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Host Cell Factor C1 (0):
Recent article
Host Cell Factor C1
Abstract
We report that the PHD and Jumonji C (JmjC) domain-containing protein, PHF8, while using multiple substrates, including H3K9me1/2 and H3K27me2, also functions as an H4K20me1 demethylase. PHF8 is recruited to promoters by its PHD domain based on interaction with H3K4me2/3 and controls G1-S transition...
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PMID: 20622854
PDF is available here.
PDF is available here.
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Abstract
We report that the Caenorhabditis elegans homolog of host cell factor 1 (HCF-1) represents a new longevity modulator and functions as a negative regulator of DAF-16. In C. elegans, hcf-1 inactivation caused a daf-16-dependent lifespan extension of up to 40% and heightened resistance to specific stre...
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PMID: 18828672
PDF is available here.
PDF is available here.
Journal of Virology (82)19 2008
Abstract
HCF-1 is a cellular transcriptional coactivator that is critical for mediating the regulated expression of the immediate-early genes of the alphaherpesviruses herpes simplex virus type 1 and varicella-zoster virus. HCF-1 functions, at least in part, by modulating the modification of nucleosomes at t...
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PMID: 18667495
PDF is available here.
PDF is available here.
Abstract
We describe a candidate pluripotency factor, Ronin, that possesses a THAP domain, which is associated with sequence-specific DNA binding and epigenetic silencing of gene expression. Ronin is expressed primarily during the earliest stages of murine embryonic development, and its deficiency in mice pr...
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PMID: 18585351
PDF is available here.
PDF is available here.
Otology & Neurotology (29)4 2008
Abstract
Several single-nucleotide polymorphisms (SNPs) within the host cell factor C1 (HCFCI) gene displayed a significant increase in prevalence of the major allele in subjects with MD disease. The most individually significant SNP is rs2266886. The minor allele at this site displays an odds ratio of 0.26...
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PMID: 18520591
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (283)18 2008
Abstract
We show that PRC and PGC-1alpha differ in their interactions with nuclear hormone receptors but are highly similar in their direct binding to several nuclear transcription factors implicated in the expression of the respiratory chain. Surprisingly, neither coactivator binds NRF-2(GABP), a multisubun...
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PMID: 18343819
PDF is available here.
PDF is available here.
Molecular Cell (27)2 2007
Abstract
In a recent issue of Molecular Cell, Tyagi et al. (2007) show that E2F1, a positive regulator of S phase entry, recruits cofactor HCF-1 and associated hSet1/MLL histone H3 lysine 4 methyltransferase complex, facilitating the activation of genes required for proliferation.
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PMID: 17643366
PDF is available here.
PDF is available here.
Molecular Cell (27)1 2007
Abstract
We show that the human G1 phase regulator HCF-1 associates with both activator (E2F1 and E2F3a) and repressor (E2F4) E2F proteins, properties that are conserved in insect cells. Human HCF-1-E2F interactions are versatile: their associations and binding to E2F-responsive promoters are cell-cycle sele...
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PMID: 17612494
PDF is available here.
PDF is available here.
Abstract
Originally identified as an essential component of the herpes simplex virus immediate early (IE) gene enhancer complex, the transcriptional coactivator host cell factor-1 (HCF-1) has been implicated in a broad range of cellular regulatory circuits. The protein mediates activation through multiple in...
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PMID: 17578910
PDF is available here.
PDF is available here.
Journal of Pathology (211)3 2007
Abstract
We identified a novel gene, Vascular Calcification Associated Factor (VCAF), which was shown to be important in pericyte osteogenic differentiation. The aim of this study was to determine the localization and expression pattern of VCAF in human cells and tissues. Immunohistochemical analysis of seve...
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PMID: 17154367
PDF is available here.
PDF is available here.
Abstract
To investigate the role of HCF proteins in animal development, we have characterized the effects of loss of the HCF-1 homolog in C. elegans, called Ce HCF-1. Two large hcf-1 deletion mutants (pk924 and ok559) are viable but display reduced fertility. Loss of Ce HCF-1 protein at reduced temperatures...
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PMID: 18043729
PDF is available here.
PDF is available here.
Molecular and Cellular Biochemistry (288)1-2 2006
Abstract
We show here that E2F4 specifically and directly interacts with HCF-1. Mutational analysis showed E2F4 independently targets the kelch domain and the basic domain (residues 450-902) of HCF-1, both of which are required for normal cell-cycle progression via separate determinants. The HBM-containing d...
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PMID: 16633736
PDF is available here.
PDF is available here.
Hepatology (43)6 2006
Abstract
We performed a genomic analysis of the host cell response following binding of HCV to cell surface proteins. As ligands for HCV-host cell surface interaction, we used recombinant envelope glycoproteins and HCV-like particles (HCV-LPs) recently shown to bind or enter hepatocytes and human hepatoma ce...
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PMID: 16729312
PDF is available here.
PDF is available here.
Abstract
Limited proteolytic processing is an important transcriptional regulatory mechanism. In various contexts, proteolysis controls the cytoplasmic-to-nuclear transport of important transcription factors or removes domains to produce factors with altered activities. The transcriptional coactivator host c...
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PMID: 16624878
PDF is available here.
PDF is available here.
Abstract
We use dominant trans-activating (Vp16 fusion) or trans-repressing (engrailed fusion) forms of Meis1 to define its biochemical functions that contribute to leukemogenesis. Surprisingly, Vp16-Meis1 (but not engrailed-Meis1) functioned as an autonomous oncoprotein that mimicked combined activities of...
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PMID: 16648484
PDF is available here.
PDF is available here.
Biochemistry (Washington) (44)30 2005
Abstract
We describe the expression, purification, and characterization of the domains from the human HCF and of the full-length HCF from Caenorhabditis elegans. The purified recombinant C. elegans HCF can substitute for the human HCF in efficiently forming a multiprotein complex on a herpes simplex virus pr...
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PMID: 16042417
PDF is available here.
PDF is available here.
Genes to Cells (10)7 2005
Abstract
We set to investigate the regulatory mechanism of the Rb promoter that allows adequate up-regulation in differentiating myoblasts. We report that Rb expression is regulated by the transcription factors GABP, HCF-1 and YY1. Before induction of differentiation, Rb is expressed at a low level and GABP...
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PMID: 15966902
PDF is available here.
PDF is available here.
Abstract
The mammalian transcriptional coactivator host cell factor-1 (HCF-1) functions in concert with Oct-1 and VP16 to assemble the herpes simplex virus (HSV) immediate early (IE) transcription enhancer core complexes that mediate the high level transcription of these genes upon infection. Although this t...
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PMID: 15522876
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (279)32 2004
Abstract
The mammalian transcriptional coactivator HCF-1 is a critical component of the multiprotein herpes simplex virus immediate early gene enhancer core complex. The protein has also been implicated in basic cellular processes such as cell-cycle progression, transcriptional coactivation, and mRNA process...
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PMID: 15190068
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (279)29 2004
Abstract
We conducted a two-hybrid interaction screen in yeast using a GT1-7 cDNA library to search for specific Oct-1 cofactors. Using this approach, we isolated Pbx1b, a TALE homeodomain transcription factor that specifically associates with Oct-1. We show that heterodimers containing Pbx/Prep1 or Pbx/Meis...
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PMID: 15138251
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (279)28 2004
Abstract
We used Oct-1 antisense transformants to determine that Oct-1 represses the interferon-gamma response of the endogenous HLA-DRA gene. This determination is consistent with results from a chromatin immunoprecipitation assay, indicating that Oct-1 occupies the endogenous HLA-DRA promoter when the HLA-...
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PMID: 15105429
PDF is available here.
PDF is available here.
Abstract
We report the biochemical purification of MLL and demonstrate that it associates with a cohort of proteins shared with the yeast and human SET1 histone methyltransferase complexes, including a homolog of Ash2, another Trx-G group protein. Two other members of the novel MLL complex identified here ar...
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PMID: 15199122
PDF is available here.
PDF is available here.
Molecular Cell (14)6 2004
Abstract
We show that HCF-1C subunit depletion causes extensive mitotic defects, including a switch from monomethyl to dimethyl lysine 20 of histone H4 (H4-K20) and defective chromosome alignment and segregation. Consistent with these activities, the HCF-1C subunit can associate with chromatin independently...
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PMID: 15200950
PDF is available here.
PDF is available here.
Journal of Molecular Biology (339)5 2004
Abstract
We have demonstrated that N Oct-3 presents a non-cooperative homodimerization on these two additional targets and can also give rise to heterodimers with HNF-3beta. Surprisingly, despite the high degree of conservation of the respective POU subunits, the ubiquitous POU protein Oct-1 can only form mo...
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PMID: 15178247
PDF is available here.
PDF is available here.
Abstract
We located a potential transcriptional silencer in a 52bp sequence whose integrity is necessary for silencing the proximal enhancer promoter element (PEP) in multiplying keratinocytes. Octamer-binding sites were noticed in this fragment and the specific binding of Oct-2 transcription factor was dete...
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PMID: 15120610
PDF is available here.
PDF is available here.
Abstract
Vertebrate snRNA and snRNA-type genes occur in independent transcription units with external promoters. The transcription level from the basal promoter is enhanced by the distal sequence element DSE. This element contains almost invariably two activator submotifs, the Staf binding site and the octam...
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PMID: 15087134
PDF is available here.
PDF is available here.
Abstract
We explored the binding of octamer (Oct) transcription factors to the HIV-1 long terminal repeat (LTR) by gel shift assays and showed none of the previously identified four potential Oct binding sites bound Oct-1 or Oct-2. Overexpression of Oct-1 or Oct-2 had no effect on HIV-1 LTR activity in trans...
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PMID: 15051391
PDF is available here.
PDF is available here.
Abstract
We propose that hormone-independent NF1 binding may be involved in maintaining transcriptional competence and establishment of tissue-specific gene networks....
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PMID: 15024090
PDF is available here.
PDF is available here.
Endocrinology (145)3 2004
Abstract
We have previously shown that cytokine-induced iNOS expression is cycloheximide (CHX) sensitive and requires nuclear factor-kappa B (NF-kappa B) activation. In the present study, we show that an octamer motif located 20 bp downstream of the proximal NF-kappa B binding site in the rat iNOS promoter i...
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PMID: 14630716
PDF is available here.
PDF is available here.
Abstract
The POU domain transcription factors Oct-1 and Oct-2 interact with the octamer element, a motif conserved within Ig promoters and enhancers, and mediate transcription from the Ig loci. Inactivation of Oct-2 by gene targeting results in normal B cell development and Ig transcription. To study the rol...
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PMID: 14762167
PDF is available here.
PDF is available here.
Abstract
We have cloned and sequenced a new mouse Oct-1 isoform, named mOct-1Z. This novel isoform differs markedly at the C-terminus from the previously identified Oct-1 isoforms A, B, and C. It is generated by alternative splicing from the Oct-1 gene and its transcript exhibits a frameshift followed by an...
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PMID: 14729276
PDF is available here.
PDF is available here.
Abstract
Expression of the herpes simplex virus (HSV) immediate early (IE) genes is regulated by a multiprotein complex that is assembled on the TAATGARAT enhancer core element. The complex contains the cellular POU domain protein Oct-1, the viral transactivator VP16, and the cellular cofactor host cell fact...
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PMID: 14745036
PDF is available here.
PDF is available here.
Abstract
Oct-1 is a sequence-specific DNA binding transcription factor that is believed to regulate a large group of tissue-specific and ubiquitous genes. Both Oct-1 and the related but tissue-restricted Oct-2 protein bind to a DNA sequence termed the octamer motif (5'-ATGCAAAT-3') with equal affinity in vit...
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PMID: 14729950
PDF is available here.
PDF is available here.
Journal of Immunology (172)2 2004
Abstract
We previously reported that murine hs4 was regulated by NF-kappaB, octamer binding proteins, and Pax5 (B cell-specific activator protein). In this study we report that human hs4 is regulated differently. EMSAs and Western analysis of normal B cells before and after stimulation with anti-IgM plus ant...
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PMID: 14707079
PDF is available here.
PDF is available here.
Virus Research (99)1 2004
Abstract
We have carried out a differential display analysis on HIV-1-infected macrophages that were treated, or not, with murabutide. Sequencing of the differentially regulated cDNA bands and verification of the reproducibility of the murabutide effects, by reverse transcription-polymerase chain reaction or...
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PMID: 14687943
PDF is available here.
PDF is available here.
Nucleic Acids Research (32)4 2004
Abstract
We present a general high-throughput approach to accurately quantify DNA-protein interactions, which can facilitate the identification of functional genetic polymorphisms. The method tested here on two structurally distinct transcription factors (TFs), NF-kappaB and OCT-1, comprises three steps: (i)...
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PMID: 14990752
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (278)51 2003
Abstract
We show that the HCF-binding motif occurs in a wide spectrum of DNA-binding proteins and transcriptional cofactors. Three well characterized examples were further analyzed for their ability to use HCF-1 as a coactivator. Krox20, a zinc finger transcription factor required for Schwann cell differenti...
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PMID: 14532282
PDF is available here.
PDF is available here.
Insect Molecular Biology (12)6 2003
Abstract
We demonstrate that HCF-1 is an early protein and localizes to the cell nucleus. Coprecipitation experiments revealed that HCF-1 interacts with itself but none of the other late expression factors required for replication in Tn-368 cells. HCF-1 mutants were constructed and utilized to search for the...
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PMID: 14986926
PDF is available here.
PDF is available here.
Abstract
We now show that thrombopoietin-dependent activation of the cyclin D1 promoter depends on the integrity of a new bipartite proximal element that specifically binds STAT5A and -B transcription factors. We demonstrate that the stable recruitment of STAT5 to this element in vitro requires the integrity...
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PMID: 14645506
PDF is available here.
PDF is available here.
Abstract
These results demonstrate that the Zfhep zinc finger homeodomain motif functions as a protein-binding domain in vitro, and suggests that Zfhep may modulate the activity of POU domain transcription factors. However, neither the Zfhep ZHD nor the HD bound DNA in EMSA or selected a DNA-binding site fro...
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PMID: 14672405
PDF is available here.
PDF is available here.
Cancer Research (63)21 2003
Abstract
We provide evidence that DNA-PK participates in altering specific gene expression in response to DNA damage by modulating the stability and transcriptional regulatory potential of the essential transcription factor octamer transcription factor 1 (Oct-1). Histone H2B and U2 RNA, whose expression are...
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PMID: 14612514
PDF is available here.
PDF is available here.
Abstract
We show here that it is also induced by a typical HDAC inhibitor, trichostatin A (TSA), through its promoter, in a p53-independent manner. To identify the mechanism of activation of the gadd45 promoter, we performed luciferase reporter analyses and electrophoretic mobility shift assays. These reveal...
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PMID: 14586402
PDF is available here.
PDF is available here.
Journal of Virology (77)22 2003
Abstract
We report that Oct-1 is posttranscriptionally modified late in infection, that the modification is mediated by the virus but does not involve viral protein kinases or cdc2 kinase activated by the virus late in infection, and that the modified Oct-1 has a reduced affinity for its cognate DNA site. Th...
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PMID: 14581529
PDF is available here.
PDF is available here.
Abstract
We analyse the subcellular localisation of the CeHCF protein in live transgenic worms and in mammalian cells. We constructed a green fluorescent protein (GFP) fusion of CeHCF and studied localisation after ectopic expression under the control of a heat shock protein promoter. The CeHCF-GFP protein a...
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PMID: 14629117
PDF is available here.
PDF is available here.
Molecular and Cellular Endocrinology (207)1-2 2003
Abstract
A human pituitary cDNA library was screened using a yeast one-hybrid system to find a factor binding Pit-1 binding elements in the PRL gene other than Pit-1. Beside colonies containing Pit-1 or Oct-1 cDNA, three colonies contained mPOU cDNA, a member of the POU protein family. Immunohistochemical an...
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PMID: 12972181
PDF is available here.
PDF is available here.
Circulation Research (93)4 2003
Abstract
We demonstrate that the TZDs rosiglitazone (RSG), troglitazone (TRO), and a novel non-TZD partial PPARgamma agonist (nTZDpa) induce caspase-mediated apoptosis of human coronary VSMCs. Induction of VSMC apoptosis correlated closely with an upregulation of growth arrest and DNA damage-inducible gene 4...
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PMID: 12881480
PDF is available here.
PDF is available here.
Abstract
We have studied the cis-acting elements involved in the repression of neuropeptide Y (NPY) gene expression in a gonadotropin-releasing hormone (GnRH) neuronal cell model, GT1-7 cells. Using transient transfection of the human NPY 5(') regulatory region into the GT1-7 neurons, we have found a repress...
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PMID: 12878188
PDF is available here.
PDF is available here.
Journal of General Virology (84)Pt 8 2003
Abstract
We analysed the U3 region in detail in order to understand the transcriptional regulatory mechanism of HERV-W. Two transcription factor (TF) binding sites for Oct-1 and C/EBP were important as a silencer and an enhancer, respectively, for transcriptional regulation. Furthermore, it was possible to d...
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PMID: 12867655
PDF is available here.
PDF is available here.
Abstract
We have isolated and functionally characterized a multicomponent Oct-1 coactivator, OCA-S which is essential for S phase-dependent histone H2B transcription. The p38 component of OCA-S binds directly to Oct-1, exhibits potent transactivation potential, is selectively recruited to the H2B promoter in...
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PMID: 12887926
PDF is available here.
PDF is available here.
Abstract
Histone gene expression in mammalian cells is codependent upon the Oct-1 transcription factor and its cognate, OCA-S coactivator complex. Surprisingly, GADPH plays an essential role in the OCA-S complex and confers redox dependence upon the in vitro transcription of histone genes.
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PMID: 12887915
PDF is available here.
PDF is available here.
Immunology Letters (88)1 2003
Abstract
We studied regulation of transcription of the Oct-1 gene using reporter gene assays of promoter-luciferase gene-constructs. It was shown that transcription of the Oct-1 gene is regulated by two promoters located upstream of the exon 1U and upstream of the exon 1L. The promoter located upstream of th...
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PMID: 12853155
PDF is available here.
PDF is available here.
Genes & Development (17)13 2003
Abstract
We find that transcriptionally inactive promoters contain TBP and high levels of histone H1, and are present to varying extents in both untreated and dexamethasone (DEX)-treated 3134 cells. In contrast, the basally active promoter, present in untreated cells, is bound to RNA Pol II, TBP, and Oct1, c...
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PMID: 12842912
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (278)26 2003
Abstract
There is some evidence that the potent cytokine tumor necrosis factor (TNF) is able to induce tolerance after repeated stimulation of cells. To investigate the molecular mechanisms mediating this phenomenon, the expression of interleukin-8 (IL-8), which is regulated by transcription factors NF-kappa...
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PMID: 12707271
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1627)2-3 2003
Abstract
We first identified the transcriptional regulatory element of the CYP2D4 gene. CYP2D4 is of interest in brain pharmacology and physiology because this enzyme can be involved in the metabolism of endogenous and exogenous compounds, which act on the central nervous system. Transfection studies using a...
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PMID: 12818430
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (278)25 2003
Abstract
We show here that the HoxC4 and Oct-1 homeodomain proteins together with the Ku70/Ku86 heterodimer bind as a complex to newly identified switch (S) regulatory ATTT elements (SREs) in the Igamma and Iepsilon promoters and downstream regions to dampen basal germ line Igamma-Cgamma and Iepsilon-Cepsilo...
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PMID: 12672812
PDF is available here.
PDF is available here.
Abstract
When herpes simplex virus (HSV) infects human cells, it is able to enter two modes of infection: lytic and latent. A key activator of lytic infection is a virion protein called VP16, which, upon infection of a permissive cell, forms a transcriptional regulatory complex with two cellular proteins - t...
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PMID: 12826401
PDF is available here.
PDF is available here.
Journal of Virology (77)11 2003
Abstract
We report that a third cellular protein, octamer-1 protein (Oct-1), binds to minimal packaging domains. In vitro binding analyses and in vivo packaging assays were used to examine the relevance of these DNA binding activities to Ad DNA packaging. The results of these experiments reveal that COUP-TF...
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PMID: 12743282
PDF is available here.
PDF is available here.
EMBO Journal (22)10 2003
Abstract
We have used small-interfering RNA (siRNA) to inactivate HCF-1 in an array of normal and transformed mammalian cells to identify its cellular functions. Our results show that HCF-1 is a broadly acting regulator of two stages of the cell cycle: exit from mitosis, where it ensures proper cytokinesis,...
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PMID: 12743030
PDF is available here.
PDF is available here.
European Journal of Biochemistry (270)10 2003
Abstract
These results clearly demonstrate that multiple cis DNA elements in a clustered region work cooperatively to regulate constitutive fgl2 expression and interact with inducible elements to regulate viral-induced fgl2 expression in endothelial cells....
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PMID: 12752447
PDF is available here.
PDF is available here.
International Immunology (15)5 2003
Abstract
The beta chain, a component of the high-affinity receptor for IgE (FcepsilonRI), plays an important role in IgE-mediated allergic reaction. The beta chain accelerates the function of FcepsilonRI by amplification of its surface expression and of signal transduction in effector cells such as mast cell...
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PMID: 12697656
PDF is available here.
PDF is available here.