Abstract
Clinical, gross and histopathological investigations were carried out into large-scale mortalities on eastern Mediterranean bluefin tuna, Thunnus thynnus (L.), farms. Fish showed only nervous signs and darkened colour. At post-mortem the liver was bronze coloured and the pyloric area waxy in consist...
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PMID: 18234015
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Abstract
We provide data for the novel finding that genetic deficiency of PECAM-1 potentiates the development and progression of NASH. We found that the rate of development and severity of diet-induced NASH are markedly enhanced in PECAM-1-deficient [knockout (KO)] mice relative to wild-type (WT) mice, as me...
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PMID: 17932230
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Abstract
A 13-year-old Siamese cat was presented for investigation of lethargy and progressive abdominal enlargement. Serum chemistry revealed severe reduction of total and ionised serum calcium. The omentum appeared hyperechoic with scattered hypoechoic foci on abdominal ultrasound examination. Elevated ser...
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PMID: 17175190
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Abstract
Twenty domestic shorthaired (DSH) and 20 Siamese (S) kittens were allocated into 4 breed-specific groups, of 10 kittens each, that were fed exclusively cooked sardines (F groups) or commercial feline canned food based on oily fish (C groups) for a 4-month period. Clinical signs were scored every 15...
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PMID: 17028379
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Abstract
The association of pancreatic disorders with fat necrosis in domestic animals is rare. This report concerns a case of cutaneous/subcutaneous necrotizing panniculitis and steatitis associated with a pancreatic adenocarcinoma in an 11-year-old male Siamese cat. Clinical investigation revealed variably...
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PMID: 16359310
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Abstract
A 4-year-old female Siberian Husky was diagnosed with pyogranulomatous steatitis at the site of a recurrence of left anal sac rupture (day 1). Carprofen and orbifloxacin were given for 13 days without improvement. A single dose of meloxicam was administered prior to surgical resection of the anal sa...
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PMID: 16276063
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Abstract
Rich diet and lack of exercise are causing a surge in obesity, insulin resistance and steatosis, which can evolve into steatohepatitis. Steatosis and nonalcoholic steatohepatitis (NASH) can also be induced by drugs such as amiodarone, tamoxifen and some antiretroviral drugs. There is growing evidenc...
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PMID: 15223984
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Abstract
Pansteatitis is caused by the consumption of high levels of unsaturated fatty acids and/or the insufficient intake of vitamin E, leading to inflammation of adipose tissue. This disease has been related to fish-based diets. However, non-conventional diets must also be considered. The authors present...
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PMID: 12948502
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Abstract
Five young adult pet marmosets (Callithrix spp.) were presented with weight loss (5/5); fecal retention (3/5); diarrhea (2/5); impaired locomotion (3/5); anemia (4/4); hypoproteinemia or hypoalbuminemia (3/4); elevations of creatine phosphokinase, lactic dehydrogenase, and alanine aminotransferase (...
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PMID: 12949411
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Abstract
Interpretation of abnormalities in liver function tests is a common problem faced by clinicians. This has become more common with the introduction of automated routine laboratory testing. Not all persons with one or more abnormalities in these tests actually have liver disease. The various biochemic...
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PMID: 12840117
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Abstract
A 2-year-old Miniature Dachshund was admitted to the hospital because of fever, frequent vomiting, and watery diarrhea. An intra-abdominal mass and a gastric ulcer were detected. At laparotomy, the omentum was yellow but not icteric, irregularly thickened, and fragile, and a large mass involving the...
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PMID: 12479330
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Abstract
This study presents a new description, based on histopathological and ultrastructural studies, of a disease affecting the common dab Limanda limanda (L.). The condition can be recognised by the presence of multiple orange or yellow lesions in the pterygophorial region of the fish. The principal hist...
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PMID: 10918980
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Abstract
A free-ranging juvenile female red-tailed hawk (Buteo jamaicensis) that was unable to fly was admitted to a rehabilitation center and died 1 day later. Hematology and serum chemistry abnormalities included moderate regenerative anemia, elevated creatine kinase, and hyperphosphatemia. Necropsy reveal...
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PMID: 10749450
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Abstract
Steatitis due to vitamin E deficiency occurred in three 10-wk-old boat-billed herons (Cochlearius cochlearius) despite daily placement of a powdered vitamin supplement on the fish that was subsequently washed off by the parents. Physical findings included emaciation, yellow-brown subcutaneous nodule...
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PMID: 10484150
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Abstract
We suggest that these signs of acute imbalance of lipid metabolism can be the result of the chemical modification (blocking) of key lysyl residues on the LDL protein B-100 by the activated AFB1 molecule. Modified LDLs are not recognised by their specific receptors and thus are rejected by peripheral...
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PMID: 10073532
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Abstract
Medical records of 9 cats with chylous ascites that underwent exploratory celiotomy were reviewed. In 7 cats, chylous ascites was associated with intra-abdominal neoplasia: 4 cats had an unresectable tumor (hemangiosarcoma, 3 cats; paraganglioma, 1 cat) within the mesenteric root; 2 had malignant ly...
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PMID: 7890576
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Abstract
Twelve groups of eight rats and two control groups of sixteen rats were given semisynthetic diets with 40% energy as fat for a period of 76 d. All diets contained a minimum of 3% energy as linoleic acid and comparable basal levels of D-alpha- and D-gamma-tocopherol. The diets varied in fat compositi...
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PMID: 7918321
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Abstract
We investigated the anticholelithogenic and choleretic activities and the general pharmacological action of taurohyodeoxycholic acid (THDCA, Io, Praxis, CAS 2958-04-5), a new biliary acid advocated for use as anticholelithogenic agent. THDCA had no significant activity on the CNS (spontaneous locomo...
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PMID: 8216446
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Abstract
These results show that immunocompromised mice fed low levels of dietary protein form significantly increased immunogenic lipid peroxidation adducts during cocaine treatment....
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PMID: 1318159
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Abstract
Young adult mice infected with MCMV were shown to develop inflammatory lesions in the peripancreatic and salivary gland adipose tissues. MCMV replication was detected by immunoperoxidase staining and electron microscopy in adipocytes, fibroblasts, endothelial cells and pericytes in brown and white a...
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PMID: 2169300
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Abstract
We used electron microscopy (SEM and TEM) and Sudan black staining methods followed by morphometric evaluation techniques. MDCK (Madin-Darby-canine-kidney) cells were treated with valproic acid (VPA; 10, 100, 1000 micrograms/ml medium for 22 hrs) and gentamicin (1, 10, 50 micrograms/ml for 60 min)....
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PMID: 2485195
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Abstract
The fractionation and physicochemical characterization of the complex molecular components composing the plasma lipoprotein spectrum in the goose, a potential model of liver steatosis, are described. Twenty lipoprotein subfractions (d less than 1.222 g/ml) were separated by isopycnic density gradien...
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PMID: 3411248
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Abstract
Equine steatitis is a rare condition which is usually reported in foals. A case of generalised steatitis in an adult pony mare is described and compared with steatitis in other species. It is concluded that the condition resembled that recorded in foals but that its aetiopathogenesis remains obscure...
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PMID: 3381450
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Abstract
A 7-month-old male Quarter Horse was examined because of severe cachexia, which had begun 2 months earlier. The foal was emaciated and weak despite an excellent appetite. Percutaneous biopsy revealed multiple areas of subcutaneous steatitis with mineralization. Radiography demonstrated calcification...
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PMID: 3733507
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Abstract
Steatitis and fat necrosis were identified in a group of 123 American alligators (Alligator mississippiensis) kept in an enclosed pond and fed a diet of only fish for more than 10 years. All affected animals were outwardly healthy and had had no signs of disease in the period immediately before slau...
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PMID: 6643233
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Abstract
Steatosis was induced in rabbits by subacute administration of isoniazid (INH, 50 mg/kg po). Concomitant treatment with pyridoxine (vitamin B6, 25 mg/kg po) antagonized both development of the hepatic lesions and the elevation of plasma concentrations of lipids. Rabbit acetylating ability was sixfol...
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PMID: 6883201
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Abstract
The administration of high-dose valproic acid (VPA) (750 mg per kg) consistently produced significant microvesicular steatosis in mature Sprague-Dawley rats after 48 hr. Similar changes occurred in animals pretreated with phenobarbital which received a lower dose of VPA (350 mg per kg), but no steat...
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PMID: 6815046
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Abstract
Histological examination revealed that 4-methylfurazan-3-carboxylic acid hydrazide (I); 3-methylfuroxan-4-carboxylic acid hydrazide (II); 4-methylfurazan-3-carboxylic acid amide(III); 4-methylfuroxan-3-carboxylic acid amide (IV), caused hepatic and intestinal lesion in the mouse. At the higher doses...
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PMID: 7225247
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Abstract
There was 1% mortality among female guppies just imported from Southeast Asia. Moribund fish showed discoloration, lethargy and kyphosis. Microscopically, myopathy and steatitis were observed, together with an extensive ceroid storage. These findings are indicative of vitamin E deficiency, and illus...
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PMID: 553194
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Abstract
Basal and hormone-stimulated lipolysis of adipose tissue was measured at successive stages during the development of fish oil-induced yellow fat disease in rats. Changes of lipolytic activity at an early stage of yellow fat disease were not seen. There was a significant increase of basal lipolysis a...
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PMID: 695228
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Abstract
Yellow fat disease was induced in young rats given a vitamin E-deficient diet supplemented with 15% fish oil. The changes in adipose tissue of this oil-induced disorder were different from those of natural yellow fat disease in horse, pig and mink. In the natural disease all fat depots had the early...
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PMID: 625860
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Abstract
Adipose tissue in various stages of fish oil-induced yellow fat disease in the rat had the same acid phosphatase and 5-nucleotidase activity pattern as similar stages of the disorder in mink and pig. A weak acid phosphatase and 5-nucleotidase activity was seen in interstitial lipofuscin-laden macrop...
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PMID: 625862
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Abstract
Liver samples from 71 patients with various liver diseases were obtained by needle-biopsy and examined by the direct fluorescent antibody technique. Immunocytes reacting with specific conjugated anti-IgG, A, M sera were counted. An attempt to correlate i-munocytochemical observations with Ig-levels...
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PMID: 772547
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Abstract
Human red cell and plasma lipids are determined in alcoholic patients with various forms of liver diseases including steatosis, cirrhosis and hepatitis. No relation between serum lipids and red cell lipids content have could be demonstrated. A relation is shown between morphology and lipids red cell...
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PMID: 1240054
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Abstract
When adipose tissues of horses and ponies affected with generalized steatitis were extracted by acetone, methanol and chloroform, non-extractable lipids were found to be present, which had become insoluble as a result of peroxidation and polymerization and had acquired autofluorescent characteristic...
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PMID: 4141135
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