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Central Nervous System Infections (2):
Recent article
Central Nervous System Infections
Progress in Neurobiology (91)2 2010
Abstract
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Neurocirugia (21)3 2010
Abstract
In patients who underwent early meningomyelocele repair there was no significant difference between sac and ventricular CSF. There were also no positive cultures in samples taken from both areas. In comparison, in the group submitted to late repair, the number of cells in the sac and ventricle CSF s...
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PMID: 20571726
PDF is available here.
PDF is available here.
Abstract
Blastomycosis is an endemic mycosis that occurs predominantly in North America in the north central United States and provinces of Canada, southern states, and those midwestern states that border the Mississippi River basin. It causes acute and chronic pneumonias and disseminated infection with cuta...
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PMID: 20463245
PDF is available here.
PDF is available here.
Neurological Research (32)3 2010
Abstract
The incidence of congenital cytomegalovirus infection reported from Latin American countries ranges from 0 to 6.8% in different settings. Congenital cytomegalovirus infection is a common cause of hearing deficits and mental impairment in children. However, the impact of this infection as a cause of...
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PMID: 20406606
PDF is available here.
PDF is available here.
Neurological Research (32)3 2010
Abstract
We found and reviewed 303 articles and their related references. We provide the available information on the pathology, life cycle and diagnostic modalities (laboratory tests and imaging) along with possible complications of the disease. Current treatment methods of hydatid cyst in the brain and spi...
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PMID: 20406602
PDF is available here.
PDF is available here.
Abstract
Brain infections caused by fungi of the Pseudallescheria / Scedosporium-complex weeks or months after a near drowning event should be considered, since mortality rate is high and specific diagnostic methods are necessary for fungal detection. Voriconazole is the only authorised antimycotic drug avai...
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PMID: 20232269
PDF is available here.
PDF is available here.
Medicinski pregled (63 Suppl 1) 2010
Abstract
INTRODUCTION: The aim of antimicrobial treatment of infections in the central nervous system (CNS) is to eradicate the bacterial cause. The choice of antibiotics should take into account its activity, pharmacokinetic properties, results of clinical trials, side effects and total trea...
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PMID: 21438200
PDF is available here.
PDF is available here.
Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] / Ministerstvo meditsinskoi i mikrobiologicheskoi promyshlennosti SSSR (55)1-2 2010
Abstract
The use of cytoflavin solution in complex therapy of patients with neuroinfection was studied. It showed a favourable effect on the disease clinical process, evident from less pronounced intoxication and meningeal signs by the 11th day of the treatment and improvement of the liquorological picture....
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PMID: 20583556
PDF is available here.
PDF is available here.
Archives of Neurology (66)8 2009
Abstract
I will focus on emerging virus infections of the central nervous system (CNS). Part 1 will introduce the basic features of emerging infections, including their definition, epidemiology, and the frequency of CNS involvement. Important mechanisms of emergence will be reviewed, including viruses spread...
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PMID: 19667214
PDF is available here.
PDF is available here.
Abstract
Abstract
Stroke is the first cause of disability in adults worldwide. Central nervous system infections as a cause of stroke are not uncommon. The common central nervous system infections associated with stroke can be categorised into viral, bacterial, parasitic and of fungal origin. In HIV infection, centra...
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PMID: 19886375
PDF is available here.
PDF is available here.
Journal of Neuroimmunology (211)1-2 2009
Abstract
We examined CPMV uptake during infection of mice with neurotropic mouse hepatitis virus (MHV). CPMV localized mainly to the CNS endothelium in areas that contained an intact blood brain barrier. However, in inflammatory lesions containing macrophage/microglial cell infiltration and IgG, CPMV could b...
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PMID: 19394707
PDF is available here.
PDF is available here.
Abstract
Our development of successful strategies in prevention and treatment of bacterial meningitis requires multifactorial concepts and approaches, which include advances in vaccinology, epidemiology of meningitis, emergence of antimicrobial-resistant pathogens, knowledge of pharmacokinetics and pharmacod...
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PMID: 19445565
PDF is available here.
PDF is available here.
Brain Injury (23)5 2009
Abstract
This study revealed different experiences of caring for younger adults with ABI vs. older adults with dementia, thereby supporting targeted development of services to sustain families affected by these conditions....
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PMID: 19301166
PDF is available here.
PDF is available here.
Abstract
Fifty-five consecutive patients with pyogenic spinal infections were identified. Statistical analysis demonstrated that the presence of an epidural abscess, chronic liver failure, or a distant nonspinal infection were the only significant risk factors for neurologic involvement. CONCLUSION: The curr...
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PMID: 19333086
PDF is available here.
PDF is available here.
Georgian medical news ()168 2009
Abstract
The aim of the research was to determine clinical and echographic features of central nervous system damage and immunological peculiarities of new born with prenatal infections of different etiology. 132 newborns with various intrauterine infections were included to the actual study. The following r...
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PMID: 19359727
PDF is available here.
PDF is available here.
Medical Journal of Australia (190)4 Suppl 2009
Abstract
Postnatal infection may represent a preventable risk factor for onset of psychotic disorders in adolescence and early adulthood. The mechanism of action is likely to involve site-directed triggering of the brain's innate immune system, mediated principally through localised activation of microglial...
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PMID: 19220168
PDF is available here.
PDF is available here.
Abstract
Central nervous system infections have long been recognized as among the most devastating of diseases. This article describes the changing pattern and epidemiology of a variety of common central nervous system infections, including meningitis, encephalitis, and brain abscesses, and reviews pathophysi...
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PMID: 19218021
PDF is available here.
PDF is available here.
Abstract
In cases involving a febrile child having convulsions, the possibility of infections of the central nervous system should be considered and the necessary diagnostic investigations performed. If the febrile convulsion does not end by itself in five minutes, it will be treated as an epileptic seizure....
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PMID: 20175323
PDF is available here.
PDF is available here.
Abstract
The authors present selected results of the analysis of medical histories of the subjects who died from complications of inflammatory aural diseases and paranasal sinus pathology in multifield city hospitals of Moscow for the period from 1993 till 2003. The character and the frequency of each intrac...
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PMID: 19365358
PDF is available here.
PDF is available here.
Abstract
Parasite infections in the central nervous system (CNS) are a major cause of morbidity and mortality worldwide, second only to HIV infection. Finding appropriate therapeutic measures to control CNS parasite infections requires an understanding of the tissue-specific host response. CNS parasitic dise...
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PMID: 19688329
PDF is available here.
PDF is available here.
Abstract
We review evidence for a role of TLRs in innate immune responses against viral infections of the central nervous system. By far the most extensive literature pertains to TLR3. Data from various laboratories have shown that TLR3 is expressed in cells endogenous to the CNS, particularly in astrocytes...
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PMID: 19688328
PDF is available here.
PDF is available here.
Epilepsy & Behavior (14)1 2009
Abstract
The proportion of patients who died within 30 days was 15.8%. The frequency of deaths among female patients (22.1%) was higher than that among males (12.5%). The most prominent etiologic factors in death were CNS infection, toxic/metabolic disease, and head trauma. The most frequently used treatment...
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PMID: 18834956
PDF is available here.
PDF is available here.
Clinical Neuropathology (28)3 2009
Abstract
Our primary aim was to investigate whether there is any association between thickness of the hydatid cyst's wall and size and whether it has any effect on intact removal of the cyst, independent of the surgeons' technique. Sixteen cases of echinococcal hydatid cyst of the central nervous system, ope...
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PMID: 19537139
PDF is available here.
PDF is available here.
Leukemia & Lymphoma (50)1 2009
Abstract
We summarise aspects on epidemiology, clinical symptoms and prognosis of CNS infections in patients with malignancies. Additionally, we give an overview on the diagnostics and management of cerebral infections in these patients including evidence evaluation of efficacy of treatment....
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PMID: 19031169
PDF is available here.
PDF is available here.
Abstract
Cryptococcus gattii was isolated from a 1.5-year-old dog with systemic cryptococcosis in Oregon. The dog had no link to Vancouver Island or British Columbia, Canada. Samples from a nasal swab and from a granulomatous mass within the cranial cavity were pooled for culture. Colonies on Sabouraud dextr...
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PMID: 19139515
PDF is available here.
PDF is available here.
Abstract
From 1999-2007, the most common causes of neuroinvasive arboviral disease in the United States, after West Nile virus (WNV), were California (CAL) serogroup viruses, St. Louis encephalitis virus (SLEV), and eastern equine encephalitis virus (EEEV). The CAL serogroup virus disease was primarily repor...
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PMID: 19052314
PDF is available here.
PDF is available here.
Archives of Neurology (65)12 2008
Abstract
In patients with central nervous system infections undergoing continuous electroencephalographic monitoring, ESz and/or PEDs were frequent, occurring in 48% of our cohort. More than half of the ESz had no clinical correlate. Both ESz and PEDs were independently associated with poor outcome. Addition...
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PMID: 19064748
PDF is available here.
PDF is available here.
Georgian medical news ()165 2008
Abstract
Recent advances in nervous system imaging techniques have greatly improved the diagnosis and treatment of central nervous system infections. Nowadays, the most useful imaging modalities are harmless to the patient and widely available. Whereas Analysis of CSF, biopsy, and laboratory analysis remain...
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PMID: 19124925
PDF is available here.
PDF is available here.
Abstract
Our cases of monophasic, multiphasic and recurrent DEM, invoking possible causative triggers, point to the conclusion that DEM has to be regarded as a separate disease; its similarities with NMO raise the expectations that other specific autoantibodies will be identified to explain DEM and its varia...
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PMID: 18703274
PDF is available here.
PDF is available here.
Abstract
Seminars in Neurology (28)4 2008
Abstract
Neuroimaging plays a crucial role in the diagnosis and therapeutic management of neurologic infections. This article summarizes imaging findings in brain abscesses, ventriculitis, viral diseases, and opportunistic infections. In cases of uncomplicated meningitis, cranial computed tomography is suffi...
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PMID: 18843578
PDF is available here.
PDF is available here.
Abstract
Central nervous system (CNS) infections continue to be an important cause of morbidity and mortality. Microbial invasion and traversal of the blood-brain barrier is a prerequisite for CNS infections. Pathogens can cross the blood-brain barrier transcellularly, paracellularly and/or in infected phago...
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PMID: 18604221
PDF is available here.
PDF is available here.
Abstract
The median age of the patients was 37 years (16-78 years), and 17 patients were female; 35 patients had convulsive status epilepticus, and 2 patients had nonconvulsive status epilepticus. Twenty patients had encephalitis (Japanese 4, herpes simplex 3, nonspecific 12), including 1 patient with malari...
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PMID: 18589058
PDF is available here.
PDF is available here.
Abstract
We reviewed all the available reports on CNS infections, focusing on the geographical distribution, infection routes, immunity status of infected individuals, type and location of infections, clinical manifestations, treatment and outcome. A total of 99 case reports were identified, with similar per...
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PMID: 18331448
PDF is available here.
PDF is available here.
Abstract
We prospectively collected clinical and cerebrospinal data for 16 patients with intraventricular haemorrhage, with an external ventricular drain inserted, with or without spontaneous subarachnoid haemorrhage. Three (18.8%) patients had cerebrospinal fluid infection, with appropriate changes in antib...
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PMID: 18342513
PDF is available here.
PDF is available here.
Abstract
We here report a 64-year-old female and a 53-year-old male patient who both suffered from severe parainfectious autoimmune neurological syndromes in combination with different forms of anemia, in the case of the first patient to a transfusion-requiring degree. With this report we would like to stres...
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PMID: 18512187
PDF is available here.
PDF is available here.
Abstract
Common pathogens, such as tuberculosis, Cryptococcus, and Listeria, still occur commonly as the major causes of central nervous system infection in systemic vasculitides. However, rare pathogens could be responsible among those immunocompromised hosts, and they should not be overlooked. The manifest...
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PMID: 18451720
PDF is available here.
PDF is available here.
Abstract
fMLP can cause selective DA neuronal loss at concentrations as low as 10(-13) M. Further, fMLP (10(-13) M) led to a significant reduction in DA uptake capacity in neuron/glia (N/G) cultures, but not in microglia-depleted cultures, indicating an indispensable role of microglia in fMLP-induced neuroto...
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PMID: 18470306
PDF is available here.
PDF is available here.
Neurologic Clinics (26)2 2008
Abstract
Central nervous system (CNS) infections presenting to the emergency room include meningitis, encephalitis, brain and spinal epidural abscess, subdural empyema, and ventriculitis. These conditions often require admission to an intensive care unit (ICU) and are complications of ICU patients with neuro...
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PMID: 18514821
PDF is available here.
PDF is available here.
Abstract
Sporadic, late-onset Alzheimer's disease (LOAD) is a non-familial, progressive neurodegenerative disease that is now the most common and severe form of dementia in the elderly. That dementia is a direct result of neuronal damage and loss associated with accumulations of abnormal protein deposits in...
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PMID: 18487846
PDF is available here.
PDF is available here.
Journal of the Neurological Sciences (266)1-2 2008
Abstract
Infective pathologies were the most common etiology for multiple enhancing lesions of the brain. Tuberculosis was the commonest infective pathology, followed by neurocysticercosis. Neoplastic diseases were common non-infective causes. In majority, brain lesions were metastatic manifestation of a sys...
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PMID: 17945258
PDF is available here.
PDF is available here.
Journal of Virology (82)5 2008
Abstract
Replication of the neurotropic mouse hepatitis virus strain JHM (JHMV) is controlled primarily by CD8(+) T-cell effectors utilizing gamma interferon (IFN-gamma) and perforin-mediated cytotoxicity. CD4(+) T cells provide an auxiliary function(s) for CD8(+) T-cell survival; however, their direct contr...
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PMID: 18094171
PDF is available here.
PDF is available here.
Journal of Rheumatology (35)3 2008
Abstract
Archives of Neurology (65)2 2008
Abstract
Perioperative neurologic complications are frequent in heart transplant recipients, but most are transient and inconsequential. However, perioperative stroke is the most important neurologic complication affecting survival in the first year after heart transplant. Infectious diseases of the central...
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PMID: 18268192
PDF is available here.
PDF is available here.
Neurosurgery (62 Suppl 2) 2008
Abstract
Neurosurgery (62 Suppl 2) 2008
Abstract
The most common infections affecting the brain, namely, cranial epidural abscess, subdural empyema, brain abscess, viral infection, tuberculosis, and neurocysticercosis, can each be associated with significant mass effect on the cerebrum that is greatly reduced through surgery. This relief, in combi...
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PMID: 18596452
PDF is available here.
PDF is available here.
Laryngoscope (118)2 2008
Abstract
We report only one (1%) postoperative mortality in this series and only seven major complications in six patients, including two cases of stroke, one case of cerebrospinal fluid (CSF) leak, and four cases of delayed osteoradionecrosis. No patients in this series developed tension pneumocephalus. The...
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PMID: 18030165
PDF is available here.
PDF is available here.
Abstract
Innate immunity in the CNS depends primarily on the functions of glial cells, astrocytes and microglia, which are important for the early control of pathogen replication and direct the recruitment and activation of cells of the adaptive immune system required for pathogen clearance. Efficient immune...
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PMID: 17920811
PDF is available here.
PDF is available here.
Abstract
Infectious disease continues to evolve, presenting new and challenging clinical situations for practitioners. Specific to device-related and neurosurgical-related CNS infections, Gram-positive organisms are of growing concern. Current Infection Disease Society of America guidelines for the treatment...
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PMID: 18251666
PDF is available here.
PDF is available here.
Abstract
Serious viral CNS infections during childhood appear to be associated with the later development of schizophrenia and nonaffective psychoses. The association with specific viruses suggests that the risk is related to infectious agents with a propensity to invade the brain parenchyma....
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PMID: 18056223
PDF is available here.
PDF is available here.
Abstract
Abstract
I alleles and acquired immunodeficiency syndrome (AIDS) have been reported, the role MHC class I alleles play in restricting development of HIV-induced organ-specific diseases, including neurologic disease, has not been characterized. This study examined the relationship between expression of the MH...
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PMID: 18978944
PDF is available here.
PDF is available here.
Terapevticheskii arkhiv (80)11 2008
Abstract
Przeglad epidemiologiczny (62 Suppl 1) 2008
Abstract
Lakartidningen (105)47 2008
Abstract
Pediatric Neurology (38)1 2008
Abstract
With the advent of magnetic resonance imaging as a rapid and accurate way to diagnose arterial ischemic stroke, cerebrospinal fluid assessment is rarely performed, unless infectious or inflammatory processes are obvious. Recent advances in the understanding of the pathophysiology of childhood stroke...
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PMID: 18054685
PDF is available here.
PDF is available here.
Abstract
Compared with the background hospital population, German Shepherd dogs and female dogs were overrepresented (odds ratio [OR] 43, 95% confidence interval [CI] 20-91, P < .0001, and OR 2.9, 95% CI 1.2-6.7, P= .02), respectively, with 20 of the 30 dogs being German Shepherd dogs and 77% (23 of 30) of t...
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PMID: 18647155
PDF is available here.
PDF is available here.
Lancet Neurology (7)1 2008
Abstract
Anales del Sistema Sanitario de Navarra (31 Suppl 1) 2008
Abstract
We set out, from the clinical, diagnostic and therapeutic point of view, those that are most frequent in our environment and some that, although very infrequent, might require emergency attention due to their severity....
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PMID: 18528447
PDF is available here.
PDF is available here.