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Proteinase Inhibitory Proteins, Secretory (4):
Recent article
Proteinase Inhibitory Proteins, Secretory
Abstract
We previously identified a cell-autonomous signaling cascade that triggers pro-Th2 cytokine thymic stromal lymphopoietin (TSLP) production in LEKTI-deficient epidermis. This signaling is initiated by unrestricted kallikrein 5 (KLK5) activity, which directly activates proteinase-activated receptor 2...
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PMID: 20703245
PDF is available here.
PDF is available here.
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Abstract
We investigated biological functions and inhibitory effects of HAI-1 and HAI-2 using uterine LMS cell line SK-LMS-1 and SKN. The expression levels of HAI-1 and HAI-2 were significantly decreased in uterine LMS specimens relative to corresponding uterine normal smooth muscle and leiomyoma specimens....
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PMID: 20664929
PDF is available here.
PDF is available here.
Abstract
We report that matriptase proteolytically cleaves Ln-332 in the β3 chain. Substrate specificity was confirmed by blocking cleavage with the matriptase inhibitor, Kunitz domain-1. Transwell migration assays showed that DU145 cell motility was significantly enhanced when plated on matriptase-cleaved...
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PMID: 20672321
PDF is available here.
PDF is available here.
Abstract
C10 significantly inhibited secretion of both fluorescent ceramide and LEKTI in cultured normal human epidermal keratinocytes and a reconstructed human epidermis. C10 also disturbed the polarized localization of fluorescent ceramide and LEKTI in the reconstructed epidermis. Electron microscopy revea...
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PMID: 20654784
PDF is available here.
PDF is available here.
Abstract
In an ongoing investigation of compounds from natural products that exhibit anti-aging properties, hydroxyhibiscone A (1), a new furanosesquiterpenoid, together with hibiscone D (2), was isolated from the root bark of Hibiscus syriacus. Utilizing UV, IR, NMR, and MS spectroscopic analyses, these che...
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PMID: 20798580
PDF is available here.
PDF is available here.
Arthritis & Rheumatism (62)7 2010
Abstract
Matriptase gene expression was significantly elevated in OA cartilage compared with NOF cartilage, and matriptase was immunolocalized to OA chondrocytes. We showed that matriptase activated proMMP-1 and processed proMMP-3 to its fully active form. Exogenous matriptase significantly enhanced cytokine...
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PMID: 20506309
PDF is available here.
PDF is available here.
Abstract
We have recently documented the importance of NE in the pathophysiology of liver ischemia/reperfusion injury, a local Ag-independent inflammation response. This study was designed to explore putative cytoprotective functions of clinically available Sivelestat in liver ischemia/reperfusion injury. ME...
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PMID: 20160675
PDF is available here.
PDF is available here.
Abstract
Whereas most drug trials in ARDS have been negative, some studies suggest that targeting therapies at subgroups of patients may be successful. Proposed subgroups include early versus late-phase ARDS, direct versus indirect lung injury, and patients with altered coagulation. Corticosteroids have bene...
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PMID: 19952736
PDF is available here.
PDF is available here.
Abstract
Abstract
The fungus Phaeosphaeria spartinae is an endophyte of the marine alga Ceramium sp. Investigation of this marine-derived fungus led to the isolation of the new natural products spartinol A (1), B (2), C (3) and D (4). The structures of these closely related compounds were established from extensive s...
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PMID: 19967974
PDF is available here.
PDF is available here.
Abstract
We determined the expression and activation status of matriptase in seminal fluid and urine and the distribution and subcellular localization of the protease in the prostate and kidney. The in vivo studies revealed that while the latent matriptase is localized at the basolateral surface of the ducta...
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PMID: 19535514
PDF is available here.
PDF is available here.
Abstract
Our understanding of gene-environment interactions should lead to a better use of some topical products, avoidance of others, and the increased use and development of products that can repair the skin barrier....
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PMID: 19494826
PDF is available here.
PDF is available here.
Abstract
We attempted to investigate the inhibitory effects of HAI-1 using cervical carcinoma cell lines SiHa with integrated human papillomavirus (HPV) 16 and HeLa with integrated HPV 18. HAI-1 expression in cervical cancer (n=91) were assessed by immunohistochemistry. HAI-1 was found to be a potential inhi...
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PMID: 19578736
PDF is available here.
PDF is available here.
Abstract
We suggest a possible role for SPINK9 in the site-specific epidermal differentiation of palms and soles....
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PMID: 19194479
PDF is available here.
PDF is available here.
Abstract
We could also show that matriptase was complexed to HAI-1 in normal human skin, whereas in SCCs, the enzyme was present in an unassociated form. Both a specific peptide agonist for PAR(2) and the proteinase domain of matriptase were able to induce intracellular calcium mobilization and inhibition of...
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PMID: 19242518
PDF is available here.
PDF is available here.
Oncology Reports (22)1 2009
Abstract
We aimed to identify and validate novel serum protein profiles specific for breast cancer, and assess the influence of clinical (subjects age) and pre-analytical (sample storage duration) variables on the constructed classifiers. To this end, sera of breast cancer patients (n=152) and healthy contro...
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PMID: 19513525
PDF is available here.
PDF is available here.
Clinica Chimica Acta (402)1-2 2009
Abstract
ITIH4 is an anti-inflammatory protein, and suggests that further investigation into its potential use in the diagnosis and prognosis of AIS is warranted....
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PMID: 19263524
PDF is available here.
PDF is available here.
Journal of Antibiotics (62)6 2009
Abstract
Brain Research (1259) 2009
Abstract
We examined the effects of specific neutrophil elastase inhibitor, ONO-5046, on hippocampal CA1 neuronal death in relation to neutrophil elastase activity in the plasma and its distribution in the brain and to caspase-3/7 activity. ONO-5046 (5 and 10 mg/kg) or saline (control group) was administrate...
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PMID: 19168036
PDF is available here.
PDF is available here.
Abstract
We discuss the relevance of loss-of-function mutations in the filaggrin gene within the context of other candidate gene studies and suggest possible applications for future research. Knowledge of genetic factors in eczema may translate into a clearer understanding of pathogenic mechanisms and hence...
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PMID: 19209157
PDF is available here.
PDF is available here.
Abstract
We investigated the role of HAI-1 and HAI-2, and evaluated their clinical importance in ovarian cancer. The distribution of cases that scored positive for each of the biological parameters examined was correlated with HAI-1 and HAI-2 expression status obtained by immunohistochemistry. There was a si...
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PMID: 19148468
PDF is available here.
PDF is available here.
Abstract
We have previously demonstrated the potency of coumarinic derivatives to inhibit human leukocyte elastase. Given the anti-inflammatory activities of some coumarins, we investigated the capacity of our coumarinic derivatives to inhibit inflammation and whether their anti-elastase activity was essenti...
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PMID: 18840548
PDF is available here.
PDF is available here.
BMC Cancer (9)1 2009
Abstract
The mRNA level of prostasin was slightly but significantly decreased in both mild/moderate dysplasia (p < 0.001) and severe dysplasia (p < 0.01) and in carcinomas (p < 0.05) compared to normal tissue from the same individual. The mRNA level of PN-1 was more that two-fold elevated in colorectal cance...
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PMID: 19555470
PDF is available here.
PDF is available here.
Abstract
We found that matriptase expression levels were significantly higher in Pca_local (P<0.0001) and HGPIN (P<0.05) compared with benign prostate tissue. Matriptase levels were significantly decreased in metastatic cancer when compared with all other tissue types (P<0.05). Compared with benign prostate...
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PMID: 18813126
PDF is available here.
PDF is available here.
Abstract
These results suggest that sivelestat is beneficial in acute lung injury associated with lung bacterial infection and that this inhibitor rather decreases infection by preserving host defense system....
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PMID: 18992355
PDF is available here.
PDF is available here.
Abstract
AHGF may be a potential tumor marker for prostate cancer. Further studies in large groups of patients are needed to define the clinical value of AHGF.
2008 Wiley-Liss, Inc....
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PMID: 19021204
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (283)43 2008
Abstract
We show that HAI-2 displays potent inhibitory activity toward matriptase, forms SDS-stable complexes with the serine protease, and blocks matriptase-dependent activation of its candidate physiological substrates proprostasin and cell surface-bound pro-urokinase plasminogen activator. To further expl...
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PMID: 18713750
PDF is available here.
PDF is available here.
Virchows Archiv (453)4 2008
Abstract
We show that the membrane form of HAI-1 was significantly upregulated immunohistochemically in epithelial cells under adverse conditions including tissue injury, necroinflammatory reactions, and invasion of carcinomas. To analyze the mechanism underlying these in vivo observations, we examined the e...
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PMID: 18769935
PDF is available here.
PDF is available here.
Abstract
No association was seen with the SPINK5 or KLK7 variants in the case-control analysis; however, a weaker effect was observed for the SPINK5 variant with maternal transmission in the family-based study. No interactions were seen between the polymorphisms in KLK7, SPINK5, and FLG. CONCLUSION: The SPIN...
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PMID: 18774391
PDF is available here.
PDF is available here.
Abstract
A liquid chromatography/tandem mass spectrometric (LC/MS/MS) analytical procedure for the quantification of eight proteolytic fragments from inter-alpha-trypsin inhibitor heavy chain 4 (ITIH(4)) in human plasma and serum has been developed. The eight peptide fragments only differ in length at the N-...
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PMID: 18752334
PDF is available here.
PDF is available here.
Abstract
Eppin binds Sg on the surface of human spermatozoa with the C-terminal of Eppin (amino acids 75-133). rSg was digested with PSA and many low molecular weight fragments were produced. When rEppin is bound to rSg, then digested by PSA, incomplete digestion and a 15-kDa fragment results. Antibody bindi...
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PMID: 18645681
PDF is available here.
PDF is available here.
Abstract
We characterized matriptase complexes of 110 kDa in human milk, which contained no HAI-1 and resisted dissociation in boiling SDS in the absence of reducing agents. These complexes were further purified and dissociated into 80-kDa and 45-kDa fragments by treatment with reducing agents. Proteomic and...
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PMID: 18550704
PDF is available here.
PDF is available here.
Abstract
We treated him with antibiotics, trimethoprim-sulfamethoxazole, ganciclovir, fos-fluconazole, steroid pulse therapy and sivelestat sodium hydrate. Respiratory failure was relieved within 5 days following treatment. The percentage of neutrophils in the BAL fluid was elevated (44.6%). Neutrophil elast...
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PMID: 18592991
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1783)6 2008
Abstract
We show that LEI can bind the exportin Crm1, and we identify on LEI a nuclear export signal involved in the control of LEI/L-DNase II nuclearization in healthy cells. Point mutation of this site increases the accumulation of the molecule in the nucleus and triggers cell death....
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PMID: 18342633
PDF is available here.
PDF is available here.
Abstract
We administered sivelestat sodium hydrate, a neutrophil elastase inhibitor, to 11 patients with AAD who were medically treated to prevent lung injury. We compared their clinical course with that of 12 patients of control group in which sivelestat was not used prophylacticaly. Although there were 5 p...
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PMID: 18536289
PDF is available here.
PDF is available here.
Abstract
Four proteins differed significantly between patients with IC and AC subjects. The AC subjects had a greater concentration of a uromodulin (P = .019) and two kininogens (P = .023, .046). The patients with IC had a greater concentration of inter-alpha-trypsin inhibitor heavy chain H4 (P = .019). CONC...
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PMID: 18455532
PDF is available here.
PDF is available here.
Abstract
We were unable to demonstrate truncated proteins in tissue from patients with NS, we used recombinant protein to test the hypothesis that the length of LEKTI correlated with protease inhibitory activity. Genotype/phenotype correlations were observed with cutaneous severity, growth retardation, skin...
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PMID: 17989726
PDF is available here.
PDF is available here.
Chinese Medical Journal (121)7 2008
Abstract
About 18.33 mg His6-Eppin was obtained from 1-L flask culture. The produced polyclonal antibodies against His6-Eppin recognized the Eppin protein both in human epididymis and in HEK293T cells by over-expression of the recombinant human Eppin. CONCLUSION: The purified His6-Eppin protein has biologica...
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PMID: 18466682
PDF is available here.
PDF is available here.
Molecular and Cellular Biochemistry (311)1-2 2008
Abstract
We evaluated the effect of neutrophil elastase inhibitor, sivelestat sodium hydrate on ischemia-reperfusion injury in the rat bladder. Rat abdominal aorta was clamping with a small clip to induce ischemia-reperfusion injury in the bladder. Eight-week-old male Sprague Dawley rats were divided into fo...
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PMID: 18165924
PDF is available here.
PDF is available here.
Abstract
We are interested in these protease inhibitors. By accessing the Novartis mouse expression database, we found that the four WAP family members, SLPI, WFDC2, WFDC5, and WFDC12, are highly expressed in the oral organs, such as the trachea, tongue, and salivary glands. Since their WAP domains play pivo...
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PMID: 18360692
PDF is available here.
PDF is available here.
Abstract
This review covers protease-antiprotease imbalance in the development of emphysema in smokers. This imbalance is likely to play a major pathogenic role in the development of emphysema in subjects with severe alpha1-antitrypsin deficiency who smoke because of a deficient antiprotease protection again...
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PMID: 18371259
PDF is available here.
PDF is available here.
Abstract
Atopic dermatitis (AD) is a chronic inflammatory skin disorder with an increasing prevalence in industrialized countries. AD belongs to the group of allergic disorders that includes food allergy, allergic rhinitis, and asthma. A multifactorial background for AD has been suggested, with genetic as we...
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PMID: 18209506
PDF is available here.
PDF is available here.
Journal of Surgical Research (145)1 2008
Abstract
These results indicate that NE inhibitor, FR136706, inhibits the induction of a variety of inflammatory mediators such as cytokines, chemokines, and nitric oxide, in part through the inhibition of nuclear factor-kappa B activation, resulting in the prevention of fulminant liver failure....
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PMID: 17936791
PDF is available here.
PDF is available here.
Abstract
We have used the recently developed binding mode model for a group of cinnamic acid derivative elastase inhibitors and created bornyl (3,4,5-trihydroxy)-cinnamate. This ligand exhibited improved binding affinity predicted by means of free energy calculations. An organic synthesis scheme for the liga...
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PMID: 18078761
PDF is available here.
PDF is available here.
Experimental Parasitology (118)2 2008
Abstract
BmSI-7 and BmSI-6, two Boophilus microplus subtilisin inhibitors (BmSI) were purified and characterized from eggs. The inhibitors isolated by classical purification methods presented molecular masses of 7408 and 7271Da, respectively, by MALDI-TOF-MS. Both BmSI-7 and BmSI-6 inhibited neutrophil elast...
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PMID: 17889850
PDF is available here.
PDF is available here.
Nephrology (13)1 2008
Abstract
Increased levels of proteinuria were observed in the nephritic rats (groups A, B and C) compared with group D. The proteinuria level was significantly suppressed by sivelestat in groups A and B in a dose-dependent fashion compared with group C. The light microscopy revealed an increased glomerular c...
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PMID: 18199098
PDF is available here.
PDF is available here.
Abstract
We have recently characterized ITIH5, a novel member of the ITIH gene family, and showed that its messenger RNA is lost in a high proportion of breast tumours. In the present study, an ITIH5-specific polyclonal antibody was generated, validated with western blot and used for immunohistochemical anal...
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PMID: 17653090
PDF is available here.
PDF is available here.
Pediatric Dermatology (25)2 2008
Abstract
Pediatric Dermatology (25)3 2008
Abstract
We report a 23-day-old girl who presented with severe primary pulmonary hypertension, exfoliative erythroderma, and trichorrhexis invaginata. Genetic studies confirmed a premature termination mutation R350X in exon 12 of SPINK5. This mutation further supports the genotypic-phenotypic prediction that...
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PMID: 18577046
PDF is available here.
PDF is available here.
Journal of Anesthesia (22)4 2008
Abstract
The P/F ratio was higher in the sivelestat group compared with the control group and there were significant differences between the two groups immediately after weaning form CPB, and at 12 h after weaning from CPB (P < 0.05). The RI was lower in the sivelestat group compared with the control group a...
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PMID: 19011770
PDF is available here.
PDF is available here.
Abstract
We overexpressed and purified a sequence comprising the 15th domain of LEKTI for further characterisation. Here, we present a high yield expression system for recombinant production and efficient purification of LEKTI domain 15 as a highly soluble protein with a uniform disulfide pattern that is ide...
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PMID: 17936012
PDF is available here.
PDF is available here.
Abstract
Genetic studies on chronic inflammatory diseases have resulted in an emphasis on the epithelial interface with the environment and the genes that influence this interaction. This study examines the expression of key epithelial genes implicated in the pathogenesis of other inflammatory disorders for...
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PMID: 18588753
PDF is available here.
PDF is available here.
Abstract
Matriptase is a member of an expanding group of type II transmembrane serine proteases. Recently, much has been learned about the biochemistry, cellular biology, normal tissue physiology, and human pathology of this protease, and of its inhibitor, termed the hepatocyte growth factor inhibitor-1 (HAI...
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PMID: 17981575
PDF is available here.
PDF is available here.
Proteomics (7)23 2007
Abstract
There are several physiological roles postulated for aqueous humor, a liquid located in the anterior and posterior chamber of the eye, such as maintenance of the intraocular pressure, provision of nutrients, and removal of metabolic waste from neighboring tissues and provision of an...
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PMID: 18040985
PDF is available here.
PDF is available here.
Abstract
Abstract
We tested the expressions of matriptase and hepatocyte growth factor activator inhibitor-1 (HAI-1) maybe associated with the progression of colorectal adenocarcinoma. Immunohistochemical analysis of matriptase and HAI-1 was performed in tissue microarray slides of 91 colorectal adenocarcinomas with...
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PMID: 18274158
PDF is available here.
PDF is available here.
Human Cell (20)4 2007
Abstract
We have previously reported that the expression of HAI-1 suppresses the in vitro invasive capability of human glioblastoma cells. In this study we examined the role of each KD in the anti-invasive effect of HAI-1. Engineered over-expression of the mature membrane-form HAI-1 suppressed in vitro fibri...
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PMID: 17949349
PDF is available here.
PDF is available here.
Circulation (116)16 2007
Abstract
Taken together, we identified 54 putatively secreted cardiac proteins. PI16, a novel protein secreted from the heart, is strongly upregulated early in heart failure and inhibits growth of cardiomyocytes both in vitro and in vivo. PI16 might represent a novel therapeutic target in heart failure....
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PMID: 17909105
PDF is available here.
PDF is available here.
Abstract
We examined the importance of hepatocyte growth factor activator inhibitor-1 (HAI-1) which is known to inhibit a number of HGF-activating molecules. We reduced the expression of this molecule in both PC-3 and DU-145 cell lines using hammerhead ribozyme technology, and we examined various important c...
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PMID: 17786295
PDF is available here.
PDF is available here.
Development (134)19 2007
Abstract
We describe zebrafish that are mutant in the serine protease inhibitor Hai1a (Spint1la), which display disrupted epidermal integrity. These defects are further enhanced upon combined loss of hai1a and its paralog hai1b. By applying in vivo imaging, we demonstrate that Hai1-deficient keratinocytes ac...
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PMID: 17728346
PDF is available here.
PDF is available here.