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Foot-and-Mouth Disease (0):
Recent article
Foot-and-Mouth Disease
Epidemiology and Infection (139)2 2011
Abstract
We study patterns of evolution in foot-and-mouth disease (FMD) serotype C virus isolates from Kenya, one of the few places in the world where serotype C has been endemic and is suspected to remain. The nucleotide sequences encoding the capsid protein VP1 from eight isolates collected between 1967 an...
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PMID: 20334728
PDF is available here.
PDF is available here.
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Virus/Uirusu (60)2 2010
Abstract
I would like to note this point and discuss future preventive measures....
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PMID: 21488337
PDF is available here.
PDF is available here.
Abstract
We highlight the current research directions taken with four diseases considered as important constraints to international trade in animals: avian influenza, Newcastle disease, foot-and-mouth disease and diarrheal disease caused by enterotoxigenic Escherichia coli. We also discuss appropriate plant...
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PMID: 20673018
PDF is available here.
PDF is available here.
Abstract
This article reviews the options for use of virus detection techniques for decentralized testing of samples from suspected secondary outbreaks of foot-and-mouth disease (FMD). These options have been expanded by the advent of new tests including disposable lateral flow devices (LFDs) that detect vir...
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PMID: 20545909
PDF is available here.
PDF is available here.
Epidemiology and Infection (138)8 2010
Abstract
In Uganda, limiting the extent of foot-and-mouth disease (FMD) spread during outbreaks involves short-term measures such as ring vaccination and restrictions of the movement of livestock and their products to and from the affected areas. In this study, the presence of FMD virus RNA was investigated...
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PMID: 20003615
PDF is available here.
PDF is available here.
Abstract
We captured marsh deer from June to October 1998 and collected blood from 108 animals and esophageal-pharyngeal fluid from 53. Serum was tested for antibodies against three FMDV serotypes (O, A, and C) by liquid-phase-blocking sandwich enzyme-linked immunosorbent assay (ELISA). Esophageal-pharyngeal...
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PMID: 20688701
PDF is available here.
PDF is available here.
Abstract
Many studies have shown transmission of foot-and-mouth disease virus (FMDV) within groups of pigs, even when vaccinated, but only limited information is available on transmission between pens. Three new experiments were carried out in two replicates, which consisted of infectious pigs housed in a ce...
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PMID: 20416264
PDF is available here.
PDF is available here.
Journal of Virological Methods (166)1-2 2010
Abstract
A single serum-dilution liquid phase ELISA (slpELISA) was standardized to be used for serological evaluation of herd immunity against foot-and-mouth disease. The absorbance value at a dilution 1:64 of each serum sample was interpolated in a standard curve by plotting the antibody titers of six contr...
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PMID: 20170683
PDF is available here.
PDF is available here.
Abstract
Abstract
An immunochromatographic strip was developed for the serological detection of type O foot-and-mouth disease (FMD) in swine. In the strip, the expressed protein of VP1, the main protective antigen of FMDV, labeled with colloidal gold was used as the detector, the staphylococcal protein A (SPA) and sw...
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PMID: 20100515
PDF is available here.
PDF is available here.
Veterinary Record (166)18 2010
Abstract
Abstract
Naturally occurring foot-and-mouth disease (FMD) in wildlife is a relatively mild condition but occasionally it can be devastating as has been documented in impala in South Africa and in mountain gazelles in Israel. This report describes pathological changes in an adult male gazelle with FMD from an...
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PMID: 20649158
PDF is available here.
PDF is available here.
Abstract
The ability of foot-and-mouth disease (FMD) vaccine to protect sheep and goats from a homologous direct in-contact challenge and the effect on virus excretion from the nasal secretions and oropharynx was examined. An experimental oil adjuvant O(1) Manisa FMD vaccine protected sheep and goats from cl...
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PMID: 20352490
PDF is available here.
PDF is available here.
B cell epitopes within VP1 of type O foot-and-mouth disease virus for detection of viral antibodies.
Abstract
In this study, the coding region of type O FMDV capsid protein VP1 and a series of codon optimized DNA sequences coding for VP1 amino acid residues 141-160 (epitope1), tandem repeat 200-213 (epitope2 (+2)) and the combination of two epitopes (epitope1-2) was genetically cloned into the prokaryotic e...
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PMID: 20960280
PDF is available here.
PDF is available here.
Journal of Virology (84)4 2010
Abstract
We demonstrated that type I interferon (IFN-alpha/beta) or a combination of IFN-alpha/beta and type II IFN (IFN-gamma) delivered by a replication-defective human adenovirus 5 (Ad5) vector protected swine when challenged 1 day later with foot-and-mouth disease virus (FMDV). To gain a more comprehensi...
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PMID: 19955313
PDF is available here.
PDF is available here.
Abstract
We sought to investigate if a DNA construct expressing IL-9 (designed as proV-IL9) as a molecular adjuvant enhance antigen specific immune responses elicited by the pcD-VP1 DNA vaccination. Mice immunized with pcD-VP1 combined with proV-IL9 developed a strong humoral response. In addition, the coino...
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PMID: 20445754
PDF is available here.
PDF is available here.
Abstract
The prophylactic use of vaccines against exotic viral infections in production animals is undertaken exclusively in regions where the disease concerned is endemic. In such areas, the infection pressure is very high and so, to assure optimal protection, the most efficient vaccines are used. However,...
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PMID: 20021307
PDF is available here.
PDF is available here.
Abstract
Fading immune protection in farmed animals may present a problem, particularly in free-ranging animals in nomadic and transhumant pastoral systems, where animals are not readily available for large-scale blanket vaccination programmes. Two veterinary examples of fading immune protection are discusse...
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PMID: 20105497
PDF is available here.
PDF is available here.
Abstract
The objective of this study was to investigate the inactivation and degradation of foot-and-mouth disease (FMD) virus during composting of infected pig carcasses as measured by virus isolation in tissue culture and by real-time reverse transcriptase polymerase chain reaction (RRT-PCR). Three FMD-inf...
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PMID: 20357957
PDF is available here.
PDF is available here.
Veterinary Research (41)3 2010
Abstract
We used an attenuated Salmonella choleraesuis (C500) vaccine strain, to carry the plasmid that expresses siRNA directed against the polymerase gene 3D (p3D-NT56) of FMDV. We used guinea pigs to evaluate the inhibitory effects of recombinant S. cho (p3D-NT56/S. cho) on FMDV infection. The results sho...
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PMID: 20167192
PDF is available here.
PDF is available here.
Veterinary Research (41)3 2010
Abstract
We investigated the use of heat shock protein 70 (Hsp70) as a molecular chaperone to target viral antigen to the Major Histocompatibility Complex (MHC) class II pathway of antigen presenting cells and generate enhanced MHC II-restricted CD4+ T cell responses in cattle. Monocytes and CD4+ T cells fro...
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PMID: 20167197
PDF is available here.
PDF is available here.
Abstract
Due to its strong impact on economics and trading the Foot-and-Mouth-Disease (FMD) is one of the most important animal diseases within animal husbandry. Because no recent specific field observation for FMD exists in Germany, the risk assessment needs validated epidemiological models to prepare decis...
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PMID: 20329640
PDF is available here.
PDF is available here.
Epidemiology and Infection (138)1 2010
Abstract
A series of simulation experiments was conducted to determine how estimates of the latent and infectious periods, number of neighbours (contacts) and population size impact on the predicted magnitude and distribution of foot-and-mouth disease (FMD) outbreaks in white-tailed deer in southern Texas. O...
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PMID: 19480725
PDF is available here.
PDF is available here.
Abstract
We characterized the phenotype and function of NK cells from swine (F. N. Toka et al., J. Interferon Cytokine Res. 29:179-192, 2009). In the present study, we report the analysis of NK cells isolated from animals infected with FMDV and tested ex vivo and show that NK-dependent cytotoxic activity aga...
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PMID: 19828769
PDF is available here.
PDF is available here.
Abstract
Livestock contributes significantly to the world economy. However, animal diseases are still a major constraint on economic growth, the reduction of poverty and food security. Among the most significant diseases is foot and mouth disease (FMD), a highly contagious, multi-species animal disease with...
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PMID: 20462147
PDF is available here.
PDF is available here.
Abstract
Between November 2000 and the end of 2007, five outbreaks of foot and mouth disease (FMD) occurred in cattle in the area adjacentto the Kruger National Park (KNP) in the north-eastern corner of South Africa. To help understand the factors behind these outbreaks a qualitative risk assessment based on...
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PMID: 20462150
PDF is available here.
PDF is available here.
Abstract
Immunohistochemical (IHC) and fluorescent antibody (FA) techniques were optimized for the detection of Foot-and-mouth disease virus (FMDV) structural and nonstructural proteins in frozen and paraformaldehyde-fixed, paraffin-embedded (PFPE) tissues of bovine and porcine origin. Immunohistochemical lo...
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PMID: 19901278
PDF is available here.
PDF is available here.
Abstract
Abstract
This study reports the development of distinct fluorescence-based multiplex rRT-PCR arrays, which are comprised of unique primer pairs that are statistically modeled from publicly available sequences, for overall foot-and-mouth disease virus and serotype-specific detection. Performance of the multip...
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PMID: 19427333
PDF is available here.
PDF is available here.
Canadian Veterinary Journal (50)10 2009
Abstract
Vaccination against foot-and-mouth disease (FMD) might be one of the control measures used during an FMD epidemic depending on the local epidemiological situation, the status of the country, and the opinion of policy makers. A sound decision on vaccination can be made only if there is sufficient sci...
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PMID: 20046605
PDF is available here.
PDF is available here.
Abstract
We perform a retrospective analysis of the culling of contiguous premises as performed in 2001 and a simulation study of the effects of this policy on reducing the number of farms affected by disease. Our simulation results support previous studies and show that a national policy of contiguous premi...
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PMID: 19570791
PDF is available here.
PDF is available here.
Abstract
Median number of interstate animal movements (movement of cattle into or out of California) was 0.17/mo; on the basis of this median, beef cattle were moved interstate > 2 times/y. Respondents kept beef cattle at up to 5 locations throughout the year. More than 40% of the movements from the responde...
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PMID: 19719450
PDF is available here.
PDF is available here.
Abstract
We investigated how the size and distribution of wild deer and feral pigs - species that might act as potential foot-and-mouth disease (FMD) virus maintenance hosts - might affect the persistence and spread of FMD. We used a susceptible-latent-infected-recovered geographic-automata model and spatial...
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PMID: 19515439
PDF is available here.
PDF is available here.
Abstract
We present some of the tools of the FMD BioPortal System (www.fmd.ucdavis.edu/bioportal), which is a web-based system that facilitates near real-time information sharing, visualization, and advanced space-time cluster analysis for foot-and-mouth disease (FMD). Using this system, FMD information that...
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PMID: 19505735
PDF is available here.
PDF is available here.
Biotechnology Letters (31)8 2009
Abstract
Foot-and-mouth disease (FMD) and infectious bovine rhinotracheitis (IBR) are two important infectious diseases of cattle. Using bovine herpesvirus type 1 (BHV-1) as a gene delivery vector for development of live-viral vaccines has gained widespread interest. In this study, a recombinant BHV-1 was co...
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PMID: 19343503
PDF is available here.
PDF is available here.
Abstract
We constructed FMDV Asial/JS/China/2005 strain full-length cDNA clone with Arg-Gly-Asp receptor recognition site by sequence. We obtained rescued virus by plasmid cotransfection. The results of sequencing, indirect immunofluorescence, electron microscope and sulk mice pathogenicity analysis showed f...
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PMID: 19873760
PDF is available here.
PDF is available here.
Abstract
We use a well-developed spatio-temporal model of the spread of foot-and-mouth disease, parameterized to match the 2001 UK outbreak, to address the relationship between the scale of the epidemic and the nature of the initially infected farm. We show that there is considerable heterogeneity in both th...
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PMID: 19269297
PDF is available here.
PDF is available here.
Methods in Molecular Biology (551)551 2009
Abstract
Nucleic acid sequencing is now commonplace in most research and diagnostic virology laboratories. The data generated can be used to compare novel strains with other viruses and allow the genetic basis of important phenotypic characteristics, such as antigenic determinants, to be elucidated. Furtherm...
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PMID: 19521878
PDF is available here.
PDF is available here.
Veterinary Microbiology (137)1-2 2009
Abstract
We constructed a recombinant baculovirus that simultaneously expressed the genes for the P12A and 3C proteins of Asia I FMDV from individual promoters. The capsid proteins expressed in High Five insect cells were processed by viral 3C protease, as shown by Western blotting, and were antigenic, as re...
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PMID: 19167843
PDF is available here.
PDF is available here.
Virus/Uirusu (59)1 2009
Abstract
The Laboratory of Enteroviruses of the Department of Virology II, National Institute of Infectious Diseases, is functioning as a WHO-designated Collaborating Center for Virus Reference and Research (Enterovirus) in virus isolation and identification, development, evaluation, and quality control of n...
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PMID: 19927988
PDF is available here.
PDF is available here.
Abstract
We consider the risk of infection to flocks or herds from airborne virus emitted from a known infected premises. We show that airborne infection can be predicted quickly and with a good degree of accuracy, provided that the source of virus emission has been determined and reliable geo-referenced her...
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PMID: 18757269
PDF is available here.
PDF is available here.
Abstract
PCR results showed that VP1 gene was successfully inserted into the genome of BHV-1/gE(-). The expression of VP1 in infected cells was proved by indirect immunofluorescence assay and Western blotting. CONCLUSION: The research provided a basis for development of BHV-1 vector vaccines for FMD and othe...
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PMID: 19637579
PDF is available here.
PDF is available here.
Abstract
These results suggest that the FMD outbreaks reported in Israel and Palestine in 2006 and 2007 were likely a consequence of different epidemics associated with the circulation and spread of FMD virus strains from different regions of the Middle East....
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PMID: 19245666
PDF is available here.
PDF is available here.
Abstract
Livestock movements are important in spreading infectious diseases and many countries have developed regulations that require farmers to report livestock movements to authorities. This has led to the availability of large amounts of data for analysis and inclusion in computer simulation models devel...
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PMID: 19267879
PDF is available here.
PDF is available here.
Viral Immunology (22)2 2009
Abstract
We found that levels of antibody production, T-cell proliferation, and CTL activity were significantly increased compared with the DNA vaccine alone. Compared with the adjuvant effects of CpG ODNs on DNA vaccination, similar levels of antibody production and T-cell proliferation, and higher levels o...
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PMID: 19327000
PDF is available here.
PDF is available here.
Abstract
The monthly incidence of listeriosis infections in England and Wales had 2 sudden increases during April 2001 (41%) and March 2003 (48%). Although no causative association is demonstrated, these increases correspond to key dates relating to the onset and aftermath of the 2001 foot and mouth disease...
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PMID: 19239766
PDF is available here.
PDF is available here.
Abstract
Although present conventional foot-and-mouth disease (FMD) vaccines can prevent clinical disease, protection is short lived ( approximately 6 months), often requiring frequent revaccination for prophylactic control, and vaccination does not induce rapid protection against challenge or prevent the de...
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PMID: 19249976
PDF is available here.
PDF is available here.
Abstract
We investigated in vivo inhibitory effect of shRNA on FMDV replication in BHK-21 cells and guinea pigs. The results showed that transfection of 3D shRNA could reduce virus growth by three folds when cells were challenged with 10(2) TCID(50) of FMDV. Pretreated guinea pigs with 3DshRNA were protected...
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PMID: 18810649
PDF is available here.
PDF is available here.
Bing du xue bao = Chinese journal of virology / [bian ji, Bing du xue bao bian ji wei yuan hui] (25)2 2009
Abstract
A rapid detection of foot-and-mouth disease virus (FMDV) was established by using reverse transcription loop-mediated isothermal amplification (RT-LAMP) method, meanwhile its specificity and sensitivity were assessed. The results showed that the FMDV RNA could be amplified by incubation at 65degrees...
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PMID: 19678569
PDF is available here.
PDF is available here.
Abstract
Foot-and-mouth disease virus (FMDV) serotype O is the most predominant among the endemic serotypes in India. A stable,full-length cDNA clone of FMDV type O 1 BFS 1860 preceded by a bacteriophage T7 polymerase promoter was assembled in a plasmid vector pGEM R- - 7Zf(-). An 8.2 kb PCR product was ampl...
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PMID: 19430118
PDF is available here.
PDF is available here.
Abstract
We performed a logistic regression analysis, using early versus late detection of disease as the outcome of interest.During the 2001 FMD outbreak in the United Kingdom, infected premises were more likely to be detected early under the following circumstances: 1) cattle (particularly dairy) were infe...
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PMID: 19337614
PDF is available here.
PDF is available here.
Veterinary Research (40)3 2009
Abstract
We consider all the available experimental data from studies utilizing either experimental or readily available, commercially produced vaccines, in order to assess their likely effectiveness as an additional means of controlling FMD transmission and spread in an emergency. Overall it is concluded th...
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PMID: 19040829
PDF is available here.
PDF is available here.
Abstract
We report on the use of data from an animal experiment conducted 10 years ago to quantify transmission of foot-and-mouth disease virus between non-vaccinated sheep and from sub-clinically infected sheep to in-contact pigs. This new analysis utilises a state-of-the-art Generalised Linear Model to est...
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PMID: 19326033
PDF is available here.
PDF is available here.
Veterinary Research (40)3 2009
Abstract
We conducted a series of simulation experiments to determine how seasonal estimates of the spatial distribution of white-tailed deer impact the predicted magnitude and distribution of potential FMD outbreaks. Outbreaks were simulated in a study area comprising two distinct ecoregions in South Texas,...
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PMID: 19134466
PDF is available here.
PDF is available here.
Journal of Virology (83)2 2009
Abstract
We identified selection and relaxed constraints due to genetic drift through analyses of synonymous sites. Finally, we investigated interactions between mutations that showed coevolving patterns and analyzed, based on protein structures, slightly deleterious and compensatory mutational dynamics. Spe...
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PMID: 19004952
PDF is available here.
PDF is available here.
Journal of Dairy Science (92)1 2009
Abstract
We demonstrate that there is no association among neutralizing antibody titers against foot and mouth disease virus, bovine viral diarrhea virus, or bovine herpesvirus type 1 and polymorphism of the BoLA DRB3.2 gene. Conversely, there is strong association between BoLA DRB3.2*0902 and low antibody t...
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PMID: 19109295
PDF is available here.
PDF is available here.
Archives of Virology (154)4 2009
Abstract
These results revealed that the 3'UTR can tolerate foreign sequences that do not disrupt essential signals required for virus replication....
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PMID: 19288053
PDF is available here.
PDF is available here.
Abstract
Tijdschrift voor diergeneeskunde (133)24 2008
Abstract
The consequences of the outbreak of foot-and-mouth disease in 2001 in The Netherlands can still be noticed in the daily work of the veterinarians involved. In particular, the number off arm animals has decreased, regulations have changed, and cattle farmers have become more confrontational. While th...
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PMID: 19170335
PDF is available here.
PDF is available here.
Abstract
We have assembled a comprehensive data set of gene sequences representing the global diversity of the disease and inferred the time-scale and evolutionary history for FMDV. Serotype-specific rates of evolution and divergence times were estimated using a Bayesian coalescent framework. We report that...
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PMID: 18945462
PDF is available here.
PDF is available here.