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T-Box Domain Proteins (0):
Recent article
T-Box Domain Proteins
Abstract
We selected gelatin as ECM (extracellular matrix) to support differentiation of mES (mouse embryonic stem) cells into TE (trophectoderm), as gelatin was less expensive and widely used. We found that 0.2% and 1.5% gelatin were the suitable concentrations to induce TE differentiation by means of detec...
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PMID: 21091439
PDF is available here.
PDF is available here.
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Abstract
We describe the use of computer-controllable suspension bioreactors to form EBs in an automated and highly reproducible process and their subsequent differentiation along the osteoblast lineage. The development of the differentiating cells taken from bioreactor EBs to EBs formed in static control cu...
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PMID: 21042990
PDF is available here.
PDF is available here.
Neural Development (6)1 2011
Abstract
We studied the temporal generation and diversity of Neurog2-positive precursor progeny using an inducible genetic fate mapping approach. We show that all subtypes of glutamatergic neurons derive from Neurog2 positive progenitors during development of the OB. Projection neurons, that is, mitral and t...
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PMID: 21466690
PDF is available here.
PDF is available here.
Abstract
We examined piebald, a pigmentation phenotype in both human and Merino sheep, by analysing multiple data types using a systems approach. First, a case control analysis of 49,034 ovine SNP was performed which confirmed a multigenic basis for the condition. We combined these results with gene expressi...
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PMID: 21701676
PDF is available here.
PDF is available here.
Development (137)22 2010
Abstract
We identify in the mouse a subpopulation of the first (crescent-forming) field marked by endothelin receptor type A (Ednra) gene expression, which contributes to chamber myocardium through a unique type of cell behavior. Ednra-lacZ/EGFP-expressing cells arise in the ventrocaudal inflow region of the...
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PMID: 20929948
PDF is available here.
PDF is available here.
Cell Host & Microbe (8)3 2010
Abstract
We characterized the fecal microbial communities in the recently described T-bet(-/-) ×Rag2(-/-) ulcerative colitis (TRUC) model driven by T-bet deficiency in the innate immune system. 16S rRNA-based analysis of TRUC and Rag2(-/-) mice revealed distinctive communities that correlate with host genot...
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PMID: 20833380
PDF is available here.
PDF is available here.
Abstract
We showed that TCF-1 deficiency limited proliferation of CD8(+) effector T cells and impaired their differentiation toward a central memory phenotype. Moreover, TCF-1-deficient memory CD8(+) T cells were progressively lost over time, exhibiting reduced expression of the antiapoptotic molecule Bcl-2...
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PMID: 20727791
PDF is available here.
PDF is available here.
Abstract
We have now examined the role of GPx1 in the activation, differentiation, and functions of CD4(+) T helper (Th) cells. TCR stimulation increased the intracellular ROS concentration in Th cells in a time-dependent manner, and such TCR-induced ROS generation was found to promote cell proliferation. GP...
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PMID: 20367278
PDF is available here.
PDF is available here.
Genes & Development (24)16 2010
Abstract
We show that Tbr2-positive cortical intermediate (basal) neuronal progenitors (INPs) dictate the migratory route and control the amount of subpallial GABAergic interneurons in the subventricular zone (SVZ) through a non-cell-autonomous mechanism. In fact, Tbr2 interneuron attractive activity is mode...
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PMID: 20713522
PDF is available here.
PDF is available here.
Abstract
We report that a combination of three developmental transcription factors (i.e., Gata4, Mef2c, and Tbx5) rapidly and efficiently reprogrammed postnatal cardiac or dermal fibroblasts directly into differentiated cardiomyocyte-like cells. Induced cardiomyocytes expressed cardiac-specific markers, had...
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PMID: 20691899
PDF is available here.
PDF is available here.
Abstract
Circulation Research (106)12 2010
Abstract
We aim to identify the signaling molecules and transcription factors that regulate PE specification.
Here, we present the first genetic evidence that bone morphogenetic protein (Bmp) signaling in conjunction with the T-box transcription factor Tbx5a is essential for PE specification...
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PMID: 20413782
PDF is available here.
PDF is available here.
Circulation Research (106)12 2010
Abstract
Abstract
Cardiovascular anomalies are present in 80% of neonates with 22q11.2 deletion syndrome. Three genes in chromosome 22q11.2 (TBX1, CRKL, and ERK2) have been identified whose haploinsufficiency causes dysfunction of the neural crest cell and anterior heart field and anomalies of 22q11.2 deletion syndro...
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PMID: 20494672
PDF is available here.
PDF is available here.
Abstract
We investigated the effect of all-trans retinoic acid on trinitrobenzene sulfonic acid (TNBS)-induced murine colitis, and the possible mechanism. Mice were intraperitoneally treated daily with all-trans retinoic acid (the agonist of RAR-alpha) or LE135 (the antagonist of RAR-alpha) or medium, and sa...
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PMID: 20187766
PDF is available here.
PDF is available here.
Abstract
We show that mesoderm specific deletion of Tbx1, a T-box transcription factor and gene for velo-cardio-facial/DiGeorge syndrome, results in defects in formation of the proximal mandible by shifting expression of Fgf8, Bmp4 and their downstream effector genes in mouse embryos at E10.5. This occurs wi...
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PMID: 20501333
PDF is available here.
PDF is available here.
Journal of Neuroscience (30)20 2010
Abstract
We use in utero electroporation and genetic fate mapping to show that SNPs and RGCs cohabit the VZ but display different cell cycle kinetics and generate phenotypically different progeny. In addition, we find that RGC progeny undergo additional rounds of cell division as intermediate progenitor cell...
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PMID: 20484645
PDF is available here.
PDF is available here.
Chinese Medical Journal (123)9 2010
Abstract
Tbx1 might play an essential role in the development of pharyngeal neural crest cells in zebrafish. Cardiac performance is impaired by Tbx1 knock down in zebrafish....
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PMID: 20529560
PDF is available here.
PDF is available here.
Nature Neuroscience (13)5 2010
Abstract
We show that Magoh, a component of the exon junction complex (EJC) that binds RNA, controls mouse cerebral cortical size by regulating NSC division. Magoh haploinsufficiency causes microcephaly because of INP depletion and neuronal apoptosis. Defective mitosis underlies these phenotypes, as depletio...
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PMID: 20364144
PDF is available here.
PDF is available here.
Abstract
The frequency of both the -1993T and the -1514T allele were significantly higher in SLE patients than in controls. By haplotype analysis, there was significantly decreased frequency of the haplotype at positions -1993C/-1514C in the case group compared with the control group (p = 0.0002). Multifacto...
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PMID: 20429676
PDF is available here.
PDF is available here.
Abstract
230 patients with ToF were studied by karyotyping, comprehensive 22q11.2 deletion testing and sequencing of TBX1, NKX2.5 and JAG1, as well as molecular karyotyping in selected patients. Pathogenic genetic aberrations were found in 42 patients (18%), with 22q11.2 deletion as the most common diagnosis...
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PMID: 19948535
PDF is available here.
PDF is available here.
Abstract
The single SNP analysis showed allele frequency of rs2289292 (exon 8, the only tagging SNP) and rs3809624 (5' untranslated region) demonstrated significant difference between CS cases and controls (P = 0.017 and P = 0.033). No SNP was found to be correlated with clinical phenotype. Moreover, the 2 m...
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PMID: 20228709
PDF is available here.
PDF is available here.
Abstract
Through the variation of the levels of gene and protein, our study showed that IL-18 and IL-18Ralpha might upregulate the expression of Th1-cytokines in ITP patients. It is also suggested that IL-18 has potential association with the development of ITP. Especially, it may provide a new treatment met...
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PMID: 20627039
PDF is available here.
PDF is available here.
Abstract
We found a novel mutation in a highly conserved residue in the T-box DNA binding domain (I121M) segregating with CHD in a three generation kindred. Four mutation carriers revealed cardiac phenotypes in terms of cribriform ASDII, large patent foramen ovale or cardiac valve defects. Interestingly, ter...
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PMID: 19762328
PDF is available here.
PDF is available here.
Genome Research (20)4 2010
Abstract
We used chromatin immunoprecipitation with DNA microarray hybridization (ChIP-chip) analysis to investigate targets of the TFs-TCFAP2C, EOMES, ETS2, and GATA3-and a chromatin remodeling factor, SMARCA4. We then evaluated the transcriptional states of target genes using transcriptome analysis and gen...
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PMID: 20176728
PDF is available here.
PDF is available here.
Psychiatry Research (175)3 2010
Abstract
We measured platelet activation in 104 patients with stable CHD, including 58 with a current episode of major depression and 46 without past or current major depression. Participants were instructed not to take aspirin for 7 days prior to the study appointment. Platelet activation was measured by pl...
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PMID: 20034674
PDF is available here.
PDF is available here.
Abstract
We term OSK) constitutes the minimal requirement for generating iPS cells from mouse embryonic fibroblasts. These cells are thought to resemble embryonic stem cells (ESCs) on the basis of global gene expression analyses; however, few studies have tested the ability and efficiency of iPS cells to con...
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PMID: 20139965
PDF is available here.
PDF is available here.
Abstract
We review the features of novel IHC marker antibodies applicable to selected nonglial tumors in the nervous system, based on recently published reports and our own experiences. We discuss (1) aquaporin-1 and alpha-inhibin for hemangioblastoma, (2) beta-catenin for craniopharyngioma, (3) brachyury fo...
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PMID: 20179436
PDF is available here.
PDF is available here.
Abstract
We demonstrate that interleukin-12 (IL-12) enhanced and sustained antigen and costimulatory molecule (B7.1)-induced mTOR kinase activity in naive CD8+ (OT-I) T cells via phosphoinositide 3-kinase and STAT4 transcription factor pathways. Blocking mTOR activity by rapamycin reversed IL-12-induced effe...
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PMID: 20060330
PDF is available here.
PDF is available here.
Null mutations in Drosophila Optomotor-blind affect T-domain residues conserved in all Tbx proteins.
Abstract
We have isolated and molecularly characterized four new omb mutations, three of them are missense mutations of amino acids fully conserved in all Tbx proteins. We interpret the functional defects in the framework of the known structure of the human TBX3 protein and provide evidence for loss of Omb D...
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PMID: 20033428
PDF is available here.
PDF is available here.
Abstract
This comprehensive SNP discovery data can be used to select SNPs to genotype for future association studies assessing the role of TBX1 and phenotypic variability in individuals with 22q11.2DS.
Copyright 2009 Wiley-Liss, Inc....
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PMID: 19645056
PDF is available here.
PDF is available here.
Abstract
This editorial addresses the debate concerning the origin of adult nucleus pulposus cells in the light of profiling studies by Minogue and colleagues. In their report of several marker genes that distinguish nucleus pulposus cells from other related cell types, the authors provide novel insights int...
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PMID: 20497604
PDF is available here.
PDF is available here.
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology (26)1 2010
Abstract
After two series of transfection, the siRNA-FAM(+) cells were about 50% in the transfected cells. The IFN-gamma(+) cells in CD4(+) T cells (50.20%) decreased in the cells transfected with T-bet siRNA (18.46%) but no obvious decrease was observed in the cells transfected with Eomes siRNA, whereas the...
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PMID: 20056084
PDF is available here.
PDF is available here.
Abstract
The high expression of T-bet and IFN-gamma and the low expression of GATA3 and IL-4 indicate the existence of Th1 polarization in children with acute ITP. This might be related to the regulation of T-bet and GATA3....
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PMID: 20113630
PDF is available here.
PDF is available here.
Abstract
We have recently demonstrated that immunization with Salmonella enterica Typhimurium expressing the VapA antigen protects mice against R. equi infection. We now report that oral vaccination of mice with this recombinant strain results in high and persistent fecal levels of antigen-specific IgA, and...
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PMID: 20072623
PDF is available here.
PDF is available here.
Science Signaling (3)127 2010
Abstract
We show that a key function of the developmentally essential Nodal-Smads2/3 (Smad2 and Smad3) signaling pathway is to recruit the histone demethylase Jmjd3 to target genes, thereby counteracting repression by Polycomb. Smads2/3 bound to Jmjd3 and recruited it to chromatin in a manner that was depend...
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PMID: 20571128
PDF is available here.
PDF is available here.
Nature Genetics (41)11 2009
Abstract
We identified unique duplications of a region on 6q27 in four multiplex families with at least three cases of chordoma, a cancer of presumed notochordal origin. The duplicated region contains only the T (brachyury) gene, which is important in notochord development and is expressed in most sporadic c...
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PMID: 19801981
PDF is available here.
PDF is available here.
Oncology Reports (22)5 2009
Abstract
We attempted to clarify the immunological status of SNs with or without micrometastasis in breast cancer patients. SNs were identified by the dye- and gamma probe-guided method. Total RNA was extracted from the SNs, and the expression of T-BET, GATA-3, and FOXP3 were evaluated using quantitative rea...
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PMID: 19787238
PDF is available here.
PDF is available here.
Human Molecular Genetics (18)21 2009
Abstract
We report a Tbx22(null) mouse, which has a submucous cleft palate (SMCP) and ankyloglossia, similar to the human phenotype, with a small minority showing overt clefts. We also find persistent oro-nasal membranes or, in some mice a partial rupture, resulting in choanal atresia. Each of these defects...
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PMID: 19648291
PDF is available here.
PDF is available here.
Journal of Immunology (183)8 2009
Abstract
We show that IL-27 had surprisingly little effect on committed Th17 cells, despite its expression of a functional IL-27R. Contrary to de novo differentiation of Th17 cells, IL-27 did not suppress expression of retinoid-related orphan receptor (ROR)gammat or RORalpha in committed Th17 cells. Consiste...
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PMID: 19786534
PDF is available here.
PDF is available here.
Leukemia & Lymphoma (50)10 2009
Abstract
We demonstrated that HCL cells highly express the transcription factor T-box-expressed-in-T-cells (T-bet). T-bet is the master regulator of the T-helper (Th)1 cell response regulating interferon gamma (IFN-gamma) production and also plays a central role in the T-cell independent Th1-like B-cell resp...
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PMID: 19757302
PDF is available here.
PDF is available here.
Abstract
To investigate the role of transcription factors T-bet and GATA-3 in the pathogenesis of systemic lupus erythematosus (SLE).
The expression of T-bet and GATA-3 mRNA in the peripheral blood mononuclear cells (PBMCs) of 60 patients with SLE and 20 normal control subject...
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PMID: 19861286
PDF is available here.
PDF is available here.
Journal of Neuroscience (29)30 2009
Abstract
Expression of cyclins D1 (cD1) and D2 (cD2) in ventricular zone and subventricular zone (SVZ), respectively, suggests that a switch to cD2 could be a requisite step in the generation of cortical intermediate progenitor cells (IPCs). However, direct evidence is lacking. Here, cD1 or cD2 was seen to c...
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PMID: 19641124
PDF is available here.
PDF is available here.
Journal of Immunology (183)3 2009
Abstract
We show here that programming involves regulation of a common set of approximately 355 genes including T-bet and eomesodermin. Much of the gene regulation program is initiated in response to Ag and costimulation within 24 h but is then extinguished unless a cytokine signal is available. Histone deac...
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PMID: 19592655
PDF is available here.
PDF is available here.
Development (136)15 2009
Abstract
We demonstrate that a distal enhancer for the connexin 30.2 (Cx30.2, also known as Gjd3) gene, which encodes a gap junction protein required for normal atrioventricular (AV) delay in mice, is necessary and sufficient to direct expression to the developing AV conduction system (AVCS). Moreover, we sh...
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PMID: 19592579
PDF is available here.
PDF is available here.
Abstract
We confirmed the upregulation of the chemokine receptor CXCR3 on KLF2-deficient T cells. However, we showed that this was a cell-nonautonomous effect, as revealed by CXCR3 upregulation on wild-type bystander cells in mixed bone-marrow chimeras with KLF2-deficient cells. Furthermore, KLF2-deficient T...
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PMID: 19592277
PDF is available here.
PDF is available here.
Journal of Immunology (183)1 2009
Abstract
We report that Tbx21 deficiency in the NOD mouse completely blocks insulitis and diabetes due to defects both in the initiation of the anti-islet immune response and in the function of CD4(+) effector T cells. We find defective priming of naive islet-reactive T cells by the innate immune system in T...
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PMID: 19535634
PDF is available here.
PDF is available here.
Journal of Immunology (183)1 2009
Abstract
In contrast to CD4 T cells, CD8 T cells inherently differentiate into IFN-gamma-producing effectors. Accordingly, while generation of IFN-gamma-producing Th1 CD4 T cells was profoundly impaired in mice deficient for both type-I IFN and IL-12 signaling in response to infection with Listeria monocytog...
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PMID: 19542449
PDF is available here.
PDF is available here.
Abstract
These results suggest that a shift toward the Th1 pathway of Th cell activation occurs in MsPGN patients, and that sinomenine has the potential to counter this shift in the Th1/Th2 balance and thereby produce therapeutic effects....
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PMID: 19336263
PDF is available here.
PDF is available here.
Developmental Biology (331)1 2009
Abstract
The Hedgehog (Hh) signaling pathway is essential for patterning many structures in vertebrates including the nervous system, chordamesoderm, limb and endodermal organs. In the sea urchin, a basal deuterostome, Hh signaling is shown to participate in organizing the mesoderm. At gastru...
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PMID: 19393640
PDF is available here.
PDF is available here.
Clinical Nephrology (71)6 2009
Abstract
This study is the first to reveal increased mRNA expression levels of GATA-3 and Stat5A in PBMC from MCNS patients in nephrosis. This study also supports recent findings suggesting the role of IL-13 in the development of MCNS. A predominant Th2 type of T cell activation may be involved in the pathog...
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PMID: 19473628
PDF is available here.
PDF is available here.
Journal of Immunology (182)10 2009
Abstract
We used a murine model of Trypanosoma cruzi infection, a protozoan parasite that causes Chagas disease in humans. Infection of Tbx21(-/-) mice led to normal, unimpaired development of Ag-specific CD4(+) T cells producing IFN-gamma. However, a robust Th17 response developed concomitant with Th1 respo...
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PMID: 19414771
PDF is available here.
PDF is available here.
Journal of Immunology (182)10 2009
Abstract
IL-10 production by Th17 cells is critical for limiting autoimmunity and inflammatory responses. Gene array analysis on Stat6 and T-bet double-deficient Th17 cells identified the Th2 transcription factor c-Maf to be synergistically up-regulated by IL-6 plus TGFbeta and associated with Th17 IL-10 pro...
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PMID: 19414776
PDF is available here.
PDF is available here.
Cancer Letters (278)2 2009
Abstract
We used SW13 carcinoma cells which express inactive p53 and have no detectable p16 or p21 CDK-inhibitors as a model to study these functions. Expression of TBX2 in SW13 cells had no effect on the cell cycle but promoted anchorage-independence and increased resistance to apoptotic stimuli including U...
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PMID: 19216023
PDF is available here.
PDF is available here.
Distinguishing chordoid meningiomas from their histologic mimics: an immunohistochemical evaluation.
Abstract
Our findings demonstrate that in conjunction with clinical and radiographic findings, immunohistochemical evaluation with a panel of D2-40, EMA, brachyury, and GFAP is most useful in distinguishing chordoid meningioma from chordoid glioma, skeletal myxoid chondrosarcoma, extraskeletal myxoid chondro...
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PMID: 19194275
PDF is available here.
PDF is available here.
Abstract
We describe methods for the clonal expansion of engineered hESCs and make available a suite of lentiviral vectors for that combine Blasticidin, Neomycin and Puromycin resistance based drug selection of pure populations of stem cells and cardiomyocytes with ubiquitous or lineage-specific promoters th...
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PMID: 19352491
PDF is available here.
PDF is available here.
Hereditas (Beijing) (31)4 2009
Abstract
These results indicates that the down expression of TBX5 might not be caused by mutation and methylation in the 1 200 bp region upstream of gene, and might be regulated by abnormal expression of NKX2-5 gene in heart muscle of CHD....
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PMID: 19586889
PDF is available here.
PDF is available here.
Abstract
We have used proteomic tools to look at all the major proteins involved in the TBX1-mediated pathways in an attempt to better understand the molecular interactions instrumental to its cellular functions. We found more than 90 proteins that could be targeted by TBX1 through different mechanisms. The...
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PMID: 19178302
PDF is available here.
PDF is available here.
Abstract
Expression of T-bet mRNA in esophageal cancer patients (stage I and II: 0.27 +/- 0.05 ng/L, stage III and IV: 0.12 +/- 0.02 ng/L) was significantly lower than that in the healthy controls (1.35 +/- 0.14 ng/L), but the expression of GATA-3 mRNA in esophageal cancer patients (stage I and II: 0.45 +/-...
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PMID: 19615257
PDF is available here.
PDF is available here.
Hepatology (49)3 2009
Abstract
We show that in the mouse the transcriptional repressor Tbx3, a member of the T-box protein family, is required for the transition from a hepatic diverticulum with a pseudo-stratified epithelium to a cell-emergent liver bud. In Tbx3-deficient embryos, proliferation in the hepatic epithelium is sever...
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PMID: 19140222
PDF is available here.
PDF is available here.