Find your PDFs fast.
Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Selenoproteins (3):
Recent article
Selenoproteins
Abstract
We knocked out the expression of this protein class in T-cells or macrophages of mice by targeting the removal of the selenocysteine tRNA gene using loxP-Cre technology. Mice with selenoprotein-less T-cells manifested reduced pools of mature and functional T-cells in lymphoid tissues and an impairme...
|
PMID: 20576203
PDF is available here.
PDF is available here.
| < More recent | Older article > |
Abstract
We demonstrate that deletion of the filamentous protein Septin 5 imparts immature synapses with striking morphological and functional features reminiscent of mature synapses. This includes synaptic vesicles tightly localized to active zones, resistance to the slow Ca(2+) buffer EGTA and a reduced nu...
|
PMID: 20624595
PDF is available here.
PDF is available here.
Zhonghua Yixue Zazhi (90)26 2010
Abstract
To investigate the change of selenoprotein S1 (SEPS1) hepatic expression in septic mouse induced by LPS attack.
The septic murine model induced by LPS attack was established. Ten mice were randomly selected as control group from 84 BALB/c mice and others as septic group. The mice were sacrificed aft...
|
PMID: 20979832
PDF is available here.
PDF is available here.
New Zealand Medical Journal (123)1316 2010
Abstract
Selenium is an essential mineral and severe selenium deficiency is known to cause significant health problems. It has been well documented that New Zealand soil is low in selenium. Recent studies have addressed the roles of selenoproteins in the eyes, with evidence suggesting that selenium supplemen...
|
PMID: 20648102
PDF is available here.
PDF is available here.
Abstract
Selenium (Se) is an essential trace mineral mediating its biological function primarily through selenoproteins. Accumulated lines of evidence indicate important roles of selenoproteins in the maintenance of optimal brain functions via redox regulation. Decreased expression of several selenoproteins...
|
PMID: 20219520
PDF is available here.
PDF is available here.
Abstract
We review our current understanding of the molecular pathogenesis of several CMD types and how these mechanisms may be therapeutically targeted....
|
PMID: 20425232
PDF is available here.
PDF is available here.
Abstract
The levels of the serum thyroid hormone (free T4 and free T3) are determined not only by thyroid hormone synthesis/secretion but also by their metabolism. Thyroid hormone metabolism is mediated by three selenoproteins, selenodeiodinase type 1, 2, and 3 (D1, D2, and D3), the expression and function o...
|
PMID: 20408442
PDF is available here.
PDF is available here.
Bioscience Reports (29)5 2009
Abstract
We studied the complete selenoproteome in the mouse to uncover additional selenoprotein mRNAs that are highly regulated by Se status. Mice were fed on Se-deficient, Se-marginal and Se-adequate diets (0, 0.05 and 0.2 microg of Se/g respectively) for 35 days, and selenoprotein mRNA levels in liver and...
|
PMID: 19076066
PDF is available here.
PDF is available here.
Biochemistry (Washington) (48)35 2009
Abstract
We analyzed changes in Sep15 expression in murine fibroblast NIH3T3 cells in response to tunicamycin, brefeldin A (brefA), thapsigargin, and DTT that lead to accumulation of unfolded proteins within the ER. We show that expression of this protein is transcriptionally up-regulated in response to adap...
|
PMID: 19650649
PDF is available here.
PDF is available here.
Biochemical Journal (422)1 2009
Abstract
Selenoproteins are proteins containing selenium in the form of the 21st amino acid, selenocysteine. Members of this protein family have many diverse functions, but their synthesis is dependent on a common set of cofactors and on dietary selenium. Although the functions of many selenoproteins are unk...
|
PMID: 19627257
PDF is available here.
PDF is available here.
Abstract
We determined the change of the MAPK pathway, secretase activity, and Tau phosphorylation in the transgenic rat overexpressing human selenoprotein M. Based on these results, we concluded that, i) CMV/GFP-hSelM Tg rats showed a high activity level of antioxidant enzyme in the brain tissues, ii) in re...
|
PMID: 19513540
PDF is available here.
PDF is available here.
Molecular and Cellular Biochemistry (327)1-2 2009
Abstract
We generated recombinant GPx-3 (rGPX-3) constructs with various 3'-UTR, as well as a Sec73Cys mutant. In transfected Cos7 cells, the Sec73Cys mutant was expressed at higher levels than the wild type rGPx-3, although the wild type rGPx-3 had higher specific activity, similar to plasma purified GPx-3....
|
PMID: 19219623
PDF is available here.
PDF is available here.
Abstract
Total serum Se concentrations in SBP2 deficient subjects respond to selenomethionine supplementation but this effect is not indicative for improved selenoprotein synthesis. Se is obviously not a limiting factor in the SBP2 deficient individuals when regular daily Se intake is provided. These finding...
|
PMID: 19265499
PDF is available here.
PDF is available here.
Biochemical Journal (418)1 2009
Abstract
We generated transgenic mice expressing the Trsp transgene lacking the STAF-binding site and made these mice dependent on the transgene for survival by removing the wild-type Trsp. The level of Sec tRNA was unaffected or slightly elevated in heart and testis, but reduced approximately 60% in liver a...
|
PMID: 18973473
PDF is available here.
PDF is available here.
Abstract
The goal of this paper was to study the accumulation of selenium (Se) in different cultivars of brown rice and its distribution in fractions. The results of the study showed that Se content in brown rice increased significantly (P < 0.01) as the external selenite or selenate concentrations increased...
|
PMID: 19154168
PDF is available here.
PDF is available here.
Abstract
The impact of gene knockdown on A. marginale tick infections, both after acquiring infection and after a second transmission feeding, was determined and studied by light microscopy. Silencing of these genes had a different impact on A. marginale development in different tick tissues by affecting inf...
|
PMID: 19607704
PDF is available here.
PDF is available here.
BMC Gastroenterology (9)1 2009
Abstract
Among cases, the distribution of genotypes was as follows: 88.4% were GG, 11.2% were GA, and 0.4% were AA. Among controls, the distribution was as follows: 92.5% were GG, 7.2% were GA, and 0.3% were AA. Among males, carrying the A allele was associated with an increased odds of gastric cancer, compa...
|
PMID: 19144102
PDF is available here.
PDF is available here.
Evolutionary history of selenocysteine incorporation from the perspective of SECIS binding proteins.
Abstract
In this report we present a phylogeny of the eukaryotic SECIS binding protein family which includes SBP2 and a related protein we herein term SBP2L. Here we show that SBP2L is an SBP2 paralogue in vertebrates and is the only form of SECIS binding protein in invertebrate deuterostomes, suggesting a k...
|
PMID: 19744324
PDF is available here.
PDF is available here.
Abstract
We have taken advantage of this dependency to modulate the expression of Sec tRNA that in turn modulates the expression of selenoproteins by generating transgenic, conditional knockout, transgenic/standard knockout and transgenic/conditional knockout mouse models, all of which involve the Sec tRNA g...
|
PMID: 19783940
PDF is available here.
PDF is available here.
Journal of Nutrition (138)12 2008
Abstract
We therefore conclude that redox-regulated proteins, such as PTP1B, represent important interfaces between dietary antioxidants such as Se and the regulation of metabolic processes....
|
PMID: 19022953
PDF is available here.
PDF is available here.
Abstract
We describe some of the recent progress in our understanding of the mechanisms of Sel synthesis. The impact of maternal Se intake on offspring is also discussed. The key regulatory point of Sel synthesis is Se itself, which acts predominantly at post-transcriptional levels, although recent findings...
|
PMID: 18790070
PDF is available here.
PDF is available here.
Abstract
Abstract
These results indicate a role for selenoproteins in protecting DNA from damage and support human data implicating GPx-1 as a possible target of the chemoprotective effect of selenium....
|
PMID: 18720346
PDF is available here.
PDF is available here.
Abstract
Recent studies in a variety of model systems have increased the understanding of the anticarcinogenic mechanisms of selenium compounds. These include effects on gene expression, DNA damage and repair, signaling pathways, regulation of cell cycle and apoptosis, metastasis and angiogenesis. These effe...
|
PMID: 18827575
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (283)42 2008
Abstract
We report that SK-Hep1 hepatocytes grew on methionine-S-sulfoxide and consumed this compound by import and methionine-S-sulfoxide reductase (MsrA)-dependent reduction, but methionine-R-sulfoxide reductases were not involved in this process, and methionine-R-sulfoxide could not be used by the cells....
|
PMID: 18697736
PDF is available here.
PDF is available here.
Abstract
To investigate the role of SelS in bacterial lipopolysaccharide (LPS) induced inflammatory response, some parameters in LPS-stimulated HepG2 cells were comparatively studied fore-and-aft SelS silence. LPS induced the decreases of cytoplasmic glutathione peroxidase (GPx-1) mRNA expression and activit...
|
PMID: 18675776
PDF is available here.
PDF is available here.
Abstract
We review the relevant literature and present expression data of both selenium-dependent and -independent peroxidases in the murine thyroid....
|
PMID: 18498223
PDF is available here.
PDF is available here.
Abstract
Mutations affecting the seemingly unrelated gene products, SepN1, a selenoprotein of unknown function, and RyR1, the major component of the ryanodine receptor intracellular calcium release channel, result in an overlapping spectrum of congenital myopathies. To identify the immediate developmental an...
|
PMID: 18713863
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (283)29 2008
Abstract
We generated mice with selenoprotein-less T cells by cell type-specific ablation of the Sec tRNA([Ser]Sec) gene (trsp). Herein, we show that these mutant mice exhibit decreased pools of mature T cells and a defect in T cell-dependent antibody responses. We also demonstrate that selenoprotein deficie...
|
PMID: 18487203
PDF is available here.
PDF is available here.
Abstract
Exposure of cells to As2O3, arsenite or auranofin led to a concentration-dependent reduction of selenium metabolism into selenoproteins. Knockdown of TrxR1, using small inhibitory RNA, did not affect selenium metabolism. Exposure of cells to monomethylarsonic acid, a potent inhibitor of TrxR, did no...
|
PMID: 18587442
PDF is available here.
PDF is available here.
Chinese Medical Journal (121)13 2008
Abstract
SelS protein may be involved in insulin resistance in Chinese with T2DM by acting as the SAA receptor, thus playing an important role in the development of T2DM and atherosclerosis....
|
PMID: 18710632
PDF is available here.
PDF is available here.
Abstract
We have searched for genes implicated in astrocyte resistance to ischemia using oxygen and glucose deprivation (OGD) as a stroke model. A RNA differential display approach uncovered the OGD induction of selenoprotein-S-encoding gene SEPS1. This endoplasmic reticulum (ER) resident protein is known to...
|
PMID: 18498015
PDF is available here.
PDF is available here.
Abstract
Descriptive studies in humans investigating the relationship between selenium (Se) status and asthma have presented inconsistent results. The concept of low Se status as a potential risk factor for increased prevalence or severity of asthma is based on the role that Se, through its incorporation int...
|
PMID: 18588550
PDF is available here.
PDF is available here.
Acta Crystallographica Section D (D64)Pt 7 2008
Abstract
The X-ray polarization anisotropy of anomalous scattering in crystals of brominated nucleic acids and selenated proteins is shown to have significant effects on the diffraction data collected at an absorption edge. For conventionally collected single- or multi-wavelength anomalous diffraction data,...
|
PMID: 18566507
PDF is available here.
PDF is available here.
Biochemical Journal (413)1 2008
Abstract
We found that the complete loss of selenoproteins in liver was compensated for by an enhanced expression of several phase II response genes and their corresponding gene products. The replacement of selenoprotein synthesis in mice carrying mutant Trsp transgenes, wherein housekeeping, but not stress-...
|
PMID: 18373496
PDF is available here.
PDF is available here.
FASEB Journal (22)6 2008
Abstract
We studied the role of selenoprotein T (SelT), a selenocysteine (Sec) -containing protein with no known function, which we have identified as a novel target gene of the neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) during PC12 cell differentiation. SelT was found to be ubiq...
|
PMID: 18198219
PDF is available here.
PDF is available here.
Abstract
We discuss the classes of RYR1 mutations which have been associated with CCD, MmD and related neuromuscular phenotypes....
|
PMID: 18313359
PDF is available here.
PDF is available here.
Cell and Tissue Research (332)3 2008
Abstract
We therefore investigated the expression of selenoproteins in various regions of the rat brain, various subcellular fractions and several brain cell lines by (75)Se-labelling, gel electrophoretic separation and autoradiography, with the (75)Se tracer as the selenoprotein marker. Quantitative evaluat...
|
PMID: 18317814
PDF is available here.
PDF is available here.
Abstract
We describe a variable degree of clinical severity. Major complications were early respiratory failure, impaired increase in weight and orthopedic problems. There seems to be no correlation between skeletal muscle weakness and respiratory failure....
|
PMID: 17951086
PDF is available here.
PDF is available here.
European Journal of Nutrition (47 Suppl 2) 2008
Abstract
The rapid advance in the knowledge of different selenoproteins and their biological functions has opened up new possibilities for the understanding of the biological effects of selenium supplementation. A wide variety of effects of different forms and doses of selenium has been observed in a number...
|
PMID: 18458833
PDF is available here.
PDF is available here.
Abstract
The GPX4c718t SNP both alters protein binding to the 3'UTR in vitro and influences the concentration of lymphocyte GPx4 and other selenoproteins in vivo. The latter is consistent with competition for selenium in selenoprotein synthesis, and, at low selenium intake, the SNP thus may influence suscept...
|
PMID: 18400727
PDF is available here.
PDF is available here.
Iubmb Life (60)4 2008
Abstract
We discuss the various proteins known to function in eukaryotic selenoprotein biosynthesis, including several players whose roles have only been elucidated very recently....
|
PMID: 18344183
PDF is available here.
PDF is available here.
Abstract
Women with preeclampsia were 1.34 times more likely to have the GA or AA genotype (P = .0039; 95% confidence interval [CI] 1.09 to 1.64) and 1.22 times more likely to carry the A allele (P = .023; odds ratio, 1.22; 95% CI, 1.02 to 1.46). CONCLUSION: The A allele of the SEPS1-105G>A polymorphism is a...
|
PMID: 18068137
PDF is available here.
PDF is available here.
Abstract
Abstract
An adequate selenium (Se) status has for long been considered to prevent the development of various forms of cancer. However, underlying molecular mechanisms remained unknown. In mammals, selenium exerts its functions as selenocysteine incorporated into selenoproteins. Therefore, Se compounds can ei...
|
PMID: 18357548
PDF is available here.
PDF is available here.
Abstract
A short survey of historic and current methods for the synthesis of selenocysteine, selenocystine, and derivatives and related compounds is presented, with an additional emphasis on the formation of selenocysteine-derived Se-S bridges. The majority of methods to the amino acid starts with protected...
|
PMID: 18357547
PDF is available here.
PDF is available here.
Abstract
Selenoprotein synthesis in Escherichia coli strictly depends on the presence of a specific selenocysteine insertion sequence (SECIS) following the selenocysteine-encoding UGA codon of the respective mRNA. It is recognized by the selenocysteine-specific elongation factor SelB, leading to cotranslatio...
|
PMID: 18165360
PDF is available here.
PDF is available here.
Cancer Letters (259)2 2008
Abstract
Since damage to DNA and other cellular molecules by reactive oxygen species ranks high as a major culprit in the onset and development of colorectal cancer, the aim of the present study is to clarify the role of antioxidant seleonoproteins including glutathione peroxidase (GPx), thioredoxin reductas...
|
PMID: 18054426
PDF is available here.
PDF is available here.
Abstract
Over the past 2 decades our understanding of the pathologic mechanisms that lead to heart failure (HF) has evolved from simplistic hemodynamic models to more complex models that have implicated neurohormonal activation and adverse cardiac remodeling as important mechanisms of disease progression. 3-...
|
PMID: 18222351
PDF is available here.
PDF is available here.
Abstract
Selenoprotein is associated with a variety of serious diseases, including infectious diseases, neurodegenerative disorders, cancer and cardiovascular disease. The aim of this study was to produce a new transgenic (Tg) rat expressing human selenoprotein M (SelM) in order to examine the protective fun...
|
PMID: 18204783
PDF is available here.
PDF is available here.
Abstract
We might identify additional useful molecular biomarkers for assessment of Se status. To characterize Se regulation of the entire rat selenoproteome, weanling male rats were fed a Se-deficient diet (...
|
PMID: 19106321
PDF is available here.
PDF is available here.
Abstract
We carried out comparative gene expression analyses for the complete selenoproteome and associated biosynthetic factors. Using the Allen Brain Atlas, we evaluated 159 regions of adult mouse brain and provided experimental analyses of selected selenoproteins. All 24 selenoprotein mRNAs were expressed...
|
PMID: 18032379
PDF is available here.
PDF is available here.
Abstract
We generated a conditional knock-out mouse for the tRNA(Sec) gene (Trsp). Deletion of Trsp in either macrophages or liver elevated oxidative stress and activated the transcriptional induction of cytoprotective antioxidant and detoxification enzyme genes, including glutathione S-transferase P1 and NA...
|
PMID: 18039655
PDF is available here.
PDF is available here.
Abstract
Selenium is incorporated into proteins as selenocysteine (Sec), which is dependent on its specific tRNA, designated tRNA([Ser]Sec). Targeted removal of the tRNA([Ser]Sec) gene (Trsp) in mouse hepatocytes previously demonstrated the importance of selenoproteins in liver function. Herein, analysis of...
|
PMID: 17996733
PDF is available here.
PDF is available here.
Abstract
Ribosomal protein and translation factor genes were up-regulated in response to increased selenium intake. We hypothesize that this up-regulation is linked to increased selenoprotein production and enhanced lymphocyte function....
|
PMID: 18175754
PDF is available here.
PDF is available here.
Abstract
Selenium is essential for normal spermatogenesis of mammals and its critical role is mainly mediated by two selenoproteins, namely phospholipid hydroperoxide glutathione peroxidase (PHGPx/GPx4) and Selenoprotein P. PHGPx/GPx4 is the major selenoprotein expressed by germ cells in the testis, having m...
|
PMID: 19856162
PDF is available here.
PDF is available here.
Abstract
Dietary selenium intake is regarded as an important factor in determining optimal health and susceptibility to disease. Therefore, it is critical to understand the interaction between selenium intake and molecular events at the genetic and cellular level. This article addresses two facets of this in...
|
PMID: 18494599
PDF is available here.
PDF is available here.
Abstract
Selenium functions as a part of proteins known as selenoproteins. Through these selenoproteins, selenium functions as a defensive mechanism for oxidative stress, for the regulation of thyroid hormone activity, and for the redox status of vitamin C and other molecules. In several of its roles, seleni...
|
PMID: 18390782
PDF is available here.
PDF is available here.
Protein Science (17)1 2008
Abstract
We report that aquatic arthropods possess many selenoproteins also detected in other animals and unicellular eukaryotes, and that most of these proteins were either lost or replaced with cysteine-containing homologs in insects. As a result of this selective selenoproteome reduction, fruit flies and...
|
PMID: 18156471
PDF is available here.
PDF is available here.
Abstract
The biosynthesis of selenoproteins was studied in relation to milk formation and mammary cell biology by incubating the bovine mammary cell line MAC-T with ((75)Se)selenite. Intracellular proteins and proteins secreted into the cell culture medium were separated by 2D electrophoresis, the selenoprot...
|
PMID: 18755398
PDF is available here.
PDF is available here.