Abstract
Approximately two-thirds of the patients with severe sepsis or septic shock are first encountered in the emergency departments (EDs) of western countries, in which bacteremia is present in about 50% of patients with severe sepsis. The situation of bacteremia presenting to the EDs in...
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PMID: 21524617
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Abstract
To investigate daptomycin pharmacokinetics in critically ill patients receiving continuous venovenous hemodialysis to develop dosing recommendations.
Prospective, open-label pharmacokinetic study.
: Intensive care units located within a teaching medical center.
Eight adults with known/suspected Gram...
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PMID: 20890189
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Abstract
We defined initially inappropriate antibiotic therapy as occurring when the patient either was not administered an antibiotic within 24 hrs of sepsis onset or was treated with an antibiotic to which the culprit pathogen was resistant in vitro. The cohort included 760 subjects (mean age 59.3 ± 16.3...
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PMID: 20890186
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Abstract
Reports detailing bacteremia caused by Chryseobacterium indologenes remain limited, with most cases reported in Taiwan. The clinical significance of C. indologenes has not been fully established. This retrospective study investigated the clinical features and antimicrobial susceptibi...
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PMID: 21195977
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Abstract
We find no evidence for such a general recommendation. As neutropenic patients and patients with rheumatoid arthritis are generally more prone to develop periprosthetic infections it can be considered in these cases to give prophylactic antibiotics before more extensive dental treatments....
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PMID: 21073830
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Abstract
We conducted a retrospective cohort study to determine exposures associated with illness. Eligible patients had an invasive procedure in the 4 days before or after the procedure date of the initial case-patients. Infection control assessments were made, and environmental specimens collected.
Four la...
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PMID: 20975462
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Abstract
In 538 febrile episodes in 188 children enrolled prospectively, 62% of children were neutropenic and 86% had infection-related fever. Respiratory infection was the commonest febrile cause (60%). Bacteremia occurred more often in neutropenic than non-neutropenic episodes (20% vs. 3%) and was accompan...
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PMID: 20526229
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Abstract
We present the case of a previous healthy child, who ultimately succumbed to H. influenzae type B meningitis where multiple factors were likely responsible for his acquisition of the disease....
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PMID: 20930601
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Jay K Varma,
Kimberly D McCarthy,
Theerawit Tasaneeyapan,
Patama Monkongdee,
Michael E Kimerling,
Eng Buntheoun,
Delphine Sculier,
Chantary Keo,
Praphan Phanuphak,
Nipat Teeratakulpisarn,
Nibondh Udomsantisuk,
Nguyen H Dung,
Nguyen T N Lan,
Nguyen T B Yen and
Kevin P Cain
Abstract
We performed a single Myco/F Lytic blood culture. Fifty-eight (2.9%) had a clinically significant BSI (i.e., a blood culture positive for an organism known to be a pathogen). Mycobacterium tuberculosis accounted for 31 (54%) of all BSIs, followed by fungi (13 [22%]) and bacteria (9 [16%]). Of patien...
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PMID: 20875282
PDF is available here.
Abstract
Pylephlebitis is the septic thrombosis of the portal vein. Hypercoagulability and intra-abdominal sepsis are the main predisposing factors. A 25-year-old man presented to a primary health care center complaining of fever, epigastric pain, and jaundice. He was initially diagnosed with a gastrointesti...
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PMID: 20689494
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Abstract
Bordetella bronchiseptica bacteremia is often associated with various infection in animals. The majority of B bronchiseptica infections reported in humans are cases of pneumonia. Very few cases have been reported in patients with a history of acquired immune deficiency syndrome (AIDS). The patient d...
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PMID: 20689480
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Abstract
We defined community strain MRSA (CoSt-MRSA) and hospital strain MRSA (HoSt-MRSA) according to the results of staphylococcus cassette chromosome mec (SCCmec) molecular typing: CoSt-MRSA isolates had SCCmec type IV or V genes, and HoSt-MRSA isolates had SCCmec type I, II, or III genes. We quantitativ...
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PMID: 20827105
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Abstract
We report two cases of bacteremic pneumonia due to Pseudomonas aeruginosa in non-neutropenic solid-organ cancer. Both subjects had sudden sepsis or septic shock but few respiratory symptoms. Chest radiography showed a diffuse unilateral decrease in permeability, becoming necrotizing pneumonia and lu...
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PMID: 20960938
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Wang-Huei Sheng,
Chun-Hsing Liao,
Tsai-Ling Lauderdale,
Wen-Chien Ko,
Yao-Shen Chen,
Jien-Wei Liu,
Yeu-Jun Lau,
Li-Hsin Wang,
Ke-Sun Liu,
Tung-Yuan Tsai,
San-Yi Lin,
Meng-Shiuan Hsu,
Le-Yin Hsu and
Shan-Chwen Chang
Abstract
Risk factors and outcome in patients who acquire nosocomial infections due to carbapenem-resistant Acinetobacter baumannii (CRAB) are rarely investigated.
A multicenter retrospective study was conducted to analyze the clinical and microbiological data of patients with nosocomial infections due to A....
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PMID: 20646946
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Abstract
A 4-year-old fully immunised male presented to a regional hospital in the West Kimberley with fever and lethargy. Blood cultures yielded serogroup B Neisseria meningitidis, resistant to benzylpenicillin (minimum inhibitory concentration (MIC) 1.0 mg/L). The patient was treated with intravenous ceftr...
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PMID: 21090191
PDF is available here.
Abstract
We hypothesized that VLBW infants with prior GI tract colonization with gentamicin-susceptible GNB who developed bloodstream infections (BSI) would do so with gentamicin-susceptible GNB.
A prospective cohort study of VLBW infants was performed in 2 level III neonatal intensive care units from Septem...
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PMID: 20539251
PDF is available here.
Abstract
We report on 2 cases of pylephlebitis in a 12-year-old girl and a 13-year-old boy, following undiagnosed appendicitis. In the 1st case, the young girl had been misdiagnosed with Salmonella infection and was given antibiotics; in the 2nd case, the boy had retrocecal appendicitis that was clinically s...
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PMID: 20719483
PDF is available here.
Abstract
Gram-positive bacteria such as Staphylococcus aureus have been a common cause of infection among liver transplant (LT) recipients in recent decades. The understanding of local epidemiology and its evolving trends with regard to pathogenic spectra and antibiotic susceptibility is beneficial to prophy...
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PMID: 20819529
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Abstract
Of the 97 patients diagnosed with ESBL-producing E. coli bacteremia, six were excluded owing to incomplete follow-up and missing data. Comparisons were made between 91 patients and their controls. Multivariate analysis identified urinary catheterization [odds ratio (OR) = 6.21, 95% confidence interv...
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PMID: 20688291
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Abstract
We used bioluminescent strains of Staphylococcus aureus to monitor the formation of infection foci during the first 24 h of hematogenous bacterial dissemination. Clinically derived EDIN-expressing S. aureus strains S25 and Xen36 produced many disseminated foci. EDIN had no detectable impact on infec...
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PMID: 20479081
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Abstract
We found that age and prophylaxis, but not the type of catheter, were associated with a significantly reduced risk of bacteremia.
Children with ALL receiving SMX-TMP prophylaxis during induction therapy experienced fewer febrile episodes, fewer days with fever demanding intravenous a...
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PMID: 20583218
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Abstract
I = 45.1%), stratification of datasets by monotherapy mortality risk demonstrated substantial benefit in the most severely ill subset (monotherapy risk of death >25%; odds ratio of death, 0.51; 95% confidence interval, 0.41-0.64; I = 8.6%). Of those datasets that could be stratified by the presence...
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PMID: 20562695
PDF is available here.
Abstract
To investigate the effect of antibiotic lock solutions for preventing catheter-related bacteraemia in patients receiving haemodialysis.
Retrospective study.
University teaching hospital, Hong Kong.
Consecutive patients from March 2006 to April 2007 who had central venous catheter insertion for haemo...
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PMID: 20683069
PDF is available here.
Abstract
Catheter-related BSI is the major source of nosocomial BSI in the NICU. Prematurity, low Apgar scores at birth and prolonged CVC use are risk factors for the development of BSI....
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PMID: 20704794
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Abstract
These recommendations from the Advisory Committee on Immunization Practices (ACIP) update the previous recommendations for anthrax vaccine adsorbed (AVA) (CDC. Use of anthrax vaccine in the United States: Recommendations of the Advisory Committee on Immunization Practices [ACIP]. MMWR 2000;49:1-20;...
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PMID: 20651644
PDF is available here.
Abstract
We found two nonribosomal peptide secondary metabolites--the aureusimines, made by S. aureus--that are not antibiotics, but function as regulators of virulence factor expression and are necessary for productive infections. In vivo mouse models of bacteremia showed that strains of S. aureus unable to...
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PMID: 20522739
PDF is available here.
Abstract
We characterize the spectrum of microbial agents and susceptibility to antibiotic treatment, especially to rifampicin, in these patients. We carried out a retrospective analysis of wound-swaps and blood cultures in 48 patients with infected prosthetic vascular grafts or primary infectious vascular c...
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PMID: 20211934
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Abstract
An AIDS patient was admitted to a tertiary care hospital in central India with fever, weight loss, breathlessness, night sweats, diarrhoea, BMI 14 kg/m2, Hemoglobin 8 gm% and CD4 counts 120 cells/cumm. His blood culture by BACTEC 460 TB system revealed Mycobacterium avium bacteremia and stool cultur...
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PMID: 21043313
PDF is available here.
Abstract
We demonstrated that a surprisingly large fraction of Neisseria meningitidis disease isolates are lipid A mutants, due to inactivating mutations in the lpxL1 gene. The lpxL1 mutants activate human TLR4 much less efficiently than wild-type bacteria, which may be advantageous by allowing them to escap...
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PMID: 20439476
PDF is available here.
Abstract
Vaccines against primary pneumonic plague, a potential bioweapon, must be tested for efficacy in well-characterized nonhuman primate models. Telemetered cynomolgus macaques (Macaca fascicularis) were challenged by the aerosol route with doses equivalent to approximately 100 50% effective doses of Ye...
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PMID: 20385751
PDF is available here.
Abstract
We report the microbiological characteristics of what are believed to be the two first carbapenem-resistant VIM metallo-beta-lactamase (MBL)-producing P. putida strains in Spain, which were isolated from patients at the University Hospital Complex of Santiago de Compostela. Both patients were immuno...
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PMID: 20360397
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Abstract
This is the first report, to our knowledge, of two temporally and geographically related nosocomial Asaia lannensis infections in a paediatric setting. Two patients with idiopathic dilated cardiomyopathy awaiting cardiac transplantation developed bacteraemia during their hospital stay. The physical...
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PMID: 20339020
PDF is available here.
Kwan Soo Ko,
Ji-Young Lee,
Jin Yang Baek,
Ji-Yoeun Suh,
Mi Young Lee,
Ji Young Choi,
Joon-Sup Yeom,
Yeon-Sook Kim,
Sook-In Jung,
Sang Yop Shin,
Sang Taek Heo,
Ki Tae Kwon,
Jun Seong Son,
Shin-Woo Kim,
Hyun-Ha Chang,
Hyun Kyun Ki,
Doo Ryeon Chung,
Kyong Ran Peck and
Jae-Hoon Song
Abstract
To investigate the antimicrobial resistance, extended-spectrum beta-lactamases (ESBLs) and clones of Klebsiella pneumoniae isolates causing bacteraemia or urinary tract infection (UTI) in Korea, a total of 406 K. pneumoniae isolates from patients with bacteraemia (221 isolates) and UTI (185 isolates...
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PMID: 20360396
PDF is available here.
Abstract
We report the case of a 10-year-old girl developing GBS bacteremia during corticosteroid therapy for chronic idiopathic thrombocytopenic purpura. Brought to the emergency room due to sudden high fever and abdominal pain, she was in compensated shock. White blood cell count was 19,600/mm3 and C-react...
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PMID: 20715558
PDF is available here.
Abstract
Catheter-related bacteremia (CRB) is a major cause of morbidity and mortality especially among patients receiving hemodialysis. Antibiotic lock therapy represents a promising technique in the treatment of CRB. Several studies have evaluated antibiotics in combination with heparin as an interdialytic...
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PMID: 20345391
PDF is available here.
Abstract
We review the current epidemiology, risk factors, diagnostic strategy and contemporary management of CIED infection. In addition, we address the vexing question of how to best manage patients with Staphylococcus aureus bacteremia, in the setting of an implanted device, but no overt clinical signs of...
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PMID: 20586567
PDF is available here.
Abstract
We review recent changes in the epidemiology, diagnosis and treatment of BSI (excluding candidemia). The evidence of the impact of healthcare-association in many community-onset episodes and the increase in drug-resistant pathogens causing BSI in the community and hospitals is reviewed. The emergenc...
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PMID: 20586566
PDF is available here.
Abstract
For the ciprofloxacin 400 mg intravenously every 8 h regimen, the 24-h AUC/MIC at MICs of 0.5 and 1 microg/ml were 218.63 +/- 78.75 and 109.31 +/- 39.37, respectively. For the ciprofloxacin 400 mg intravenously every 12 h regimen, the 24-h AUC/MIC at MICs of 0.5 and +/- microg/ml were 144.07 +/- 57....
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PMID: 20649056
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Abstract
Even though recurrent gram-negative BSI was relatively uncommon in the general population, up to 15% of patients with gram-negative BSI developed a recurrent episode within 10 years of the initial episode.
Copyright (c) 2010 The British Infection Society. Published by Elsevier Ltd. All rights reserv...
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PMID: 20378069
PDF is available here.
Abstract
Non-faecalis and non-faecium Enterococcus species can cause protean manifestations which vary with the infecting Enterococcus species. Misidentification of unusual enterococcal species might occur by the commercial identification methods and accurate identification with molecular methods is required...
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PMID: 20433865
PDF is available here.
Abstract
Few data exist concerning possible infectious complications associated with endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA). The present prospective evaluation was undertaken in order to determine the incidence of bacteraemia and infectious complications...
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PMID: 19926733
PDF is available here.
Jun Seong Son,
Jae-Hoon Song,
Kwan Soo Ko,
Joon Sup Yeom,
Hyun Kyun Ki,
Shin-Woo Kim,
Hyun-Ha Chang,
Seong Yeol Ryu,
Yeon-Sook Kim,
Sook-In Jung,
Sang Yop Shin,
Hee Bok Oh,
Yeong Seon Lee,
Doo Ryeon Chung,
Nam Yong Lee and
Kyong Ran Peck
Abstract
We compared clinical characteristics of community-acquired (CA), hospital-acquired (HA), and healthcare-associated (HCA) BSI. We performed a prospective nationwide multicenter surveillance study from 9 university hospitals in Korea. Total 1,605 blood isolates were collected from 2006 to 2007, and 1,...
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PMID: 20592888
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Abstract
We have repeatedly detected Candidatus Neoehrlichia mikurensis, a bacterium first described in Rattus norvegicus rats and Ixodes ovatus ticks in Japan in 2004 in the blood of a 61-year-old man with signs of septicemia by 16S rRNA and groEL gene PCR. After 6 weeks of therapy with doxycycline and rifa...
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PMID: 20587186
PDF is available here.