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Borna Disease (0):
Recent article
Borna Disease
Journal of Virology (84)13 2010
Abstract
Thanks to new technologies which enable rapid and unbiased screening for viral nucleic acids in clinical specimens, an impressive number of previously unknown viruses have recently been discovered. Two research groups independently identified a novel negative-strand RNA virus, now designated avian b...
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PMID: 20219910
PDF is available here.
PDF is available here.
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Veterinary Pathology (47)2 2010
Abstract
Borna disease is a severe viral-induced disorder of the central nervous system of horses, sheep, and a few other animal species, occurring in certain areas of central Europe. Pathogenesis and epidemiology of natural Borna disease virus (BDV) infections are still not fully understood;...
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PMID: 20133953
PDF is available here.
PDF is available here.
Cell and Tissue Research (338)2 2009
Abstract
We have investigated the extent to which entorhinal axons react to this loss of granule cells. Unexpectedly, anterograde DiI tracing has shown a prominent layered termination of the entorhinal projection, despite an almost complete loss of granule cells at 9 weeks after infection. Combined light- an...
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PMID: 19806365
PDF is available here.
PDF is available here.
Abstract
BDV p24 RNA fragments were found only in Kazakh Tobet (a shepherd dog) in 8 breeds of 150 cases and their overall positive rate was 11.0% (10/91). Compared with the strain of He/80 from horse and that of S6 from sheep in Germany, the homologous similarities of Kazakh Tobet was 99.2% and 95.7%, and t...
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PMID: 20193374
PDF is available here.
PDF is available here.
Abstract
We performed reverse transcriptase polymerase chain reaction (RT-PCR) in the 10th generation of treated cells to examine the expression of BDV phosphoprotein. The proliferation of treated cells and control cells was examined by methyl thiazolyl tetrazolium assay (MT). RESULT: The recombinant plasmid...
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PMID: 19388275
PDF is available here.
PDF is available here.
Abstract
BDV CIC positivity was detected in 66.7% of psychiatric patients (26/39) on day 0, in 53.9% (14/26) on day 28 and in 52.9% on day 56 (9/17). The control group was 22.2% (28/126) positive. The incidence of BDV CIC was significantly higher in psychiatric patients than in healthy individuals (p=0.001)....
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PMID: 19855370
PDF is available here.
PDF is available here.
Antiviral Research (80)3 2008
Abstract
We assessed the effect of ribavirin on the proliferation of Borna disease virus (BDV) in the brain. The intracranial inoculation of ribavirin reduced viral propagation in the acutely infected brain, resulting in protection from fatal neurological disorders. We found that the treatment with ribavirin...
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PMID: 18778737
PDF is available here.
PDF is available here.
Abstract
The expression profiles of BDV-GP, BDV-N and their mRNAs are significantly different, indicating that BDV-GP expression is regulated in vivo. This might be achieved by restricted nuclear export and/or maturation of BDV-intron II mRNA or limited translation as a viral mechanism to escape from the imm...
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PMID: 18282160
PDF is available here.
PDF is available here.
Abstract
Our results suggested common exposure to BDV or a related virus in the general Japanese population. Low avidity IgG and persistent IgM suggested delayed immune response against BDV or a related virus. The specific IgA indicated mucosal involvement....
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PMID: 18786855
PDF is available here.
PDF is available here.
Brain Research (1219) 2008
Abstract
We investigated BDV dependent changes in astroglial GJ connexins (Cx) Cx43, and Cx30 in the Lewis rat cerebellum, 4, and 8 weeks after neonatal infection. On the mRNA level, RT-PCR demonstrated a BDV dependent increase in cerebellar Cx43, and a decrease in Cx30, 8, but not 4 weeks p.i. On the protei...
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PMID: 18538309
PDF is available here.
PDF is available here.
Journal of General Virology (89)Pt 6 2008
Abstract
The Borna disease virus (BDV) proteins X and P are translated from a bicistronic viral mRNA. Here, it was shown that the rescue of recombinant BDV from cDNA was enhanced approximately eightfold if reconstitution of the viral polymerase complex was performed with an expression vector encoding X and P...
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PMID: 18474560
PDF is available here.
PDF is available here.
Journal of Neurovirology (14)3 2008
Cannabinoid rescue of striatal progenitor cells in chronic Borna disease viral encephalitis in rats.
Abstract
A growing number of environmental and pharmacologic manipulations have been shown to influence adult neurogenesis. Borna disease virus (BDV) in rats causes cortical and subcortical infection with extrapyramidal motor symptoms, and hippocampal infection suppresses neurogenesis. Given the known effect...
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PMID: 18569459
PDF is available here.
PDF is available here.
Virus Genes (36)2 2008
Abstract
The neurotropic Borna disease virus (BDV) causes typically a persistent virus infection of the central nervous system. In order to investigate whether an adapted virus replication contributes to BDV persistence in vivo, a fast and reliable real-time RT-PCR assay was constructed to quantify the amoun...
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PMID: 18273698
PDF is available here.
PDF is available here.
Veterinary Microbiology (127)3-4 2008
Abstract
We hypothesized that enteric neurons may be targets of BDV replication. The presence of BDV-specific antigen in subpopulations of the ENS was investigated. Four-week-old Lewis rats were infected intracerebrally and sacrificed 4-14 weeks post infection (p.i.). BDV-immunoreactive neurons were found in...
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PMID: 17961937
PDF is available here.
PDF is available here.
Journal of Virological Methods (148)1-2 2008
Abstract
I and intron II). The two remaining reference genes biased the ratios of BDV-transcripts in the immunolabelled brain sections significantly. Secondly, 100 immunolabelled neurons and astrocytes were harvested using laser microdissection and amplification of all viral transcripts revealed 681 and 168...
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PMID: 18054393
PDF is available here.
PDF is available here.
Abstract
Journal of Virology (82)4 2008
Hippocampal poly(ADP-Ribose) polymerase 1 and caspase 3 activation in neonatal bornavirus infection.
Abstract
We evaluate hippocampal PARP-1 mRNA and protein expression levels, activation, and cleavage, as well as apoptosis-inducing factor (AIF) nuclear translocation and executioner caspase 3 activation, in NBD rats. PARP-1 mRNA and protein levels were increased in NBD hippocampi. PARP-1 expression and acti...
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PMID: 18057239
PDF is available here.
PDF is available here.
Neuroscience Letters (431)1 2008
Abstract
We investigated whether the neurobehavioral abnormalities genetically induced by BDV P influence experimental prion disease. The effect of the phosphoprotein on prion diseases was evaluated based on the incubation time and survival curve, as well as the abnormal isoform of prion protein (PrP(Sc)) le...
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PMID: 18155836
PDF is available here.
PDF is available here.
Abstract
We evaluated the mechanisms whereby astrocytes can contribute to activation of microglia in neuron-glia-microglia mixed cultures. We found that persistent infection of neuronal cells leads to activation of uninfected astrocytes as measured by elevated expression of RANTES. Activation of astrocytes t...
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PMID: 19014432
PDF is available here.
PDF is available here.
Abstract
Numerous interactions of the immune system with the central nervous system have been described recently. Mood and psychotic disorders, such as severe depression and schizophrenia, are both heterogeneous disorders regarding clinical symptomatology, the acuity of symptoms, the clinical course, the tre...
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PMID: 18623121
PDF is available here.
PDF is available here.
APMIS. Supplementum ()124 2008
Abstract
APMIS. Supplementum ()124 2008
Abstract
In the early 1970s a fatal neurological disorder in cats was reported in the areas around Lake Mälaren in central Sweden. The major signs were hind-leg ataxia, as well as absence or marked decrease in postural reactions and in some cases behavioural changes. The pathology of the disorder was char...
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PMID: 18771097
PDF is available here.
PDF is available here.
APMIS. Supplementum ()124 2008
Abstract
A description of Bipolar Disorder and its treatment costs. The prevalence of various psychiatric disorders in the United States in which Borna Disease Virus (BDV) may play a role. My personal history of Bipolar Disorder including: diagnoses and treatment of Borna Disease Virus infection.
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PMID: 18771102
PDF is available here.
PDF is available here.
APMIS. Supplementum ()124 2008
Abstract
APMIS. Supplementum ()124 2008
Abstract
Borna disease virus (BDV) causes neurological disease in horses, however, there is no consensus as to the extent or significance of human infection. BDV antigen levels in plasma (BDVpAg) and anti-BDV were measured by ELISAs. Confirmation was by Western blot (WB), immunofluorescence assay (IFA) or BD...
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PMID: 18771108
PDF is available here.
PDF is available here.
APMIS. Supplementum ()124 2008
Abstract
APMIS. Supplementum ()124 2008
Abstract
APMIS. Supplementum ()124 2008
Abstract
We examined 3481 blood samples of different horses by ELISA. 1841 (50%) were BDV-infected. Approximately 40% of the infected horses were clinically healthy and approximately 43% were clinically ill. The relatively high infection rate could be justified by the fact that these subjects had more or les...
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PMID: 18771095
PDF is available here.
PDF is available here.
APMIS. Supplementum ()124 2008
Abstract
APMIS. Supplementum ()124 2008
Abstract
In Europe, Borna disease virus (BDV) infection has been linked with staggering disease. The aim of this study was serological investigation for BDV infection in Australian cats. De-identified sera were obtained from domestic cats presented at various veterinary clinics. BDV antigen levels were measu...
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PMID: 18771098
PDF is available here.
PDF is available here.
APMIS. Supplementum ()124 2008
Abstract
APMIS. Supplementum ()124 2008
Abstract
We found encephalitic lesions and a highly reproducable multifocal retinopathy preferentially located in the posterior pole of the eye....
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PMID: 18771100
PDF is available here.
PDF is available here.
APMIS. Supplementum ()124 2008
Abstract
Patients with affective disorders show an enhanced prevalence of Borna disease virus (BDV)-infection. Furthermore, BDV causes latent infection preferably in limbic central nervous structures and is suggested to be causally related to subtypes of affective disorders, especially with melancholic clini...
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PMID: 18771101
PDF is available here.
PDF is available here.
APMIS. Supplementum ()124 2008
Abstract
APMIS. Supplementum ()124 2008
Abstract
APMIS. Supplementum ()124 2008
Abstract
APMIS. Supplementum ()124 2008
Abstract
APMIS. Supplementum ()124 2008
Abstract
APMIS. Supplementum ()124 2008
Abstract
Journal of General Virology (88)Pt 11 2007
Abstract
We previously showed that mouse adaptation of cDNA-derived Borna disease virus (BDV) strain He/80(FR) was associated exclusively with mutations in the viral polymerase complex. Interestingly, independent mouse adaptation of non-recombinant He/80 was correlated with different alterations in the polym...
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PMID: 17947539
PDF is available here.
PDF is available here.
Journal of Virology (81)20 2007
Abstract
We generated BDV mutants that feature TQLEISSI in place of TELEISSI. We show that adoptive transfer of BDV N-specific CD8 T cells induced neurological disease in B10.BR mice persistently infected with wild-type BDV but not with the mutant virus expressing TQLEISSI. Surprisingly, the mutant virus rep...
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PMID: 17686872
PDF is available here.
PDF is available here.
Veterinary Research Communications (31 Suppl 1)s1 2007
Abstract
Journal of Virology (81)16 2007
Abstract
We used cultures of neurons grown on multielectrode arrays, allowing a real-time monitoring of the electrical activity across the network shaped by synaptic transmission. Although infection did not affect spontaneous neuronal activity, it selectively blocked activity-dependent enhancement of neurona...
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PMID: 17553893
PDF is available here.
PDF is available here.
Journal of Virology (81)15 2007
Abstract
We determined the molecular basis of adaptation by studying mutations acquired by a cDNA-derived BDV strain during one brain passage in rats and three passages in mice. The adapted virus propagated efficiently in mouse brains and induced neurological disease. Its genome contained seven point mutatio...
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PMID: 17522214
PDF is available here.
PDF is available here.
Abstract
Borna disease virus (BDV) is a non-segmented, negative-stranded RNA virus, which infects cells of the central nervous system (CNS) in many different species. BDV is the causative agent of the neurological disorders in horses and sheep termed classical Borna disease (BD), as well as staggering diseas...
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PMID: 17376545
PDF is available here.
PDF is available here.
Journal of Neurovirology (13)3 2007
Abstract
The authors evaluated a role of glutamate (GLU) excitotoxicity in neonatal Borna disease virus (BDV) infection-associated neuronal injury by measuring extracellular levels of GLU in the striatum of 70-day-old Fischer344 rats using in vivo microdialysis. The effects of BDV infection on the protein le...
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PMID: 17613708
PDF is available here.
PDF is available here.
Journal of Virology (81)11 2007
Abstract
We examined the expression of an astrocyte-derived factor, S100B, in the brains of Lewis rats persistently infected with BDV. S100B is a Ca(2+)-binding protein produced mainly by astrocytes. A prominent role of this protein appears to be the promotion of vascular inflammatory responses through inter...
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PMID: 17376896
PDF is available here.
PDF is available here.
Abstract
We recently demonstrated that the vast majority of BDV genomes and antigenomes possess uniformly trimmed 5' termini, even if the virus is recovered from complementary DNA encoding a hypothetical full-length viral genome. Here we discuss different mechanisms which might lead to the selective 5'-termi...
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PMID: 17372677
PDF is available here.
PDF is available here.
Abstract
We isolated the virus from brain samples of a heifer with Borna disease in Japan. We demonstrate that the brain lysate contained replication products of BDV and induced viral propagation in rat glioma cells, suggesting that a replication-competent BDV existed in the bovine brain. This field strain o...
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PMID: 17306587
PDF is available here.
PDF is available here.
Journal of Virology (81)6 2007
Abstract
Our investigation reveals regional discrimination between patterns of PC subset loss, defined by zebrin II/EAAT4 expression domains, following neonatal viral infection. These findings suggest a differential vulnerability of PC subsets during the early stages of virus-induced neurodegeneration....
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PMID: 17182680
PDF is available here.
PDF is available here.
Abstract
Borna disease is a severe, immunopathological disorder of the central nervous system caused by the infection with the Borna disease virus (BDV). The detection of BDV in diseased animals, mainly sheep and horses, is achieved by histological, immunohistochemical and serological approaches and/or PCR-b...
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PMID: 17014984
PDF is available here.
PDF is available here.
Abstract
We examined the ability of opioid and nonopioid agents with overlapping ionic mechanisms and actions similar to kappa opioid agonists, to block seizures in rat models of encephalitis due to Borna Disease virus and Herpes Simplex Virus Type-1. Naltrindole, a delta antagonist and thus a kappa opioid s...
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PMID: 17126318
PDF is available here.
PDF is available here.
Behavioural Brain Research (176)1 2007
Abstract
We briefly review our animal model of ASD based on neonatal Borna disease virus (BDV) infection and present new data about abnormal social interaction in adult BDV-infected rats. We found that neonatal BDV infection profoundly affected social behaviors in adult rats. Compared to the control rats, bo...
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PMID: 16860408
PDF is available here.
PDF is available here.
Abstract
All Borna disease virus (BDV) sequences derived from human specimens published till date were thoroughly analysed and compared to sequences of BDV laboratory strains and to BDV sequences from animals which succumbed to classical Borna disease (BD). Despite high sequence conservation of the BDV genom...
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PMID: 17342788
PDF is available here.
PDF is available here.
Abstract
BDV-specific antibodies were detected in 10 horses, 2 cats, as well as 2 horses and 1 dog from farms housing a previously detected seropositive horse. Interestingly, BDV-specific antibodies were further detected in three wild rodents. In humans, BDV-specific antibodies were detected in a veterinaria...
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PMID: 17129759
PDF is available here.
PDF is available here.
Veterinary Pathology (44)1 2007
Abstract
We performed a detailed quantitative morphologic study of retinal tissue from Borna-diseased horses. BD was diagnosed by detection of pathognomonic Joest-Degen inclusion bodies in the postmortem brains. Paraffin sections of paraformaldehyde-fixed retinae were used for histologic and immunohistochemi...
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PMID: 17197624
PDF is available here.
PDF is available here.
Journal of Virology (80)24 2006
Abstract
We observed proliferation of microglia cells that acquired the round morphology and expressed major histocompatibility complex molecules of classes I and II. These manifestations of microglia activation were observed in the absence of direct BDV infection of microglia or overt neuronal toxicity. In...
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PMID: 17020949
PDF is available here.
PDF is available here.
Journal of Virology (80)17 2006
Abstract
We report the presence of endoplasmic reticulum (ER) stress markers and activation of the unfolded protein response in the NBD hippocampus and cerebellum. Specific findings included enhanced PERK-mediated phosphorylation of eif2alpha and concomitant regulation of ATF4 translation; IRE1-mediated spli...
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PMID: 16912310
PDF is available here.
PDF is available here.
Abstract
Borna disease virus (BDV) is highly neuronotropic. Recently, more and more investigations indicated that BDV infection was close related to human neuropsychic disorders. However, the mechanism underlying the disorders was unclear to date. Some investigators thought neuronal plasticity changes by BDV...
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PMID: 17037079
PDF is available here.
PDF is available here.
Abstract
The paper uses interviews and observational data gathered among a group of UK scientists and civil servants responsible for managing a study examining the possible transmission to humans of Borna disease virus (BDV), a disease primarily of farm animals. From a science and technology studies perspect...
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PMID: 16530903
PDF is available here.
PDF is available here.