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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Disease Models, Animal (0):
Recent article
Disease Models, Animal
Nature Medicine (17)12 2011
Abstract
We identify a MEK-independent role for RAF in tumor growth. Specifically, in mitotic cells, CRAF becomes phosphorylated on Ser338 and localizes to the mitotic spindle of proliferating tumor cells in vitro as well as in murine tumor models and in biopsies from individuals with cancer. Treatment of tu...
|
PMID: 22081024
PDF is available here.
PDF is available here.
| < More recent | Older article > |
Nature Medicine (17)12 2011
Abstract
We identify a MEK-independent role for RAF in tumor growth. Specifically, in mitotic cells, CRAF becomes phosphorylated on Ser338 and localizes to the mitotic spindle of proliferating tumor cells in vitro as well as in murine tumor models and in biopsies from individuals with cancer. Treatment of tu...
|
PMID: 22081024
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We identify a MEK-independent role for RAF in tumor growth. Specifically, in mitotic cells, CRAF becomes phosphorylated on Ser338 and localizes to the mitotic spindle of proliferating tumor cells in vitro as well as in murine tumor models and in biopsies from individuals with cancer. Treatment of tu...
|
PMID: 22081024
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We discuss the conceptual and practical issues to consider when attempting to model genetic diseases using iPSCs....
|
PMID: 22146428
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We discuss the conceptual and practical issues to consider when attempting to model genetic diseases using iPSCs....
|
PMID: 22146428
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We discuss the conceptual and practical issues to consider when attempting to model genetic diseases using iPSCs....
|
PMID: 22146428
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We describe the small molecule b-AP15 as a previously unidentified class of proteasome inhibitor that abrogates the deubiquitinating activity of the 19S regulatory particle. b-AP15 inhibited the activity of two 19S regulatory-particle-associated deubiquitinases, ubiquitin C-terminal hydrolase 5 (UCH...
|
PMID: 22057347
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We describe the small molecule b-AP15 as a previously unidentified class of proteasome inhibitor that abrogates the deubiquitinating activity of the 19S regulatory particle. b-AP15 inhibited the activity of two 19S regulatory-particle-associated deubiquitinases, ubiquitin C-terminal hydrolase 5 (UCH...
|
PMID: 22057347
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We describe the small molecule b-AP15 as a previously unidentified class of proteasome inhibitor that abrogates the deubiquitinating activity of the 19S regulatory particle. b-AP15 inhibited the activity of two 19S regulatory-particle-associated deubiquitinases, ubiquitin C-terminal hydrolase 5 (UCH...
|
PMID: 22057347
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We identify a central role for the inflammatory complement system in the pathogenesis of osteoarthritis. Through proteomic and transcriptomic analyses of synovial fluids and membranes from individuals with osteoarthritis, we find that expression and activation of complement is abnormally high in hum...
|
PMID: 22057346
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We identify a central role for the inflammatory complement system in the pathogenesis of osteoarthritis. Through proteomic and transcriptomic analyses of synovial fluids and membranes from individuals with osteoarthritis, we find that expression and activation of complement is abnormally high in hum...
|
PMID: 22057346
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We identify a central role for the inflammatory complement system in the pathogenesis of osteoarthritis. Through proteomic and transcriptomic analyses of synovial fluids and membranes from individuals with osteoarthritis, we find that expression and activation of complement is abnormally high in hum...
|
PMID: 22057346
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We used paired-end transcriptome sequencing to explore the landscape of gene fusions in a panel of breast cancer cell lines and tissues. We observed that individual breast cancers have a variety of expressed gene fusions. We identified two classes of recurrent gene rearrangements involving genes enc...
|
PMID: 22101766
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We used paired-end transcriptome sequencing to explore the landscape of gene fusions in a panel of breast cancer cell lines and tissues. We observed that individual breast cancers have a variety of expressed gene fusions. We identified two classes of recurrent gene rearrangements involving genes enc...
|
PMID: 22101766
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We used paired-end transcriptome sequencing to explore the landscape of gene fusions in a panel of breast cancer cell lines and tissues. We observed that individual breast cancers have a variety of expressed gene fusions. We identified two classes of recurrent gene rearrangements involving genes enc...
|
PMID: 22101766
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We identify a MEK-independent role for RAF in tumor growth. Specifically, in mitotic cells, CRAF becomes phosphorylated on Ser338 and localizes to the mitotic spindle of proliferating tumor cells in vitro as well as in murine tumor models and in biopsies from individuals with cancer. Treatment of tu...
|
PMID: 22081024
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We discuss the conceptual and practical issues to consider when attempting to model genetic diseases using iPSCs....
|
PMID: 22146428
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We describe the small molecule b-AP15 as a previously unidentified class of proteasome inhibitor that abrogates the deubiquitinating activity of the 19S regulatory particle. b-AP15 inhibited the activity of two 19S regulatory-particle-associated deubiquitinases, ubiquitin C-terminal hydrolase 5 (UCH...
|
PMID: 22057347
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We identify a central role for the inflammatory complement system in the pathogenesis of osteoarthritis. Through proteomic and transcriptomic analyses of synovial fluids and membranes from individuals with osteoarthritis, we find that expression and activation of complement is abnormally high in hum...
|
PMID: 22057346
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We used paired-end transcriptome sequencing to explore the landscape of gene fusions in a panel of breast cancer cell lines and tissues. We observed that individual breast cancers have a variety of expressed gene fusions. We identified two classes of recurrent gene rearrangements involving genes enc...
|
PMID: 22101766
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We identify a MEK-independent role for RAF in tumor growth. Specifically, in mitotic cells, CRAF becomes phosphorylated on Ser338 and localizes to the mitotic spindle of proliferating tumor cells in vitro as well as in murine tumor models and in biopsies from individuals with cancer. Treatment of tu...
|
PMID: 22081024
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We discuss the conceptual and practical issues to consider when attempting to model genetic diseases using iPSCs....
|
PMID: 22146428
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We describe the small molecule b-AP15 as a previously unidentified class of proteasome inhibitor that abrogates the deubiquitinating activity of the 19S regulatory particle. b-AP15 inhibited the activity of two 19S regulatory-particle-associated deubiquitinases, ubiquitin C-terminal hydrolase 5 (UCH...
|
PMID: 22057347
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We identify a central role for the inflammatory complement system in the pathogenesis of osteoarthritis. Through proteomic and transcriptomic analyses of synovial fluids and membranes from individuals with osteoarthritis, we find that expression and activation of complement is abnormally high in hum...
|
PMID: 22057346
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We used paired-end transcriptome sequencing to explore the landscape of gene fusions in a panel of breast cancer cell lines and tissues. We observed that individual breast cancers have a variety of expressed gene fusions. We identified two classes of recurrent gene rearrangements involving genes enc...
|
PMID: 22101766
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We identify a MEK-independent role for RAF in tumor growth. Specifically, in mitotic cells, CRAF becomes phosphorylated on Ser338 and localizes to the mitotic spindle of proliferating tumor cells in vitro as well as in murine tumor models and in biopsies from individuals with cancer. Treatment of tu...
|
PMID: 22081024
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We discuss the conceptual and practical issues to consider when attempting to model genetic diseases using iPSCs....
|
PMID: 22146428
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We describe the small molecule b-AP15 as a previously unidentified class of proteasome inhibitor that abrogates the deubiquitinating activity of the 19S regulatory particle. b-AP15 inhibited the activity of two 19S regulatory-particle-associated deubiquitinases, ubiquitin C-terminal hydrolase 5 (UCH...
|
PMID: 22057347
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We identify a central role for the inflammatory complement system in the pathogenesis of osteoarthritis. Through proteomic and transcriptomic analyses of synovial fluids and membranes from individuals with osteoarthritis, we find that expression and activation of complement is abnormally high in hum...
|
PMID: 22057346
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We used paired-end transcriptome sequencing to explore the landscape of gene fusions in a panel of breast cancer cell lines and tissues. We observed that individual breast cancers have a variety of expressed gene fusions. We identified two classes of recurrent gene rearrangements involving genes enc...
|
PMID: 22101766
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We identify a MEK-independent role for RAF in tumor growth. Specifically, in mitotic cells, CRAF becomes phosphorylated on Ser338 and localizes to the mitotic spindle of proliferating tumor cells in vitro as well as in murine tumor models and in biopsies from individuals with cancer. Treatment of tu...
|
PMID: 22081024
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We discuss the conceptual and practical issues to consider when attempting to model genetic diseases using iPSCs....
|
PMID: 22146428
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We describe the small molecule b-AP15 as a previously unidentified class of proteasome inhibitor that abrogates the deubiquitinating activity of the 19S regulatory particle. b-AP15 inhibited the activity of two 19S regulatory-particle-associated deubiquitinases, ubiquitin C-terminal hydrolase 5 (UCH...
|
PMID: 22057347
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We identify a central role for the inflammatory complement system in the pathogenesis of osteoarthritis. Through proteomic and transcriptomic analyses of synovial fluids and membranes from individuals with osteoarthritis, we find that expression and activation of complement is abnormally high in hum...
|
PMID: 22057346
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We used paired-end transcriptome sequencing to explore the landscape of gene fusions in a panel of breast cancer cell lines and tissues. We observed that individual breast cancers have a variety of expressed gene fusions. We identified two classes of recurrent gene rearrangements involving genes enc...
|
PMID: 22101766
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We identify a MEK-independent role for RAF in tumor growth. Specifically, in mitotic cells, CRAF becomes phosphorylated on Ser338 and localizes to the mitotic spindle of proliferating tumor cells in vitro as well as in murine tumor models and in biopsies from individuals with cancer. Treatment of tu...
|
PMID: 22081024
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We discuss the conceptual and practical issues to consider when attempting to model genetic diseases using iPSCs....
|
PMID: 22146428
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We describe the small molecule b-AP15 as a previously unidentified class of proteasome inhibitor that abrogates the deubiquitinating activity of the 19S regulatory particle. b-AP15 inhibited the activity of two 19S regulatory-particle-associated deubiquitinases, ubiquitin C-terminal hydrolase 5 (UCH...
|
PMID: 22057347
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We identify a central role for the inflammatory complement system in the pathogenesis of osteoarthritis. Through proteomic and transcriptomic analyses of synovial fluids and membranes from individuals with osteoarthritis, we find that expression and activation of complement is abnormally high in hum...
|
PMID: 22057346
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We used paired-end transcriptome sequencing to explore the landscape of gene fusions in a panel of breast cancer cell lines and tissues. We observed that individual breast cancers have a variety of expressed gene fusions. We identified two classes of recurrent gene rearrangements involving genes enc...
|
PMID: 22101766
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We identify a MEK-independent role for RAF in tumor growth. Specifically, in mitotic cells, CRAF becomes phosphorylated on Ser338 and localizes to the mitotic spindle of proliferating tumor cells in vitro as well as in murine tumor models and in biopsies from individuals with cancer. Treatment of tu...
|
PMID: 22081024
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We discuss the conceptual and practical issues to consider when attempting to model genetic diseases using iPSCs....
|
PMID: 22146428
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We describe the small molecule b-AP15 as a previously unidentified class of proteasome inhibitor that abrogates the deubiquitinating activity of the 19S regulatory particle. b-AP15 inhibited the activity of two 19S regulatory-particle-associated deubiquitinases, ubiquitin C-terminal hydrolase 5 (UCH...
|
PMID: 22057347
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We identify a central role for the inflammatory complement system in the pathogenesis of osteoarthritis. Through proteomic and transcriptomic analyses of synovial fluids and membranes from individuals with osteoarthritis, we find that expression and activation of complement is abnormally high in hum...
|
PMID: 22057346
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We used paired-end transcriptome sequencing to explore the landscape of gene fusions in a panel of breast cancer cell lines and tissues. We observed that individual breast cancers have a variety of expressed gene fusions. We identified two classes of recurrent gene rearrangements involving genes enc...
|
PMID: 22101766
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We identify a MEK-independent role for RAF in tumor growth. Specifically, in mitotic cells, CRAF becomes phosphorylated on Ser338 and localizes to the mitotic spindle of proliferating tumor cells in vitro as well as in murine tumor models and in biopsies from individuals with cancer. Treatment of tu...
|
PMID: 22081024
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We discuss the conceptual and practical issues to consider when attempting to model genetic diseases using iPSCs....
|
PMID: 22146428
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We describe the small molecule b-AP15 as a previously unidentified class of proteasome inhibitor that abrogates the deubiquitinating activity of the 19S regulatory particle. b-AP15 inhibited the activity of two 19S regulatory-particle-associated deubiquitinases, ubiquitin C-terminal hydrolase 5 (UCH...
|
PMID: 22057347
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We identify a central role for the inflammatory complement system in the pathogenesis of osteoarthritis. Through proteomic and transcriptomic analyses of synovial fluids and membranes from individuals with osteoarthritis, we find that expression and activation of complement is abnormally high in hum...
|
PMID: 22057346
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We used paired-end transcriptome sequencing to explore the landscape of gene fusions in a panel of breast cancer cell lines and tissues. We observed that individual breast cancers have a variety of expressed gene fusions. We identified two classes of recurrent gene rearrangements involving genes enc...
|
PMID: 22101766
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We identify a MEK-independent role for RAF in tumor growth. Specifically, in mitotic cells, CRAF becomes phosphorylated on Ser338 and localizes to the mitotic spindle of proliferating tumor cells in vitro as well as in murine tumor models and in biopsies from individuals with cancer. Treatment of tu...
|
PMID: 22081024
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We discuss the conceptual and practical issues to consider when attempting to model genetic diseases using iPSCs....
|
PMID: 22146428
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We describe the small molecule b-AP15 as a previously unidentified class of proteasome inhibitor that abrogates the deubiquitinating activity of the 19S regulatory particle. b-AP15 inhibited the activity of two 19S regulatory-particle-associated deubiquitinases, ubiquitin C-terminal hydrolase 5 (UCH...
|
PMID: 22057347
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We identify a central role for the inflammatory complement system in the pathogenesis of osteoarthritis. Through proteomic and transcriptomic analyses of synovial fluids and membranes from individuals with osteoarthritis, we find that expression and activation of complement is abnormally high in hum...
|
PMID: 22057346
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We used paired-end transcriptome sequencing to explore the landscape of gene fusions in a panel of breast cancer cell lines and tissues. We observed that individual breast cancers have a variety of expressed gene fusions. We identified two classes of recurrent gene rearrangements involving genes enc...
|
PMID: 22101766
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We identify a MEK-independent role for RAF in tumor growth. Specifically, in mitotic cells, CRAF becomes phosphorylated on Ser338 and localizes to the mitotic spindle of proliferating tumor cells in vitro as well as in murine tumor models and in biopsies from individuals with cancer. Treatment of tu...
|
PMID: 22081024
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We discuss the conceptual and practical issues to consider when attempting to model genetic diseases using iPSCs....
|
PMID: 22146428
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We describe the small molecule b-AP15 as a previously unidentified class of proteasome inhibitor that abrogates the deubiquitinating activity of the 19S regulatory particle. b-AP15 inhibited the activity of two 19S regulatory-particle-associated deubiquitinases, ubiquitin C-terminal hydrolase 5 (UCH...
|
PMID: 22057347
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We identify a central role for the inflammatory complement system in the pathogenesis of osteoarthritis. Through proteomic and transcriptomic analyses of synovial fluids and membranes from individuals with osteoarthritis, we find that expression and activation of complement is abnormally high in hum...
|
PMID: 22057346
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We used paired-end transcriptome sequencing to explore the landscape of gene fusions in a panel of breast cancer cell lines and tissues. We observed that individual breast cancers have a variety of expressed gene fusions. We identified two classes of recurrent gene rearrangements involving genes enc...
|
PMID: 22101766
PDF is available here.
PDF is available here.