available here.
PDF is available here.
Journal of Proteomics (74)5 2011
Abstract
We herein identified the aberrant plasma proteins in NPC patients. We first removed the top-seven abundant proteins from plasma samples of healthy controls and NPC patients, and then labeled the samples with different fluorescent cyanine dyes. The labeled samples were then mixed equally and fraction...
|
PMID: 21376147
PDF is available here.
PDF is available here.
Immunobiology (216)5 2011
Abstract
We have investigated the molecular mechanisms underlying the peculiar cross-presentation efficiency of human dendritic cells (DCs) differentiated from monocytes in the presence of Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) and Interferon (IFN)-α (IFN-DCs). To this end, we evaluated t...
|
PMID: 21093097
PDF is available here.
PDF is available here.
Abstract
We determined the effects of arbutin on TCCSUP human bladder carcinoma cell proliferation. Arbutin did not exhibit any cytotoxic effects in TCCSUP cells at concentrations of < 500 microg/ml. To determine the effects of arbutin on cell proliferation, TCCSUP cells were treated with arbutin at various...
|
PMID: 21612160
PDF is available here.
PDF is available here.
Abstract
The BRAF(T1799A) mutation is reported to be associated to aggressive, persistent, and recurrent tumor in papillary thyroid carcinoma (PTC) patients. Association of the BRAF(T1799A) mutation in the primary tumor with the clinicopathological characteristics of PTC patients was analyzed...
|
PMID: 21441079
PDF is available here.
PDF is available here.
Abstract
We characterized the proteomes of pancreatic ductal adenocarcinoma (PDAC) cells and normal pancreatic duct cells by mass spectrometry using LTQ-Orbitrap, and identified more than 1200 proteins from each sample. On the basis of spectra count label-free quantification approach, we identified a large n...
|
PMID: 21309613
PDF is available here.
PDF is available here.
Abstract
We summarize all the inhibitors of uPAR that have been created so far. Finally, we discuss the functions of uPAR in the development, functioning, and pathology of the central nervous system....
|
PMID: 20874700
PDF is available here.
PDF is available here.
Abstract
A substantial proportion of patients with rheumatoid arthritis do not respond to tumor necrosis factor blocking therapy. Results of a large genome-wide association study demonstrate evidence of novel genetic factors that determine response to treatment, which could provide a basis fo...
|
PMID: 21304506
PDF is available here.
PDF is available here.
Journal of Cell Science (124)Pt 6 2011
Abstract
We report here that kindlin-2 interacts with multiple phosphoinositides, preferentially with phosphatidylinositol 3,4,5-trisphosphate. Although integrin-binding is essential for focal adhesion localization of kindlin-2, phosphoinositide-binding is not required for this process. Using biologically an...
|
PMID: 21325030
PDF is available here.
PDF is available here.
Abstract
We mapped 2 differential transcriptome data of MSCs compared, one to mononuclear cells and the other to fibroblasts, onto the membrane proteome data, the analysis of which led to an identification of transmembrane 4 L6 family member 1 (TM4SF1) as a surface protein marker candidate that could discrim...
|
PMID: 20486778
PDF is available here.
PDF is available here.
Proteomics (11)4 2011
Abstract
The simultaneous analysis of a wide array of proteins may provide valuable information on the activation and suppression of cellular systems at different stages of the exposure-disease continuum. In this review, results of proteomic studies in the field of toxicology are covered, foc...
|
PMID: 21246732
PDF is available here.
PDF is available here.
Abstract
This review describes the current treatment of human epidermal growth factor receptor-2 (HER2)-positive breast cancer with a focus on recently reported clinical trials.Treatment of resistant disease and central nervous system metastases will be reviewed as will new agents that are be...
|
PMID: 21500375
PDF is available here.
PDF is available here.
Abstract
We generated a cell line that was resistant to the IGF-1R/InsR benzimidazole inhibitors, BMS-554417 and BMS-536924, and compared expression profiles of the parental and resistant cells lines using Affymetrix GeneChip Human Genome U133 arrays. Compared with MCF-7 cells, breast cancer resistance prote...
|
PMID: 21220496
PDF is available here.
PDF is available here.
Acta Crystallographica Section F (67)Pt 1 2011
Abstract
The Gram-positive spore-forming bacterium Bacillus anthracis causes anthrax by secreting anthrax toxin, which consists of protective antigen (PA), lethal factor and oedema factor. Binding of PA to receptors triggers the multi-step process of anthrax toxin entry into target cells. Two...
|
PMID: 21206026
PDF is available here.
PDF is available here.
Abstract
We identified the chicken chorioallantoic membrane (CAM) as a model system to study the endogenous function of TEM8 in blood vessels as we found that TEM8 expression was induced transiently between day 10 and 12 of embryonic development, when the vascular tree is undergoing final development and gro...
|
PMID: 21829615
PDF is available here.
PDF is available here.
Abstract
We investigated an ER-associated degradation-related protein in adipocytes, namely osteosarcoma amplified 9 (OS-9), a protein that is reported to have lectin activity and to be involved in ER quality control. We found that OS-9 is expressed at high levels in both types of fat tissues - brown and wh...
|
PMID: 21523322
PDF is available here.
PDF is available here.
Abstract
We found that expression of MAGE I proteins, MAGE-A3 or MAGE-C2, relieved repression of a reporter gene by ZNF382, a KZNF with tumor suppressor activity. ChIP of MAGE I (-) HEK293T cells showed KAP1 and H3me3K9 are normally bound to the ID1 gene, a target of ZNF382, but that binding is greatly reduc...
|
PMID: 21876767
PDF is available here.
PDF is available here.
Abstract
Identification of somatic mutations in cancer is a major goal for understanding and monitoring the events related to cancer initiation and progression. High resolution melting (HRM) curve analysis represents a fast, post-PCR high-throughput method for scanning somatic sequence altera...
|
PMID: 21264207
PDF is available here.
PDF is available here.
Abstract
Phosphorylation dysregulation has been implicated in various diseases including cancer. The phosphorylation change of proteins in secretome may be a novel source for the discovery of biomarkers and drug targets. In this study, the phosphoproteins in cancer secretome (phosphosecretome...
|
PMID: 20726782
PDF is available here.
PDF is available here.
Abstract
We identified genes that are regulated during the estrous cycle in murine ovarian surface epithelium and analysed these profiles to identify genes dysregulated in human ovarian cancer, using publically available datasets. We identified 338 genes that are regulated in murine ovarian surface epitheliu...
|
PMID: 21423607
PDF is available here.
PDF is available here.
Abstract
We report a case of t-ALL with t(11;19)(q23;p13.3) and MLL-MLLT1 (alias ENL) gene rearrangement confirmed by cytogenetic analysis, multiplex reverse transcription-PCR (multiplex RT-PCR), and DNA sequencing in a patient who had undergone treatment for breast cancer. A 40-yr-old woman developed acute...
|
PMID: 21239865
PDF is available here.
PDF is available here.
Gene Expression Patterns (11)5-6 2011
Abstract
We found that Tem1 gene expression was initially detectable in the dorsal aortic wall, the heart, the umbilical vessels, the first branchial arch, and the cephalic mesenchyme at E9.5. From E10.5 to E14.5, Tem1 gene expression was additionally seen mainly in the genital tubercle, the mesonephros, the...
|
PMID: 21402174
PDF is available here.
PDF is available here.
Abstract
We used new domain-specific antibodies and small interfering RNA technology to uncover physiological functions of kindlin-2 in human dermal fibroblasts in vitro and in adult skin in situ. In primary dermal fibroblasts, kindlin-2 is essential for the integrin clustering and activation, and it regulat...
|
PMID: 20861856
PDF is available here.
PDF is available here.
Abstract
We found that AHNAK knock-out (AHNAK(-/-)) mice have a strong resistance to high-fat diet-induced obesity. In this study, we applied (1)H NMR-based metabolomics with multivariate statistical analysis to compare the altered metabolic patterns detected in urine from high-fat diet (HFD) fed wild-type a...
|
PMID: 21094140
PDF is available here.
PDF is available here.
Abstract
We found that there were few biochemical differences in post-translational modifications between membrane-anchored and soluble forms of CR-1. Flow cytometric analysis revealed an intercellular transfer of the membrane-bound form of CR-1 between cells. CR-1-expressing cells formed unique membrane ext...
|
PMID: 21055389
PDF is available here.
PDF is available here.
British Journal of Cancer (103)12 2010
Abstract
We sought to demonstrate quantitative promoter methylation across a panel of tumour suppressor genes (TSGs) in both Ca ex PSA and PSA.
Quantitative methylation-specific real-time polymerase chain reaction (qMSP) analysis of p16(INK4A), CYGB, RASSF1, RARβ, human telomerase reverse transcriptase (hTE...
|
PMID: 21063414
PDF is available here.
PDF is available here.
Abstract
Abstract
The identification of key pathways dysregulated in non-small cell lung cancer (NSCLC) is an important step toward understanding lung pathogenesis and developing new therapeutic approaches.
Toward this goal, reverse-phase protein lysate arrays (RPPA) were used to compa...
|
PMID: 21124077
PDF is available here.
PDF is available here.
AAPS Journal (12)4 2010
Abstract
We have developed a new nanoparticle technology that can, in one step, capture, concentrate, and separate the peptidome from high-abundance blood proteins. Herein, we describe an initial pilot study whereby the peptidome content of ovarian and prostate cancer patients is investigated with this metho...
|
PMID: 20549403
PDF is available here.
PDF is available here.
Abstract
Tumor protein D52 is expressed at high levels in exocrine cells containing large secretory granules where it regulates Ca(2+)-dependent protein secretion; however, D52 expression is also highly induced in multiple cancers. The present study investigated a role for the Ca(2+)-dependent phosphorylatio...
|
PMID: 20946871
PDF is available here.
PDF is available here.
Abstract
We show that a West Nile virus (WNV) mutant (E218A) that lacks 2'-O MTase activity was attenuated in wild-type primary cells and mice but was pathogenic in the absence of type I interferon (IFN) signalling. 2'-O methylation of viral RNA did not affect IFN induction in WNV-infected fibroblasts but in...
|
PMID: 21085181
PDF is available here.
PDF is available here.
Abstract
We reported previously that dynamic changes in DNA methylation occurred during MCA/DEN-induced rat lung carcinogenesis. Here, we used the same animal model to further study the evolution of methylation alterations in tumor suppressor genes (TSGs) DAPK1, FHIT, RASSF1A, and SOCS-3. We found that none...
|
PMID: 20970405
PDF is available here.
PDF is available here.
Journal of Proteomics (73)12 2010
Abstract
We focus on the presentation of main methodological approaches that have been developed for the study of secreted proteins and the results thereof from the analysis of secretome in different types of malignancies; special emphasis is given on correlation of findings with protein expression in body f...
|
PMID: 20637910
PDF is available here.
PDF is available here.
Abstract
We aim to provide an overview of the current knowledge on the ABCB1 and ABCG2 transporter expression profiles in the placenta and fetal tissues in humans relative to other species.
The available information on ABCB1 and ABCG2 temporal expression profiles in placenta and fetus indicates rather good c...
|
PMID: 20738225
PDF is available here.
PDF is available here.
Abstract
The ATP-binding cassette transporter ABCG2 is a well-known major mediator of multi-drug resistance in cancers. Beyond multi-drug resistance, experimental and recent clinical studies demonstrate a role for ABCG2 as a determinant of drug pharmacokinetic, safety and efficacy profiles.
The clinical evid...
|
PMID: 20873966
PDF is available here.
PDF is available here.
Cancer Biology & Therapy (10)10 2010
Abstract
Here, we have identified S100P (an EF-hand calcium binding protein) as a novel downstream target. We show by realtime RT-PCR that S100P mRNA levels are elevated in 14/17 (82%) colon tumor tissues as compared to paired adjacent normal colonic tissues. S100P expression is stimulated in the presence of...
|
PMID: 20890108
PDF is available here.
PDF is available here.
Abstract
We present here a new ES cell line, SS-ES-1, established from the left thoracic tumor of a 16-year-old female patient. The SS-ES-1 cells retained genotype, morphology, and growth rate for over 150 passages. Immunocytochemical staining showed the strong immunoreactivity for cytokeratin, epithelial me...
|
PMID: 20962673
PDF is available here.
PDF is available here.
Abstract
We evaluated the percentage of positive cytoplasmic and nuclear staining (focal ≤10%, multifocal=10% to 50%, and diffuse ≥50%) and staining intensity (weak, moderate, and strong). HPV-DNA analysis by polymerase chain reaction was performed on 5 OSCC. Ichthyosis uteri, all UCSCC and 1 OSCC (arisi...
|
PMID: 20881863
PDF is available here.
PDF is available here.
Nucleic Acids Research (38)20 2010
Abstract
We therefore designed a novel DNA-based targeted sequencing approach to screen systematically for fusions within the 90 human TKs; it should detect 92% of known TK fusions. We deliberately paired 'in-solution' DNA capture with 454 sequencing to minimize starting material requirements, take advantage...
|
PMID: 20587502
PDF is available here.
PDF is available here.
Bulletin du cancer (97)11 2010
Abstract
While no real improvement in the long term survival has been obtained in lung cancer, during this decade a significant improvement in cancer control has been obtained by biology driven targeted therapy as with anti EGFR tyrosine kinase. Two phases can be described in the knowledge of lung cancer bio...
|
PMID: 21051316
PDF is available here.
PDF is available here.
Bulletin du cancer (97)11 2010
Abstract
Numerous molecular abnormalities have been described in lymphomas. They are of diagnostic and prognostic value and are taken into account for the WHO classification of these tumors. They also shed some light on the underlying molecular mechanisms involved in lymphomas. Overall, four types of molecul...
|
PMID: 21084243
PDF is available here.
PDF is available here.
Bulletin du cancer (97)11 2010
Abstract
We will present here a general classification of the main pathways of cell signalling and some of the recurrent mechanisms used for the transmission of information between cells and inside cells....
|
PMID: 21047720
PDF is available here.
PDF is available here.
Abstract
We have now isolated, quantified, and characterized human proteasomes that are intermediate between the standard proteasome and the immunoproteasome. They contain only one (β5i) or two (β1i and β5i) of the three inducible catalytic subunits of the immunoproteasome. These intermediate proteasomes...
|
PMID: 20937868
PDF is available here.
PDF is available here.
Biochemical Journal (432)1 2010
Abstract
We have previously identified the PKC (protein kinase C)-anchoring protein RACK1 (receptor for activated C-kinase 1), as a specific binding partner for the cAMP-specific phosphodiesterase PDE4D5, suggesting a potential site for cross-talk between the PKC and cAMP signalling pathways. In the present...
|
PMID: 20819076
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)43 2010
Abstract
We show here that zinc mesoporphyrin, a validated fluorescent heme analog, is transported by ABCG2. We also show that the ABCG2 large extracellular loop ECL3 constitutes a porphyrin-binding domain, which strongly interacts with heme, hemin, PPIX, ZnPPIX, CoPPIX, and much less efficiently with pheoph...
|
PMID: 20705604
PDF is available here.
PDF is available here.
EMBO Journal (29)20 2010
Abstract
We identified novel targets of HSF1 in mammalian cells, which suppress the aggregation of polyglutamine (polyQ) protein. Among them, we show that one of the nuclear factor of activated T cells (NFAT) proteins, NFATc2, significantly inhibits polyQ aggregation in cells and is required for HSF1-mediate...
|
PMID: 20834230
PDF is available here.
PDF is available here.
Abstract
We used specific AHNAK1 and AHNAK2 antibodies to analyzed the detailed localization of both proteins in mouse skeletal muscle. Co-localization of AHNAK1 and AHNAK2 with vinculin clearly demonstrates that both proteins are components of the costameric network. In contrast, no AHNAK expression was det...
|
PMID: 20833135
PDF is available here.
PDF is available here.
British Journal of Cancer (103)8 2010
Abstract
Inhibitors of DNA-binding proteins (Id1-4), lacking the basic DNA-binding domain, function as dominant inhibitors of cell-cycle regulators. Overexpression of Id proteins promotes cancer cell proliferation and resistance against apoptosis. Level of Id protein expression, especially of Id1, correlates...
|
PMID: 20842131
PDF is available here.
PDF is available here.
Nutrition and Cancer (62)7 2010
Abstract
We identified a new protein family that is named the 6 trans-membrane protein of prostate (STAMP) that appear to have important functions in prostate cancer. At least one member of the STAMP family is also implicated in metabolic homeostasis and nutrition response. Here, we review the current biolog...
|
PMID: 20924965
PDF is available here.
PDF is available here.
Abstract
We evaluated the substitution of murine constant regions for their human counterpart within the DMF5 MART-1-specific TCR. Unlike previous studies, all modified TCRs were inserted into retroviral vectors and analyzed for expression and function following a clinical transduction protocol. PBL were tra...
|
PMID: 20628878
PDF is available here.
PDF is available here.
Genetika (Moskva) (46)10 2010
Abstract
Polymorphic variants of cytochrome P4501A1 (CYP1A1), glutathione-S-transferase M1 (GSTM1) and T1 (GSTT1) distribution was studied in patients with chronic myeloid leukemia (CML) and healthy individuals. It was shown that homozygotes for the GSTT1 gene deletion occur significantly more frequently in...
|
PMID: 21254556
PDF is available here.
PDF is available here.
Clinical Breast Cancer (10)5 2010
Abstract
Our results demonstrated the prognostic relevance of BM DTCs assessed by a multimarker mRNA panel consisting of TWIST1, CK19, and hMAM in operable breast cancer patients....
|
PMID: 20920982
PDF is available here.
PDF is available here.
Histology and histopathology (25)10 2010
Abstract
We investigate by immunohistochemistry the relationship between E-cadherin and dysadherin in 111 cases of primary lung carcinomas (53 squamous cell carcinomas, 21 adenocarcinomas, 13 large cell carcinomas, and 24 small cell carcinomas), and their distant metastases. The intensity, the expression pat...
|
PMID: 20712010
PDF is available here.
PDF is available here.
Abstract
Abstract
We present two cases of retroperitoneal solitary fibrous tumors diagnosed after surgical removal. We provide a literature review showing the basic clinical, pathologic and therapeutic features of these tumors.
Copyright © 2010 Elsevier España, S.L. All rights reserved....
|
PMID: 20850908
PDF is available here.
PDF is available here.
Abstract
We have used the highly sensitive two-dimensional gel electrophoresis (2-DE) coupled with matrix-assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF-MS) for the identification of proteins differentially expressed in tumoral and neighboring normal mucosa. We have detected...
|
PMID: 19842058
PDF is available here.
PDF is available here.
Anticancer Research (30)10 2010
Abstract
These results show a possible role for SeePico™ Stain in cancer proteomics using 2-DE and MS....
|
PMID: 21036714
PDF is available here.
PDF is available here.
FEBS Letters (584)18 2010
Abstract
We reported the up-regulation of miR-24 in TSCC. MiR-24 up-regulation reduced the expression of RNA-binding protein dead end 1 (DND1). Knockdown of miR-24 led to enhanced expression of DND1. The direct targeting of miR-24 to the DND1 mRNA was predicted bioinformatically and confirmed by luciferase r...
|
PMID: 20816961
PDF is available here.
PDF is available here.