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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Ribosomal Proteins (4):
Recent article
Ribosomal Proteins
Abstract
We identify a previously unknown target of POA as the ribosomal protein S1 (RpsA), a vital protein involved in protein translation and the ribosome-sparing process of trans-translation. Three PZA-resistant clinical isolates without pncA mutation harbored RpsA mutations. RpsA overexpression conferred...
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PMID: 21835980
PDF is available here.
PDF is available here.
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Abstract
I and III in the species B. cenocepacia is found to be responsible for the unusual distribution of essential genes. The present work may contribute to the understanding of how the secondary chromosomes of multipartite bacterial genomes originate and evolve. The computer program, DEG_match, for compa...
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PMID: 21078295
PDF is available here.
PDF is available here.
EMBO Journal (29)23 2010
Abstract
We find that mTORC2 can colocalize with actively translating ribosomes and can stably interact with rpL23a, a large ribosomal subunit protein present at the tunnel exit. Exclusively during translation of Akt, mTORC2 mediates phosphorylation of the nascent polypeptide at the turn motif (TM) site, Thr...
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PMID: 21045808
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)45 2010
Abstract
We characterized the Lsm protein from the haloarchaeon Haloferax volcanii using in vitro and in vivo approaches. H. volcanii encodes a single Lsm protein, which belongs to the Lsm1 subfamily. The lsm gene is co-transcribed and overlaps with the gene for the ribosomal protein L37e. Northern blot anal...
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PMID: 20826804
PDF is available here.
PDF is available here.
Abstract
Ribosomes are self-assembling macromolecular machines that translate DNA into proteins, and an understanding of ribosome biogenesis is central to cellular physiology. Previous studies on the Escherichia coli 30S subunit suggest that ribosome assembly occurs via multiple parallel pathways rather than...
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PMID: 21030658
PDF is available here.
PDF is available here.
Cell Cycle (9)19 2010
Abstract
We report that depletion of L37 leads to cell cycle arrest in a L11- and p53-dependent manner. DNA damage can initiate ribosomal stress, although little is known about the mechanisms involved. We have found that some genotoxic insults, namely, UV light and cisplatin, lead to proteasomal degradation...
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PMID: 20935493
PDF is available here.
PDF is available here.
Abstract
These results indicated that AccRPL17 might play an important role in insect development, and the importance of AccRPL17 in participating in abiotic stresses is discussed.
© 2010 Wiley Periodicals, Inc....
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PMID: 20734330
PDF is available here.
PDF is available here.
Abstract
We calibrate rates of amino acid divergence by using structural information from the full set of crystallized proteins in bacteria. In agreement with previous reports, we show that rates of amino acid evolution correlate negatively with the number of per-amino acid atomic interactions. Calibration o...
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PMID: 20466746
PDF is available here.
PDF is available here.
Parasitology Research (107)5 2010
Abstract
A fragment of ribosomal protein L24 was obtained from the complementary deoxyribonucleic acid (cDNA) library of Haemaphysalis longicornis eggs. The complete sequence of the clone was subsequently obtained using rapid amplification of the cDNA ends (RACE). Ribosomal protein L24 from H. longicornis ha...
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PMID: 20676684
PDF is available here.
PDF is available here.
Cancer Cell (18)3 2010
Abstract
We generated mice carrying a cancer-associated cysteine-to-phenylalanine substitution in the zinc finger of Mdm2 that disrupted its binding to RPL5 and RPL11. Mice harboring this mutation, retain normal p53 response to DNA damage, but lack of p53 response to perturbations in ribosome biogenesis. Los...
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PMID: 20832751
PDF is available here.
PDF is available here.
Autoimmunity Reviews (9)11 2010
Abstract
In clinical practice, it is sometimes difficult to diagnose a relapse in patients suffering from systemic lupus erythematosus (SLE) and lupus nephritis (LN) having potential complications, including renal failure and death. Some immunological markers can help to determine their association with LN a...
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PMID: 20601199
PDF is available here.
PDF is available here.
Abstract
We used a genome-wide approach to uncover sex-specific parent-of-origin allelic effects in the adult mouse brain. Our study identified preferential selection of the maternally inherited X chromosome in glutamatergic neurons of the female cortex. Moreover, analysis of the cortex and hypothalamus iden...
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PMID: 20616234
PDF is available here.
PDF is available here.
Abstract
Zebrafish models have significantly contributed to our understanding of vertebrate development and, more recently, human disease. The growing number of genetic tools available in zebrafish research has resulted in the identification of many genes involved in developmental and disease...
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PMID: 20679337
PDF is available here.
PDF is available here.
Abstract
Because of its rarity, pathologic and clinical features of Hodgkin lymphoma-like posttransplant lymphoproliferative disorder (HL-like PTLD) are not well understood, and it is unclear whether its biological behavior is more closely related to classical Hodgkin disease or to monomorphic B-cell PTLD. T...
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PMID: 19578050
PDF is available here.
PDF is available here.
Molecular Cell (39)2 2010
Abstract
We have carried out a comprehensive analysis of cytoplasmic maturation, ordering the known steps into a coherent pathway. Maturation is initiated by the ATPase Drg1. Downstream, assembly of the ribosome stalk is essential for the release of Tif6. The stalk recruits GTPases during translation. Becaus...
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PMID: 20670889
PDF is available here.
PDF is available here.
Abstract
We now report the shared presence of two rps3 introns, namely the rps3i74 and the rps3i249, in the mitochondria of all the classes representing the surviving lineages of gymnosperms, and unveil several lineages experiencing intron loss. Interestingly, the rps3 intron gains and losses within the four...
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PMID: 20605476
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)29 2010
Abstract
We show a novel regulatory role of ribosomal protein methylation. Using an in vitro methyltransferase assay, we found that Schizosaccharomyces pombe Set13, a SET domain protein encoded by SPAC688.14, specifically methylates lysine 55 of ribosomal protein L42 (Rpl42). Mass spectrometric analysis reve...
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PMID: 20444689
PDF is available here.
PDF is available here.
Abstract
We describe a case of 3-month-old infant who presented with severe anemia, elevated levels of HbF and adenosine deaminase and bilateral hydronephrosis, who was later confirmed as DBA by mutation analysis using the direct sequencing method. Direct sequencing analysis of RPS19 gene was performed with...
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PMID: 20603584
PDF is available here.
PDF is available here.
Abstract
We appealed to alternative nuclear sequences of 27 ribosomal proteins (RPs) to generate a data matrix of 10,731 nucleotides for 22 holometabolan taxa, including two strepsipteran species. Phylogenetic relationships among holometabolan insects were analyzed under several nucleotide-coding schemes to...
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PMID: 20348001
PDF is available here.
PDF is available here.
Abstract
We screened several cellular promoters that are constitutively active yet noninducible to external stimuli. The ribosomal protein RPS30 promoter was chosen; its TATA signal and sp1 site location were optimized. The modified promoter (RPS30M) is selective to post-transcriptional effects of AU-rich el...
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PMID: 20418359
PDF is available here.
PDF is available here.
Abstract
Regulatory nascent chains interact with the ribosomal exit tunnel and modulate their own translation. To characterize nascent chain recognition by the ribosome at the atomic level, extensive molecular dynamics simulations of TnaC, the leader peptide of the tryptophanase operon, inside the exit tunne...
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PMID: 20462496
PDF is available here.
PDF is available here.
médecine/sciences (26)5 2010
Abstract
Biochemistry (New York) (75)5 2010
Abstract
We particularly focused on methylation of transcription factors and other nuclear nonhistone proteins. The methylated lysine residues serve as markers attracting nuclear "reader" proteins that possess different chromatin-modifying activities....
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PMID: 20632931
PDF is available here.
PDF is available here.
Abstract
Cold denaturation is a general property of globular proteins, and the process provides insight into the origins of the cooperativity of protein folding and the nature of partially folded states. Unfortunately, studies of protein cold denaturation have been hindered by the fact that the cold denature...
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PMID: 20225821
PDF is available here.
PDF is available here.
Marine Biotechnology (12)2 2010
Abstract
The molecular events in the ovaries of Fenneropenaeus merguiensis De Man during vitellogenesis were investigated. The ribosomal protein L10a (RPL10a) was characterized and cloned. It consisted of 669 bp and the deduced polypeptide had 217 amino acids (GeneBank/EBI accession number FJ623402). The cal...
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PMID: 19697087
PDF is available here.
PDF is available here.
Microbiology (156)Pt 4 2010
Abstract
Spontaneous streptomycin-resistant derivatives of Erwinia carotovora subsp. carotovora strain ATTn10 were isolated. Sequencing of the rpsL locus (encoding the ribosomal protein S12) showed that each mutant was missense, with a single base change, resulting in the substitution of the wild-type lysine...
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PMID: 20056700
PDF is available here.
PDF is available here.
Abstract
We first extract some potential transcriptional regulatory motifs based on a statistical comparative analysis. 98% of these motifs are accordance with experimental analyses. Then by pairing these motifs each other, we identify some potential synergistic motif pairs between upstream regions and intro...
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PMID: 20430699
PDF is available here.
PDF is available here.
Journal of Cell Biology (189)1 2010
Abstract
We demonstrate that nascent polypeptideâassociated complex (NAC), another ribosome-tethered system, is functionally connected to SSBâRAC and the cytosolic Hsp70 network. Simultaneous deletions of genes encoding NAC and SSB caused conditional loss of cell viability under protein-folding str...
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PMID: 20368618
PDF is available here.
PDF is available here.
Abstract
SLE with the presence of anti-P antibodies is characterized by an early onset and high disease activity....
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PMID: 20332713
PDF is available here.
PDF is available here.
Haematologica (95)3 2010
Abstract
The 5q- syndrome should be considered a quantitative rather than qualitative bone marrow defect. This observation might open the way to new therapeutic concepts....
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PMID: 19815832
PDF is available here.
PDF is available here.
Abstract
We initiated a phosphoproteomic investigation of P-proteins from Populus dormant terminal buds. Using gel-free (in-solution) protein digestion and phosphopeptide enrichment combined with a nanoUPLC-ESI-MS/MS strategy, we identified six phosphorylation sites on eight P-proteins from Populus dormant t...
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PMID: 20072825
PDF is available here.
PDF is available here.
Abstract
We have demonstrated that rpsL, encoding the S12 protein of the small ribosomal subunit, can be used as a counterselectable marker in Borrelia burgdorferi, the causative agent of Lyme disease. Mutations in rpsL confer streptomycin resistance. Streptomycin susceptibility is dominant in an rpsL merodi...
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PMID: 19966024
PDF is available here.
PDF is available here.
Abstract
We have characterized a set of 106 clinical isolates of Mycobacterium tuberculosis using phenotypic drug susceptibility testing (DST) to determine the extent of resistance to each agent and cross-resistance between agents. These results were compared with polymorphisms in the DNA sequences of riboso...
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PMID: 20032248
PDF is available here.
PDF is available here.
Abstract
Diamond Blackfan anemia (DBA) is an inherited bone marrow failure syndrome characterized by erythroid failure, congenital anomalies and predisposition to cancer. Recently, the notion of DBA as a disorder of ribosome biogenesis has been clarified. Correlations between molecular underpinnings and dise...
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PMID: 19915471
PDF is available here.
PDF is available here.
Abstract
We performed sequence-based strain typing and resistance gene characterization of 46 Linr isolates that were collected from local and national sources between the years 2004 and 2007. Resistance was found to occur in at least three clonal complexes (CCs; lineages) of S. aureus and in at least four s...
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PMID: 19933808
PDF is available here.
PDF is available here.
Abstract
We have previously shown the upregulation and downregulation of RP genes in tumors of colorectal and nasopharyngeal carcinomas (NPCs), respectively. Herein, we show that a subset of RP genes for the large ribosomal subunit is differentially expressed among cell lines derived from the human nasophary...
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PMID: 19927161
PDF is available here.
PDF is available here.
Abstract
Caragana [Caragana jubata (Pall.) Poir] is a temperate plant that thrives well under extremes of cold in high altitude of Himalaya and hence the plant is expected to be a source of genes that might play an important role in tolerance to low temperature (LT). In order to identify LT inducible gene(s)...
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PMID: 19757181
PDF is available here.
PDF is available here.
Abstract
We demonstrate that despite the lack of a zinc-finger-containing homolog of Rmt3/PRMT3 in the budding yeast Saccharomyces cerevisiae, Rps2 is partially modified to generate asymmetric dimethylarginine and monomethylarginine residues. We find that this modification of Rps2 is dependent upon the major...
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PMID: 20035717
PDF is available here.
PDF is available here.
Abstract
RPS14 is a component of the 40S ribosomal subunit encoded by the RPS14 gene and is required for its maturation. The cDNA and the genomic sequence of RPS14 were cloned successfully from the giant panda (Ailuropoda melanoleuca) using RT-PCR technology and touchdown-PCR, respectively; they were both se...
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PMID: 20957604
PDF is available here.
PDF is available here.
Abstract
We show that (i) conventional references genes such as ACTB and GAPDH are highly variable between cancerous and non-cancerous samples, (ii) reference genes identified for lung cancer do not perform well for other cancer types (breast and brain), (iii) reference genes identified through SAGE show low...
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PMID: 20682026
PDF is available here.
PDF is available here.
Cell Research (20)1 2010
Abstract
The nuclear factor-kappa B (NF-kappaB) transcription factor plays a critical role in diverse cellular processes associated with proliferation, cell death, development, as well as innate and adaptive immune responses. NF-kappaB is normally sequestered in the cytoplasm by a family of inhibitory protei...
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PMID: 19997086
PDF is available here.
PDF is available here.
BMC Molecular Biology (11)1 2010
Abstract
The most stable reference genes were Rpl32, Gapdh and Polr2a in mouse post-infarction heart failure, Polr2a, Rpl32 and Tbp in rat post-infarction heart failure and Rpl32 and Pgk1 in human heart failure (ischemic disease and cardiomyopathy). The overall most stable reference genes across all three sp...
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PMID: 20331858
PDF is available here.
PDF is available here.
BMC Plant Biology (10) 2010
Abstract
We tested the hypothesis that RPL24B and eIF3h affect translation reinitiation in a similar fashion. First, like eif3h mutants, rpl24b mutants under-translate the AtbZip11 mRNA, and the detailed spectrum of translational defects in rpl24b is remarkably similar to that of eif3h. Second, eif3h mutants...
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PMID: 20799971
PDF is available here.
PDF is available here.
Genome Biology (11)5 2010
Abstract
We hypothesize that the fast turnover relative to the slow generation time in Prochlorococcus may enable a swift response to environmental changes through rapid recycling of nucleotides, which could be advantageous in nutrient poor oceans. Our growing understanding of RNA half-lives will help us int...
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PMID: 20482874
PDF is available here.
PDF is available here.
Abstract
We have previously demonstrated that vaccination with ribosomal proteins extracts administered in combination of CpG oligodeoxynucleotides protects susceptible BALB/c mice against primary Leishmania major infection. Here, we evaluate the long-term immunity to secondary infection conferred by this va...
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PMID: 20145701
PDF is available here.
PDF is available here.
Hepato-gastroenterology (57)101 2010
Abstract
We attempted to specifically quantify transcripts of faecal cytokeratin 19 (CK19) and ribosomal protein L19 (RPL19) RNA expression of colorectal cancer and clarify their correlation with clinicopathological parameters and survival in combination.
Solid fecal samples were collected and preserved befo...
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PMID: 21033215
PDF is available here.
PDF is available here.
Abstract
Recombinant human ribosomal protein S16 (rpS16) is shown to bind specifically to a fragment of its own pre-mRNA that includes exons 1 and 2, intron 1, and part of intron 2, and to inhibit the splicing of the fragment in vitro. The weaker binding of other recombinant human ribosomal proteins, S10 and...
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PMID: 20198863
PDF is available here.
PDF is available here.
Abstract
We expressed a series of mutated alleles of NOC4 in yeast cells and analysed whether the corresponding protein variants support vegetative growth, interact with Nop14p, and are incorporated into the SSU-processome. The data reveal that the essential C-terminus of Noc4p which contains 237 aminoacids...
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PMID: 20019888
PDF is available here.
PDF is available here.
Abstract
Ribosomes provide the basis for protein production and this drives cell growth. Recent studies, both in yeast and in higher eukaryotes, are beginning to reveal new mechanisms underlying the elaborate control of ribosome biogenesis, which requires coordinate regulation of all three RNA polymerases. T...
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PMID: 19796927
PDF is available here.
PDF is available here.
Psychoneuroendocrinology (34 Suppl 1) 2009
Abstract
We will focus on the role of RPL7 (ribosomal protein L7; also known as L7/SPA) on sexual differentiation of the zebra finch song system. Collectively, these studies provide information about the role of steroid receptor coactivators on development of the zebra finch song system as well as on sexual...
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PMID: 19524373
PDF is available here.
PDF is available here.
Abstract
We report that the overexpression of mitochondrial ribosomal protein MRPS18-2 (S18-2) can immortalize primary rat embryonic fibroblasts (REFs). The immortalized cells (18IM) lose contact inhibition, form foci, and are capable of anchorage-independent growth. Concurrently, mesodermal markers, such as...
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PMID: 19903879
PDF is available here.
PDF is available here.
Abstract
Babesia bovis is a tick-borne pathogen that remains an important constraint for the development of cattle industries in tropical and subtropical regions of the world. Effective control can be achieved by vaccination with live attenuated phenotypes of the parasite. However, these phenotypes have a nu...
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PMID: 20027467
PDF is available here.
PDF is available here.
Abstract
We provide evidence that recombinant Nob1 forms a tetramer that binds directly to pre-rRNA analogs containing cleavage site D. Analysis of Nob1's affinity to a series of RNA truncations, as well as Nob1-dependent protections of pre-rRNA in vitro and in vivo demonstrate that Nob1's binding site cente...
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PMID: 19706509
PDF is available here.
PDF is available here.
Molecular Cell (35)3 2009
Abstract
MDM2 associates with ribosomal protein S7, and this interaction is required to inhibit MDM2's E3 ligase activity, leading to stabilization of MDM2 and p53. Notably, the MDM2 homolog MDMX facilitates the inhibition of MDM2 E3 ligase activity by S7. Further, ablation of S7 inhibits MDM2 and p53 accumu...
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PMID: 19683495
PDF is available here.
PDF is available here.
Abstract
We report a methodology that simultaneously uses residual dipolar couplings (RDC) and the small-angle X-ray scattering (SAXS) restraints to mutually orient subunits and define the global shape of multicomponent proteins and protein complexes. Our methodology is implemented in an efficient algorithm...
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PMID: 19722627
PDF is available here.
PDF is available here.
Abstract
We revealed that a fusion protein of thymosin alpha1 and L12 is partly N(alpha)-acetylated in E. coli. Through deletion of some N(alpha)-acetyltransferases by Red recombination, we found that, when rimJ is disrupted, the fusion protein is completely unacetylated. The relationship of rimJ and N(alpha...
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PMID: 19352641
PDF is available here.
PDF is available here.
Abstract
We elucidate the specific EPRS phosphorylation events that regulate GAIT-mediated gene silencing. IFN-gamma induces sequential phosphorylation of Ser(886) and Ser(999) in the noncatalytic linker connecting the synthetase cores. Phosphorylation of both sites is essential for EPRS release from the par...
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PMID: 19647514
PDF is available here.
PDF is available here.
Abstract
We used a system-based approach, including whole genome expression and biological function analysis, to elucidate the pathways underlying tissue specificity and clinical severity of this condition. Levels of over 48K RNA transcripts from EBV-transformed lymphoblasts of deaf and hearing individuals w...
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PMID: 19482502
PDF is available here.
PDF is available here.
Journal of Molecular Biology (390)5 2009
Abstract
We showed that duplexes corresponding to those in Saccharomyces cerevisiae are only observed in vitro after addition of one of two proteins: Imp3p or Imp4p. Here, we used fluorescence-based and other in vitro assays to determine whether these proteins possess RNA chaperone activities and to assess w...
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PMID: 19482034
PDF is available here.
PDF is available here.
Abstract
The aim of this study was to characterize 160 clinical Mycobacterium tuberculosis isolates from Guangdong with respect to their drug susceptibility phenotypes to three common anti-tuberculosis drugs, isoniazid (INH), rifampin (RIF) and streptomycin (SM), and with respect to genetic mutations in the...
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PMID: 19628903
PDF is available here.
PDF is available here.