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Seminal Plasma Proteins (2):
Recent article
Seminal Plasma Proteins
Abstract
We find that an L-system generated sequence can be inserted into the OR1D2 subfamily-specific star model and novel full-length olfactory receptors can be generated. This remarkable mathematical principle could be utilized for making new subfamily olfactory receptor members from any olfactory recepto...
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PMID: 20826948
PDF is available here.
PDF is available here.
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Abstract
We ectopically expressed either PSP94 or CRISP-3 alone or PSP94 along with CRISP-3 in three prostate cell lines (PC3, WPE1-NB26 and LNCaP) and performed growth inhibition assays. Reverse transcription-polymerase chain reaction and Western blot analysis were used to screen prostate cell lines for PSP...
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PMID: 20676114
PDF is available here.
PDF is available here.
Archives of Toxicology (84)5 2010
Abstract
Sperm hyperactivation is crucial for a successful fertilization; however, the influence of fluoride (F) to hyperactivation is still in its infancy. The purpose of this study was to investigate the effect of sodium fluoride (NaF) on sperm hyperactivation, Ca2+/CALM-CAMK2 signaling, and CatSper1 and C...
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PMID: 20052459
PDF is available here.
PDF is available here.
Abstract
Defining the molecular characteristics of seminal plasma proteins is essential for understanding their function in physiological and pathological conditions. Starting from the predicted importance of human seminal plasma gelatin-binding proteins, comprising fibronectin (FN) and FN-related molecules,...
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PMID: 20173767
PDF is available here.
PDF is available here.
Abstract
The seminal vesicles of adult sand rat contain a major secretory protein band (MW 21 kDa) designated as Psammomys obesus seminal vesicles protein of 21 kDa (POSVP(21)). This protein is abundant in secretions, regulated by androgens and also present in the vaginal plug. POSVP(21) accounts for over 22...
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PMID: 20400972
PDF is available here.
PDF is available here.
Abstract
We describe the action of AF-2364 on human sperm in vitro, as well as the mechanisms involved. AF-2364 specifically blocked human sperm motility in vitro. Further experiments revealed that AF-2364 can target sperm mitochondrial permeability transition (MPT) pores to induce the loss of sperm mitochon...
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PMID: 20418891
PDF is available here.
PDF is available here.
Journal of Cell Science (123)Pt 9 2010
Abstract
We produced a mouse line that lacked SPESP1 (sperm equatorial segment protein 1) and analyzed the fertilizing ability of the sperm. The average number of pups that were fathered by Spesp1(+/-) and Spesp1(-/-) males was significantly lower than that of wild-type fathers. In these mouse lines, fewer s...
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PMID: 20375058
PDF is available here.
PDF is available here.
Abstract
Microdeletions were detected in 7.80% of the patients (63/808), 9.16% in the men with nonobstructive azoospermia (46/502) and 5.56% in those with severe oligozoospermia (17/306). Complete AZFa and AZFb (P5/Proximal P1) deletions were associated with azoospermia, whereas AZFc deletion with variable s...
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PMID: 20626158
PDF is available here.
PDF is available here.
Abstract
We undertook this study to find new members of the cancer-testis gene family appropriate for cancer immunotherapy
We analyzed the expression of six testis-specific genes called ODF1, ODF2, ODF3, ODF4, LEMD1 and SPATA19 in 30 prostate cancer and 25 benign prostate hyperplasia (BPH) samples by RT-PCR...
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PMID: 20682177
PDF is available here.
PDF is available here.
Abstract
A total of 172 differential proteins were identified, of which, 89 were exclusively from the asthenozoospermia and 83 exclusively from the healthy fertile men. According to the molecular function, these differential proteins were mainly the types of signal transduction and catalytic activity. CONCLU...
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PMID: 20369545
PDF is available here.
PDF is available here.
Abstract
We previously reported postacrosomal sheath WW domain binding protein (PAWP) as a candidate sperm borne, oocyte-activating factor. PAWP enters the oocyte during fertilization and induces oocyte activation events including meiotic resumption, pronuclear formation, and egg cleavage. However, in order...
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PMID: 20017143
PDF is available here.
PDF is available here.
Abstract
Azoospermia factor (AZF) microdeletions of the Y chromosome, which occur in 1 - 55% of infertile men, are closely associated with severe spermatogenic failure and represent the most frequent molecular genetic causes of azoospermia and severe oligozoospermia. Researches on AZF and its related genes,...
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PMID: 20369704
PDF is available here.
PDF is available here.
Abstract
Initially, 18 SNPs and 4 haplotypes showed associations with AIA. However, after correcting the data for multiple testing, only one SNP showed an association with AIA (corrected P-value = 0.03, OR = 1.63, 95% CI = 1.23-2.16), showing increased susceptibility to AIA compared with that of ATA cases. O...
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PMID: 20513247
PDF is available here.
PDF is available here.
Abstract
We hypothesised that the protein component of SP is responsible for this effect. To test this hypothesis, varying concentrations of total SP protein or SP proteins fractionated by heparin binding were assayed for their ability to inhibit in vitro capacitation, as well as cooling- and cryopreservatio...
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PMID: 20591323
PDF is available here.
PDF is available here.
Abstract
The effect of supplementation of sex-sorted and non-sorted spermatozoa with seminal plasma protein (SPP) on fertility after cervical insemination was examined in the present study. Spermatozoa were sorted into high purity X and Y chromosome-bearing spermatozoa or not sorted and then either supplemen...
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PMID: 20353720
PDF is available here.
PDF is available here.
Journal of Andrology (31)2 2010
Abstract
This study investigated whether specific proteins from distinct seminal plasma fractions of boars could be related to in vivo fertility. Nine boars with acceptable sperm motility and morphology for use in artificial insemination demonstrated major differences in total number born and...
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PMID: 19713565
PDF is available here.
PDF is available here.
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics (26)6 2009
Abstract
In 6 cases with deletions of AZFb+c, there was 1 case with sY98/sY1206 deletion, 4 cases with P5/distal-P1 recombination and 1 with P4/distal-P1 recombination. In 3 cases with deletions in AZFb, 1 case showed P5/P3 deletion and 2 cases showed P5/proximal-P1 recombination with DAZ1 and DAZ2 deletions...
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PMID: 19953495
PDF is available here.
PDF is available here.
Abstract
Profound loss of adipose and other tissues is a hallmark of cancer cachexia, a debilitating condition associated with increased morbidity and mortality. Fat loss cannot be attributable to reduced appetite alone as it precedes the onset of anorexia and is much more severe in experimental models of ca...
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PMID: 19719894
PDF is available here.
PDF is available here.
Abstract
We lack a comprehensive picture of the specific proteins produced by different accessory tissues. Here, we perform proteomic investigations of six regions of the male reproductive tract in mice -- seminal vesicles, anterior prostate, dorsolateral prostate, ventral prostate, bulbourethral gland, and...
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PMID: 19420050
PDF is available here.
PDF is available here.
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics (26)4 2009
Abstract
Chromosome abnormalities were found in 102 out of 489 azoospermic patients (20.86%), among them 86 (84.31%) cases had sex chromosome abnormalities, with 73 cases being Klinefelter syndrome. Y chromosome microdeletions were detected in 58 (11.86%) cases out of the 489 patients, and deletion of the AZ...
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PMID: 20017309
PDF is available here.
PDF is available here.
Abstract
We evaluated the diagnostic efficiency and the time required of an in-house automated capillary electrophoresis method for Y microdeletions screening and applied it to estimate the prevalence of Y microdeletions in 100 infertile males affected by azoospermia or severe oligozoospermia (sperm count <5...
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PMID: 19542738
PDF is available here.
PDF is available here.
Animal Reproduction Science (110)3-4 2009
Abstract
Knowledge of the different patterns of gene expression along the male reproductive tract can assist in understanding the physiological processes of species-specific reproduction in mammals. In the present work, expression profiles of buck spermadhesin (bodhesin) genes along the reproductive tract by...
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PMID: 18321667
PDF is available here.
PDF is available here.
Abstract
We have now studied the complex between human MSP and CRISP-3 with multidimensional NMR. 15N-HSQC spectra show substantial differences between free and complexed hMSP. Using several 3D-NMR spectra of triply labeled hMSP in complex with a recombinant N-terminal domain of CRISP-3, most of the backbone...
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PMID: 19026612
PDF is available here.
PDF is available here.
Abstract
Low purification efficiency and incomplete characterization of male goat (buck) spermadhesins (Bdhs) prompted us to develop an effective system to produce recombinant Bdhs (rBdhs). Bdh-2 cDNA was inserted into a prokaryotic expression plasmid, pTrcHis TOPO. The pTrcHis-Bdh-2 system was constructed t...
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PMID: 19866434
PDF is available here.
PDF is available here.
Journal of Heredity (100)4 2009
Abstract
We investigate molecular interactions that underlie this form of chemical communication. Recent data show that molecules and cells from both sexes participate in this "ballet," facilitating the mutually beneficial outcome of increased progeny production. Examples to be presented include the storage...
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PMID: 19349638
PDF is available here.
PDF is available here.
Advances in Genetics (68) 2009
Abstract
We illustrate this by reviewing the roles played by seminal fluid proteins (Sfps) in molecular social interactions between males and females of the fruit fly Drosophila melanogaster. Sfps, which are produced by males and transferred to females during mating, are involved in inherently social interac...
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PMID: 20109658
PDF is available here.
PDF is available here.
Abstract
Seminal plasma improves the functional integrity of compromised ram spermatozoa but has been reported to be toxic to sorted spermatozoa. The present study attempted to clarify this paradoxical effect and improve the functional integrity of spermatozoa following sorting and cryopreservation. The in v...
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PMID: 19383263
PDF is available here.
PDF is available here.
Abstract
Sperm hyperactivation is characterised by high-amplitude, asymmetrical flagellar bending and is required to penetrate the oocyte zona pellucida. It was proposed that hyperactivation also enables spermatozoa to reach the oocyte by assisting escape from the oviductal sperm reservoir. To test this hypo...
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PMID: 19210926
PDF is available here.
PDF is available here.
Abstract
Protein content and properties in the seminal plasma of Atlantic halibut (Hippoglossus hippoglossus) were assayed using spectrophotometric and electrophoretic methods. The protein concentration ranged from 6.4 +/- 3.1 to 19.4 +/- 3.4 mg ml(-1) and anti-proteolytic activity from 585.2 +/- 104.6 to 29...
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PMID: 18958592
PDF is available here.
PDF is available here.
Abstract
We detected microdeletions in AZF region in 3 cases of affected men and in other 3 casses we found mutation F508del (heterozygotes) in CFTR gene with T5 variant in trans position. Except this we detected in 5 affected men "only" heterozygous mutations in CFTR gene and in 12 men "only" the T5 variant...
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PMID: 19170365
PDF is available here.
PDF is available here.
Hereditas (Beijing) (30)11 2008
Abstract
The main function of ZAG gene is to enable the decomposition of fat, and reduced fat content. In this study, polymorphisms of four loci (Z1, Z2, Z3, Z4) at the coding region of the bovine ZAG gene were detected in 145 Jiaxian red cattle, and polymorphisms were found on Z1, Z3, Z4 loci. The fragments...
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PMID: 19073549
PDF is available here.
PDF is available here.
Journal of Rheumatology (35)11 2008
Abstract
Serum and salivary concentrations of androgens were low in SS. Substrate to end-product ratios and correlations suggest that in SS salivary glands DHEA is effectively converted to testosterone, but that there are defects in converting testosterone further to dihydrotestosterone (DHT). In healthy con...
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PMID: 18843777
PDF is available here.
PDF is available here.
Abstract
We report cell-free production of a human olfactory receptor 17-4 (hOR17-4) using the wheat germ extract. Using the simple method, we also successful produced two additional olfactory receptors. To obtain soluble olfactory receptors and to increase yield, we directly added different detergents in va...
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PMID: 18840687
PDF is available here.
PDF is available here.
Abstract
We describe Y chromosomes in apparently normal males carrying null and duplicated alleles at the microsatellite DYS448, which lies in the proximal part of the azoospermia factor c (AZFc) region, important in spermatogenesis, and made up of "ampliconic" repeats that act as substrates for nonallelic h...
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PMID: 18470947
PDF is available here.
PDF is available here.
Abstract
We use a proteomic approach to identify seminal proteins that are transferred to females during copulation and that may be involved in fertilization barriers between two hybridizing field crickets (Gryllus firmus and Gryllus pennsylvanicus). Analyses of patterns of divergence suggest that much of th...
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PMID: 18495616
PDF is available here.
PDF is available here.
Animal Reproduction Science (107)3-4 2008
Abstract
We found that sperm harvested from different parts of the epididymis (caput, corpus and cauda) had a varying, but generally poor, ability to undergo the acrosome reaction in vitro. At ejaculation, however, sperm mix with seminal plasma which contains various components, including the small membranou...
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PMID: 18550301
PDF is available here.
PDF is available here.
Human Reproduction (23)9 2008
Abstract
The human HEL-75 gene is located on chromosome 20p13 and encodes a 95 amino acid protein with a predicted N-terminal signal peptide of 22 amino acids. The protein has six conserved cysteine residues, characteristic of members of the beta-defensin superfamily, as well as several potential post-transl...
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PMID: 18343807
PDF is available here.
PDF is available here.
Human Reproduction (23)9 2008
Abstract
The findings indicate that some monophyletic Y chromosomes may be associated with predisposition to specific subtypes of partial AZFc deletion and adverse effect on spermatogenesis. Although these deletions were not confirmed with gene dosage analysis, the results suggest that Y chromosome backgroun...
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PMID: 18579508
PDF is available here.
PDF is available here.
Abstract
Abstract
The azoospermia factor (AZF) locus in Yq11 is now functionally subdivided in three distinct spermatogenesis loci: AZFa, AZFb and AZFc. After knowledge of the complete genomic Y sequence in Yq11, 14 Y genes encoding putatively functional proteins and expressed in human testis are found to be located...
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PMID: 18462373
PDF is available here.
PDF is available here.
Molecular Immunology (45)14 2008
Abstract
We have previously shown that allergens can be represented by allergen motifs. A motif group was found containing venom antigen 5 sequences from different vespids. Using an optimized amino acid profile based on antigen 5 sequences for searching cross-reactive proteins, three human semen proteins bel...
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PMID: 18632155
PDF is available here.
PDF is available here.
Human Reproduction (23)7 2008
Abstract
AZFc rearrangements/polymorphisms are transmitted to sons and may represent a risk factor for decreased testis function and male subfertility, which needs confirmation in further studies in larger cohorts. However, deletions of two DAZ gene copies are compatible with normal spermatogenesis and ferti...
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PMID: 18440997
PDF is available here.
PDF is available here.
Abstract
We examined gene expression profiles of whole female flies at four time points following copulation. We found that, soon after copulation ends, a large number of small-magnitude transcriptional changes occurred in the mated female. At later time points, larger magnitude changes were seen, although t...
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PMID: 18562649
PDF is available here.
PDF is available here.
Abstract
I and anti-PSP II), PSP I and PSP II proteins were immunodetected in tissue extracts and in secretory tissues of cauda epididymis, prostate, seminal vesicles and Cowper's glands on the blots and by an indirect immunofluorescence technique, respectively. Moreover, the ability of PSP proteins to bind...
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PMID: 18031827
PDF is available here.
PDF is available here.
Abstract
The azoospermia factor b (AZFb) and azoospermia factor c (AZFc) regions in the human Y chromosome consist of five palindromes constructed from six distinct families of amplicons and are prone to rearrangement. Partial deletion and duplication in the region can cause azoospermia or oligozoospermia an...
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PMID: 18445645
PDF is available here.
PDF is available here.
Fertility and Sterility (89)6 2008
Abstract
OBJECTIVE: To measure histone-H4 acetylation and involvement of the AZFc region in testicular mixed atrophy. DESIGN: Prospective study. SETTING: University-affiliated medical center. PATIENT(S): Azoospermic men (n = 23) who underwent testicular sperm extraction and preparation for intracytoplasmic s...
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PMID: 18001726
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1784)6 2008
Abstract
The major protein from bovine seminal plasma, PDC-109 binds selectively to choline phospholipids on the sperm plasma membrane and plays a crucial role in priming spermatozoa for fertilization. The microenvironment and accessibility of tryptophans of PDC-109 in the native state, in the presence of ph...
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PMID: 18402784
PDF is available here.
PDF is available here.
Human Reproduction (23)5 2008
Abstract
In the present study, no significant differences in the frequency of gr/gr deletions between different patient and control groups were observed. We concluded that the relationship between gr/gr deletions and male infertility remains unclear and that it is too early to systematically test for gr/gr d...
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PMID: 18326516
PDF is available here.
PDF is available here.
Fertility and Sterility (89)5 2008
Abstract
OBJECTIVE: To evaluate the relationship between the status of homologous recombination and population-specific alleles in infertile Japanese males with azoospermia factor (AZF)-a deletions and to characterize the clinical features of these patients. DESIGN: Retrospective deletion study in infertile...
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PMID: 17624343
PDF is available here.
PDF is available here.
Biology of Reproduction (78)5 2008
Abstract
We hypothesized that seminal plasma factors could be involved in DRM disruption and redistribution of DRM-associated proteins. Our results indicate that: 1) the sperm-associated proteins, P25b and adenylate kinase 1, are linked to DRM of epididymal spermatozoa, but were exclusively associated with d...
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PMID: 18235103
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1784)5 2008
Abstract
The mannose-binding capability of recombinant wild-type boar spermadhesin AQN-1 and of its site-directed mutants in the highly-conserved region around of the single glycosylation site (asparagine 50) of some spermadhesins, where the carbohydrate binding site has been proposed to be located, was chec...
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PMID: 18359302
PDF is available here.
PDF is available here.
Abstract
A significant population difference in Y-haplogroup distribution was found between the groups of normozoospermia and azoospemia or oligozoospermia, and between the patient groups with oligozoospermia and azoospermia without AZFc deletions. Interpopulation comparison of Y haplogroup frequencies showe...
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PMID: 18156437
PDF is available here.
PDF is available here.
Abstract
We review the current knowledge concerning the impact of cytokines on uterine physiology and pathophysiology. Cytokines influence a range of uterine functions during the menstrual cycle, implantation, pregnancy and labour. The synergistic interactions between individual cytokines are intricate and d...
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PMID: 18266939
PDF is available here.
PDF is available here.
Abstract
We evaluate the effect of SBG over boar sperm. We show that the presence of SBG produces alterations of the acrosome morphology of sperm only when they are incubated in capacitating conditions. SBG binds to the periacrosomal region of sperm undergoing capacitation. Its presence induces an increase o...
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PMID: 17786920
PDF is available here.
PDF is available here.
Abstract
A vaccine formula comprised of five recombinant human intra-acrosomal sperm proteins was inoculated into female monkeys to test whether specific antibodies to each component immunogen could be elicited in sera and whether antibodies elicited by the vaccine affected in vitro fertilization. Acrosomal...
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PMID: 17643494
PDF is available here.
PDF is available here.
Abstract
Despite the identification of an increasing number of candidate genes involved in spermatogenesis, the armamentarium of diagnostic genetic tests in male infertility remains extremely limited. A number of new causative mutations have been reported for hypogonadotrophic hypogonadism but still the gene...
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PMID: 18413059
PDF is available here.
PDF is available here.
Animal Reproduction Science (105)1-2 2008
Abstract
Previous studies from our laboratory have reported empirical associations between bovine seminal plasma protein(s) (BSP) A1/A2 and 30 kDa and osteopontin (OPN) in accessory sex gland fluid and bull fertility. These BSP and OPN are believed to bind to sperm at ejaculation and to remain bound until sp...
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PMID: 18207674
PDF is available here.
PDF is available here.
Abstract
The mean peak heights of 2 lower-abundance proteins expressed in the seminal plasma of the severe oligospermic men were statistically different from the healthy fertile males (P<0.05). Fifteen different proteins existed between the nonobstructive azoospermic and the severe oligospermic group, 7 of w...
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PMID: 18481418
PDF is available here.
PDF is available here.
Theriogenology (69)5 2008
Abstract
We evaluated sperm parameters from Frisian ram semen incubated for various intervals with SP from all seasons and stored at -18 or -196 degrees C. At both temperatures, SP from autumn or winter increased (P<0.05) sperm motility, whereas no SP, or SP from spring or summer, had no effect. However, nei...
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PMID: 18242682
PDF is available here.
PDF is available here.
Animal Reproduction Science (104)2-4 2008
Abstract
Previous cryopreservation studies with buffalo cauda epididymal spermatozoa have reported a deleterious effect of seminal plasma heparin binding protein (HBP). The amount of HBP used in these studies was meager compared to the normal level of HBP in the buffalo ejaculate, still the damage induced up...
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PMID: 17433582
PDF is available here.
PDF is available here.