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Myeloid-Lymphoid Leukemia Protein (0):
Recent article
Myeloid-Lymphoid Leukemia Protein
Fortschritte der Arzneimittelforschung. Progress in drug research. Progres des recherches pharmaceutiques (67) 2011
Abstract
Acute leukemia is characterized by clonal expansion of hematopoietic stem and progenitor cells with blocked differentiation. Clinical and experimental evidences suggest that acute myeloid leukemia (AML) is the product of several functionally cooperating genetic alterations including chromosomal tran...
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PMID: 21141731
PDF is available here.
PDF is available here.
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Abstract
We report a case of t-ALL with t(11;19)(q23;p13.3) and MLL-MLLT1 (alias ENL) gene rearrangement confirmed by cytogenetic analysis, multiplex reverse transcription-PCR (multiplex RT-PCR), and DNA sequencing in a patient who had undergone treatment for breast cancer. A 40-yr-old woman developed acute...
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PMID: 21239865
PDF is available here.
PDF is available here.
Bulletin du cancer (97)11 2010
Abstract
The genetic origins of the development of malignant haematological disorders have been established at the beginning of the 80ies. Systematic characterization of chromosomal structural abnormalities and, more recently by DNA microarray approaches and sequencing of tumour genomes have allowed the iden...
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PMID: 21051318
PDF is available here.
PDF is available here.
Abstract
The biological factors of leukemia cells are associated with treatment outcomes in childhood ALL. Multiplex RT-PCR assay is an efficient and sensitive diagnostic tool that may improve the ability to accurately and rapidly risk-stratify children with ALL....
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PMID: 20930648
PDF is available here.
PDF is available here.
Abstract
We report herein mechanistic details concerning the role of these transcription factors in human peripheral blood Th2 cell development. Silencing c-Myb in normal human naive CD4(+) cells under Th2 cell-promoting conditions blocked up-regulation of GATA-3 and interleukin-4, and in effector/memory CD4...
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PMID: 20484083
PDF is available here.
PDF is available here.
Abstract
We have found that high levels of histone acetylation--the hallmarks of active chromosome regions in vivo--can increase the affinity of reconstituted nucleosomes to the SET domain of ALL-1 histone methyltransferase in a defined system in vitro.
Copyright (c) 2010 Elsevier Inc. All rights reserved....
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PMID: 20493169
PDF is available here.
PDF is available here.
Abstract
Our results suggest that increased risk of infant leukemia development in patients with NQO1 *1*3 polymorphism is partially dependent on the inhibition of p53 pathway, though further studies are needed to fully understand the pathological role of C465T variant in the development of childhood leukemi...
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PMID: 21073132
PDF is available here.
PDF is available here.
Abstract
The majority of cases of acute leukemia belong to a specific lineage origin, either lymphoid or myeloid, and therefore are classified as acute lymphoblastic leukemia (ALL) or acute myelogenous leukemia (AML), based on morphologic features and cytochemical and immunophenotypic profile of the blast ce...
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PMID: 20513125
PDF is available here.
PDF is available here.
Abstract
We report a case of therapy-related ALL (t-ALL) with MLL gene rearrangement in a patient who had undergone treatment for breast cancer. A 60-yr-old woman with breast cancer underwent breast-conserving surgery followed by 6 cycles of adjuvant chemotherapy (cyclophosphamide, epirubicin, and fluorourac...
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PMID: 20603585
PDF is available here.
PDF is available here.
Abstract
We recommend a systematic approach to be used in all cases of acute leukemia starting with FISH analyses using a commercially available MLL split signal probe. Should an abnormality be discovered, the analysis has to be completed by further molecular cytogenetic and genomic PCR methods in order to u...
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PMID: 20206559
PDF is available here.
PDF is available here.
Leukemia & Lymphoma (51)4 2010
Abstract
We observed a high concordance using both methods, but the panel was very useful in the detection of an inv(16)(p13q22), a cryptic t(15;17)(q22;q21), and a cryptic deletion of the CBFbeta allele not detected with cytogenetics. Moreover, in six of nine patients (67%) without metaphases or with non-ev...
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PMID: 20233056
PDF is available here.
PDF is available here.
Clinical Cancer Research (16)7 2010
Abstract
Gal-1 transcripts were significantly more abundant in MLL-rearranged B-ALLs. All 32 primary MLL-rearranged B-ALLs exhibited abundant Gal-1 immunostaining, regardless of the translocation partner, whereas only 2 of 81 germline-MLL B-ALLs expressed Gal-1. In addition, Gal-1 was selectively detected in...
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PMID: 20332322
PDF is available here.
PDF is available here.
Abstract
Abstract
The B-ALL children with different fusion genes have different clinical characteristics, immunophenotypes and prognosis....
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PMID: 20350423
PDF is available here.
PDF is available here.
Abstract
We examined the binding of two SET domain-containing proteins, ALL1 and SET7, to chromatin substrates. The SET domains from these proteins bind and methylate intact nucleosomes poorly but can recognize disrupted nucleosomal structures associated with transcribed chromatin. Interestingly, the remodel...
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PMID: 19752191
PDF is available here.
PDF is available here.
Abstract
We will discuss the implications of these findings that point towards an evolutionary conservation of PcG/trxG mediated gene regulation in higher eukaryotes....
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PMID: 20083900
PDF is available here.
PDF is available here.
Abstract
We present the solution structure of the MLL CXXC domain in complex with DNA, showing how the CXXC domain distinguishes nonmethylated from methylated CpG DNA. On the basis of the structure, we generated point mutations that disrupt DNA binding. Introduction of these mutations into the MLL-AF9 fusion...
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PMID: 20010842
PDF is available here.
PDF is available here.
Molecular Cancer (9) 2010
Abstract
We have recently observed that GC resistance in T-ALL cell lines is associated with a proliferative metabolism and reduced expression of MLL. In this study we have further explored the relationship between MLL status and GC sensitivity.
Negative correlation of MLL expression with GC resistance in 15...
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PMID: 20979663
PDF is available here.
PDF is available here.
Abstract
We summarize some typical chromosomal abnormalities or gene mutations associated with myeloid leukemia on the basis of this hypothesis....
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PMID: 19860182
PDF is available here.
PDF is available here.
Abstract
Acute myeloid leukemia (AML) is a malignant hematopoietic neoplasm characterized by clonal proliferation of tumor cells that arise from the hematopoietic stem/progenitor population within the bone marrow. Cytogenetic abnormalities or point mutations of the hematopoiesis-specific genes are frequently...
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PMID: 19860185
PDF is available here.
PDF is available here.
Future Oncology (5)8 2009
Abstract
Genomic rearrangements of the locus 11q23 are frequently observed in aggressive acute leukemias with poor prognosis. These chromosomal aberrations fuse the mixed-lineage leukemia (MLL) gene to one of more than 50 partners. The resulting mixed-lineage leukemia fusions often code for chimeric transcri...
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PMID: 19852741
PDF is available here.
PDF is available here.
Abstract
We show that the histone 3/lysine 4 (H3/K4) HMT and the transcriptional regulator MLL associate with telomeres and contribute to their H3/K4 methylation and transcription in a telomere length-dependent manner. In human diploid fibroblasts, RNA interference-mediated MLL depletion affects telomere chr...
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PMID: 19528237
PDF is available here.
PDF is available here.
Abstract
Leukemia Research (33)7 2009
Abstract
MLL leukemias are characterized cytogenetically by reciprocal translocations of the MLL gene at 11q23 and clinically by unfavorable outcomes. Evidence indicating that MLL leukemias are resistant to apoptosis encourages the identification of agents that induce cell death by other mechanisms. The AF4-...
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PMID: 19232721
PDF is available here.
PDF is available here.
Journal of Clinical Oncology (27)19 2009
Abstract
PURPOSE To determine the prognostic importance of the meningioma 1 (MN1) gene expression levels in the context of other predictive molecular markers, and to derive MN1 associated gene- and microRNA-expression profiles in cytogenetically normal acute myeloid leukemia (CN-AML). PATIENTS AND METHODS MN...
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PMID: 19451432
PDF is available here.
PDF is available here.
Abstract
These results indicate that resistance to DX and MTX in human OS cell lines is a multigenic process involving gene copy number and expression changes....
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PMID: 19105235
PDF is available here.
PDF is available here.
Abstract
We directly observe the dynamic process through which the KIX domain of CREB binding protein communicates allosteric information between binding sites. KIX mediates cooperativity between pairs of transcription factors through binding to two distinct interaction surfaces in an allosteric manner. We s...
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PMID: 19203263
PDF is available here.
PDF is available here.
Abstract
We analyzed the dynamic association of MLL and H3K4 trimethylation at different stages of the cell cycle. Interestingly, MLL1, which is normally associated with transcriptionally active chromatins (G1 phase), dissociates from condensed mitotic chromatin and returns at the end of telophase when the n...
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PMID: 19220463
PDF is available here.
PDF is available here.
Abstract
We analysed gene expression of 40 paediatric AML-M4/M5 patients excluding inv(16) and t(8;21) patients, and found striking differences among the patients in an age-associated manner. In particular, most of the infants displayed very distinct gene expression. On the basis of this difference, we divid...
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PMID: 19120366
PDF is available here.
PDF is available here.
Abstract
We cloned 105 known and 8 new miRNA genes expressed in patients' leukemia cells. Instead of known miRNA genes, new miRNA genes were not evolutionarily conserved. Quantification of 19 selected miRNA genes revealed an aberrant expression in ALL as compared with normal CD34+ cells (P
PDF is available here.
PDF is available here.
Abstract
In the hematopoietic system, menin was found to interact with MLL, a large protein encoded by the mixed linage leukemia gene that acts as a histone H3 methyltransferase. The MLL gene is a recurrent target for translocations in both acute myeloid and acute lymphoid leukemias. MLL gene rearrangements i...
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PMID: 20175452
PDF is available here.
PDF is available here.
Abstract
Thiopurines (such as azathioprine and 6-mercaptopurine) are widely used for the treatment of patients suffering from malignancies, rheumatic disease, inflammatory bowel disease and solid organ transplant rejection. These drugs are activated and eliminated by a number of enzymes in the human body. Th...
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PMID: 20045992
PDF is available here.
PDF is available here.
Molecular Cancer (8) 2009
Abstract
Using MS-MLPA (methylation-specific multiplex ligation-dependent probe amplification assay), methylation of 24 different TSG was analyzed in 28 MLLmu and MLLwt acute leukemia cell lines. On average, 1.8/24 TSG were methylated in MLLmu AML cells, while 6.2/24 TSG were methylated in MLLwt AML cells. H...
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PMID: 19835597
PDF is available here.
PDF is available here.
Critical Reviews in Oncogenesis (15)1-2 2009
Abstract
We describe what is known thus far about septin deregulation in myeloid neoplasia. Septin abnormalities in myeloid neoplasia can be divided into two major groups. First, some septins (SEPT2, SEPT5, SEPT6, SEPT9, and SEPT11) have been repeatedly identified as in-frame fusion partners of the MLL gene...
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PMID: 20136629
PDF is available here.
PDF is available here.
Cancer Research (68)24 2008
Abstract
We survey MLL gene rearrangements that are associated with acute leukemia and discuss molecular pathways leading to these rearrangements....
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PMID: 19074864
PDF is available here.
PDF is available here.
Abstract
Polymorphisms in NQO1, a gene coding for the phase II enzyme involved in the detoxification of quinone carcinogens, have been associated with childhood leukemia in some studies, although the observed direction and magnitude of effects have been inconsistent. Therefore, the authors systematically rev...
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PMID: 18945694
PDF is available here.
PDF is available here.
Abstract
Abstract
Leukemia & Lymphoma (49)12 2008
Abstract
We have analysed 159 children included in the Brazilian Collaborative Study Group of Infant Acute Leukemia. FLT3-D835 mutations and FLT3-ITD were detected by PCR-RFLP assay and standard PCR amplification, respectively. Mean age at diagnosis was 11.3 months. Overall, 7.5% (ITDs n=6 and D835 n=6) of p...
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PMID: 19052976
PDF is available here.
PDF is available here.
Abstract
We evaluated twin 4-month-old monozygotic baby boys who presented with MLL-rearranged precursor-B acute lymphoblastic leukemia. Two different MLL/AF4 variants were found in both the twins, the first involving MLL intron 8 and AF4 intron 3 and the second stemming from translocations of MLL exon 10 an...
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PMID: 19131787
PDF is available here.
PDF is available here.
Abstract
We show that inclusion of the PHD fingers in the MLL fusion protein MLL-AF9 blocked immortalization of hematopoietic progenitors. Inclusion of 2 or more PHD fingers reduced association with the Hoxa9 locus and suppressed Hoxa9 up-regulation in hematopoietic progenitors. These data provide an explana...
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PMID: 18796627
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (283)47 2008
Abstract
We describe the identification of a conserved arginine containing motif, called the "Win" or WDR5 interaction motif, that is essential for the assembly and H3K4 dimethylation activity of the MLL1 core complex. Here we present a 1.7-A crystal structure of WDR5 bound to a peptide derived from the MLL1...
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PMID: 18829459
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (283)47 2008
Abstract
We have determined the biophysical basis for the interaction between the human WDR5 and MLL1. Our studies reveal that WDR5 preferentially recognizes a previously unidentified and conserved arginine-containing motif, called the "Win" or WDR5 interaction motif, which is located in the N-SET region of...
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PMID: 18829457
PDF is available here.
PDF is available here.
Abstract
We have recently described a model system whereby we expressed the MA9 fusion gene in human CD34(+) Umbilical Cord Blood (UCB) cells and showed that these cells transformed to acute myeloid or lymphoid leukemia when injected into immunodeficient mice. The Mixed Lineage Leukemia (MLL) oncogenes are u...
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PMID: 18948748
PDF is available here.
PDF is available here.
Abstract
We report pharmacological, physiological and genetic studies that demonstrate an oncogenic requirement for GSK3 in the maintenance of a specific subtype of poor prognosis human leukaemia, genetically defined by mutations of the MLL proto-oncogene. In contrast to its previously characterized roles in...
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PMID: 18806775
PDF is available here.
PDF is available here.
Journal of Clinical Oncology (26)31 2008
Abstract
CEBPA mutations predicted better event-free (P = .007), disease-free (P = .014), and overall survival (P < .001) independently of other molecular and clinical prognosticators. Among patients with CEBPA mutations, 91% were in the CN-AML molecular high-risk group. Within this group, CEBPA mutations pr...
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PMID: 18809607
PDF is available here.
PDF is available here.
Leukemia Research (32)10 2008
Abstract
We analyzed whether additional chromosomal abnormalities (ACA) other than 11q23 translocation could affect the disease behavior and its prognosis. Eighteen of seventy-four patients with infant acute lymphoblastic leukemia showed ACA, including three-way translocations in four, other novel translocat...
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PMID: 18448165
PDF is available here.
PDF is available here.
Abstract
We therefore generated mice expressing the Mll-PTD in the absence of Mll-WT. These Mll(PTD/-) mice die at birth unlike the normal life expectancy of Mll(PTD/WT), Mll(WT/-), and Mll(WT/WT) mice. Using Mll(WT/WT) fetal liver cells (FLC) as baseline, we compared Mll(PTD/-) with Mll(PTD/WT) FLC and foun...
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PMID: 18617636
PDF is available here.
PDF is available here.
Magyar Onkológia (52)3 2008
Abstract
Primary genetic abnormalities of leukemia cells have important prognostic significance in childhood acute leukemia. In the last two years 30 newly diagnosed or recurrent childhood ALL bone marrow samples were analyzed for chromosomal abnormalities with conventional G-banding and interphase-fluoresce...
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PMID: 18845499
PDF is available here.
PDF is available here.
Abstract
Abstract
We report a case of de novo acute monocytic leukemia (M5b) with t(11;17)(q23;q25). MLL involvement was revealed by fluorescent in situ hybridization (FISH) analysis, and an MLL/SEP9 fusion transcript was detected by RT-PCR. Sequencing analysis further showed that, in contrast to originally reported...
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PMID: 18642054
PDF is available here.
PDF is available here.
Abstract
We characterized the impact of etoposide on primary human long-term repopulating HSC that represent only a minor portion of CD34+ cells. The proliferative capacity of HSC is dramatically increased following both a single and multiple exposures to etoposide as determined by their ability to engraft b...
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PMID: 18510699
PDF is available here.
PDF is available here.
Abstract
We report that acute myeloid leukemia (AML) with an aberrant histone methyltransferase, the mixed lineage leukemia partial tandem duplication (MLL-PTD), exhibits increased global DNA methylation versus AML with MLL-wildtype (MLL-WT; P = .02). Among the differentially methylated genes, the SLC5A8 tum...
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PMID: 18566324
PDF is available here.
PDF is available here.
Archives of Dermatology (144)9 2008
Abstract
Review of the literature identified 13 reported cases of B-LBL occurring primarily in the skin, in addition to our 2 cases. Precursor B-cell lymphoblastic lymphoma is more common in children and in young adults, with a tropism for the head and neck region. Histologically, B-LBL must be differentiate...
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PMID: 18794461
PDF is available here.
PDF is available here.
Abstract
Cancer Research (68)15 2008
Abstract
Reciprocal chromosomal translocations at the MLL gene locus result in expression of novel fusion proteins, such as MLL-ENL, associated with leukemia. The three PHD finger cassette, one of the highly conserved domains in MLL, is absent in all fusion proteins. This domain has been shown to interact wi...
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PMID: 18676843
PDF is available here.
PDF is available here.
Abstract
Seminars in Oncology (35)4 2008
Abstract
We will discuss the most relevant gene alterations, including NPM1 gene mutations, internal tandem duplications (ITD) or tyrosine kinase domain (TKD) mutations of the FLT3 gene, CEBPA gene mutations, and partial tandem duplications (PTD) of the MLL gene, as well as mutations in the NRAS and WT1 gene...
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PMID: 18692685
PDF is available here.
PDF is available here.
Abstract
We report a case of chronic myelomonocytic leukemia (CMML) with a 46,XY,t(11;19)(q23;p13.1) karyotype that transformed to acute myeloid leukemia (AML) without showing any karyotypic evolution. Interphase fluorescent in situ hybridization analysis showed the split MLL signals in 95% of bone marrow ce...
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PMID: 18617060
PDF is available here.
PDF is available here.
Abstract
We evaluated the prevalence of BCR/ABL, MLL, and ETV6/RUNX1 rearrangements as well as CDKN2A (alias p16) deletion in a group of Mexican children with acute lymphoblastic leukemia (ALL) to determine whether the changes coexist, and to compare the incidences found with other reports in the literature....
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PMID: 18617057
PDF is available here.
PDF is available here.