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MSX1 Transcription Factor (0):
Recent article
MSX1 Transcription Factor
Developmental Biology (343)1-2 2010
Abstract
We inactivated Msx1 and Msx2 conditionally in neural crest. We show that Wnt1-Cre inactivation of up to three Msx1/2 alleles results in a progressively larger defect in the neural crest-derived frontal bone. Unexpectedly, in embryos lacking all four Msx1/2 alleles, the large defect is filled in with...
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PMID: 20398647
PDF is available here.
PDF is available here.
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Reproduction (139)5 2010
Abstract
This study was conducted to investigate the effect of suppressing transcription factor gene MSX1 on the development of in vitro produced bovine oocytes and embryos, and identify its potential target genes regulated by this gene. Injection of long double-stranded RNA (LdsRNA) and smal...
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PMID: 20176746
PDF is available here.
PDF is available here.
Reproduction (139)5 2010
Abstract
This study was conducted to investigate the effect of suppressing transcription factor gene MSX1 on the development of in vitro produced bovine oocytes and embryos, and identify its potential target genes regulated by this gene. Injection of long double-stranded RNA (LdsRNA) and smal...
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PMID: 20176746
PDF is available here.
PDF is available here.
Reproduction (139)5 2010
Abstract
This study was conducted to investigate the effect of suppressing transcription factor gene MSX1 on the development of in vitro produced bovine oocytes and embryos, and identify its potential target genes regulated by this gene. Injection of long double-stranded RNA (LdsRNA) and smal...
|
PMID: 20176746
PDF is available here.
PDF is available here.
Reproduction (139)5 2010
Abstract
This study was conducted to investigate the effect of suppressing transcription factor gene MSX1 on the development of in vitro produced bovine oocytes and embryos, and identify its potential target genes regulated by this gene. Injection of long double-stranded RNA (LdsRNA) and smal...
|
PMID: 20176746
PDF is available here.
PDF is available here.
Reproduction (139)5 2010
Abstract
This study was conducted to investigate the effect of suppressing transcription factor gene MSX1 on the development of in vitro produced bovine oocytes and embryos, and identify its potential target genes regulated by this gene. Injection of long double-stranded RNA (LdsRNA) and smal...
|
PMID: 20176746
PDF is available here.
PDF is available here.
Reproduction (139)5 2010
Abstract
This study was conducted to investigate the effect of suppressing transcription factor gene MSX1 on the development of in vitro produced bovine oocytes and embryos, and identify its potential target genes regulated by this gene. Injection of long double-stranded RNA (LdsRNA) and smal...
|
PMID: 20176746
PDF is available here.
PDF is available here.
Reproduction (139)5 2010
Abstract
This study was conducted to investigate the effect of suppressing transcription factor gene MSX1 on the development of in vitro produced bovine oocytes and embryos, and identify its potential target genes regulated by this gene. Injection of long double-stranded RNA (LdsRNA) and smal...
|
PMID: 20176746
PDF is available here.
PDF is available here.
Abstract
We suggest that in CGCG and PGCG of the jaws, PTHrP-positive immature osteoblasts activate PTHR1-positive mature osteoblasts to produce RANKL which interacts with RANK on the PTHrP/PTHR1-positive osteoclast-precursor cells found in abundance in the stroma of giant cell lesions and induces osteoclast...
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PMID: 20060342
PDF is available here.
PDF is available here.
Abstract
We have confirmed that 2.75 mg/kg body weight OTA, given at gestational day 7.5, induces significant developmental craniofacial anomalies in mice and we have demonstrated the down expression of Dlx5, a member of Dlx gene family, that seems to be responsible of the observed deformities. These results...
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PMID: 20036863
PDF is available here.
PDF is available here.
Human Molecular Genetics (18)15 2009
Abstract
We determined the structural and functional consequences of these paired domain missense mutations and correlated our findings with the associated dental phenotype variations. In vitro testing included subcellular localization, protein-protein interactions between MSX1 and mutant PAX9 proteins, bind...
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PMID: 19429910
PDF is available here.
PDF is available here.
Abstract
We sequenced the MSX1 gene of three unrelated patients with sporadic, non-syndromic oligodontia: 2 boys aged 8.5 and 15 years old and one girl aged 15.5 years old. We have thus identified a homozygotic deletion of 11 nucleotides in the intron, near the 5' splicing site, in two patients, who also car...
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PMID: 19346736
PDF is available here.
PDF is available here.
Abstract
Vertebrate Msx sequences sort into distinct Msx1, Msx2 and Msx3 clades. The sister-group relationship between MSX1 and MSX2 reflects their derivation from the 4p/5q chromosomal paralogon, a derivative of the original "MetaHox" cluster. We demonstrate physical linkage between Msx and other MetaHox ge...
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PMID: 19154605
PDF is available here.
PDF is available here.
Cells Tissues Organs (189)1-4 2009
Abstract
We used transgenic mice with a knock-in for Msx1 or Msx2. Msx expression was analyzed on whole-mount experiments on heterozygous mice. The results were confirmed by quantitative RT-PCR on mandible and tibia samples. Steady-state levels of Msx2 mRNA were determined at 2 ages, at postnatal day 14 and...
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PMID: 18769023
PDF is available here.
PDF is available here.
Cells Tissues Organs (189)1-4 2009
Abstract
Our group showed that the Msx1 gene is submitted to bidirectional transcription generating a long noncoding antisense (AS) RNA. During tooth development, Msx1 sense (S) and AS RNAs showed specific patterns of expression. Thus, the aim of the present study was to analyze the relation between Msx1 S a...
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PMID: 18728357
PDF is available here.
PDF is available here.
Abstract
In 37 litters consisting of 163 pups, we found 47 affected pups in a total population of 2104. The male:female ratio was 1:0.96. Affected pups showed isolated cleft lip and/or cleft palate; no attendant disorders have been reported. Despite a high degree of relationship, two affected pups displayed...
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PMID: 19115787
PDF is available here.
PDF is available here.
Abstract
There were six up- and four down-regulated miRNAs. Because every miRNA regulates hundreds of genes, we focused only on those related to bone formation. Among them, the most notable are BMP4 and 7, which are both up-regulated in osteoblasts cultured on Ti disks. CONCLUSION: The detected miRNAs differ...
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PMID: 18241218
PDF is available here.
PDF is available here.
Archives of Oral Biology (53)8 2008
Abstract
Dental evaluation showed that the most commonly missing teeth are the mandibular second premolars, followed by the maxillary second premolars and maxillary lateral incisors, and subsequently the maxillary first premolars. The probability of missing a particular type of tooth is not always bilaterall...
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PMID: 18374898
PDF is available here.
PDF is available here.
Developmental Dynamics (237)8 2008
Abstract
We could analyze the expression of these homeogenes in the adult mouse. We observed that Msx genes are prominently expressed in a subset of blood vessels. The Msx2nlacZ allele is mainly expressed in a restricted population of mural cells in peripheral arteries and veins. Msx1nlacZ is expressed to a...
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PMID: 18627106
PDF is available here.
PDF is available here.
Cardiovascular Research (78)3 2008
Abstract
Employing an yeast 2-hybrid screen and subsequent in vitro pull-down experiments we demonstrate that muscle segment homeobox genes Msx1 and Msx2 are able to bind the cardiac T-box proteins Tbx2, Tbx3, and Tbx5. This interaction, as that of the related Nkx2.5 protein, is supported by the T-box and ho...
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PMID: 18285513
PDF is available here.
PDF is available here.
Congenital Anomalies (48)2 2008
Abstract
Morphological and immunohistological examinations were performed to reveal the mechanisms of cleft palate induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). ICR strain mice 8-10 weeks of age were used in the study. TCDD was administered in olive oil on gestation day (GD) 12.5 with gastric tube...
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PMID: 18452487
PDF is available here.
PDF is available here.
Developmental Biology (317)2 2008
Abstract
We have used a combination of multi-species comparative genomics, mouse transgenic analysis and in-situ hybridisation to predict and validate the existence of a remote ultra-conserved enhancer that supports the expression of the Msx1 gene in migrating mouse cardiac neural crest and the outflow tract...
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PMID: 18358468
PDF is available here.
PDF is available here.
Journal of Neuroscience (28)14 2008
Abstract
We expressed transcription factors involved in the development of midbrain dopaminergic neurons in rat and human neural progenitors. Using retroviral-mediated transgene delivery, we overexpressed Lmx1a (LIM homeobox transcription factor 1, alpha), Msx1 (msh homeobox homolog 1), Ngn2 (neurogenin 2),...
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PMID: 18385323
PDF is available here.
PDF is available here.
Abstract
Our study provides new insights into regulatory mechanisms governing enamelin expression....
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PMID: 18353004
PDF is available here.
PDF is available here.
Abstract
We describe ultrasensitivity, the phenomenon equivalent to an all-or-none response, in dissociated neural precursor cells (NPCs) exposed to bone morphogenetic protein 4 (Bmp4). NPC ultrasensitivity is evident at the population and single-cell levels based on Msx1 induction, a well known Bmp target r...
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PMID: 18292231
PDF is available here.
PDF is available here.
Developmental Biology (315)1 2008
Abstract
We show that redifferentiation does not occur by endochondral ossification but by the direct ossification of blastema cells that form the rudiment of the digit tip. Once formed the rudiment elongates by appositional ossification in parallel with unamputated control digits. Regenerated digits are con...
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PMID: 18234177
PDF is available here.
PDF is available here.
Experimental Cell Research (314)4 2008
Abstract
We report that inducible expression of PHOX2B in the neuroblastoma cell line SJNB-8 down-regulates MSX1, a homeobox gene important for embryonic neural crest development. Inducible expression of MSX1 in SJNB-8 caused inhibition of both cell proliferation and colony formation in soft agar. Affymetrix...
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PMID: 18201699
PDF is available here.
PDF is available here.
Abstract
While both Msx1-/- and Msx2-/- single homozygous mutant mice exhibited normal valve formation, we observed hypoplastic AV cushions and malformed AV valves in Msx1-/-; Msx2-/- mutants, indicating redundant functions of Msx1 and Msx2 during AV valve morphogenesis. In Msx1/2 null mutant AV cushions, we...
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PMID: 18667074
PDF is available here.
PDF is available here.
Abstract
We first employed annealing control primer-based RT-PCR to screen candidate genes differentially expressed in the Müllerian ducts between male and female. Four differentially expressed genes (MSX2, GAL10, VCP and PLCH1) were partially sequenced. The expression of mRNA of the latter genes and MSX1...
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PMID: 18956347
PDF is available here.
PDF is available here.
Abstract
WNT signalling regulates cell proliferation, differentiation, polarity and organisation. The present study investigated the effects of progesterone (P4) on the endometrial WNT system in relation to blastocyst development and growth in sheep. Ewes received daily intramuscular injections of either cor...
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PMID: 19007558
PDF is available here.
PDF is available here.
Developmental Biology (311)2 2007
Abstract
We have used a combination of comparative genomics, mouse transgenic analysis, in situ hybridisation and immunohistochemistry to identify a highly conserved and tissue-specific regulatory sub-domain within the previously characterised Msx1 gene proximal enhancer element that supports the expression...
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PMID: 17727834
PDF is available here.
PDF is available here.
Developmental Biology (311)1 2007
Abstract
We show that mice lacking Smad4 in NCCs have persistent truncus arteriosus (PTA), severe OFT cushion hypoplasia, defective OFT elongation, and mispositioning of the OFT. Cardiac NCCs lacking Smad4 have increased apoptosis, apparently due to decreased Msx1/2 expression. This contributes to the reduct...
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PMID: 17916348
PDF is available here.
PDF is available here.
Abstract
These findings show a positive association between the MSX1 CA polymorphism and CL+/-P in a Colombian group population....
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PMID: 18177186
PDF is available here.
PDF is available here.
Abstract
We chose to explore the molecular relationship between Pax9, Msx1 and Bmp4. In humans, unlike in mice, a heterozygous mutation in either PAX9 or MSX1 suffices to cause tooth agenesis of a predominantly molar or more premolar pattern, respectively. Our laboratory and others have identified several PA...
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PMID: 17973693
PDF is available here.
PDF is available here.
Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology (42)9 2007
Abstract
MSX1 gene is associated with NSCLP, and MSX1 gene may be directly involved either in the etiology of NSCLP or in linkage disequilibrium with disease-predisposing sites....
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PMID: 18070437
PDF is available here.
PDF is available here.
British Dental Journal (203)4 2007
Abstract
The congenital absence of teeth is one of the commonest developmental abnormalities seen in human populations. Familial hypodontia or oligodontia represents an absence of varying numbers of primary and/or secondary teeth as an isolated trait. While much progress has been made in understanding the de...
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PMID: 17721480
PDF is available here.
PDF is available here.
Developmental Biology (308)2 2007
Abstract
We show that combined deficiencies of Msx1 and Msx2 cause conotruncal anomalies associated with malalignment of the cardiac outflow tract (OFT). Msx1 and Msx2 play dual roles in outflow tract morphogenesis by both protecting secondary heart field (SHF) precursors against apoptosis and inhibiting exc...
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PMID: 17601530
PDF is available here.
PDF is available here.
Abstract
We therefore produced conditional alleles of Msx1 and Msx2. We constructed targeting vectors with LoxP sites flanking the homeodomain-encoding second exons and Frt sites flanking a neo gene. These vectors were used to produce targeted ES cells and mice with floxed alleles. The functionality of the L...
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PMID: 17654563
PDF is available here.
PDF is available here.
Abstract
Tooth development is under strict genetic control. During the last decade, studies in molecular genetics have led to the identification of gene defects causing the congenital absence of permanent teeth. Analyses of PAX9 and MSX1 in nine families with hypodontia and oligodontia revealed one new PAX9...
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PMID: 17697174
PDF is available here.
PDF is available here.
Abstract
Ban II did not digest PCR product (DNA) in the control group (195 bp band on electrophoresis gel) but digested the affected allele (106 bp and 89 bp bands). There is a statistically significant correlation between tooth agenesis and MSX1 mutation (P < 0.001). CONCLUSION: The results indicated that M...
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PMID: 17559452
PDF is available here.
PDF is available here.
Abstract
We performed EMSA analysis using two different regions from the distal enhancer and nuclear protein extracts from embryos. The results showed that in the presence of a Bicoid consensus binding site a DNA-protein complex can be formed. The identification of the proteins involved in this complex by ma...
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PMID: 17499211
PDF is available here.
PDF is available here.
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics (24)3 2007
Abstract
The allele frequencies of the CA repeat microsatellite DNA in Hunan Han normal population were in good agreement with Hardy-Weinberg equilibrium. The polymorphism information content and heterozygosity of CA repeat microsatellite DNA were 0.50 and 0.50 respectively. The allele CA4 frequency in CL/P...
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PMID: 17557248
PDF is available here.
PDF is available here.
Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology (42)6 2007
Abstract
The HPDLC can differentiate into osteoblast-like cells by mechanical stretch induction through the activation of some osteogenesis genes....
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PMID: 17888257
PDF is available here.
PDF is available here.
Developmental Dynamics (236)5 2007
Abstract
We examined the expression patterns of several regulatory genes, including BMP4, FGF8, MSX1, PAX9, PITX2, and SHOX2, and compared them with that found in mice. All of these genes are known to play critical roles in murine tooth development. Our results show that these genes exhibit basically similar...
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PMID: 17394220
PDF is available here.
PDF is available here.
l Orthodontie Française (78)1 2007
Abstract
Many genes that interact in a complex and interdependent manner participate in the development of the craniofacial complex. One of them, the Msxl homeobox gene, a transcription factor, is expressed from early developmental stages to adulthood in accordance with specific spatio-temporal patterns. Whe...
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PMID: 17571531
PDF is available here.
PDF is available here.
Yonsei Medical Journal (48)1 2007
Abstract
We performed case-parent trio and case- control studies on 6 single nucleotide polymorphisms (SNPs) in the MSX1 gene using a sample of 52 CL/P and CP probands from Korea. In the case-control study, the allele frequencies of 6 MSX1 SNPs were compared between 52 oral cleft cases and 96 unmatched contr...
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PMID: 17326252
PDF is available here.
PDF is available here.
Abstract
We analyzed the morphological changes, the expression pattern of some genes, the proliferation index and apoptosis in developing heart of embryos at E13.5 from streptozotocin-induced diabetic mice. Morphological analysis has shown the persistent truncus arteriosus combined with a ventricular septal...
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PMID: 17967198
PDF is available here.
PDF is available here.
Abstract
We have extended previous studies by performing a more detailed analysis of these genes during mouse palate development. We found that the expression patterns of Shox-2 and Meox-2 are dynamic during palate development. At embryonic day 12.5 (E12.5), Shox-2 expression is localized to the anterior end...
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PMID: 17294368
PDF is available here.
PDF is available here.
Mechanisms of Development (124)9-10 2007
Abstract
We generated Msx1(-/-);Msx2(-/-) mice. These double mutant embryos died at E17 to E18 with no formation of the frontal bone. There was no apparent defect in CNC migration into the presumptive frontal bone primordium, but differentiation of the frontal mesenchyme and establishment of the frontal prim...
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PMID: 17693062
PDF is available here.
PDF is available here.
Physiological Genomics (28)1 2006
Abstract
We generated direct candidates of blastocyst-specific genes which may play an important role in determining the fate of the embryo after transfer....
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PMID: 17018689
PDF is available here.
PDF is available here.
Abstract
By using a systematic biological screen we identified multiple genes that are methylated with high penetrance in primary lung, breast, colon, and prostate cancers. The cross-tumor methylation pattern we observed for these novel markers suggests that we have identified a partial promoter hypermethyla...
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PMID: 17194187
PDF is available here.
PDF is available here.
Abstract
We found that the BMP2-, BMP4-, and BMP6-induced expression of Msx transcription factors (Msx1 and Msx2) preceded the down-regulation of SMC marker expression in cultured differentiated VSMCs. Either Msx1 or Msx2 markedly reduced the myocardin-dependent promoter activities of SMC marker genes (SM22a...
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PMID: 17030628
PDF is available here.
PDF is available here.
Angle Orthodontist (76)6 2006
Abstract
The Fgf and Msx gene expression in the cranial base was different from that of other skeletons....
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PMID: 17090159
PDF is available here.
PDF is available here.
Trends in Neurosciences (29)11 2006
Abstract
In a screen for homeobox transcription factors expressed in the embryonic ventral midbrain, Andersson et al. recently identified Lmx1a and Msx1. Using in ovo electroporation in chick embryos, they showed that these factors are crucial for initiating the differentiation of neuroepithelial progenitor...
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PMID: 17030431
PDF is available here.
PDF is available here.
Stem Cells (24)11 2006
Abstract
We show that bovine inner cell masses from nuclear transfer and fertilized embryos, grown on feeders in serum-free medium, form polarized rosette structures expressing nestin, Pax6, Pax7, Sox1, and Otx2 and exhibiting interkinetic nuclear migration activity and cell junction distribution as in the d...
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PMID: 16931774
PDF is available here.
PDF is available here.
Abstract
We now understand much better our own health problems. In some cases, we can modify our lifestyle and diet in order to prevent "environmental factors" from triggering the mutated genes inherited from our parents. Good examples are diabetes and cardiovascular diseases. If we realize we might have inh...
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PMID: 17087397
PDF is available here.
PDF is available here.
Mechanisms of Development (123)9 2006
Abstract
We have investigated the timing of the requirement for BMP signalling during tail regeneration. If noggin expression is induced followed by partial amputation of the tail, then wound closure and the formation of the neural ampulla occur normally but outgrowth of the regeneration bud is inhibited. Fu...
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PMID: 16938438
PDF is available here.
PDF is available here.
Developmental Dynamics (235)8 2006
Abstract
We have derived a clonal subline that undergoes cardiogenesis in response to high density, but without requiring exposure to DMSO. The new subline retains the capacity to differentiate into skeletal muscle and neuronal cells in response to DMSO and retinoic acid. However, upon aggregation, these Oct...
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PMID: 16773658
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (281)27 2006
Abstract
We demonstrate that Pax9 is able to directly regulate Msx1 expression and interact with Msx1 at the protein level to enhance its ability to transactivate Msx1 and Bmp4 expression during tooth development. In addition, we tested how a missense mutation (T62C) in the paired domain of PAX9 that is resp...
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PMID: 16651263
PDF is available here.
PDF is available here.
Developmental Biology (295)1 2006
Abstract
We rendered limb bud mesenchyme insensitive to BMP signals through the type I receptor, BMPR-IA. Conditional mutants had shortened limbs and almost complete agenesis of the autopod because of reduced cell proliferation. Reduced expression of downstream BMP signaling targets, Msx1, Msx2 and gremlin i...
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PMID: 16630606
PDF is available here.
PDF is available here.