Abstract
We have tested the hypotheses that CT is expressed in the chicken pituitary gland, and that its expression is influenced by sexual maturation or in response to ovarian steroid administration. We have detected robust expression of CT cDNA in the chicken pituitary gland by reverse transcription/polyme...
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PMID: 17093921
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Abstract
We demonstrate that the UBB is composed of two types of cells: one expressing T/ebp/Nkx2.1 and the other expressing p63. The former cell type, accounting for a majority of the UBB, requires T/ebp/Nkx2.1 for their survival. In contrast, the p63-positive cells, even in the absence of T/ebp/Nkx2.1 expr...
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PMID: 16342117
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Abstract
We found that ultimobranchial C cells of chick embryos cultured in the presence of nicotinamide continued to grow for at least 60 days and exhibited profound morphological changes, resulting in the formation of dense networks of neuronal fibers. Nicotinamide, thus, facilitated the manifestation of n...
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PMID: 16217794
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Abstract
We studied a series of 10 solid cell nests (SCNs) of the thyroid and a case of cystic tumor of the atrioventricular node (CTAVN) of the heart and reviewed the literature. The CTAVN and SCNs appeared as cystic and/or solid (squamoid) structures mainly composed of polygonal or oval cells (main cells)...
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PMID: 15716232
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Abstract
Heteropneustes fossilis were subjected to 5.76 and 1.44 microg/L of cypermethrin for short- and long-term experiments, respectively. Fish were sacrificed at 24, 48, 72, and 96 h in the short-term and 7, 14, 21, and 28 days in the long-term experiment. Plasma calcium levels were determined. Ultimobra...
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PMID: 15546635
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Abstract
We examined the plasma CT and Ca levels after injecting immature goldfish with estrogen. At day 1, the plasma CT level significantly increased, whereas the plasma Ca level was not changed from its initial level. This result suggests that the trigger of CT secretion is estrogen and that estrogen dire...
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PMID: 15302261
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Abstract
We have cloned two distinct cDNAs encoding salmon-type calcitonin (sCT)-I cDNAs from the ultimobranchial gland of rainbow trout, Oncorhynchus mykiss. Both cDNAs were predicted to encode nearly identical sCT-I precursors which consisted of an N-terminal peptide of 80 amino acid residues, a putative c...
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PMID: 15226585
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Abstract
We examined the expression and localization of the prohormone convertases, PC1 and PC2, in the ultimobranchial gland of the adult bullfrog using immunohistochemical (IHC) and in situ hybridization (ISH) techniques. In the ultimobranchial gland, PC1-immunoreactive cells were columnar, and were presen...
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PMID: 14566018
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Abstract
We cloned a cDNA encoding otoconin-22 from the cDNA library constructed for the paravertebral lime sac (PVLS) of the bullfrog, Rana catesbeiana, and sequenced it. The bullfrog otoconin-22 encoded a protein consisting of 147 amino acids, including a signal peptide of 20 amino acids. The protein had c...
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PMID: 12865304
PDF is available here.
Abstract
These results suggest that, in stonefish, the ultimobranchial gland has the ability to respond physiologically to rises in plasma Ca levels, to secrete calcitonin, and to cease the secretion when the plasma Ca levels return to the initial level....
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PMID: 12692395
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Abstract
Freshwater mud eel, Amphipnous cuchia, were injected intraperitoneally daily with 100 ng of vitamin D3/100 g body weight and maintained in media containing either no calcium or different calcium concentrations. The eels were killed after 1, 3, 5, 10 and 15 days following the treatment and their seru...
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PMID: 12484415
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Abstract
These results strongly suggest that, in eels, direct raises in blood Ca levels by infusion of a high-Ca solution via blood vessels can accelerate the secretion of calcitonin from the ultimobranchial gland....
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PMID: 12362058
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Abstract
A morphological and immunohistochemical study of the ultimobranchial body of reptiles Japanese lizard and snake was carried out. The ultimobranchial body of the Japanese lizard was located adjacent to the left arch of the aorta between the trachea and esophagus. It was found as a cluster or group of...
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PMID: 11915357
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Abstract
We determined the exact volume of the gland in juveniles and adult males and females of a teleost, Ryukyuayu (Plecoglossus altivelis ryukyuensis). Furthermore, we examined plasma Ca, Na and K levels. In this species, the gland was fundamentally composed of a single follicle. The gland volume was con...
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PMID: 11732203
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Abstract
We have analyzed the neuronal properties in cultured ultimobranchial C cells isolated from embryonic chicks at different developmental stages (12--16 days of incubation) by immunohistochemistry and electron microscopy. The ultimobranchial glands mostly consist of C cell solids. In 13-day-old embryos...
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PMID: 11423073
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Abstract
Eight thyroid gland epithelial tumors were found in 7 cows and 1 bull in a retrospective study of thyroid gland lesions in slaughtered cattle. All tumors were classified as ultimobranchial thyroid carcinomas based on morphology and immunohistochemistry. All tumors consisted of solid sheets and nests...
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PMID: 11289203
PDF is available here.
Abstract
Five cases of periparathyroid salivary heterotopia associated with cysts were studied. The specimens were obtained from three men and two women age 36 to 62 years who underwent surgery for primary hyperparathyroidism (four patients) and thyroid nodule (one patient). The heterotopia-cyst combination...
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PMID: 10843286
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Abstract
A large number of enkephalin-immunoreactive cells transiently appear in chick ultimobranchial glands during embryonic development. The expression and development of proenkephalin mRNA were examined in the ultimobranchial glands by in situ hybridization with digoxigenin (DIG)-labeled oligonucleotide...
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PMID: 10678773
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Abstract
The ultrastructural features of solid cell nests (SCN), made of squamous cells, and associated calcitonin cells (C cells), of the thyroid gland were studied in only a few cases in humans. A study was performed on 8 paraffin-embedded SCN, postembedded in Epon, to look for their ultrastructural featur...
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PMID: 10721146
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Abstract
Only scant information is available in the scientific literature on the parathyroids and ultimobranchial bodies in the primitive mammals, the echidna (Tachyglossus aculeatus) and platypus (Ornithorhynchus anatinus). The major aim of this paper is to describe the morphology of the monotreme parathyro...
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PMID: 9972812
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Abstract
The intention of this review is to compare studies on the morphology and histology (light and electron microscopic) of ultimobranchial glands of various groups of reptiles. Moreover, experiments (including our investigations) on suppression or stimulation of the ultimobranchial gland are included. A...
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PMID: 9972642
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Abstract
The hypocalcemic and hypophosphatemic peptide calcitonin (CT) is secreted by mammalain thyroid parafollicular cells and fish ultimobranchial body. Over a dozen species of CTs have been cloned and/or sequenced. They can be separated into three classes based on structural and biological similarities:...
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PMID: 9864547
PDF is available here.
Abstract
The ultrastructure of the parathyroid gland and ultimobranchial gland of the snake, Elaphe quadrivirgata, was studied. The parenchyma of the parathyroid gland was consisted of chief cells arranged in cords. Oxyphil cells and water-clear cells were not recognized. The chief cells contained irregular...
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PMID: 9798400
PDF is available here.
Abstract
The aim of the present study was to compare parafollicular cells in the bison thyroid and its ultimobranchial remnants. The thyroid of 26 European bisons was fixed in Bouin's fluid, 5 microns thick paraffin sections were stained with hematoxylin and eosin. Azan or silver Grimelius methods. For immun...
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PMID: 9248580
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Abstract
An old bull, it is said by those who know, can have his troubles. Included among these are vertebral osteosclerosis and ankylosing spondylosis; this stiffening up limits, rather than accentuates, the value and reproductive potential of a stud bull past his prime. Associated with these abnormalities,...
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PMID: 8961245
PDF is available here.
Abstract
The ultimobranchial glands of 20 chickens, aged 2-3 months, were investigated for their nicotinamide adenine dinucleotide hydrogen phosphate-diaphorase (NADPH-d) reactivity and the distribution of nitric oxide synthase (NOS), using NADPH-d histochemistry and NOS immunocytochemistry respectively. For...
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PMID: 8742056
PDF is available here.
Abstract
On the basis of our previous observation that estrogen stimulates calcitonin secretion by the ultimobranchial gland in the stingray, Dasyatis akajei, experiments were conducted to examine the presence of estrogen receptor (ER) and its mRNA in the gland, employing exchange assay and Northern blot ana...
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PMID: 8713649
PDF is available here.
Abstract
These results indicate that the neuronal cells from the distal vagal ganglion enter into the ultimobranchial anlage and give rise to C cells, i.e., C cells differentiate along the neuronal lineage. During embryonic development, C cells of the chick ultimobranchial glands transiently express a number...
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PMID: 8557840
PDF is available here.
Abstract
We observed two amplified DNA fragments, differing by 200 bp which hybridized with a specific exon 4 probe. Sequence analysis indicated that they both encoded exon 4, but differed in the length of their 3' non-coding regions by use of a putative polyadenylation signal situated 200 bp upstream from t...
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PMID: 7959002
PDF is available here.
Abstract
We refer to as "main cells" and "C cells." In all cases "mixed thyroid follicles" (a unique structure lined by follicular epithelium and epidermoidlike cells) were observed in which the histochemical study confirmed the presence of intraluminal acid mucins. Adult adipose tissue and cartilage were fo...
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PMID: 7517912
PDF is available here.
Abstract
The effects of ovine prolactin (10 I.U./100 g body wt) on the ultimobranchial body and parathyroid glands were investigated in Natrix piscator for 15 days. The ultimobranchial body of the prolactin treated specimens depicts signs of increased activity whereas the parathyroid glands exhibit reduced a...
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PMID: 7936558
PDF is available here.
Abstract
The development of chicken ultimobranchial glands was studied by electron microscopy. As early as at 8 days of incubation, some cells contained a few secretory granules, although most of the ultimobranchial cells were undifferentiated. Single axons or small bundles of axons were occasionally detecte...
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PMID: 8129178
PDF is available here.
Abstract
The localization of a neuron-specific beta-tubulin isotype in the ultimobranchial glands from chickens at various stages of development was studied by means of light- and electron microscopic immunohistochemistry with a monoclonal antibody (TuJ1) against the beta-tubulin isotype, c beta 4. At 8 days...
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PMID: 8313138
PDF is available here.
Abstract
In the chicken, enkephalin-immunoreactive cells and nerve fibers are distributed in the ultimobranchial glands, which consist of C-cell groups and cyst structures. Ultrastructural features of the enkephalin cells and nerve fibers were examined by immuno-electron microscopy using both the streptavidi...
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PMID: 8269477
PDF is available here.
Abstract
C cells of the thyroid gland of 85 European bison, 43 males and 42 females, of age ranging from 1 month to 25 years were examined. For the identification of the C cells by Grimelius silver impregnation, toluidine blue, pseudoisocyanin and azur A stainings were employed. In the thyroid of the bison t...
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PMID: 8363040
PDF is available here.
Abstract
C-cells of Pleurodeles waltilii ultimobranchial bodies (ULT) were studied after a series of two-week spaceflight on the biosatellites. It was shown that under conditions of weightlessness the hypertrophy of ULT and calcitonin secretion activation occurred. Calcitonin accumulated into the ULT which r...
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PMID: 7691231
PDF is available here.
Abstract
A single injection of synthetic salmon calcitonin (sCT) or homologous ultimobranchial gland (UBG) extract caused a significant reduction in total and ultrafiltrable plasma Ca2+ in a freshwater teleost, Cyprinus carpio. A time-bound analysis on the effect of sCT or UBG extract caused a short-duration...
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PMID: 8224753
PDF is available here.
Abstract
The mid portion of the lateral thyroid lobes from 64 fetuses was systematically analysed for the presence of ultimobranchial body nests. The nests showed a prevalence of 1/24 (4.2 per cent) or 13/40 (32.5 per cent) depending on whether a single- or a multi-step sectioning method was employed, respec...
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PMID: 7684778
PDF is available here.
Abstract
The development of the thyroid, parathyroid and ultimobranchial body was examined by immunohistochemistry and morphometric analysis in the larvae of Xenopus laevis Daudin from the time immediately after hatch to the end of metamorphosis. The thyroid appeared at stage 43 and began to secrete thyroglo...
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PMID: 8462634
PDF is available here.
Abstract
Heterogeneity of the thyroid parenchyma and the sources of development of its main components are considered. The least studied are components originating from the ultimobranchial body to which "the second" system of the ultimobranchial follicles and solid epithelial cell nests belong. The data on t...
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PMID: 8154995
PDF is available here.
Abstract
A systematic immunohistochemical study of the ultimobranchial tubule (UBT) has been carried out in 45 Wistar rats of different ages (0, 5, 10, 15, 20, 25, 30, 60 and 120 days). The existence of calcitonin immunoreactive cells in the UBT wall has been demonstrated in a 5-days old rat. In addition, im...
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PMID: 1585999
PDF is available here.
Abstract
Piriform sinus fistulae are an underlying abnormality common in patients with acute suppurative thyroiditis. The fistulae arise from the hypopharynx, and end in or adjacent to the thyroid lobe. These congenital fistulae seem to be remnants of one of the pharyngeal pouches in embryonic development, b...
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PMID: 1563708
PDF is available here.
Abstract
A method for isolation of C-cells from rat fetuses was developed, and the morphological plasticity of the cells in primary culture systems was tested. Thyroid-parathyroid-ultimobranchial body (UB) complexes from 16-day rat fetuses were treated with 0.1% collagenase and 1000 PU/ml Dispase at 37 degre...
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PMID: 1729130
PDF is available here.
Abstract
Amphibians are the most diverse group as regards the endocrinology of Ca homeostasis because in them only "true" parathyroid glands made first appearance but its involvement varies greatly according to their phyletic affinities and habitats. Presence of ultimobranchial gland, parathyroid and renal 2...
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PMID: 1298408
PDF is available here.
Abstract
Vitamin D3, 25(OH) vitamin D3 and 1,25 (OH)2D3 were administered daily to unfed male Bufo andersoni for 15 days which resulted in a significant hypercalcemia and hyperphosphatemia in a dose-dependent fashion. 1,25(OH)2D3 is more potent than the other metabolites. The treatment activated ultimobranch...
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PMID: 1339166
PDF is available here.
Abstract
The minority of human thyroid follicles that contain acid mucin are often grouped in the C-cell area of the gland, and are lined by abundant C cells. They are thought to be derived from the ultimobranchial contribution to the thyroid gland. This study demonstrates the presence of thyroglobulin react...
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PMID: 1679843
PDF is available here.
Abstract
The ultimobranchial gland is an endocrine organ consisting of C cell groups. In chickens, the glands are richly supplied by nerve fibers immunoreactive for neurofilaments. It was found by immunocytochemical staining that C cells of chick ultimobranchial glands showed immunoreactivities for multiple...
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PMID: 1708788
PDF is available here.
Abstract
The annual activity of the parathyroid gland cells and those of the ultimobranchial body cells of the frog Rana temporaria is quantitatively investigated by a morphometric study. A cosinor analysis shows a periodic succession of different parameters. The secretory activity of the parathyroid cells s...
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PMID: 1935413
PDF is available here.
Abstract
We measured total and poly A+ RNAs and calcitonin content of ultimobranchial bodies of male and female pink salmon during the different stages of the reproductive cycle. Calcitonin mRNAs were analysed by hybridization of northern and dot blots with a specific probe for salmon calcitonin. Dot blot au...
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PMID: 2268342
PDF is available here.
Abstract
In the crab-eating frog Rana cancrivora, taken from a full-strength seawater pond, the in situ levels of serum Na, Cl, K, Ca, Mg, Pi, urea, and osmolarity were examined. The levels were higher than those usually reported for freshwater anurans. However, values for the monovalent salts, urea, and osm...
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PMID: 2289681
PDF is available here.
Abstract
These results indicate that the growth inhibition of LLC-PK1 by ultimobranchial CTs is mainly due to cellular death caused by the swelling of RER via a signalling pathway other than the cAMP-dependent event(s)....
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PMID: 2176131
PDF is available here.
Abstract
We determined the incidence rate (89%) and characterized the morphology of ultimobranchial body (UBB) remnants found in 18 serially sectioned neonatal thyroid glands. Although UBB remnants are often referred to as solid cell nests, we found cystic features in 55%. Ciliated columnar cells were seen i...
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PMID: 2222147
PDF is available here.
Abstract
Calcitonin (CT) levels in the ultimobranchial body and in plasma were radioimmunoassayed in rainbow trout, Salmo gairdneri, as a function of the annual cycle. In male and female, there was an important increase in the CT levels in the ultimobranchial body and in plasma. These variations in CT levels...
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PMID: 2354759
PDF is available here.