Find your PDFs fast.
Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
STAT Transcription Factors (6):
Recent article
STAT Transcription Factors
Oncotarget (2)6 2011
Abstract
STAT transcription factors transduce signals from the cell surface to the nucleus, where they regulate the expression of genes that control proliferation, survival, self-renewal, and other critical cellular functions. Under normal physiological conditions, the activation of STATs is...
|
PMID: 21680956
PDF is available here.
PDF is available here.
| < More recent | Older article > |
Clinical Immunology (137)1 2010
Abstract
We analyzed the M2 marker expression and intracellular signal transduction in the course of cytokine-driven differentiation. We found elevated spontaneous production of the chemokines CCL17, CCL18 and CCL22 and increased expression of CD206 by alveolar macrophages from patients with lung fibrosis. S...
|
PMID: 20674506
PDF is available here.
PDF is available here.
Abstract
I will focus on the establishment of these stem cells in their niche during development and the molecular mechanisms that regulate their asymmetric division in adults....
|
PMID: 20578235
PDF is available here.
PDF is available here.
Abstract
Cytokines are known to play an important role in the pathogenesis of lupus nephritis (LN) and the Jak/STAT (Janus kinase-signal transducer and activator of transcription factor) pathway is important in mediating signal transduction of cytokines. This study examined the pathogenic rol...
|
PMID: 20501525
PDF is available here.
PDF is available here.
Biochemical Journal (429)3 2010
Abstract
We describe changes in gene expression patterns and transcriptional networks that respond to dietary PQQ restriction or pharmacological administration. Rats were fed diets either deficient in PQQ (PQQ-) or supplemented with PQQ (approx. 6 nmol of PQQ/g of food; PQQ+). In addition, groups of rats wer...
|
PMID: 20491655
PDF is available here.
PDF is available here.
Abstract
We investigated potential synergism between IL-6 and IL-1 for the production of matrix metalloproteinases (MMPs) by the synovial cell line SW982. Cells were cultured with different combinations of IL-6, soluble IL-6 receptor (sIL-6R) and IL-1beta for 24h and production of MMPs was then measured. IL-...
|
PMID: 20403707
PDF is available here.
PDF is available here.
Abstract
Our data suggested that a better understanding about how interferon signals at liver cell level might be helpful in developing an effective approach to protecting against the inhibition of regeneration....
|
PMID: 20626293
PDF is available here.
PDF is available here.
Abstract
We found that mice lacking SOCS1 displayed defects in the regulation of p53 target genes including Mdm2, Pmp22, PUMA and Gadd45a. The involvement of SOCS1 in p53 activation and the DNA damage response defines a novel tumor suppressor pathway and intervention point for future cancer therapeutics....
|
PMID: 20622265
PDF is available here.
PDF is available here.
Abstract
We found that protopanaxatriol ginsenoside Rh1 suppresses NO, ROS, and TNF-alpha production in IFN-gamma-stimulated BV2 microglial cells. Rh1 inhibited the mRNA and protein expression of iNOS and TNF-alpha. To determine the regulatory mechanism of iNOS gene expression by Rh1, promoter analysis was p...
|
PMID: 20510882
PDF is available here.
PDF is available here.
Abstract
We evaluated the therapeutic efficacy of GSNO in experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis. Oral administration of GSNO (0.5 or 1.0 mg/kg) reduced disease progression in chronic models (SJL and C57BL/6) of EAE induced with PLP((139-151)) or MOG((35-55)) p...
|
PMID: 20091246
PDF is available here.
PDF is available here.
Abstract
We have previously reported that IL-27 inhibits human immunodeficiency virus type-1 (HIV-1) replication in CD4(+) T cells and monocyte-derived macrophages, even though IL-12 enhances HIV-1 replication in primary CD4(+) T cells. Further study demonstrates that IL-27 induces antiviral genes including...
|
PMID: 20235668
PDF is available here.
PDF is available here.
Nucleic Acids Research (38)11 2010
Abstract
We generated a catalog containing transcription factors associated with 2720 target genes and 6401 experimentally validated regulations. When it was available, a distinction between transcriptional activation and inhibition was included for each regulation. Next, we built a tool (www.tfacts.org) tha...
|
PMID: 20215436
PDF is available here.
PDF is available here.
Abstract
We knocked down miR-221 and miR-222 expression and found 158 differentially expressed genes with 2-fold changes in U251 glioma cells by microarray analysis. Using the KEGG pathway databases and BioCarta, we found that the IFN-alpha signaling pathway was the most significant pathway modulated by diff...
|
PMID: 20428775
PDF is available here.
PDF is available here.
Phytochemistry (71)7 2010
Abstract
We used a combination of four putative bioactive constituents, called the 4-component-system that interacted synergistically to explain the light-activated anti-inflammatory activity of an H. perforatum fraction in RAW 264.7 mouse macrophages. We also combined the constituents at concentrations dete...
|
PMID: 20303133
PDF is available here.
PDF is available here.
Abstract
Leptin is an autocrine and paracrine factor which affects the development and function of mammary gland. The purpose of this study was to investigate the presence and regulatory effect of leptin in Chinese Guan Zhong dairy goat mammary gland from the virgin state to involution. The protein expressio...
|
PMID: 20181296
PDF is available here.
PDF is available here.
Abstract
We show that chinmo is a cell-autonomous, downstream mediator of Stat92E that shares numerous functions with this protein. Loss of either gene results in malformed eyes and head capsules due to defects in eye progenitor cells. Hyperactivation of Stat92E or misexpression of Chinmo results in blood ce...
|
PMID: 20412771
PDF is available here.
PDF is available here.
Abstract
These results together demonstrated that pUC57-CpG induced partial protective immunity in shrimps against WSSV via intermediation of virus replication indirectly and could be used as a potential candidate in the development of therapeutic agents for disease control of WSSV in L. vannamei....
|
PMID: 19963004
PDF is available here.
PDF is available here.
EMBO Reports (11)3 2010
Abstract
We use transcript profiling of Drosophila haemocyte-like cells to identify JAK/STAT target genes, combined with an in vivo model for JAK-induced blood cell overproliferation, to identify the main effectors required for haematopoietic tumour development. The identified human homologues of the Drosoph...
|
PMID: 20168330
PDF is available here.
PDF is available here.
Abstract
We used a mutant cell line in which both 337Y and 512Y were substituted with phenylalanine (337F512F or FF mutant). In these cells, type I IFN failed to activate STAT1, STAT2, and STAT3 did not induce well-characterized ISGs and did not exert antiviral or antiproliferative effects. Using Oligonucleo...
|
PMID: 20038197
PDF is available here.
PDF is available here.
Abstract
We tested the effect of this cytokine family on the angiopoietin (Ang)-Tie system, which is involved in blood vessel maturation, stabilization, and regression.
Oncostatin M (OSM) increased Ang2 expression in human umbilical vein endothelial cells via Janus kinase/signal transducer an...
|
PMID: 20088942
PDF is available here.
PDF is available here.
Abstract
We tested the effect of this cytokine family on the angiopoietin (Ang)-Tie system, which is involved in blood vessel maturation, stabilization, and regression.
Oncostatin M (OSM) increased Ang2 expression in human umbilical vein endothelial cells via Janus kinase/signal transducer an...
|
PMID: 20088942
PDF is available here.
PDF is available here.
Abstract
We show that clones of cells bearing different mutations can cooperate to promote tumour growth and invasion in Drosophila. We found that the Ras(V12) and scrib(-) mutations can also cause tumours when they affect different adjacent epithelial cells. We show that this interaction between Ras(V12) an...
|
PMID: 20072127
PDF is available here.
PDF is available here.
Abstract
Our aim is to discuss the recent progress of silibinin in regulating multiple anticancer proliferative signaling pathways; the review covers literature mainly from the past 3 - 5 years. WHAT THE READER WILL GAIN: One of the strategies for tumor therapy is eradication of cancer cells through targetin...
|
PMID: 20047507
PDF is available here.
PDF is available here.
Abstract
We have been adapting flow cytometric techniques to measure the levels of expression and activation of signaling molecules within mixed populations containing NK cells and to characterize their differences within NK cell subpopulations. Approaches for evaluating the total levels of the signal transd...
|
PMID: 20033640
PDF is available here.
PDF is available here.
Abstract
We provide evidence for TLR4-dependent functional responses by LPS treated embryonal cardiomyocytes. It will be reported that LPS is able to induce TNF-alpha and NO release from cultured cardiomyocytes, while molecular and morphological evidence demonstrates the expression of TLR4 on surface membran...
|
PMID: 20388086
PDF is available here.
PDF is available here.
Abstract
Increasing evidence support the regulatory role of leptin in osteoarthritis (OA). As high circulating concentrations of leptin disrupt the physiological function of the adipokine in obese individuals, the current study has been undertaken to determine whether the elevated levels of leptin found in t...
|
PMID: 20534145
PDF is available here.
PDF is available here.
Endocrine-Related Cancer (17)2 2010
Abstract
We have hypothesized that in common obesity, high circulating leptin levels might contribute to an increased risk of breast cancer by affecting mammary cell proliferation and survival. Leptin exerts its activity not only through leptin receptor (LepR), but also through crosstalk with other signaling...
|
PMID: 20410173
PDF is available here.
PDF is available here.
Biological Chemistry (391)2-3 2010
Abstract
We show by Western blotting and reporter gene experiments in combination with the application of a specific JAK inhibitor that the human TSLP receptor, in contrast, requires the function of JAK1 and JAK2 for STAT activation. Moreover, we demonstrate that the human TSLPR mediates gene regulation not...
|
PMID: 20128689
PDF is available here.
PDF is available here.
Abstract
We discuss the signature cytokines and their associated STATs involved in the host immune response during cutaneous and visceral leishmaniasis....
|
PMID: 20300429
PDF is available here.
PDF is available here.
Abstract
Probucol is a cholesterol-lowering drug with an anti-proliferative effect. Excessive growth of glomerular mesangial cells and overexpression of transforming growth factor-beta1 (TGF-beta1) and connective tissue growth factor (CTGF) are the pathological features of diabetic nephropathy. In this study...
|
PMID: 20460752
PDF is available here.
PDF is available here.
Veterinary Research (41)1 2010
Abstract
Management of fulminant hepatic failure (FHF) continues to be one challenging problem, and experimental animal models resembling its clinical conditions are still needed. Rabbit hemorrhagic disease (RHD) fullfils many requirements of an animal model of FHF. This work investigated changes in MAPK, NF...
|
PMID: 19726019
PDF is available here.
PDF is available here.
Virology Journal (7)1 2010
Abstract
The sustained virological response to interferon-alpha (IFN-alpha) in individuals infected with hepatitis C virus (HCV) genotype 1 is only 50%, but is about 80% in patients infected with genotype 2-6 viruses. The molecular mechanisms explaining the differences in IFN-alpha responsive...
|
PMID: 20149251
PDF is available here.
PDF is available here.
Cell Cycle (8)24 2009
Abstract
We have studied the effects of high levels of Polyhomeotic (PH) protein, a member of the Polycomb Group (PcG), during the proliferation of the imaginal discs in Drosophila. Overexpression of PH protein causes induction of proliferation, accompanied with induction of JNK-dependent apoptosis. As a res...
|
PMID: 19923887
PDF is available here.
PDF is available here.
Abstract
The discovery of JAK2 mutation has greatly facilitated the approach to diagnosis of myeloproliferative neoplasms besides chronic myeloid leukemia. Since major causes of morbidity and mortality in polycythemia vera (PV) and essential thrombocythemia (ET) are represented by thrombosis, bleeding, progr...
|
PMID: 19860198
PDF is available here.
PDF is available here.
Biochemical Journal (423)1 2009
Abstract
These results indicate that epithelial responses to flagellin are potentiated by IFNgamma, most likely mediated by increased MyD88 expression. The present study adds to our understanding of the spectrum of effects of this cytokine on gut epithelium that may contribute to bacterial-driven inflammatio...
|
PMID: 19619129
PDF is available here.
PDF is available here.
Abstract
Despite the fact that classical Hodgkin lymphoma (HL) has been described more than 170 years ago, only over the last 15 years significant advances regarding its molecular pathogenesis have been achieved. The lack of a specific lineage profile in combination with the low number of the malignant monon...
|
PMID: 19760557
PDF is available here.
PDF is available here.
Abstract
We are using Drosophila follicle cells to study the mechanisms that promote cell motility. Using genetics we identified a gene regulatory network that controls the dynamic pattern of activation of JAK/STAT in anterior follicle cells. Under the influence of a graded signal, Unpaired (UPD), JAK/STAT b...
|
PMID: 19729999
PDF is available here.
PDF is available here.
Abstract
Endocrinology (150)7 2009
Abstract
We examined transcription factors regulated by PRL in the ovary and decidua of mice expressing only PRL-RS in a PRL receptor null background. These mice provide a powerful in vivo model to study the selective signaling mechanism of PRL through PRL-RS independent of PRL-RL. We also examined the regul...
|
PMID: 19342455
PDF is available here.
PDF is available here.
Endocrinology (150)7 2009
Abstract
We hypothesize that COC expansion is dependent on specific sequential changes in cumulus cells. Because IL-6 is a potent mediator of immune responses, we sought to determine what factors regulate the induction of Il6 mRNA in COCs and what impact IL-6 alone would have on COC expansion. We found that...
|
PMID: 19299453
PDF is available here.
PDF is available here.
Abstract
We show that two highly conserved and sequence-identical BMP-responsive elements located at positions -84/-79 (BMP-RE1) and -2,255/-2,250 (BMP-RE2) of the human hepcidin promoter are critical for both the basal hepcidin mRNA expression and the hepcidin response to BMP-2 and BMP-6. While BMP-RE1 and...
|
PMID: 19229506
PDF is available here.
PDF is available here.
Biochemical Journal (419)3 2009
Abstract
We demonstrated that PGLRs reside on the cell surface of astroglial cells from fetal rat brain [Nagatsuka, Horibata, Yamazaki, Kinoshita, Shinoda, Hashikawa, Koshino, Nakamura and Hirabayashi (2006) Biochemistry 45, 8742-8750]. In the present study, we observed PGLRs in astroglial lineage cells at m...
|
PMID: 19170657
PDF is available here.
PDF is available here.
International Journal of Cancer (124)10 2009
Abstract
We examined the direct tumor-killing activity of inactivated Sendai virus particle [hemagglutinating virus of Japan envelope (HVJ-E)] through induction of Type I interferon (IFN) in the hormone-resistant human prostate cancer cell lines PC3 and DU145. Preferential binding of HVJ-E to PC3 and DU145 o...
|
PMID: 19173282
PDF is available here.
PDF is available here.
Abstract
We have analyzed the molecular mechanisms of synergy in TLR ligand-stimulated human monocyte-derived macrophages and dendritic cells (moDCs). Stimulation of moDCs with the TLR8 ligand together with the TLR3 or TLR4 ligand led to synergistic IL-6, IL-10, IL-12, and TNF-alpha mRNA expression and cytok...
|
PMID: 19164128
PDF is available here.
PDF is available here.
Abstract
Recently, our understanding of helper/effector T cell differentiation has changed significantly. New subsets of T cells continue to be recognized, including Th17, Treg, and Th9 cells. In addition, the signaling pathways that contribute to their generation continue to be refined. It has become clear...
|
PMID: 19362457
PDF is available here.
PDF is available here.
Nature Immunology (10)4 2009
Abstract
An important function of receptors that signal through immunoreceptor tyrosine-based activation motifs (ITAMs) is to regulate signaling by heterologous receptors. This review describes mechanisms by which ITAM-associated receptors modulate signaling by Toll-like receptors (TLRs), tum...
|
PMID: 19295630
PDF is available here.
PDF is available here.
Nature Immunology (10)4 2009
Abstract
We review the current understanding of how cytokine signaling regulates the functions of other signaling pathways by first discussing the 'traditional' transcription-mediated consequences of cytokine signaling and then providing a detailed description of transcription-independent lateral communicati...
|
PMID: 19295629
PDF is available here.
PDF is available here.
Abstract
Cytokines are critical coordinators of the immune response necessary for resolving bacterial and viral assaults on the immune system. In particular, the IL-12 family of cytokines are key players in the regulation of T cell responses. These responses are orchestrated by monocytes, macrophages, and de...
|
PMID: 19275692
PDF is available here.
PDF is available here.
Abstract
We have previously shown the treatment of cells with chelators which preferentially bind iron inhibits IFNgamma-mediated induction of IFN regulatory factor 1 in endothelial cells. To define the mechanisms mediating inhibition of IFNgamma-induced genes, we examined IFNgamma-induced signaling pathways...
|
PMID: 18787531
PDF is available here.
PDF is available here.
Hepatology (49)3 2009
Abstract
We investigated the noncytolytic anti-HCV activity of primary CD56(+) T cells in human hepatocytes. When HCV Japanese fulminant hepatitis-1 (JFH-1)-infected hepatocytes were co-cultured with CD56(+) T cells or incubated in media conditioned with CD56(+) T cell culture supernatants (SN), HCV infectiv...
|
PMID: 19085952
PDF is available here.
PDF is available here.
Cell Host & Microbe (5)2 2009
Abstract
Our data suggest that gut homeostasis is maintained through a balance between cell damage due to the collateral effects of bacteria killing and epithelial repair by stem cell division. The Drosophila gut provides a powerful model to study the integration of stress and immunity with pathways associat...
|
PMID: 19218090
PDF is available here.
PDF is available here.
Journal of Neuroimmunology (206)1-2 2009
Abstract
We compared the effects of interferon-gamma and interferon-beta on the proliferation and differentiation of adult murine neural progenitors. Both interferons inhibited neurosphere proliferation due to cell cycle arrest in G1 but only interferon-gamma induced neuronal differentiation. Both interferon...
|
PMID: 19027965
PDF is available here.
PDF is available here.
Srpski arhiv za celokupno lekarstvo (137)1-2 2009
Abstract
Signal transducers and activators of transcription (STAT) proteins are a 7-member family of cytoplasmic transcription factors that participate in signal transduction by cytokines, hormones, and growth factors. STAT proteins control the most important cellular processes, including survival, prolifera...
|
PMID: 19370975
PDF is available here.
PDF is available here.
Abstract
Hodgkin and Reed-Sternberg (HRS) cells in classical Hodgkin lymphoma (HL) and lymphocytic and histiocytic (L&H) cells in nodular lymphocyte-predominant HL (NLPHL) are derived from germinal-center B cells. HRS cells have, however, largely lost their B cell phenotype and aberrantly express markers and...
|
PMID: 19400691
PDF is available here.
PDF is available here.
Abstract
Here we use a high-level narrative language in designing a computational model of the gp130/JAK/STAT signalling pathway and show that the model reproduces the dynamic behaviour of the pathway derived by biological observation. We then "experiment" on the model by simulation and sensitivity analysis...
|
PMID: 19368721
PDF is available here.
PDF is available here.
BMC Bioinformatics (10 Suppl 1)suppl 1 2009
Abstract
We have performed modeling and simulation studies of the JAK/STAT pathway, including the kinetics of two associated receptors (the erythropoietin receptor and thrombopoietin receptor) with the wild type and a recently reported mutation (JAK2V617F) of the JAK2 protein. CONCLUSION: We found that the d...
|
PMID: 19208156
PDF is available here.
PDF is available here.
BMC Genomics (10)1 2009
Abstract
We used DNA microarrays and meta-analysis to study how the presence of calcified plaque modifies human coronary and carotid gene expression. We identified a series of potential human atherogenic genes that are integrated in functional networks involved in atherosclerosis. Caveolae and JAK/STAT pathw...
|
PMID: 19134193
PDF is available here.
PDF is available here.
BioFactors (35)1 2009
Abstract
We will address IGF-I receptor signaling through the JAK/STAT pathway in IGF-I signaling and the role of cytokine-induced inhibitors of signaling (CIS) and suppressors of cytokine signaling (SOCS). It appears that, in addition to the canonical IGF-I signaling pathways through extracellular-regulated...
|
PMID: 19319849
PDF is available here.
PDF is available here.
Abstract
SH2 domains are modular components of a wide range of functionally diverse proteins involved in mammalian signal transduction including enzymes, adaptors, regulators and transcription factors. Members of the SH2 domain family recognize a wide variety of short tyrosine phosphorylated peptide motifs....
|
PMID: 19273114
PDF is available here.
PDF is available here.
Abstract
We established a culture of neurospheres derived from the embryonic forebrain of the Dab1(-/-) mice, yotari. Differentiating Dab1(-/-) neurospheres exhibited a higher expression of GFAP, an astrocytic marker, at the expense of neuronal markers. Under Dab1-deficient condition, the expression of Neuro...
|
PMID: 18848628
PDF is available here.
PDF is available here.