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Pregnancy Proteins (6):
Recent article
Pregnancy Proteins
Clinical Science (122)2 2012
Abstract
We aim to provide an overview of the vast literature on angiogenesis and anti-angiogenesis factors in pre-eclampsia that have been published over the last decade. We introduce work from basic research groups who have focused on the pathophysiological basis of the disease. Furthermore, we review stud...
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PMID: 21929511
PDF is available here.
PDF is available here.
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Abstract
We screened Calycolpus moritzianus (O. Berg) Burret leaves extracts by a competitive ELISA-based assay. MeOH and CHCl3 extracts and several their fractions demonstrated to be able to prevent VEGF or PlGF interaction with Flt-1, with an inhibition about 50% at concentration of 100 microg/mL. Phytoche...
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PMID: 21834229
PDF is available here.
PDF is available here.
Abstract
Review of actual trends in early prediction of preeclampsia.
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PMID: 21649998
PDF is available here.
PDF is available here.
Abstract
We have previously found a significant elevation of adipsin, an activating factor of the alternative complement pathway, in mouse placentas from spontaneous abortions. The present study was aimed to evaluate regulation of the alternative complement pathway in placentas of mouse spontaneous abortions...
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PMID: 20484840
PDF is available here.
PDF is available here.
Biology of Reproduction (83)2 2010
Abstract
I (MHC-I) region is involved at a number of levels in the establishment and maintenance of pregnancy. The aim of this study was to characterize how a bovine nonclassical MHC-I gene (NC1) is regulated. Initial serial deletion experiments of a 2-kb fragment of the NC1 promoter identified regions with...
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PMID: 20427761
PDF is available here.
PDF is available here.
Journal of Virology (84)13 2010
Abstract
Prion diseases are a group of transmissible, invariably fatal neurodegenerative diseases that affect both humans and animals. According to the protein-only hypothesis, the infectious agent is a prion (proteinaceous infectious particle) that is composed primarily of PrP(Sc), the disease-associated is...
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PMID: 20427543
PDF is available here.
PDF is available here.
Abstract
I interferons, IFN-tau has demonstrated promising antiviral activity against human viral infections in vitro. Additionally, it displays high species cross-reactivity despite its absence in humans. To date, IFN-tau has shown efficacy in reducing replication of human immunodeficiency virus, feline imm...
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PMID: 20626290
PDF is available here.
PDF is available here.
FEBS Letters (584)13 2010
Abstract
We found that overexpression of tail interacting protein of 47 kDa (TIP47), but not its truncated form (t-TIP47) protected NIH3T3 cells from hydrogen-peroxide-induced cell death, prevented the hydrogen-peroxide-induced mitochondrial depolarization determined by 5,50,6,60-tetrachloro-1,10,3,30-tetrae...
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PMID: 20556887
PDF is available here.
PDF is available here.
British Journal of Cancer (103)1 2010
Abstract
The PlGF activates ERK1/2 kinases, which are associated with cellular motility, in breast cancer cells. Several of these activating events are blocked by BP-1, which may explain its anti-tumour activity....
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PMID: 20551949
PDF is available here.
PDF is available here.
Abstract
We have recently identified a novel gene overexpressed in both thick primary and metastatic melanomas. This gene, progestagen-associated endometrial protein (PAEP), has never before been implicated in the oncogenic processes of melanoma, with its true function in oncogenesis and tumour progression r...
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PMID: 19799645
PDF is available here.
PDF is available here.
Hypertension Research (33)6 2010
Abstract
Our results show that in preeclamptic women, maternal plasma VEGF and PlGF levels were lower, whereas sFlt-1 levels were higher (P<0.05 for all) than in normotensive women. In contrast, cord plasma VEGF levels were higher (P<0.05) in preeclamptic women, whereas there was no difference in sFlt-1 leve...
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PMID: 20224572
PDF is available here.
PDF is available here.
Hypertension Research (33)5 2010
Abstract
We constructed reference range values of plasma levels of sFlt-1 and PlGF, and the sFlt-1/PlGF ratio using Elecsys sFlt-1 and Elecsys PlGF during the second half of pregnancy and evaluated their sensitivity and specificity for the diagnosis of preeclampsia. Plasma samples were collected from 144 nor...
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PMID: 20150910
PDF is available here.
PDF is available here.
Abstract
Ribosome display is a powerful cell-free technology to select a desired antibody together with its encoding mRNA. In this study, a human single-chain variable fragment (scFv) library was generated from the peripheral blood lymphocyte RNA of 10 ovarian cancer patients and then panned against bead-con...
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PMID: 19645688
PDF is available here.
PDF is available here.
Abstract
We investigated the effect of these agents on PP13 and beta-hCG levels using choriocarcinoma cell lines as surrogates for primary villous trophoblast. Five different cell lines were triggered with forskolin and cultured for 48 h. Amongst the five tested cell lines BeWo cells showed the strongest inc...
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PMID: 20347141
PDF is available here.
PDF is available here.
Anticancer Research (30)5 2010
Abstract
Gd was expressed in invasive lobular and ductal breast cancer and its expression was significantly reduced upon dedifferentiation. A non significant increase in Gd staining intensity was noted upon axillary lymph node involvement steroid receptor positivity. CONCLUSION: These results indicate that G...
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PMID: 20592348
PDF is available here.
PDF is available here.
Anticancer Research (30)5 2010
Abstract
We identified significant changes in glycodelin-A expression corresponding to grading and staging. Analysis of glycodelin expression with the PAb did not result in significant differences. Glycodelin-A staining was significantly reduced in G2 carcinomas compared to G1 ovarian cancer tissue. Moreover...
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PMID: 20592354
PDF is available here.
PDF is available here.
Abstract
We first address the synthesis, mechanisms of action, and functions of siRNAs. Then, we focus on recent advances and technologies in miRNA and protein research of the human placenta. Next, we discuss the clinical applications of miRNA in lung cancer. We also touch on "long" noncoding RNAs from inter...
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PMID: 20453418
PDF is available here.
PDF is available here.
Abstract
We show that, although anti-PlGF treatment inhibited wound healing, extravasation of B16F10 cells, and growth of a tumor engineered to overexpress the PlGF receptor (VEGFR-1), neutralization of PlGF using four novel blocking antibodies had no significant effect on tumor angiogenesis in 15 models. Al...
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PMID: 20371352
PDF is available here.
PDF is available here.
Abstract
We take advantage of carcinogen-induced and transgenic tumor models as well as ocular neovascularization to report further evidence in support of our original findings of PlGF as a promising target for anticancer therapies. We present evidence for the efficacy of additional anti-PlGF antibodies and...
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PMID: 20371353
PDF is available here.
PDF is available here.
Animal Reproduction Science (118)2-4 2010
Abstract
The influence of nutrition during the first and second trimesters of gestation on the occurrence of dystocia was investigated in 3-year-old composite-breed beef heifers. Heifers were allocated according to stratification by weight and genotype to either a high (H/-=76 MJ metabolisable energy (ME) an...
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PMID: 19762178
PDF is available here.
PDF is available here.
Biology of Reproduction (82)4 2010
Abstract
We hypothesized that IFNT contributes to antiviral activity in uterine vein blood and has endocrine actions on the CL. Preadsorption of IFNT with antiserum against recombinant ovine (ro) IFNT revealed that antiviral activity in uterine vein blood from pregnant ewes was mediated by IFNT. Endocrine ac...
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PMID: 20042537
PDF is available here.
PDF is available here.
FEBS Letters (584)5 2010
Abstract
We showed that the IRE1alpha-XBP1 pathway plays an essential role in the placenta. However, details of its function remain unclear. To address this point, we searched for IRE1alpha- or XBP1-regulated genes in the placenta, and identified the CEA family as a novel target of the IRE1alpha-XBP1 pathway...
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PMID: 20146926
PDF is available here.
PDF is available here.
Oncology Reports (23)2 2010
Abstract
We demonstrate that PLGF-1 transcript levels were significantly elevated when comparing tumours from patients with poor outcome and patients who remained disease-free (P=0.03), indicating a potential prognostic value. Immunohistochemistry demonstrated a marked increased in PGF-2 expression in tumour...
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PMID: 20043119
PDF is available here.
PDF is available here.
Abstract
We summarize data on caspase 8 in the villous trophoblast layer, with a specific focus on localization of pro- and active forms, the sites of its activation and deactivation, and its role and regulation during fusion. Moreover, we revisit the knowledge on fusogens in the villous trophoblast, compare...
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PMID: 20044137
PDF is available here.
PDF is available here.
Abstract
We conclude that caveolin-1 and caveolae have restricted distribution in the murine placenta and yolk sac and that this parallels the situation in human placenta.
Copyright 2009. Published by Elsevier Ltd....
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PMID: 20004972
PDF is available here.
PDF is available here.
Abstract
We cannot exactly explain the reversed localization of MCTs between human and murine placentas, it may be related to differences between humans and mice in the origin of lactate and its utilization by fetuses.
2009 Elsevier Ltd. All rights reserved....
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PMID: 20022372
PDF is available here.
PDF is available here.
Abstract
We examined the gene expression of key enzymes involved in Hcy metabolism in first trimester and term human placenta to determine which metabolic pathways prevail. Expression of mRNA for methionine synthase and 5,10-methylene tetrahydrofolate reductase, enzymes involved in the methionine cycle and r...
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PMID: 20036773
PDF is available here.
PDF is available here.
Chinese Medical Journal (123)2 2010
Abstract
The levels of vasoactive factors were similar between the UAP group (69 patients) and NSTE-AMI group (55 patients). The levels of sFlt-1 and PLGF in the vulnerable plaque group were significantly higher than those in the stable plaque group. The level of IL-18 was correlated positively with plaque m...
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PMID: 20137369
PDF is available here.
PDF is available here.
Abstract
We show that systemic delivery of VEGF and placental growth factor (PlGF) by protein implantation, tumors, and adenoviral vectors ablates pericytes from the mature retinal vasculature through the VEGF receptor 1 (VEGFR1)-mediated signaling pathway, leading to increased vascular leakage. In contrast,...
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PMID: 20080765
PDF is available here.
PDF is available here.
Abstract
Supplementation of aT or gT resulted in increased concentrations in serum, placentome and uterus compared to control (P<0.05). In aT group, mRNA expressions of PlGF, eNOS and HIF-1alpha in cotyledon were greater than the CON group. In gT group, mRNA expressions of VEGF, eNOS, HIF-1 alpha and HIF-2 a...
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PMID: 20624307
PDF is available here.
PDF is available here.
Clinical laboratory (56)5-6 2010
Abstract
These results confirmed that PIGF is an independent biomarker of short-term adverse outcome in patients with ACS without ST elevation and that plaque instability, represented by PIGF elevation, has an important role in the pathogenesis of future coronary events....
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PMID: 20575469
PDF is available here.
PDF is available here.
Biological Chemistry (391)2-3 2010
Abstract
The pregnancy-associated glycoproteins (PAGs) represent a complex group of putative aspartic peptidases expressed exclusively in the placentas of species in the Artiodactyla order. The ruminant PAGs segregate into two classes: the 'ancient' and 'modern' PAGs. Some of the modern PAGs possess alterati...
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PMID: 20030586
PDF is available here.
PDF is available here.
Abstract
We found that the induction of FoxP3 expression by PP14 is accompanied by down regulation of the PI3K-mTOR signaling pathway.
These data suggest that PP14 arrests T cells in a unique activated state that is not accompanied with the acquisition of effector function, together with prom...
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PMID: 20886106
PDF is available here.
PDF is available here.
Current Medicinal Chemistry (17)10 2010
The role of heat shock protein (HSP) in atherosclerosis: Pathophysiology and clinical opportunities.
Abstract
The highly conserved heat-shock proteins (HSPs) from mammals and microbial reagents are among the immunogenic proteins. Their expression is induced in response to a wide variety of physiological and environmental insults. Their functions as molecular chaperones allow cells to adapt to gradual change...
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PMID: 20156167
PDF is available here.
PDF is available here.
Abstract
We first examined LI-cadherin expression immunohistochemically in 34 specimens of human intrahepatic cholangiocarcinoma (ICC). LI-cadherin expression was positive (defined as positivity in > or = 10% of cells) in 18 of the ICCs (52.9%). LI-cadherin negativity was significantly correlated with tumor...
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PMID: 19956853
PDF is available here.
PDF is available here.
Abstract
Serum PP13, expressed as multiples of the median (MoM) of the euploid group, was not significantly different in trisomy 21 (1.12 MoM) pregnancies, but the levels were decreased in trisomy 18 (0.75 MoM), trisomy 13 (0.65 MoM), Turner syndrome (0.61 MoM) and triploidy (0.19 MoM). In both euploid and a...
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PMID: 20332643
PDF is available here.
PDF is available here.
Abstract
The addition of progesterone treatment may act synergistically with lymphocyte immunotherapy, especially in primary aborters and tertiary aborters. However, it is important to use fresh--not refrigerated--stored lymphoctes....
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PMID: 20420268
PDF is available here.
PDF is available here.
Abstract
(1) Plasma sEng concentration in patients destined to develop PTL was higher than that in normal pregnant women from 15-20 weeks of gestation. The difference became statistical significant at 28 weeks of gestation, or approximately 5-10 weeks prior to the diagnosis of 'true PTL'. (2) Backward analys...
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PMID: 19916710
PDF is available here.
PDF is available here.
Abstract
We observed significantly higher levels of pZP1, pZP3 and integrin beta1 and beta2 transcripts in oocytes collected from medium follicles as compared with small follicles (P<0.001). Moreover, we found an increased content of all investigated mRNAs in oocytes isolated from large follicles as compared...
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PMID: 19672040
PDF is available here.
PDF is available here.
Abstract
(1) The PlGF/sEng ratio and its delta and slope had an excellent predictive performance for the prediction of early-onset preeclampsia, with very high likelihood ratios for a positive test result and very low likelihood ratios for a negative test result; and (2) Although the positive likelihood rati...
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PMID: 19900040
PDF is available here.
PDF is available here.
Abstract
We examine endothelial differentiation of AFS cells in response to growth factors, shear force, and hypoxia. We isolated human AFS cells from amniotic fluid samples (1-4 cc/specimen) obtained from patients undergoing amniocentesis at 15-18 weeks of gestation (n = 10). Isolates maintained in nondiffe...
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PMID: 19508152
PDF is available here.
PDF is available here.
Chinese Medical Journal (122)20 2009
Abstract
Cath-B correlates with the growth and angiogenesis of tumors, but not with the adhesion induced by CD44v6. CA-074Me clearly inhibited cath-B expression and demonstrated an anti-neoplastic and anti-angiogenesis effect....
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PMID: 20079165
PDF is available here.
PDF is available here.
Biochemical Society Transactions (37)Pt 5 2009
Abstract
Lipid droplets are intracellular organelles that play central roles in lipid metabolism. In many cells, lipid droplets undergo active motion, typically along microtubules. This motion has been proposed to aid growth and breakdown of droplets, to allow net transfer of nutrients from sites of synthesi...
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PMID: 19754438
PDF is available here.
PDF is available here.
Abstract
We recently found that glycodelin not only reduces carcinoma cell growth in vitro, but glycodelin cDNA transfection to MCF-7 breast carcinoma cells also reduces growth of these cells in vivo, demonstrated by xenograft tumor growth in mouse mammary fat pads. These results strongly sugge...
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PMID: 19551557
PDF is available here.
PDF is available here.
Abstract
In contrast with results from in vitro studies, Cr supplementation had no effects in vivo on the time course of recovery of rat skeletal muscle mass and phenotype after notexin-induced injury....
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PMID: 19657293
PDF is available here.
PDF is available here.
Abstract
Placental growth factor (PlGF) combined with vascular endothelial growth factor (VEGF(164)) did not result in greater luciferase expression of a microencapsulated genetically transfected mouse fibroblast cell line (L929 cells) implanted subcutaneously in nominally syngeneic C3H/HeJ mice than in a co...
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PMID: 19125649
PDF is available here.
PDF is available here.
Abstract
Serum levels of endostatin, placental growth factor (PlGF), and fibroblast growth factors-1 and -2 (FGF-1 and FGF-2) were measured in 58 patients with primary osteosarcomas before therapy and in 21 healthy subjects. The incidence of serum FGF-1 in bone tumors was 2.5 times higher than in healthy ind...
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PMID: 20027339
PDF is available here.
PDF is available here.
Abstract
The present study tested the hypothesis that protein kinase C (PKC) epsilon plays a key role in the sex dichotomy of heart susceptibility to ischemia and reperfusion injury in adult offspring resulting from prenatal hypoxic exposure. Time-dated pregnant rats were divided between normoxic and hypoxic...
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PMID: 19470841
PDF is available here.
PDF is available here.
Abstract
We have shown that this phenomenon can be reproduced in a representative non-human primate model, Macaca nemestrina (J Pharmacol Exp Ther 329:1016-1022, 2009). Nelfinavir is cleared from the body predominantly by CYP3A metabolism and P-glycoprotein (P-gp) efflux. Therefore, using midazolam (MDZ) as...
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PMID: 19478134
PDF is available here.
PDF is available here.
Abstract
Human SOUL (hSOUL) is a 23 kDa haem-binding protein that was first identified as the PP(23) protein isolated from human full-term placentas. Here, the overexpression, purification and crystallization of hSOUL are reported. The crystals belonged to space group P6(4)22, with unit-cell parameters a = b...
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PMID: 19574650
PDF is available here.
PDF is available here.
Oncology Reports (22)1 2009
Abstract
This work evaluated SU11248 (sunitinib) as a potential therapeutic agent, alone or in combination with the cytotoxic agent gemcitabine or radiotherapy in a murine model of pancreatic cancer. Panc02 cells were injected subcutaneously into HsdOla/MF1 mice (n=222). Treatment was administered during 1 w...
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PMID: 19513511
PDF is available here.
PDF is available here.
Theriogenology (72)1 2009
Abstract
Interferon-tau (IFNT), which plays a major role in maternal recognition of pregnancy in cattle, is transcribed from multiple genes. Moreover, there are at least 12 cDNA variants, many presumably allelic. Although the IFNT locus is autosomal, Day 8 female blastocysts produced approximately twice as m...
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PMID: 19324401
PDF is available here.
PDF is available here.
Abstract
We describe a simple method whereby a protein of interest, when fused in frame to the E. coli chaperones DnaK or GroEL, is readily expressed in large amounts in a soluble form. This system was tested using expression of the mouse prion protein PrP, which is normally insoluble in bacteria. We show th...
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PMID: 19328840
PDF is available here.
PDF is available here.
Abstract
Determination of progesteron-induced blocking factor level in body fluids in early pregnancy might be used for the diagnosis and prognosis of threatened abortion....
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PMID: 19290853
PDF is available here.
PDF is available here.
Abstract
We have ascertained the effects of PIBF on secretion of selected type 1 and type 2 cytokines by peripheral blood mononuclear cells from healthy non-pregnant women, women undergoing normal pregnancy, women with unexplained RSM and women with PTD. Peripheral blood mononuclear cells from 30 women with...
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PMID: 19371956
PDF is available here.
PDF is available here.
Fertility and Sterility (91)5 2009
Abstract
OBJECTIVE: To evaluate the expression of biomarkers of implantation, glycodelin A (GdA), osteopontin (OPN), lysophosphatidic acid receptor 3 (LPA3), and HOXA10, in eutopic endometrium of women with and without endometriosis. DESIGN: Prospective observational study. SETTING: Clinical research center....
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PMID: 18672236
PDF is available here.
PDF is available here.
Abstract
These results show that diabetes condition affects reproductive performance, particularly uNK cell behavior, but not PlGF production....
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PMID: 19420861
PDF is available here.
PDF is available here.
Abstract
In preeclampsia, levels of placental growth factor (PlGF) become abnormal prior to soluble fms-like tyrosine kinase 1 (sFlt-1). Longitudinal measurement of changes in protein level are better predictors of disease than measurement at a single time point in pregnancy and also appear to be more strong...
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PMID: 19996864
PDF is available here.
PDF is available here.
Animal Reproduction Science (111)2-4 2009
Abstract
Most current in vitro production systems terminate at the blastocyst stage in cattle. The goal of the present research was to identify culture conditions that support individual blastocyst survival and interferon-tau (IFNT) production in cattle. In the first study, two media (medium 199 [M199] and p...
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PMID: 18394828
PDF is available here.
PDF is available here.
Abstract
We observed expression of Gd in breast cancer independent of grading. With regard to nodal status, no significant differences in the expression of Gd between cancer tissue from patients with or without axillary lymph node metastases were present. However, Gd expression was found to be significantly...
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PMID: 19224449
PDF is available here.
PDF is available here.