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Anal Gland Neoplasms (0):
Recent article
Anal Gland Neoplasms
Abstract
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Veterinary Pathology (46)4 2009
Abstract
A retrospective study was performed to characterize 64 cases of anal sac gland carcinoma (ASGC) in cats. All ASGCs diagnosed between 1995 and 2007 at a private diagnostic laboratory in the UK were reviewed. Apocrine gland origin was confirmed in a subset of these tumors by immunohistochemistry and t...
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PMID: 19276061
PDF is available here.
PDF is available here.
Abstract
Stained cytological specimens from 7 canine anal sac gland adenomas and 11 canine anal sac gland carcinomas were analyzed by computer-assisted nuclear morphometry. In each case, the nuclei of at least 100 neoplastic cells were measured, and the mean nuclear area (MNA), mean nuclear perimeter (MNP),...
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PMID: 18457852
PDF is available here.
PDF is available here.
Veterinary Record (163)20 2008
Abstract
Abstract
These results indicate that MNA, MNP, D max and D min may be used as prognostic indicators for canine perianal adenocarcinoma....
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PMID: 18822421
PDF is available here.
PDF is available here.
Abstract
A seven-year-old, neutered male ferret was referred to our hospital with two perianal masses (2.4x3.0 and 2.4x3.5 cm, respectively) that had recurred after initial surgical excision. Complete resection of the masses was impossible as there was deep invasion along the rectum. On histopathology, the m...
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PMID: 18631226
PDF is available here.
PDF is available here.
Abstract
We describe the successful treatment of an incompletely excised ASGC by using cisplatin selectively driven within the tumor cells by trains of biphasic pulses. The dog received two courses of electrochemotherapy 14 days apart. Neither systemic nor local toxicities were detected during the whole cour...
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PMID: 18396781
PDF is available here.
PDF is available here.
Abstract
We describe the outcome of a small cohort of canine patients with perianal tumors treated with bleomycin selectively driven by trains of biphasic pulses (electrochemotherapy). Twelve canine patients, eight with adenoma and four with carcinoma of the perianal glands, entered the study and received tw...
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PMID: 18365542
PDF is available here.
PDF is available here.
Veterinary Record (160)7 2007
Abstract
Veterinary Pathology (43)6 2006
Abstract
A perianal mass in a 15-year-old domestic shorthair cat with a history of a firm, painful swelling in the left ventrolateral perianal region was surgically excised and submitted for light microscopic evaluation. Histologically, this was a poorly demarcated, unencapsulated, multilobulated neoplasm th...
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PMID: 17099161
PDF is available here.
PDF is available here.
Abstract
These results demonstrate that increased AR expression is maintained throughout perianal gland cancer progression and that hepatoid gland carcinomas still express AR. Although further studies may be required to evaluate the hormonal background of these diseases, dogs bearing those carcinomas might b...
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PMID: 16427103
PDF is available here.
PDF is available here.
Abstract
Veterinary Surgery (35)3 2006
Abstract
No surgical complications occurred. Three dogs were euthanatized; median survival, 20.6 months. One dog was alive for 19 months postoperatively. One dog had 5 sequential surgical procedures: 1 iliac lymphadenectomy and 4 debulking procedures of metastatic neoplastic tissue around and dorsal to the i...
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PMID: 16635006
PDF is available here.
PDF is available here.
Abstract
This study was conducted to distinguish canine perianal gland carcinomas from adenomas using monoclonal antibodies (MAbs). The adenomas generally retain the lobular architecture, but some may contain focal areas of cellular pleomorphism. These changes may suggest malignant transformation and have le...
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PMID: 16475876
PDF is available here.
PDF is available here.
Abstract
A retrospective study of anal sac tumours without pulmonary metastases, from the author's clinical records for the period July 1989 to July 2002, was conducted to establish the response to treatment with surgery and melphalan chemotherapy. Of 21 dogs with tumours of the anal sacs 19 had apocrine gla...
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PMID: 15986909
PDF is available here.
PDF is available here.
Abstract
These results suggest that increased expression of Mdm2 is an early event in circumanal gland tumorigenesis, and may be present in the absence of nuclear p53 protein accumulation....
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PMID: 15629477
PDF is available here.
PDF is available here.
Anticancer Research (25)2A 2005
Abstract
Responses to treatment were assessed 4 weeks after the therapy; 82% of all tumors treated with electrochemotherapy responded with objective response (OR) (complete response (CR)=41%, partial response (PR)=41%), 16% responded with no change (NC) and 1 tumor (2%) went to progressive disease (PD). At t...
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PMID: 15868917
PDF is available here.
PDF is available here.
Abstract
A 4-year old, female spayed terrier was referred for hind end paresis that rapidly progressed to paralysis. Spinal radiographs revealed vertebral collapse and bony lysis. Myelography confirmed spinal cord compression and surgical exploration found an extradural soft tissue mass. Metastatic anal sac...
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PMID: 15368742
PDF is available here.
PDF is available here.
Abstract
The aim of this study was to detect immunohistochemically means growth hormone (GH) in 24 hepatoid gland adenomas and 5 hepatoid gland carcinomas and to compare the difference of immunoreactivity between types of tumors. The tumors were classified according to the WHO standards. Tissue sections whic...
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PMID: 15187372
PDF is available here.
PDF is available here.
Abstract
Sixty-one medial iliac lymph nodes of 38 different dogs (eight with adenocarcinoma of the apocrine glands of the anal sac, 13 with multicentric lymphoma, six with multicentric lymphoma but in clinical remission, and 11 control dogs) were evaluated to assess the ability of ultrasound to identify and...
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PMID: 15072149
PDF is available here.
PDF is available here.
Abstract
A 13-year-old dog was diagnosed with hypercalcemia of malignancy associated with adenocarcinoma of the anal sacs. Hypercalcemia was treated with intravenous (IV) 0.9% sodium chloride (NaCl), furosemide, calcitonin, and pamidronate. Hypomagnesemia was documented by 72 hours following a single, IV dos...
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PMID: 14736909
PDF is available here.
PDF is available here.
Abstract
Sex distribution was approximately equal (54% female, 46% male). One hundred four dogs underwent treatment consisting of surgery, radiation therapy, chemotherapy, or multimodal treatment. Median survival for treated dogs was 544 days (range, 0 to 1,873 days). Dogs treated with chemotherapy alone had...
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PMID: 14507100
PDF is available here.
PDF is available here.
Veterinary Pathology (40)3 2003
Abstract
Tumors of the perianal area of dogs are common and include multiple tumor types. Whereas perianal adenomas occur often, adenocarcinomas of the apocrine glands of the anal sac occur less frequently. A review of the literature revealed no reports of squamous cell carcinomas arising from the epithelial...
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PMID: 12724576
PDF is available here.
PDF is available here.
Abstract
Palliative radiation therapy may provide significant relief in symptoms in pets with incurable cancer. Therapy is applied over a short period of time, using larger than normal fractional doses. Palliative radiation leads to minimal or no side effects. This case report describes the situation of a mi...
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PMID: 12649955
PDF is available here.
PDF is available here.
Abstract
A 12-year-old male neutered Siamese cat presented with a history of inappetance and lethargy and an enlarged left anal sac. The anal sac was surgically excised and histopathology confirmed the diagnosis of anal sac adenocarcinoma. Perianal tumours are rare in the cat and anal sac adenocarcinoma has...
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PMID: 12468314
PDF is available here.
PDF is available here.
Abstract
We conclude that platinum chemotherapy has antitumor activity in canine apocrine gland carcinoma and that further study of these agents is warranted....
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PMID: 11822797
PDF is available here.
PDF is available here.
Abstract
A 13-year-old castrated male Bassett Hound was examined because of a 2-week history of severe constipation and tenesmus. Radiography revealed a large cystic mass in the caudal portion of the abdomen that was compressing the urethra and obstructing the pelvic canal. A small perianal mass was also not...
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PMID: 11767923
PDF is available here.
PDF is available here.
Anticancer Research (20)5A 2000
Abstract
This improved system is a sensitive and rather precise method for quantifying the AgNOR and PCNA. It provides a valuable objective measurement for differentiating benign and malignant tumors....
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PMID: 11062753
PDF is available here.
PDF is available here.
Oncology (Williston Park, N.Y.) (13)10 Suppl 5 1999
Abstract
Combined-modality therapy, including irradiation and concurrently administered chemotherapy, has become the mainstay of therapy for anal and rectal cancers. Several important lessons have been learned from clinical trials over the last several decades. Simultaneous delivery of large (bolus) doses of...
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PMID: 10550837
PDF is available here.
PDF is available here.
Abstract
Abstract
We present three different clinical types of verrucous carcinoma. The first patient presented with an anogenital verrucous carcinoma, also known as Buschke-Loewenstein tumour. The second patient had verrucous carcinoma of the heel with endophytic growth (i.e. epithelioma cuniculatum) and the third p...
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PMID: 9838724
PDF is available here.
PDF is available here.
Dermatologic Surgery (23)11 1997
Abstract
In the resected specimen of the rectal adenocarcinoma, Paget cells were present within the anal epidermis adjacent to the rectal adenocarcinoma. The Paget cells showed the same histochemical and immunohistological findings as the adenocarcinoma cells. CONCLUSION: There was a close relationship betwe...
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PMID: 9391559
PDF is available here.
PDF is available here.
Abstract
A patient with hidradenitis suppurativa (HS) is described in association with Dowling Degos disease and perianal squamous cell carcinomas. As the initial treatment for HS failed to give any satisfactory relief he sought no further medical help for the subsequent 40 years. This patient illustrates th...
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PMID: 9431718
PDF is available here.
PDF is available here.
Abstract
Survival of patients with PPD treated by WLE was higher than that for those treated with LE. Thus, wide local excision is recommended over limited local excision as a preferred treatment for PPD. Follow-up longer than 5 years seems to be indicated because of the risk of late progression to invasive...
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PMID: 9309336
PDF is available here.
PDF is available here.
Abstract
Highly conserved regions of the tumour suppressor gene p53, including the typical human tumour hot spots (codons 175, 245, 248, 249, 273 and 282), were investigated in various canine neoplasms. A mutation CGG-->TGG (arginine-->tryptophan) was detected in codon 249 in an adenoma of the circumanal gla...
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PMID: 9232781
PDF is available here.
PDF is available here.
Abstract
Perianal mucinous adenocarcinoma is a rare disease with a poor prognosis, mostly due to its advanced nature at the time of diagnosis. Chemoradiation followed by surgery may improve outcome in selected individuals....
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PMID: 9121153
PDF is available here.
PDF is available here.
Abstract
A case of benign granular cell tumor of the perianal region is presented. The patient was treated by local excision of the tumor. This is an unusual site. Superficial biopsy specimens may indicate an incorrect diagnosis of squamous cell carcinoma.
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PMID: 9406480
PDF is available here.
PDF is available here.
Abstract
Human cancer are characterized by the failure of cell cycle checkpoints resulting in genetic instability. Human papillomaviruses contribute to the development of anogenital malignancies because the E6 and R7 oncoproteins from high risk HPV types are able to disrupt the integrity of these checkpoints...
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PMID: 9284523
PDF is available here.
PDF is available here.
Abstract
Abstract
Abstract
The proliferative activity in 28 canine perianal gland tumours was examined by the quantitative evaluation of the nucleolar organiser regions associated with argyrophil proteins (AgNORs). These regions were stained with a specific silver stain and quantified directly by light microscopy and by compu...
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PMID: 7659856
PDF is available here.
PDF is available here.
Intervirology (37)3-4 1994
Abstract
Veterinary Pathology (30)4 1993
Abstract
Eight canine tumors originating from specific glandular structures in the anal region, as well as metastatic tumor tissue of two of these cases (case Nos. 7, 8), were immunohistochemically analyzed using various monoclonal antibodies (MoAbs) directed against human keratin types, vimentin, neurofilam...
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PMID: 8212457
PDF is available here.
PDF is available here.
Abstract
Chemoradiation therapy for anal cancer was carried out in 58 patients using low-dose, continuous infusion of 5-fluorouracil (5-FU) with or without continuous infusion of cisplatin (cDDP) and external beam irradiation (chemoXRT). Thirty-nine patients received 5-FU chemoXRT resulting in a local contro...
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PMID: 8210457
PDF is available here.
PDF is available here.
Abstract
Veterinary Pathology (28)1 1991
Abstract
Our results suggest that the glycosylation pattern occurring during normal keratinocyte differentiation is conserved in squamous cell carcinomas and that Griffonia simplicifolia agglutinin-I and Phytolacca americana mitogen may represent useful tools in distinguishing poorly differentiated squamous...
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PMID: 1708179
PDF is available here.
PDF is available here.
Abstract
Although neoplastic changes in canine hepatoid perianal glands (HPG) are quite common, the biological behaviour is sometimes difficult to assess on the basis of the histopathological examination. In an attempt to detect differences in the glycoconjugate expression between normal and neoplastic HPG,...
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PMID: 2267415
PDF is available here.
PDF is available here.
Veterinary Pathology (27)2 1990
Abstract
The presence of parathyroid hormone-related protein (PTHrP) in the apocrine adenocarcinoma tumor line (CAC-8) derived from a hypercalcemic dog was demonstrated by western and northern blot analyses. Western blots of CAC-8 tumor extracts revealed a major protein with a molecular weight of approximate...
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PMID: 2345942
PDF is available here.
PDF is available here.
Abstract
One hundred and thirty nine canine perineal tumours were histologically evaluated. The vast majority (134 tumours = 96.4%) appeared to originate from the characteristic glandular structures of this region. They were classified as well differentiated perianal gland tumours (58.3%), as moderately or p...
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PMID: 2515683
PDF is available here.
PDF is available here.
Abstract
The problems associated with perineal surgery depend on the surgical procedure performed. Problems are encountered before, during, and after surgery. Appropriate preoperative assessment, proper surgical technique, and thorough postoperative management are required for successful results. Immediate r...
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PMID: 2520111
PDF is available here.
PDF is available here.
Abstract
We examined tumor extracts from five APO-AS and four control tumors for adenylate cyclase-stimulating activity (ACSA). All extracts from APO-AS contained potent ACSA, whereas the four control tumors did not. The ACSA extracted from one tumor demonstrated a dose response curve parallel to that of syn...
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PMID: 3146425
PDF is available here.
PDF is available here.
Abstract
In situ hybridization was used to detect human papillomavirus (HPV) nucleic acids (type 6b, 11, 16, 18, 31, and 33) and immunohistochemistry was done to detect papillomavirus common antigen in paraffin sections of biopsy specimens. Two patients suffering from condyloma acuminatum contained HPV-6b an...
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PMID: 2853930
PDF is available here.
PDF is available here.
Veterinary Record (123)6 1988
Abstract
Abstract
Hypertestosteronemia was diagnosed in a spayed bitch with pituitary-dependent hyperadrenocorticism and perianal adenomas. Serum concentrations of cortisol and testosterone decreased after treatment with mitotane was instituted. Excessive testosterone in this dog was thought to have been produced by...
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PMID: 2839445
PDF is available here.
PDF is available here.
Histopathology (12)3 1988
Abstract
A case is reported of squamous carcinoma of the peri-anal region arising in a giant condyloma. In situ DNA hybridization showed human papillomavirus (HPV) types 6 and 11. These HPV types are commonly demonstrated in ano-genital condylomas but have not previously been reported in association with mal...
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PMID: 2835300
PDF is available here.
PDF is available here.
Abstract
The detection of Bowen's disease, a very rare condition in an unusual extension--literally covering the anogenital area--and the successful more conservative way of handling the lesions, through surgical separate steps, prompted the authors to review the literature and to report the case.
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PMID: 3268077
PDF is available here.
PDF is available here.
Abstract
Abstract
In a survey of dogs in Sydney, mastocytomas (16.1%) and histiocytomas (14.0%) were the most common in a total of 1,000 skin neoplasms. The basal cell and appendage group provided 25.5% of the neoplasms. The prevalence of the various neoplasms, the age of affected dogs, the proportion in the sexes, t...
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PMID: 3115242
PDF is available here.
PDF is available here.
Izvestiya Rossijskoj Akademii nauk. Seriya biologicheskaya/Proceedings of the Russian Academy of Sciences. Biological Series ()1 1987
Abstract
Veterinary Pathology (23)6 1986
Abstract
A serially transplantable perianal gland carcinoma (CAC-9) was developed in nude mice from a hypercalcemic dog that has been maintained through passage 20. Tumor doubling rate of CAC-9 was 3.1 +/- 0.4 days. Mithramycin (MMC) injected intraperitoneally (8 mg/kg) into nude mice bearing CAC-9 markedly...
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PMID: 2949419
PDF is available here.
PDF is available here.