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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Receptors, Cytoplasmic and Nuclear (10):
Recent article
Receptors, Cytoplasmic and Nuclear
Abstract
We have discovered that other cellular stressors are integrated with glucocorticoid signaling through a new hormone-independent phosphorylation site, Ser134, on the human glucocorticoid receptor (GR). Ser134 phosphorylation is induced by a variety of stress-activating stimuli in a p38 mitogen-activa...
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PMID: 21930780
PDF is available here.
PDF is available here.
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Cancer Research (71)22 2011
Abstract
We developed a curated database of 88 nuclear receptor cistrome data sets and other associated high-throughput data sets including 121 collaborating factor cistromes, 94 epigenomes, and 319 transcriptomes. Through integrative analysis of the curated nuclear receptor ChIP-chip/seq data sets, we disco...
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PMID: 21940749
PDF is available here.
PDF is available here.
Genes & Development (25)16 2011
Abstract
We have determined the cistrome and transcriptome for the nuclear receptor liver receptor homolog-1 (LRH-1) in exocrine pancreas. Chromatin immunoprecipitation (ChIP)-seq and RNA-seq analyses reveal that LRH-1 directly induces expression of genes encoding digestive enzymes and secretory and mitochon...
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PMID: 21852532
PDF is available here.
PDF is available here.
Abstract
Consumption of dietary grape seed procyanidins extract (GSPE) has improved the plasma lipid profile in humans and experimental animals. The effect of GSPE on the reduction of the postprandial plasma triglyceride (TG) levels has been attributed to the activation of the small heterodim...
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PMID: 21280207
PDF is available here.
PDF is available here.
FEBS Journal (278)13 2011
Abstract
Steroid hormone receptors regulate gene transcription in a highly tissue-specific manner. The local chromatin structure underlying promoters and hormone response elements is a major component involved in controlling these highly restricted expression patterns. Chromatin remodeling co...
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PMID: 21501385
PDF is available here.
PDF is available here.
Abstract
Nuclear receptors (NRs) are ligand-activated transcription factors that are important to life by regulating a wide variety of physiological and pathological functions. There are three classes of NRs defined by ligands and heterodimer partners. The Class II NRs are involved in a broad...
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PMID: 21554208
PDF is available here.
PDF is available here.
Molecular BioSystems (7)4 2011
Abstract
We utilize a metabolomics approach that detects protein-metabolite interactions to identify endogenous peroxisome proliferator-activated receptor (PPAR) ligands from tissue and cell extracts....
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PMID: 21283866
PDF is available here.
PDF is available here.
Abstract
We briefly discuss the pathophysiology of pulmonary hypertension and endothelial dysfunction, along with current treatments. We then present a focused review of recent animal studies and human trials examining the use of activators and stimulators of soluble guanylate cyclase for the treatment of pu...
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PMID: 21510726
PDF is available here.
PDF is available here.
PLoS Biology (9)3 2011
Abstract
We report on NHR-80/HNF4, a nuclear receptor that specifically mediates longevity induced by depletion of the germ line through a mechanism that implicates fatty acid monodesaturation.
nhr-80/HNF4 is induced in animals lacking a germ line and is specifically required for their extend...
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PMID: 21423649
PDF is available here.
PDF is available here.
Cell Metabolism (13)2 2011
Abstract
In mammals, most metabolic processes are influenced by biological clocks and feeding rhythms. The mechanisms that couple metabolism to circadian oscillators are just emerging. NAD-dependent enzymes (e.g., Sirtuins and poly[ADP-ribose] polymerases), redox- and/or temperature-dependent...
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PMID: 21284980
PDF is available here.
PDF is available here.
Abstract
We report a series of 13 cases of primary cutaneous epithelioid angiosarcoma and analyze their clinicopathologic features. The tumors arising in the conventional settings for cutaneous angiosarcoma (ie, in the head and neck region of elderly patients, and those occurring postradiation or associated...
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PMID: 21164288
PDF is available here.
PDF is available here.
Abstract
We present an introduction to the structure and function of nuclear receptors, specifically the estrogen, androgen, glucorticoid, peroxisome proliferator, steroid, thyroid and vitamin D receptors, and a discussion of the state-of-the-art of induced fit approaches for the nuclear receptor family....
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PMID: 20939793
PDF is available here.
PDF is available here.
Gene Expression Patterns (11)1-2 2011
Abstract
We used in situ hybridization to screen numerous expression patterns of the TFs involved in the development of the mouse thymus. More than 400 members, including unique TFs and some transcription co-factors, were tested. Among the screened TFs, 160 were found to be expressed in the thymus after E15....
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PMID: 20932939
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)52 2010
Abstract
We proposed that FtsY requires functional interaction with inner membrane lipids at a late stage of the signal recognition particle pathway. In addition, an essential lipid-binding α-helix was identified in FtsY of various origins. Theoretical considerations and in vitro studies have suggested that...
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PMID: 20956528
PDF is available here.
PDF is available here.
Bulletin du cancer (97)11 2010
Abstract
We will present here a general classification of the main pathways of cell signalling and some of the recurrent mechanisms used for the transmission of information between cells and inside cells....
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PMID: 21047720
PDF is available here.
PDF is available here.
Abstract
Peroxins are proteins that regulate the biogenesis of peroxisomes-small vesicular subcellular organelles essential for human life and health. A key peroxin - to date the best studied - is peroxin 5. Structurally, peroxin 5 is a bi-domain protein of about 70 kDa containing both globular and non-globu...
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PMID: 20633695
PDF is available here.
PDF is available here.
Abstract
We solved the crystal structure of a Rev dimer at 2.5-Å resolution. The dimer arrangement organizes arginine-rich helices at the ends of a V-shaped assembly to bind adjacent RNA sites and structurally couple dimerization and RNA recognition. A second protein-protein interface arranges higher-order...
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PMID: 20953181
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)43 2010
Abstract
We show that the amino acids (aa) 69-90 of LBR sequences are required to bind with importin β at aa 45-462, and the binding is essential for the NE membrane precursor vesicle targeting to the chromatin during the NE assembly at the end of mitosis. We also show that this binding is cell cycle-regula...
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PMID: 20576617
PDF is available here.
PDF is available here.
Laboratory Investigation (90)10 2010
Abstract
We show that contribution of intestinal FXR-Fgf15 signalling in regulation of hepatic cholesterol 7α-hydroxylase (Cyp7A1) expression depends on time of the day with increased hepatic Cyp7A1 expression in iFXR-KO mice compared with controls exclusively during the dark phase. To assess the physiologi...
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PMID: 20531290
PDF is available here.
PDF is available here.
Abstract
The transcriptional regulator SnoN has been the subject of growing interest due to its diverse functions in normal and pathological settings. A large body of evidence has established a fundamental role for SnoN as a modulator of signaling and responses by the transforming growth beta...
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PMID: 20712586
PDF is available here.
PDF is available here.
Abstract
We recently reported the chromosome region maintenance 1 (CRM1)-dependent nuclear export of intron-less human interferon-α1 (IFN-α1) mRNA, which encodes a main effecter of host innate immunity. We show that the coding region of IFN-α1 mRNA forms novel secondary structures that are responsible for...
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PMID: 20857263
PDF is available here.
PDF is available here.
Abstract
The growing number of patients with type 2 diabetes stimulates the development of new antidiabetic drugs. New targets are addressed, as SGLT2 in the kidney or enzymes of glucose metabolism in the liver which might help to lower glucose levels and to overcome insulin resistance. The forthcoming years...
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PMID: 21189647
PDF is available here.
PDF is available here.
Abstract
Asymmetric dimethylarginine (ADMA) is an endogenous methylated amino acid derived from arginine which can inhibit the activity of nitric oxide synthases. In various pathological states such as hypercholesterolemia, hyperglycemia, hyperhomocysteinemia, hypertension, coronary artery disease, heart fai...
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PMID: 20824955
PDF is available here.
PDF is available here.
Abstract
Bile acids are important regulatory molecules that can activate specific nuclear receptors and cell signaling pathways in the liver and gastrointestinal tract. In the current study, the chronic bile fistula (CBF) rat model and primary rat hepatocytes (PRH) were used to study the regulation of glucon...
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PMID: 20305288
PDF is available here.
PDF is available here.
Lung Cancer (69)2 2010
Abstract
We have recently shown that loss of ING2 expression is associated with increased genome instability. We investigated its status in a series of 120 non-small cell lung cancer (NSCLC) by using immunohistochemistry (IHC). The results showed that ING2 protein expression is downregulated in more than 50%...
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PMID: 19962781
PDF is available here.
PDF is available here.
Oncology Reports (24)2 2010
Abstract
We summarize the evidence, on which the recommendations were made, and customize the recommendations suitable for the current status....
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PMID: 20596613
PDF is available here.
PDF is available here.
Abstract
We attempted to discern whether mannose-6-phosphate receptors (MPRs) regulate transport and secretion of lysosomal enzymes in the rat epididymis, and if these events are altered when the animals are subjected to hormonal manipulation. We observed that expression of cation-dependent MPR (CD-MPR) and...
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PMID: 20564206
PDF is available here.
PDF is available here.
New Biotechnology (27)3 2010
Abstract
Since its discovery in the late 1990s by Fire and Mello, RNA interference (RNAi) has proven a useful tool for scientists working in the fields of functional genomics, biotechnology, and therapeutic development. However, one of the obstacles of making small interfering RNAs (siRNAs),...
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PMID: 20219711
PDF is available here.
PDF is available here.
Abstract
We show that NHR-6 is able to bind the canonical NR4A monomer response element and can transactivate from this site in mammalian HEK293 cells. Using a functional GFP-tagged NHR-6 fusion, we also demonstrate that NHR-6 is nuclear localized during development of the spermatheca. Mutation of the DNA-bi...
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PMID: 20506374
PDF is available here.
PDF is available here.
Abstract
We will spotlight the molecular mechanisms of receptor/ligand function and how bile acid-activated receptors regulate the innate immunity in the gastrointestinal tract and liver. The ability of these receptors to integrate metabolic and inflammatory signaling makes them particularly attractive targe...
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PMID: 20642438
PDF is available here.
PDF is available here.
Abstract
We study two alternative morphologies in the mouth of the nematode Pristionchus pacificus and the formation of teeth-like structures that are associated with bacteriovorous feeding and predatory behaviour on fungi and other worms. These teeth-like denticles represent an evolutionary novelty, which i...
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PMID: 20592728
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)29 2010
Abstract
We present crystallographic and mutagenesis data that reveal the mode of action of BAY 58-2667. The 2.3-A resolution structure of BAY 58-2667 bound to a heme NO and oxygen binding domain (H-NOX) from Nostoc homologous to that of sGC reveals that the trifurcated BAY 58-2667 molecule has displaced the...
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PMID: 20463019
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)29 2010
Abstract
We show that substrates of the nuclear export receptor CRM1 accumulate in the nucleus in the presence of 15d-PGJ(2), identifying this prostaglandin as a regulator of CRM1-dependent nuclear protein export that can be produced endogenously. Like leptomycin B (LMB), an established fungal CRM1-inhibitor...
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PMID: 20457605
PDF is available here.
PDF is available here.
Abstract
We show that FXR is expressed and functional, as assessed by target gene expression analysis, in human islets and beta-cell lines. FXR is predominantly cytosolic-localized in the islets of lean mice, but nuclear in obese mice. Compared to FXR+/+ mice, FXR-/- mice display a normal architecture and be...
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PMID: 20447400
PDF is available here.
PDF is available here.
Abstract
Responses to the Rho kinase inhibitor Y-27632 were investigated in the anesthetized rat. Under baseline conditions intravenous injections of Y-27632 decreased pulmonary and systemic arterial pressures and increased cardiac output. The decreases in pulmonary arterial pressures were enhanced when base...
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PMID: 20435851
PDF is available here.
PDF is available here.
Abstract
We evaluated cholestyramine in Zucker diabetic fatty (ZDF) rats. Although control ZDF rats had continuous increases in blood glucose and hemoglobin A1c (HbA1c) and serum glucose and a decrease in serum insulin throughout a 5-week study, the cholestyramine-treated ZDF rats showed a dose-dependent dec...
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PMID: 20413600
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1801)7 2010
Bile acids and their nuclear receptor FXR: Relevance for hepatobiliary and gastrointestinal disease.
Abstract
We discuss current knowledge of the role the bile acid-FXR interaction has in (patho)physiology of the liver, biliary and gastrointestinal tract, and proposed underlying mechanisms, based on in vitro data and experimental animal models. Given the availability of highly potent synthetic FXR agonists,...
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PMID: 20399894
PDF is available here.
PDF is available here.
FASEB Journal (24)7 2010
Abstract
We generated a series of ObR truncates with different lengths of the intracellular sequence, overexpressed them in 3 types of mammalian cells including cerebral endothelia, and quantified leptin binding and endocytosis. All mutant ObRs were able to bind and mediate the internalization of leptin. Sur...
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PMID: 20223942
PDF is available here.
PDF is available here.
Molecular Endocrinology (24)7 2010
Abstract
We summarize the recent and exciting findings presented by the speakers at the meeting....
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PMID: 20519330
PDF is available here.
PDF is available here.
Circulation Research (106)12 2010
Abstract
We have examined the role of FXR in vascular calcification.
The FXR gene, a bile acid nuclear receptor, was highly induced during osteogenic differentiation of bovine calcifying vascular cells (CVCs) and in the aorta of apolipoprotein (Apo)E(-/-) mice with chronic kidney disease whic...
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PMID: 20431060
PDF is available here.
PDF is available here.
Circulation (121)24 2010
Abstract
Adoptive transfer of Tregs protected mice from coxsackievirus B3-induced myocarditis through the transforming growth factor beta-coxsackie-adenovirus receptor pathway and thus suppresses the immune response to cardiac tissue, maintaining the antiviral immune response....
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PMID: 20530002
PDF is available here.
PDF is available here.
Abstract
Endosulfan is an organochlorine pesticide commonly used in agriculture. Endosulfan has affects on vertebrate xenobiotic metabolism pathways that may be mediated, in part, by its ability to activate the pregnane X receptor (PXR) and/or the constitutive androstane receptor (CAR) which can elevate expr...
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PMID: 20361990
PDF is available here.
PDF is available here.
Biochemistry (Washington) (49)23 2010
Abstract
Modulation of soluble guanylate cyclase (sGC) activity by nitric oxide (NO) involves two distinct steps. Low-level activation of sGC is achieved by the stoichiometric binding of NO (1-NO) to the heme cofactor, while much higher activation is achieved by the binding of additional NO (xsNO) at a non-h...
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PMID: 20459051
PDF is available here.
PDF is available here.
Circulation Research (106)10 2010
Abstract
Abstract
We have produced a fusion protein between Sulfolobus solfataricus SRP54 (Ffh) and a signal peptide connected via a flexible linker. This fusion protein oligomerizes in solution through interaction between the SRP54 and signal peptide moieties belonging to different chains, and it is functional, as d...
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PMID: 20364120
PDF is available here.
PDF is available here.
Anticancer Research (30)6 2010
Abstract
Chenodeoxycholic acid and deoxycholic acid increased CdX2 expression in Bic-1 cells. Guggulsterone reduced bile acid-induced and constitutive CdX2 expression at 5 microM. Guggulsterone (up to 5 microM) did not affect cell viability or the cell cycle and did not attenuate bile acid-induced or constit...
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PMID: 20651339
PDF is available here.
PDF is available here.
Abstract
The principal function of high-density lipoprotein (HDL) is to facilitate the reverse cholesterol transport (RCT) and inhibition of atheroma formation. Epidemiological studies and interventional trials have suggested that HDL has cardioprotective properties. However, increasing HDL concentration may...
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PMID: 20297868
PDF is available here.
PDF is available here.
Abstract
Studies in the last two decades have firmly established that nitric oxide (NO) exerts a broad range of effects on bodily functions including muscle contractility, platelet aggregation, metabolism, neuronal activity, and immune responses. The underlying mechanisms rely primarily on elevating guanosin...
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PMID: 20024580
PDF is available here.
PDF is available here.
Abstract
Endothelial cells situated at the interface between blood and the vessel wall play a crucial role in controlling vascular tone and homeostasis, particularly in determining the expression of pro- and anti-atherosclerotic genes. Many of these effects are mediated by changes in the generation and relea...
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PMID: 20012875
PDF is available here.
PDF is available here.
Pediatric Research (67)5 2010
Abstract
We assessed the effects of iNO and hyperoxia, independently and concurrently, on NO-cGMP signaling pathway and differentiation. Exposure to iNO increased cGMP levels by 40-fold after 3 d and by 8-fold after 5 d despite constant expression of phosphodiesterase-5 (PDE5). The levels of cGMP declined si...
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PMID: 20098340
PDF is available here.
PDF is available here.
Abstract
These results will be useful for identification of biomarkers for cholestasis and for determination of adaptive molecular mechanisms in cholestasis....
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PMID: 19965603
PDF is available here.
PDF is available here.
Abstract
We explored the signal transduction pathways involved in the nuclear translocation of GAPDH using confocal laser scanning microscopy of immunostained human diploid fibroblasts (HDFs). GAPDH was present mainly in the cytoplasm when cultured with 10% FBS. Serum depletion by culturing cells in a serum-...
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PMID: 20177150
PDF is available here.
PDF is available here.
Abstract
In the present study, the genotype frequencies of some SNPs related to mirtazapine metabolism in Spaniards were analyzed and showed that our study population is representative of HapMap European population. The results obtained could be analyzed with pharmacokinetic parameters of mirtazapine to eluc...
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PMID: 20218903
PDF is available here.
PDF is available here.
EMBO Reports (11)5 2010
Abstract
We have developed ultrathin FG domain films that reproduce the mode of attachment and the density of FG repeats in NPCs, and that exhibit a thickness that corresponds to the nanoscopic dimensions of the native permeability barrier. By using a combination of biophysical characterization techniques, w...
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PMID: 20379223
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1803)5 2010
Abstract
We have identified a weakly conserved Inp2-related protein in 18 species of budding yeast and analyzed the role of the identified protein in the methylotrophic yeast Hansenula polymorpha in peroxisome inheritance. Our data show that H. polymorpha Inp2 locates to peroxisomes, interacts with Myo2, and...
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PMID: 20153784
PDF is available here.
PDF is available here.
Abstract
Progressive familial intrahepatic cholestasis type 1 is a rare genetic liver disease that presents in the first year of life. Bile salts are elevated and these patients are often jaundiced. Despite the cholestasis, serum gamma-glutamyltransferase activity is normal or reduced. Pruritus is a major sy...
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PMID: 20422494
PDF is available here.
PDF is available here.
Abstract
Although hereditary or acquired defects in hepatobiliary transporter systems cause or predispose to cholestasis, adaptive bile acid transporter changes can counteract cholestasis by reducing hepatocellular and systemic concentrations of retained cholephiles. An important level in the regulation of a...
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PMID: 20422498
PDF is available here.
PDF is available here.
Abstract
Hepatobiliary transport systems are essential for the uptake and excretion of a variety of compounds including bile acids. Disruption and dysregulation of this excretory pathway result in cholestasis, leading to the intrahepatic accumulation of bile acids and other toxic compounds with progression o...
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PMID: 20422500
PDF is available here.
PDF is available here.
Genes & Development (24)8 2010
Abstract
It is a long-standing view that the circadian clock functions to proactively align internal physiology with the 24-h rotation of the earth. Recent studies, including one by Schmutz and colleagues (pp. 345-357) in the February 15, 2010, issue of Genes & Development, delineate strikingly complex conne...
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PMID: 20395363
PDF is available here.
PDF is available here.
Abstract
These results show that chronic exposure to nondioxin like PCBs impairs the function of the glutamate-NO-cGMP pathway in cerebellar neurons by different mechanisms and with different potencies. Impaired function of this pathway would contribute to the cognitive alterations induced by perinatal expos...
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PMID: 20297801
PDF is available here.
PDF is available here.