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Lateral Line System (0):
Recent article
Lateral Line System
Development (137)10 2010
Abstract
We devised a simple method to gather dynamic morphometric information about axonal terminals in toto by four-dimensional imaging. Applying this strategy to the zebrafish allowed us to correlate hair cell orientation to single afferent neurons at subcellular resolution. Here we show that in zebrafish...
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PMID: 20430744
PDF is available here.
PDF is available here.
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Abstract
Underwater vibratory sources simultaneously present acoustic and hydrodynamic disturbances. Because vibratory dipole sources are poor sonic projectors, most researchers have assumed that such sources are of greatest relevance to the lateral line system. Both hydroacoustic principles and empirical st...
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PMID: 20384404
PDF is available here.
PDF is available here.
Drug Discovery Today (15)7-8 2010
Abstract
We have used this model to screen for and identify multiple drugs that protect hair cells from aminoglycoside-induced death. The identification of multiple drugs and drug-like compounds that inhibit multiple hair cell death pathways might enable the development of protective cocktails to achieve com...
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PMID: 20096805
PDF is available here.
PDF is available here.
Journal of Experimental Biology (213)Pt 8 2010
Abstract
We performed measurements of undulatory kinematics during steady swimming in the golden shiner (Notemigonus crysoleucas) at three speeds (4.5, 11.0 and 22.0 cm s(-1)). We found that the phase shift between yaw angle and lateral velocity (20.5+/-13.1 deg., N=5) was significantly greater than the theo...
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PMID: 20348343
PDF is available here.
PDF is available here.
Biological Cybernetics (102)3 2010
Abstract
We revisit the method of conformal mapping and apply it to the setting found in mechanosensory detection systems such as the lateral-line system of fish. We derive easy-to-use equations capable of describing analytically the influence of the stimulus shape on the flow field and thus on the input to...
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PMID: 20204396
PDF is available here.
PDF is available here.
Abstract
We identified a repertoire of key genes expressed in the migrating primordium and in differentiated neuromasts. We validated the specific expression in the primordium of a subset of the identified sequences by quantitative RT-PCR, and by in situ hybridization. We also show that interfering with the...
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PMID: 21144052
PDF is available here.
PDF is available here.
Abstract
We use the eight species of the ecologically diverse New Zealand marine triplefin fish of the genus Forsterygion and one species from the sister genus Notoclinops to investigate interspecific differences in lateral line morphology and to assess the relationship between lateral line characteristics a...
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PMID: 20693784
PDF is available here.
PDF is available here.
Abstract
We present an analytically based physical-mathematical model for rapidly calculating the drag force acting on a neuromast cupula. The cupula is well approximated as an immobile sphere located inside a tube-shaped canal segment of circular cross section containing a constant property fluid in a stead...
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PMID: 18926966
PDF is available here.
PDF is available here.
Abstract
We calculate the unsteady flow past an elongated rectangular prism and a fish downstream of it, with both objects moving at the same speed. By construction, the prism generates a clean, periodic vortex street in its wake. Then, also using the Navier-Stokes solver, the pressure field associated with...
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PMID: 18926967
PDF is available here.
PDF is available here.
Abstract
We discuss general issues of signal and noise in the lateral-line system and the behavioral and physiological strategies that are used by fish to enhance signal detection in a noisy environment. In order for signal and noise to be separated, they need to differ, and we will consider those difference...
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PMID: 21392272
PDF is available here.
PDF is available here.
Abstract
The lateral line is a sensory system that allows fishes to detect weak water motions and pressure gradients. The smallest functional unit of the lateral line is the neuromast, a sensory structure that consists of a hair cell epithelium and a cupula that connects the ciliary bundles o...
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PMID: 21392273
PDF is available here.
PDF is available here.
Abstract
We test the hypothesis that mottled sculpin use excitation peaks (local 'hot spots') to determine the somatotopic location of an artificial prey (vibrating sphere/dipole source) along the body surface. Dipole orientation (axis of sphere vibration re: long axis of the fish) is manipulated to produce...
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PMID: 19137317
PDF is available here.
PDF is available here.
Physical Review Letters (102)5 2009
Abstract
We present an explicit model explaining how aquatic animals such as fish can distinguish differently shaped submerged moving objects. Our model is based on the hydrodynamic multipole expansion and uses the unambiguous set of multipole components to identify the corresponding object. Furthermore, we...
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PMID: 19257562
PDF is available here.
PDF is available here.
Abstract
We investigated how fibers in the anterior lateral line nerve of goldfish, Carassius auratus, respond to water motions generated by an object that was moved alongside the fish. Motion direction was from anterior to posterior or opposite, object diameter was between 0.1 and 4 cm and the distance betw...
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PMID: 19034462
PDF is available here.
PDF is available here.
Abstract
We show that lateral-line afferents can recognize the planar polarization of hair cells. Each neuron forms synapses with hair cells of identical orientation to divide the neuromast into functional planar-polarity compartments. We also show that afferent neurons are strict selectors of polarity that...
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PMID: 19223970
PDF is available here.
PDF is available here.
Brain Research (1244) 2008
Abstract
We characterize the behavior of dying lateral line hair cells in fish exposed to low doses of copper in the water. The concentration of copper used in our study kills hair cells in a few hours, but removal of the metal is followed by robust regeneration of new hair cells. We use a combination of mem...
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PMID: 18848822
PDF is available here.
PDF is available here.
Abstract
We have recently reported that larval lampreys possess a functional lateral line system. Here we investigated metamorphic morphological changes in the lateral line system using light and electron microscopy. Functional modifications were studied by recording the trunk lateral line nerve activity of...
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PMID: 18795304
PDF is available here.
PDF is available here.
Abstract
We developed a theoretical model of the superficial neuromast in the fish lateral line system. The cupula of the neuromast was modeled as a cylindrical beam that deflects in response to an oscillating flow field. Its accuracy was verified by comparison with prior measurements of cupular deflection i...
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PMID: 18709377
PDF is available here.
PDF is available here.
Journal of Neuroscience (28)34 2008
Abstract
We show that each afferent neuron of the posterior lateral line establishes specific contacts with hair cells of the same hair-bundle polarity. We quantify this specificity by modeling the neuron as a biased selector of hair-cell polarity and find evidence for bias from as early as 2.5 d after ferti...
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PMID: 18716202
PDF is available here.
PDF is available here.
Abstract
We investigated the encoding of amplitude and phase modulations in the distantly related African fish Gymnarchus. In both the amplitude- and time-coding pathways, primary afferents accurately estimated the time course of random modulations whereas hindbrain neurons extracted information about specif...
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PMID: 18176850
PDF is available here.
PDF is available here.
Journal of Neurophysiology (100)2 2008
Abstract
We compared the response properties of sensory neurons within three maps of the body surface that are arranged strictly in parallel to two classes of stimuli that mimic prey and conspecifics, respectively. We used information-theoretic approaches and measures of phase locking to quantify neuronal re...
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PMID: 18509073
PDF is available here.
PDF is available here.
Abstract
We present a first sample of 98 extracellularly recorded brainstem and midbrain responses to waves with curvatures ranging from 22.2-11.1 m(-1). At the frog, concurrently, wave amplitudes and their spectral composition were kept stable. Notably, 61% of 98 units displayed curvature-dependent spike ra...
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PMID: 18633622
PDF is available here.
PDF is available here.
Journal of Experimental Biology (211)Pt 13 2008
Abstract
We examined the functional consequences of morphological variation by measuring the dimensions of superficial neuromasts in zebrafish larvae (Danio rerio) and mathematically modeling their mechanics. These measurements used a novel morphometric technique that recorded landmarks in three dimensions a...
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PMID: 18552300
PDF is available here.
PDF is available here.
Abstract
We show that rosettes form cyclically from a progenitor pool at the leading zone of the primordium as neuromasts are deposited from the trailing region. fgf3/10 signals localized to the leading zone are required for rosette formation, atoh1a expression, and primordium migration. We propose that the...
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PMID: 18583612
PDF is available here.
PDF is available here.
Abstract
We discuss potential developmental and evolutionary relationships between two placode series that are usually considered to be entirely independent: lateral line placodes, which form the mechanosensory and electroreceptive hair cells of the anamniote lateral line system as well as their afferent neu...
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PMID: 17638322
PDF is available here.
PDF is available here.
Abstract
Fiber connections of the rostrolateral region of the lateral preglomerular nucleus (PGlr) were studied by tract-tracing methods in carp and goldfish. The PGlr receives fibers from the optic tectum, ventrolateral nucleus of semicircular torus, ventromedial thalamic nucleus, medial pretoral nucleus, a...
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PMID: 18381599
PDF is available here.
PDF is available here.
Journal of Morphology (269)6 2008
Abstract
Distribution, morphology, and orientation of superficial neuromasts and polarization of the hair cells within superficial neuromasts of the goldfish (Carassius auratus) were examined using fluorescence labeling and scanning electron microscopy. On each body side, goldfish have 1,800-2,000 superficia...
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PMID: 18431809
PDF is available here.
PDF is available here.
Abstract
We tested the hypothesis that variations in the intrinsic spiking mechanism of E- and I-type pyramidal cells contribute to map-specific frequency tuning. We find that E-cells exhibit a systematic change in their intrinsic spike characteristics and frequency tuning across sensory maps, whereas I-cell...
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PMID: 18367702
PDF is available here.
PDF is available here.
Developmental Dynamics (237)4 2008
Abstract
Our long-term goal is to discover genes critical for the correct formation and function of the inner ear and its sensory tissue. A novel gene, transmembrane inner ear (Tmie), was found to cause hearing-related disorders when defective in mice and humans. A homologous tmie gene in zebrafish was clone...
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PMID: 18330929
PDF is available here.
PDF is available here.
Abstract
We characterize correlated activity in response to two biologically relevant classes of sensory stimuli in the primary electrosensory nuclei, the electrosensory lateral line lobe, of the weakly electric fish Apteronotus leptorhynchus. Our results show that these neurons can display significant corre...
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PMID: 18256161
PDF is available here.
PDF is available here.
Abstract
The lateral line is a hydrodynamic sensory system that allows fishes and aquatic amphibians to detect the water motions caused, for instance, by conspecifics, predators or prey. Typically the peripheral lateral line of fishes consists of several hundred neuromasts spread over the head, trunk, and ta...
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PMID: 18228078
PDF is available here.
PDF is available here.
Environmental Pollution (151)1 2008
Abstract
The effect of chronic exposure to a low concentration (0.5 microg l(-1)) of cadmium ions was investigated on escape behaviour of sea bass, Dicentrarchus labrax, using video analysis. Observations were also performed on the microanatomy of lateral system neuromasts. When fish were exposed for 4h per...
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PMID: 17493718
PDF is available here.
PDF is available here.
Abstract
Chondrichthyans occupy a basal place in vertebrate evolution and offer a relatively unexplored opportunity to study the evolution of vertebrate brains. This study examines the brain morphology of 22 species of deep-sea sharks and holocephalans, in relation to both phylogeny and ecology. Both relativ...
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PMID: 18431055
PDF is available here.
PDF is available here.
Zoology (Jena) (111)3 2008
Abstract
We suggest that higher order lateral line neurons can do so by monitoring flow fluctuations as they move across the surface of the fish....
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PMID: 18329260
PDF is available here.
PDF is available here.
Abstract
We describe another form of escape behavior: slow forward swimming (SFS). We characterize the kinematic and electromyographic patterns of SFS and compare them with SBS and FFS. The most striking feature of SFS is nonuniformity of shape and speed of the locomotor waves propagating along the body: clo...
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PMID: 18003880
PDF is available here.
PDF is available here.
Abstract
We propose a mechanism through which fish can localize the source of these perturbations. In doing so we include the curvature of the fish body, a realistic lateral line canal inter-pore distance for the lateral-line canals, and the surface boundary layer. Using our model to explore receptor behavio...
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PMID: 18060550
PDF is available here.
PDF is available here.
Journal of Morphology (269)1 2008
Abstract
We present a detailed description of the brain and cranial nerves of Eleginops and ask how does the neural and sensory morphology of this non-Antarctic notothenioid differ from that seen in the phyletically derived Antarctic notothenioids? The brain of Eleginops is similar to those of visually orien...
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PMID: 17902153
PDF is available here.
PDF is available here.
Journal of Experimental Biology (210)Pt 23 2007
Abstract
We found that flexural stiffness is proportional to the number of hair cells, and consequently the number of kinocilia, within a neuromast. From this relationship, the flexural stiffness of an individual kinocilium was found to be 2.4 x 10(-20) N m2. Using this value, we estimate that the 11 kinocil...
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PMID: 18025022
PDF is available here.
PDF is available here.
Hearing Research (233)1-2 2007
Abstract
We found that cisplatin-induced hair cell death occurred much more slowly than had been shown to occur in aminoglycoside-induced hair cell death. By prelabeling hair cells with FM1-43FX, and assessing hair cell damage, it was established that cisplatin causes hair cell loss in the lateral line in a...
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PMID: 17709218
PDF is available here.
PDF is available here.
Abstract
We have previously characterized a transgenic zebrafish strain expressing the green fluorescent protein (eGFP) gene linked to the hsp70 gene promoter, and shown it to be a useful tool for examining cell-specific toxicity in living embryos and larvae. Here we show that the hsp70/eGFP transgene is str...
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PMID: 17706735
PDF is available here.
PDF is available here.
Abstract
To explore the possible utilization of goldfish scale in monitoring environmental toxicants as well as that for calcified tissue research, characteristics of cells in the scale were examined by identifying genes differentially expressed in those cells. Subtraction cloning was subjected to RNAs betwe...
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PMID: 17965550
PDF is available here.
PDF is available here.
Abstract
Florida manatees are large-bodied aquatic herbivores that use large tactile vibrissae for several purposes. Facial vibrissae are used to forage in a turbid water environment, and the largest perioral vibrissae can also grasp and manipulate objects. Other vibrissae distributed over the entire postfac...
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PMID: 17640045
PDF is available here.
PDF is available here.
Genes & Development (21)17 2007
Abstract
The lateral-line system is a simple sensory system comprising a number of discrete sense organs, the neuromasts, distributed over the body of fish and amphibians in species-specific patterns. Its development involves fundamental biological processes such as long-range cell migration, planar cell pol...
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PMID: 17785522
PDF is available here.
PDF is available here.
Abstract
We identify a mechanism whereby the GABA(B) component of a feedback pathway to the electrosensory lobe is recruited to regulate the intrinsic burst dynamics and coding properties of pyramidal cells for these behaviorally relevant input signals. Through recordings in an in vitro slice preparation and...
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PMID: 17581845
PDF is available here.
PDF is available here.
Abstract
We investigated the responses of anterior lateral line nerve fibers of goldfish, Carassius auratus, to unidirectional water flow (10 cm s(-1)) and to running water that contained a Kármán vortex street. Compared to still water conditions, both unidirectional water flow and Kármán vortex streets...
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PMID: 17503054
PDF is available here.
PDF is available here.
Abstract
We examined hair cells from the lateral line of the zebrafish, Danio rerio. The mechanosensory lateral line is located externally on the animal and therefore allows direct manipulation and observation of hair cells. Labeling with vital dyes revealed a rapid response of hair cells to the aminoglycosi...
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PMID: 17394157
PDF is available here.
PDF is available here.
Journal of Experimental Biology (210)Pt 11 2007
Abstract
We distinguish between rheotaxis: orientation to the large-scale flow field (olfaction, vision and superficial lateral line), eddy chemotaxis: tracking the trail of small-scale, odor-flavored turbulence (olfaction and lateral line canals), and pinpointing the source of the plume (lateral line canals...
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PMID: 17515418
PDF is available here.
PDF is available here.
Journal of Morphology (268)6 2007
Abstract
We focus on the South Atlantic bovichtids Bovichtus diacanthus, the klipfish from tide pools at Tristan da Cunha, and Cottoperca gobio, the frogmouth from the Patagonian shelf and Falkland Islands. We document the anatomy and histology of the brains, olfactory apparatus, retina, and cephalic lateral...
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PMID: 17417804
PDF is available here.
PDF is available here.
Abstract
Promormyromasts were found in the epidermis of the head of the larvae of five species of mormyrids bred in captivity. The promormyromast is a larval electroreceptor belonging to the specific lateral line system. In 12-day-old larvae this electroreceptor is characterized by a single s...
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PMID: 17299756
PDF is available here.
PDF is available here.
Abstract
We show that in response to dynamic broadband stimuli, these bursts lack some of the electrophysiological characteristics observed in response to static inputs. A simple leaky integrate-and-fire (LIF)-style model with a dendrite-dependent depolarizing afterpotential (DAP) is sufficient to match both...
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PMID: 17409177
PDF is available here.
PDF is available here.
Abstract
Abstract
We estimated the frequency-intensity (f-I) curves of P-unit electroreceptors using 4-Hz random amplitude modulations (RAMs) and using the covariance method (50-Hz RAMs). Both methods showed that P units are linear encoders of stimulus amplitude with additive noise; the gain of the f-I curve was, on...
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PMID: 17287436
PDF is available here.
PDF is available here.
Abstract
We mimic synaptic input during sensory stimulation by direct stimulation of electrosensory pyramidal cells with broadband current in vitro. The pyramidal cells respond to this stimulus with burst interspike intervals (ISIs) that are reliably and precisely correlated with the intensity of stimulus up...
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PMID: 17409176
PDF is available here.
PDF is available here.
Developmental Dynamics (236)3 2007
Abstract
We found that a subset of the morphant cranial and lateral line ganglia were disorganized, smaller, with reduced staining, and/or with altered shape compared to control embryos. Increased cell death in the morphant ganglia likely contributed to these defects. Moreover, cdh4 morphants had shorter lat...
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PMID: 17279575
PDF is available here.
PDF is available here.
Developmental Dynamics (236)3 2007
Abstract
We identify here two distinct classes of neurons in the dorsal hindbrain of developing zebrafish: (1) neurons that express the inhibitory neuronal marker Gad1/2, and (2) neurons that express the zn-5 antigen and Lhx2/9 and require the basic helix-loop-helix transcription factor Atoh1a for developmen...
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PMID: 17279576
PDF is available here.
PDF is available here.
Neurochemical Research (32)2 2007
Abstract
We have initiated a detailed characterization of the structure and biochemical composition of its myelinated central and peripheral nervous system (CNS; PNS) tissues. Myelin periods, determined by X-ray diffraction from whole, unfixed optic and lateral line nerves, were approximately 153 and approxi...
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PMID: 16951904
PDF is available here.
PDF is available here.
Abstract
We investigated how fibres in the anterior lateral line nerve of goldfish, Carassius auratus, respond to sinusoidal water motions in a background of still or running water. Two types of fibres were distinguished: type I fibres, which most likely innervate superficial neuromasts, were stimulated by r...
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PMID: 17075719
PDF is available here.
PDF is available here.
Abstract
Morphology of larval lampreys' neuromasts was found to be very similar to that of adults. Activity in the lateral line nerve, elicited by a vibrating ball, indicated a functional lateralis system. Analysis revealed at least two populations of afferents, responding to opposite directions of water flo...
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PMID: 17119976
PDF is available here.
PDF is available here.
Abstract
Here we document the expression of a second chemokine receptor gene, cxcr7, in the migrating primordium. We show that cxcr7 is highly expressed in the trailing cells of the primordium but not at all in the leading cells, a pattern that is complementary to that of cxcr4b. Even though cxcr7 is not exp...
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PMID: 17394634
PDF is available here.
PDF is available here.
Abstract
We demonstrate here a proof-of-concept artificial lateral line system. It enables a distant touch hydrodynamic imaging capability to critically augment sonar and vision systems. We show that the artificial lateral line can successfully perform dipole source localization and hydrodynamic wake detecti...
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PMID: 17132735
PDF is available here.
PDF is available here.