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Hepatitis, Animal (1):
Recent article
Hepatitis, Animal
Abstract
OBJECTIVE: To investigate the anti-apoptosis effects of Rubus alceaefolius total alkaloids in rats with hepatic injury. METHOD: The hepatic injury model of rat was induced by intraperitoneal injection with CCl4. Sixty SD rats were randomly divided into the normal group, the model group, the R. alcea...
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PMID: 20617694
PDF is available here.
PDF is available here.
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BMC Genomics (11) 2010
Abstract
At the early stages of fulminant hepatitis, expression of twenty-six genes involved in protein transport, transcription regulation and cell metabolism altered significantly. These genes form a network and have shown strong correlation with fulminant hepatitis development. Our study provides several...
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PMID: 20398290
PDF is available here.
PDF is available here.
Abstract
This experiment was preformed on an animal model of CCl4 hepatitis using 320 Wistar rats. The animals underwent combined effect of saprogel and a magnetic field during different seasons. It was shown that non-medicamentous treatment of experimental CCl4 hepatitis had the most pronounced beneficial e...
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PMID: 20364684
PDF is available here.
PDF is available here.
Extrapulmonary disorders associated with Rhodococcus equi infection in foals: 150 cases (1987-2007).
Abstract
Of 150 foals with R equi infections, 111 (74%) had at least 1 of 39 EPDs. Survival was significantly higher among foals without EPDs (32/39 [82%]) than among foals with EPDs (48/111 [43%]), but many EPDs were only recognized after death. Risk factors significantly associated with EPDs included refer...
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PMID: 19793018
PDF is available here.
PDF is available here.
Thrombosis and Haemostasis (102)2 2009
Abstract
Although hepatic stellate cells, endothelial cells, glomerular podocytes and plateles were reported to be a source of ADAMTS13, it is not clarified which source is involved in the regulation of plasma ADAMTS13 activity. It was demonstrated previously that selective hepatic stellate cell damage in ra...
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PMID: 19652891
PDF is available here.
PDF is available here.
Veterinary Record (164)3 2009
Abstract
Abstract
We analyzed the hepatic inflammatory response after intraperitoneal administration of lipopolysaccharide (LPS) given to Fisher 344 rats aged 6, 15, and 22-23 months. Induction of the acute phase proteins (APPs), haptoglobin, alpha-1-acid glycoprotein, and T-kininogen was reduced and/or retarded with...
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PMID: 19126842
PDF is available here.
PDF is available here.
Abstract
We hypothesized that chronic inhibition of sEH would attenuate a lipopolysaccharide (LPS)-induced inflammatory response in vivo. Continuous dosing of the sEH inhibitors 12-(3-adamantan-1-ylureido)-dodecanoic acid (AUDA), a polyethylene glycol ester of AUDA, and 1-adamantan-1-yl-3-(5-(2-(2-ethoxyetho...
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PMID: 18815352
PDF is available here.
PDF is available here.
Abstract
C57BL/6 mice pretreated with STS released much less alanine transaminase into plasma in response to ConA challenge and had reduced inflammatory infiltration and hepatocyte apoptosis in the liver compared with control mice pretreated with vehicle solutions. Thus, STS protected mice from CIH. In STS-p...
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PMID: 18498044
PDF is available here.
PDF is available here.
Abstract
OBJECTIVE: To investigate the protective effect on the mice acute experimental hepatic injury by Flos Gossypium herbaceum extracts (FGF-I, FGF-II). METHOD: Experimental hepatic injury model was established by a single intraperitoneal injection of 350 mg x kg(-1) D-CalN in Wistar rats. Serum samples...
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PMID: 19007020
PDF is available here.
PDF is available here.
Molecular Immunology (45)13 2008
Abstract
The alteration in the expression levels of flotillin-2, Lck, and STAT1 that occurs concomitantly with changes in lipid raft composition and structure following the administration of beta-glycolipids in ConA-induced hepatitis is microenvironment-dependent and is associated with decreased intrahepatic...
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PMID: 18572246
PDF is available here.
PDF is available here.
Ugeskrift for laeger (170)23 2008
Abstract
Helicobacter species have been found in extragastric tissues of humans and mice, and it has been shown that hepatic infection with H. hepaticus causes chronic hepatitis and hepatocellular carcinoma (HCC) in mice. 18 studies of humans with hepatobiliary diseases have been reviewed. In studies of pati...
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PMID: 18534163
PDF is available here.
PDF is available here.
Abstract
An outbreak of chlamydiosis was diagnosed in hatchling and juvenile Indopacific crocodiles (Crocodylus porosus) on a crocodile farm in Papua New Guinea. The outbreak was characterised by high mortality with hepatitis and exudative conjunctivitis. The agent appears to have been introduced with live w...
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PMID: 18846855
PDF is available here.
PDF is available here.
Avian Pathology (37)3 2008
Abstract
The occurrence of listeriosis in 12 caged canaries is described where 50% of the birds, including the female and all of the offspring, died within 2 weeks without clinical signs. At necropsy, multifocal necrotizing and partly granulomatous hepatitis, splenitis, myocarditis, interstitial nephritis, a...
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PMID: 18568661
PDF is available here.
PDF is available here.
Journal of Immunological Methods (334)1-2 2008
Abstract
We have optimised a triple colour immunofluorescent staining protocol, utilising an anti-FITC technique, to allow antibodies to macrophage markers to be used simultaneously. We highlight the substantial heterogeneity of cells in both normal liver and spleen that stain for F4/80, CD68, CD11b, and CD1...
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PMID: 18367204
PDF is available here.
PDF is available here.
Hepatology (47)5 2008
Abstract
We demonstrated that SOCS1 deletion in hepatocytes enhanced concanavalin A (ConA)-induced hepatitis, which has been shown to be dependent on activated T and natural killer T (NKT) cells. Although serum cytokine level and NKT cell activation were similar in wild-type (WT) and SOCS1-deficient mice aft...
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PMID: 18393318
PDF is available here.
PDF is available here.
Abstract
We identified bottlenose dolphins in our current population with episodic increases in serum aminotransferases, specifically alanine aminotransferase (ALT) and aspartate aminotransferase (AST), and we hypothesized that hematologic and serum biochemical changes in these animals may provide clues as t...
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PMID: 18436664
PDF is available here.
PDF is available here.
Acta Tropica (105)3 2008
Abstract
We may propose that persistently elevated TGF-beta 1 expression in infiltrating leukocytes and active HSC with marked alpha-SMA expressions may contribute to healing of injured sites through up-stimulation of collagen deposition; in contrast, abnormally persistent collagen accumulation may cause irr...
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PMID: 18178169
PDF is available here.
PDF is available here.
Abstract
We examined the effect of Meth on the development of steatohepatitis. Rats were fed (five weeks) amino acid-based Meth-choline-sufficient (A-MCS) or total deficient (MCD) diets and gavaged daily (two weeks) with vehicle (B-vehicle/MCD), or Meth replacement (C-Meth/MCD). To assess the effect of short...
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PMID: 17710550
PDF is available here.
PDF is available here.
Laboratory Investigation (88)3 2008
Abstract
We evaluated the susceptibility of concanavalin A (ConA) challenge in NOD2-deficient mice (Nod2-/-) compared to wild-type littermates. We tested the effect of muramyl dipeptide (MDP), the specific activator of NOD2, on ConA-induced liver injury in C57BL/6 mice. We studied the cellular distribution a...
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PMID: 18227809
PDF is available here.
PDF is available here.
Abstract
Experiments on white rats show that the phytopreparation Narcophyt possesses choleretic activity. In rats with experimental hepatitis induced by ethanol, the course of therapeutic and prophylactic administration of Narcophyt favorably influenced the bile secreting function of the liver, accelerated...
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PMID: 19093368
PDF is available here.
PDF is available here.
Journal of Comparative Pathology (139)2-3 2008
Abstract
In a survey of 66 894 slaughter pigs, 11 animals from three farms were found to have multifocal granulomatous lesions in the liver, caused by Actinobacillus pleuropneumoniae serotype 2. The lesions consisted of epithelioid cells and multinucleated giant cells, with asteroid bodies and discernible gr...
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PMID: 18617183
PDF is available here.
PDF is available here.
Journal of Immunology (179)10 2007
Abstract
We identified Bax and A20 as key players in TNF-induced protection from apoptotic liver damage. Because treatment with TNF itself might be a risk factor for patients, we propose that overexpression of A20 might represent an alternative approach for protection from inflammation related apoptotic live...
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PMID: 17982095
PDF is available here.
PDF is available here.
Abstract
To investigate whether Dobermanns have impaired copper excretion an intravenous radioactive copper isotope ((64)Cu) was used as a tracer. Five patients and eight normal dogs (5 normal Dobermanns and 3 Beagles) were studied. The five female Dobermann patients had a subclinical hepatitis and an increa...
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PMID: 17258253
PDF is available here.
PDF is available here.
Journal of Hepatology (47)4 2007
Abstract
Our results indicate that lack of adiponectin enhances the progression of hepatic steatosis, fibrosis, and hepatic tumor formation in an animal model of NASH. Hypoadiponectinemia in obesity could be a risk factor for NASH-related hepatic tumor formation....
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PMID: 17459514
PDF is available here.
PDF is available here.
Journal of Hepatology (47)4 2007
Abstract
These findings demonstrate the importance of TLR-4 signaling and underscore a direct link between TLR-4 and Kupffer cells in the pathogenesis of steatohepatitis....
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PMID: 17644211
PDF is available here.
PDF is available here.
Abstract
An 11-year-old Thoroughbred broodmare was evaluated for suspected hepatic dysfunction. Clinical signs of hepatic encephalopathy were evident at admission. Hepatic ultrasonographic evaluation revealed an increase in hepatic size, rounded borders and normal echogenicity. There was no evidence of chole...
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PMID: 17685983
PDF is available here.
PDF is available here.
Abstract
The results indicate that MOR agonists may prevent acute hepatitis and hold promising therapeutic use to maintain remission in both chronic inflammatory bowel and liver diseases....
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PMID: 17299060
PDF is available here.
PDF is available here.
Abstract
Abstract
COX-2 TG mice exhibited strongly increased COX-2 and PGE(2), elevated serum alanine aminotransferase level and histological hepatitis. Hepatic COX-2 expression in the TG mice resulted in activation of NF-kappaB and inflammatory cytokine cascade, with a marked expression of the proinflammatory cytoki...
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PMID: 17148503
PDF is available here.
PDF is available here.
Abstract
A new spectrophotometric method for quantitation of acetyl-CoA synthetase (ACAS) activity is developed. It has been applied for ACAS assay in the liver tissues of a woodchuck model of hepatitis virus-induced hepatocellular carcinoma (HCC). The assay is based on the established pyrophosphate (PPi) det...
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PMID: 17399795
PDF is available here.
PDF is available here.
Endocrinology (148)6 2007
Abstract
Recently it has become evident that obesity is associated with low-grade chronic inflammation. The transcription factor peroxisome proliferator-activated receptor alpha (PPARalpha) has been shown to have a strong antiinflammatory action in liver. However, the role of PPARalpha in obesity-induced inf...
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PMID: 17347305
PDF is available here.
PDF is available here.
Immunology Letters (110)1 2007
Abstract
We used attenuated spleen lymphocytes or peripheral blood lymphocytes as vaccines to investigate whether they could induce protective immune responses to prevent mice from developing CIH. We found that mice receiving such vaccination before CIH induction developed much milder diseases, exhibited a l...
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PMID: 17395274
PDF is available here.
PDF is available here.
Veterinary Microbiology (122)1-2 2007
Abstract
These results indicate that swine HEV infection can be a significant contributor to the development of moderate hepatitis in pigs regardless of the PMWS status....
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PMID: 17270366
PDF is available here.
PDF is available here.
Abstract
Administration of Con A in mouse lead to a significant increase of mGST2 gene expression without any significant effect on LTC4 S and mGST3 mRNA levels. Cs A pretreatment results in protection of liver damage, whereas fails to fully inhibit the increase of mGST2 gene expression....
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PMID: 17571306
PDF is available here.
PDF is available here.
Abstract
We explored the genetic interactions of telomeres and DNA-PKcs, a protein involved in non-homologous end-joining (NHEJ) and immune responses, in the context of a key aspect of aging and lifespan--the capacity to mount an acute and appropriate immune-mediated stress response. We observed that the com...
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PMID: 17072335
PDF is available here.
PDF is available here.
Journal of Immunology (178)9 2007
Abstract
We used the murine concanavalin A (Con A)-induced hepatitis model, in which iNKT cells, IL-12, IL-4, and IFN-gamma are equally requisite, to reevaluate this issue. We demonstrate that IL-12 interacts directly with iNKT cells, contributes to their recruitment to the liver, and enhances their IL-4 pro...
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PMID: 17442924
PDF is available here.
PDF is available here.
Abstract
We examined the role of Vbeta(+)8+NKT cells in hepatitis models and in the GSR. The absence of Vbeta(+)8+NKT cells in the liver mononuclear cells (MNC) was confirmed by the alpha-GalCer/CD1d/Ig dimer. Unexpectedly, other dimer+NKT cells including Vbeta7(+)NKT cells in these mice were found to decrea...
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PMID: 17380303
PDF is available here.
PDF is available here.
Abstract
We characterized the role of cryoglobulinemia in the development of liver disease in thymic stromal lymphopoietin (TSLP) transgenic mice that produce mixed cryoglobulinemia and develop hepatitis. The role of immune complexes in this animal model was evaluated using techniques of light, immunofluores...
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PMID: 17322382
PDF is available here.
PDF is available here.
Abstract
We investigated the involvement of HGF in cholestasis-induced hepatitis. After the BDL surgery, HGF and c-Met mRNA levels transiently increased in livers during the progression of cholestatic hepatitis. When c-Met tyrosine phosphorylation was blocked in the livers of BDL-treated mice by anti-HGF IgG...
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PMID: 17068118
PDF is available here.
PDF is available here.
Abstract
We used DNA microarrays bearing 22,012 genes to investigate at the transcriptomic level the progression of the hepatitis in LEC rats in comparison to a control obtained from LEC rats treated with D-penicillamine, a copper chelating agent known to block hepatitis development. Multivariate statistical...
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PMID: 18092909
PDF is available here.
PDF is available here.
Journal of Hepatology (46)1 2007
Abstract
Rosi directly attenuates the suppressive effects of inflammation-induced cell signaling on nuclear RXRalpha levels in liver....
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PMID: 17107731
PDF is available here.
PDF is available here.
Veterinary Pathology (43)6 2006
Abstract
A case of eosinophilic granulomatous gastroenterocolitis and hepatitis in a 1-year-old male Siberian Husky is described. The dog presented with a history of diarrhea, weakness, lethargy, and anorexia of several months' duration. Hematologic and biochemical examinations, abdominal ultrasonography, co...
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PMID: 17099165
PDF is available here.
PDF is available here.
Journal of Medical Microbiology (55)Pt 11 2006
Abstract
Microaerobic bacteria were isolated from a baboon with pancreatic islet amyloidosis and hepatitis. Phenotypic and molecular analyses identified two distinct helicobacters. Analyses of 16S rRNA demonstrated "Helicobacter macacae" in the ileum and liver, and Helicobacter cinaedi in the colon. To the b...
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PMID: 17030922
PDF is available here.
PDF is available here.
Phytotherapy Research (20)9 2006
Abstract
The antioxidative effects of pumpkin seed protein isolate (Cucurbita pepo) were investigated in vitro. The isolate exhibited about 80% radical scavenging activity, chelating activity of approximately 64% on Fe2+ ions and an inhibition of approximately 10% of xanthine oxidase. Subsequently the effect...
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PMID: 16807884
PDF is available here.
PDF is available here.
Liver International (26)6 2006
Abstract
Our results demonstrate that fibrosis in spontaneous dog liver diseases is highly comparable to their human counterparts and might serve as models for anti-fibrotic strategies....
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PMID: 16842329
PDF is available here.
PDF is available here.
Abstract
The present study is aimed at investigating the effect of curcumin (CMN) in salvaging endotoxin-induced hepatic dysfunction and oxidative stress in the liver of rodents. Hepatotoxicity was induced by administering lipopolysaccharide (LPS) in a single dose of 1 mg/kg intraperitoneally to the animals,...
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PMID: 16879252
PDF is available here.
PDF is available here.
Abstract
We investigated branched and linear polyethylenimine (B-PEI, L-PEI)-mediated plasmid DNA delivery with time in murine hepatitis induced by a subcutaneous injection of tetrachloro carbon (CCl(4)). Plasmid DNA (pDNA) encoding firefly luciferase was used as the model reporter gene. We determined lucife...
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PMID: 16675174
PDF is available here.
PDF is available here.
Biotechnology Letters (28)11 2006
Abstract
Ganoderic acid, from Ganoderma lucidum, at 8 microg/ml inhibited replication of hepatitis B virus (HBV) in HepG2215 cells over 8 days. Production of HBV surface antigen and HBV e antigen were 20 and 44% of controls without ganoderic acid. Male KM mice were significantly protected from liver injury,...
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PMID: 16786250
PDF is available here.
PDF is available here.
Abstract
The Long-Evans Cinnamon (LEC) rat, an animal model of Wilson's disease, spontaneously develops hepatitis as the result of abnormal copper accumulation in liver. The findings of this study show that copper, hydrogen peroxide, and lipid peroxides accumulate to drastically high levels in LEC rat serum...
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PMID: 16480686
PDF is available here.
PDF is available here.
Veterinary Record (158)9 2006
Abstract
Abstract
We found that mice from commercial breeding facilities may carry undetected Helicobacter infections. Taken together, we show that infection with EHS may frequently occur and spread easily in mice reared under SPF conditions despite extensive safety precautions. Moreover, there is a high prevalence o...
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PMID: 16517848
PDF is available here.
PDF is available here.
Veterinary Record (158)5 2006
Abstract
Toxicology Letters (160)3 2006
Abstract
Administration of the non-metabolizable organic anion indocyanine green (ICG) prior to a toxic dose of acetaminophen (4-acetamidophenol; APAP) reduces liver injury 24h after dosing. ICG also produces a dose-dependent decrease in bile flow in mice and rats. Studies in bile duct-cannulated rats sugges...
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PMID: 16140478
PDF is available here.
PDF is available here.
Abstract
The diseases known as hepatitis cysticercosa and pneumonitis cysticercosa are caused by migrating Cysticercus tenuicollis, the intermediate stage of Taenia hydatigena, in the liver and lung tissue of intermediate hosts like sheep, goats, cattle, pigs and squirrels. In this study, parasitological and...
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PMID: 17124659
PDF is available here.
PDF is available here.
Abstract
Median survival time from onset of disease in nonsurviving foals was 30 hours (mean 34.5 +/- 20.1; range, 16-62 hours). Common clinical findings included lethargy, recumbency, seizures, and fever. Laboratory findings included metabolic acidosis, hypoglycemia and increased activity of hepatobiliary e...
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PMID: 17063719
PDF is available here.
PDF is available here.
Poultry Science (84)12 2005
Abstract
A 42-d floor pen study was conducted with broiler chickens comparing the effects on bird performance of 12 ppm TAMUS 2032 (also known as BT) and 55 ppm bacitracin methylene disalicyclate (BMD) when fed alone or in combination with 99 ppm monensin (MON). Unmedicated and 99 ppm MON treatments were inc...
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PMID: 16479941
PDF is available here.
PDF is available here.
Toxicology (216)1 2005
Abstract
We earlier reported that ceramide synthase inhibition by FB1, the initial biochemical effect of this mycotoxin, results in modulation of cytokine network in response to accumulated free sphingoid bases. In the current study we used NZB/NZW-F1 (NZBW) mice that have modified cytokine expression and de...
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PMID: 16159691
PDF is available here.
PDF is available here.
Abstract
Abstract
A 12-year-old, neutered male domestic shorthair cat was evaluated with a life-long history of intermittent, predominantly small bowel diarrhea and a 3 day history of hematochezia. At presentation, the cat had increased liver enzyme activities and an inflammatory leukogram. Histopathology demonstrate...
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PMID: 16182186
PDF is available here.
PDF is available here.