Find your PDFs fast.
Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Biological Markers (8):
Recent article
Biological Markers
Journal of Neurochemistry (119)5 2011
Abstract
We have used neuroblastoma cells expressing NDM29 at its basal level (Mock cells) or at 5.4-fold higher levels (S1 cells) to investigate whether a functional differentiation correlates with morphological and biochemical development induced by NDM29 expression. First, analyzing the expression of spec...
|
PMID: 21933186
PDF is available here.
PDF is available here.
| < More recent | Older article > |
Clinical Science (122)2 2012
Abstract
We aim to provide an overview of the vast literature on angiogenesis and anti-angiogenesis factors in pre-eclampsia that have been published over the last decade. We introduce work from basic research groups who have focused on the pathophysiological basis of the disease. Furthermore, we review stud...
|
PMID: 21929511
PDF is available here.
PDF is available here.
Development (138)21 2011
Abstract
We demonstrate that zebrafish Neuregulin 1 (Nrg1) type III, which signals through ErbB receptors, controls Schwann cell migration in addition to its previously known roles in proliferation and myelination. Chimera analyses indicate that ErbB receptors are required in all migrating Schwann cells, and...
|
PMID: 21965611
PDF is available here.
PDF is available here.
Developmental Cell (21)4 2011
Abstract
We show that Fgf8 and Sema3f, produced by early dental epithelium, respectively, attract and repulse mesenchymal cells, which cause them to pack tightly together during mouse tooth development. Resulting mechanical compaction-induced changes in cell shape induce odontogenic transcription factors (Pa...
|
PMID: 21924961
PDF is available here.
PDF is available here.
Developmental Cell (21)4 2011
Abstract
We generated and characterized Atxn1L(-/-) and Atxn1(-/-); Atxn1L(-/-) mice. Atxn1L(-/-) mice have hydrocephalus, omphalocele, and lung alveolarization defects. These phenotypes are more penetrant and severe in Atxn1(-/-); Atxn1L(-/-) mice, suggesting that ATXN1 and ATXN1L are functionally redundan...
|
PMID: 22014525
PDF is available here.
PDF is available here.
Abstract
The omega-3 (n-3) fatty acids docosahexaenoic acid and eicosapentaenoic acid, along with γ-linolenic acid and antioxidants, may modulate systemic inflammatory response and improve oxygenation and outcomes in patients with acute lung injury.
To determine if dietary su...
|
PMID: 21976613
PDF is available here.
PDF is available here.
Journal of Surgical Research (170)2 2011
Abstract
We report the generation of hepatocyte-like cells derived from hES cells.
Hepatic endoderm cells were generated by adding activin A for 5 d- to 1-d-old embryoid bodies formed from hES cells. The hepatic endoderm cells were cocultured with mitomycin treated 3T3-J2 feeder cells....
|
PMID: 21816427
PDF is available here.
PDF is available here.
Journal of Surgical Research (170)2 2011
Abstract
We induced POLF by combining extended left hepatectomy and ischemia of the small liver remnant of 150 min duration. Subsequently, the remnant liver parenchyma was reperfused and the animals were closely monitored for 24 h.
Twelve Landrace pigs (weight 25-30 kg) were randomly assigned...
|
PMID: 21816413
PDF is available here.
PDF is available here.
Abstract
Our simple culture system might offer the potential of a source of mature β cells....
|
PMID: 21926540
PDF is available here.
PDF is available here.
Abstract
Type 2 diabetes mellitus (T2DM) and its attendant complications, such as diabetic nephropathy (DN), impose a significant societal and economic burden. The investigation of discovering potential biomarkers for T2DM and DN will facilitate the prediction and prevention of diabetes. Phos...
|
PMID: 21872008
PDF is available here.
PDF is available here.
Abstract
We tested the effect of porosity on multipotent stromal cells (MSCs) embedded in hydrogel constructs printed with a 3D fiber deposition (3DF) machine. For this, porous and solid alginate hydrogel scaffolds, with MSCs homogeneously dispersed throughout the construct, were printed and analyzed in vitr...
|
PMID: 21599540
PDF is available here.
PDF is available here.
Abstract
I at varying ratios. Maturation of cardiac function in embryoid bodies formed from hESCs was documented in terms of spontaneous contractile behavior and the mRNA and protein expression of cardiac markers. Hydrogel with high ECM content (75% ECM, 25% collagen, no supplemental soluble factors) increas...
|
PMID: 21744185
PDF is available here.
PDF is available here.
New England Journal of Medicine (365)13 2011
Abstract
We analyzed the changes in FEV(1) after administration of a bronchodilator over a 3-year period in 2163 patients. A random-coefficient model was used to evaluate possible predictors of both FEV(1) levels and their changes over time.
The mean (±SE) rate of change in FEV(1) was a decl...
|
PMID: 21991892
PDF is available here.
PDF is available here.
New England Journal of Medicine (365)13 2011
Abstract
New England Journal of Medicine (365)12 2011
Abstract
Abstract
Coronary artery disease (CAD) is a common and multifactorial arterial disease that is mainly caused by atherosclerosis. Macrophages, lymphocytes and neutrophils have been implicated in atherosclerotic plaque development. Autophagy, a highly conserved cellular process for the removal...
|
PMID: 21812771
PDF is available here.
PDF is available here.
Abstract
Sarcoidosis is a multisystemic granulomatous disorder of unknown etiology, which is characterized by a variable clinical presentation and course. The diagnosis of this disease is usually supported by the three elements: compatible clinical and radiologic findings, tissue biopsy speci...
|
PMID: 21991850
PDF is available here.
PDF is available here.
Abstract
Acute kidney injury (AKI) in the elderly patient is a common iatrogenic complication of major surgery that impacts morbidity, mortality and resource use. Several renal functional and structural changes have been described, including a substantially decreased nephron mass. Loss of renal function defin...
|
PMID: 21925405
PDF is available here.
PDF is available here.
Abstract
To evaluate the levels/activities of antioxidants and lipid peroxidation in the blood of subjects that consumed palm wine on regular bases. Subjects and Methods: Sixty-four male volunteers between the ages of 30-70years were recruited for the study. The subjects were those that visited palm wine vend...
|
PMID: 21909148
PDF is available here.
PDF is available here.
Abstract
We therefore studied the effects of cryopreservation on the viability, proliferation potential, and the pluripotency status of hESCs by combining cellular readouts and transcriptomics. We identified biological processes and pathways affected by cryopreservation in order to understand the limited sur...
|
PMID: 21279480
PDF is available here.
PDF is available here.
Abstract
We investigated whether interaction of ECs with mouse embryoid bodies (EBs) in culture promotes differentiation of pancreatic progenitors and insulin-producing cells and the mechanisms involved. We developed a co-culture system of mouse EBs and human microvascular ECs (HMECs). An increase in the exp...
|
PMID: 21298405
PDF is available here.
PDF is available here.
Abstract
We compared the efficiency of three different feeder-free cultures for differentiating mouse iPS cells into ckit+sca1+ hematopoietic progenitor cells (HPCs) and compared how differentiation and functionality varies between ES and iPS cells. Our results indicated that both iPS and ES cells can be eff...
|
PMID: 21188655
PDF is available here.
PDF is available here.
Abstract
We examined the association between ambulatory activity and biological markers of health in smokers.
Baseline data from 985 subjects enrolled in a pharmacologic smoking cessation trial were examined. Body size, blood pressure, total cholesterol (TC), low density lipoprotein cholester...
|
PMID: 21885891
PDF is available here.
PDF is available here.
Abstract
Abstract
Circulation Research (109)4 2011
Abstract
Circulation Research (109)4 2011
Abstract
We focus on emerging techniques that may form a coherently integrated pipeline to overcome present limitations to both the discovery and validation processes....
|
PMID: 21817166
PDF is available here.
PDF is available here.
Abstract
We examined serum markers of bone turnover using ELISA - C-terminal crosslinking telopeptide of type I collagen (CTX-I), total osteocalcin (total OC), procollagen type I N propeptide (PINP) and bone alkaline phosphatase (bone ALP). We investigated bone morphogenetic protein-2 (BMP-2) in the proximal...
|
PMID: 21901984
PDF is available here.
PDF is available here.
Abstract
Psoriatic arthritis (PsA) is a chronic inflammatory arthropathy associated with psoriasis that affects the peripheral joints, spine, and entheses. Most patients with PsA present with peripheral synovitis of the oligoarticular or polyarticular subtype. As one of the targets of this di...
|
PMID: 21503693
PDF is available here.
PDF is available here.
Abstract
The goals of this study were to characterize urine-derived stem cells obtained from the upper urinary tract (uUSC), induce these cells to differentiate into urothelial and smooth muscle cells, and determine whether they could serve as a potential stem cell source for bladder tissue e...
|
PMID: 21513463
PDF is available here.
PDF is available here.
Abstract
The aim of the study was to construct small-diameter vascular grafts using canine mesenchymal stem cells (cMSCs) and a pulsatile flow bioreactor. cMSCs were isolated from canine bone marrow and expanded ex vivo. cMSCs were then seeded onto the luminal surface of decellularized arteri...
|
PMID: 21784877
PDF is available here.
PDF is available here.
Abstract
We obtained and analysed samples of blood serum from 23 patients with MF, and 29 psoriasis patients and 22 healthy donors as controls. Protein profiling was carried out using SELDI TOF MS SELDI-TOF and also profiling of 27 cytokines with multiplex immunoassay technology was implemented....
|
PMID: 21751413
PDF is available here.
PDF is available here.
Proteomics (11)16 2011
Abstract
We investigated the ability of this platform to discriminate between the "sputome" of patients with asthma and chronic obstructive pulmonary disease, and between these groups and those of healthy control subjects. Six m/z peaks emerged as potential diagnostic peptidic patterns able to differentiate...
|
PMID: 21751363
PDF is available here.
PDF is available here.
Abstract
Introduction: The knowledge base of drug-induced liver injury (DILI) continues to grow each year as additional drugs are identified as hepatotoxins. There is still a need to improve our ability to predict and diagnose DILI in the preclinical and post-approval settings. Areas covered:...
|
PMID: 21510822
PDF is available here.
PDF is available here.
Abstract
We found that RB is an appropriate marker for bait uptake studies of 10 mg RB per kg target animal mass. Whiskers with follicles provided the best sample for RB detection....
|
PMID: 21719849
PDF is available here.
PDF is available here.
Abstract
We characterized levels of acute-phase reactants (C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), white blood cell (WBC) count), adhesion molecules (E-selectin, vascular cell adhesion molecule-1), and coagulation products (fibrinogen, plasminogen activator inhibito...
|
PMID: 21233809
PDF is available here.
PDF is available here.
Abstract
We reported an in vitro test-bed for screening cell integration between injected test cells and host CM using the engineered heart tissue as a recipient. The objective of this study is to expand our system to diabetic cardiomyopathy conditions. Patients with diabetes show dysfunction of CMs independ...
|
PMID: 21417718
PDF is available here.
PDF is available here.
Abstract
We present the results from the first two rounds of the program.
The program is open for laboratories using commercially available kits for Aβ, T-tau, or P-tau. CSF samples (aliquots of pooled CSF) are sent for analysis several times a year from the Clinical Neurochemistry Laborator...
|
PMID: 21784349
PDF is available here.
PDF is available here.
Abstract
Recent investigations of regulatory myeloid cell mobilization and amplification in response to cancer and chronic inflammation associated with infectious disease and autoimmunity have provided numerous insights into the suppressive mechanisms, pathobiology and potential pharmaceutica...
|
PMID: 21315784
PDF is available here.
PDF is available here.
Abstract
Our 3-month study in nondiabetic hypertensive patients showed a decrease in biomarkers of IR and chronic systemic inflammation with the PIO monotherapy and the PIRA combination only, which may help to explain some findings in other cardiovascular outcome trials.
© 2011 Diabetes Tech...
|
PMID: 21880242
PDF is available here.
PDF is available here.
Abstract
Our 3-month study in nondiabetic hypertensive patients showed a decrease in biomarkers of IR and chronic systemic inflammation with the PIO monotherapy and the PIRA combination only, which may help to explain some findings in other cardiovascular outcome trials.
© 2011 Diabetes Tech...
|
PMID: 21880242
PDF is available here.
PDF is available here.
Abstract
New England Journal of Medicine (364)24 2011
Abstract
Abstract
Abstract
Metrics such as relative hazards and relative risks do not account for the prevalence of a marker over time and its relation to whether and when an outcome occurs. Uncommon markers that have good predictive values and common markers that are poorly predictive may not be (clinically) useful in predict...
|
PMID: 21571873
PDF is available here.
PDF is available here.
Abstract
In this paper, the authors describe a simple method for making longitudinal comparisons of alternative markers of a subsequent event. The method is based on the aggregate prediction gain from knowing whether or not a marker has occurred at any particular age. An attractive feature of the method is th...
|
PMID: 21571871
PDF is available here.
PDF is available here.
Abstract
We propose using the levels of the four metabolites for diagnosing NAFLD at various stages. Furthermore, the probability of developing NAFLD at a particular stage was assessed by multinomial logistic regression (MLR) based on the clinical results of the four serum metabolites....
|
PMID: 21563774
PDF is available here.
PDF is available here.
Abstract
We first harvested a cell sheet from rabbit bone marrow stromal cells using a continuous culture method and a scraping technique. The obtained sheet was then cut into fragments of multicellular aggregates, each of which was composed of a certain number of cells, extracellular matrix, and intercellul...
|
PMID: 21091305
PDF is available here.
PDF is available here.
Abstract
Albuminuria is an important risk marker for adverse cardiovascular (CV) and renal outcomes and mortality. The relationship between albuminuria and risk is continuous and linear, like that of blood pressure and cardiovascular risk. Evidence now supports increased risk even at levels t...
|
PMID: 21649844
PDF is available here.
PDF is available here.
Abstract
Antibodies against the wheat storage globulin Glo-3A from a patient with both type 1 diabetes (T1D) and celiac disease were enriched to identify potential molecular mimicry between wheat antigens and T1D target tissues. Recombinant Glo-3A was used to enrich anti-Glo-3A immunoglobulin G antibodies fro...
|
PMID: 21766094
PDF is available here.
PDF is available here.
Abstract
We report a successful management of primary AIN patient by estimating the granulopoiesis according to CRP levels without administration of G-CSF or increase of prednisolone when peripheral neutrophil counts dropped down. Transient elevation of CRP associated with severe drop down in neutrophil coun...
|
PMID: 21316504
PDF is available here.
PDF is available here.
Abstract
We studied the expression of several genes associated with pluripotency in zebrafish embryonic cells versus differentiated cells and the expression of some of these genes is recorded throughout embryonic development. Some of the commonly accepted pluripotency markers are also tested in embryonic cel...
|
PMID: 21563922
PDF is available here.
PDF is available here.
The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of... (55)3 2011
Abstract
We will outline studies that support the dynamic hypothesis by: 1) testing slope differences among biomarkers; 2) describing how biomarkers map all neuropathological and clinical changes starting from the detection of amyloid burden, to neurodegeneration, and symptoms; and finally 3) identifying the...
|
PMID: 21532538
PDF is available here.
PDF is available here.
Liver Transplantation (17)6 2011
Abstract
We used sequential high-abundance protein depletion and isobaric tag for relative and absolute quantitation liquid chromatography-tandem mass spectrometry to characterize the serum proteome in serum samples of patients with or without ACR. Seven of the 41 proteins identified as differentially abunda...
|
PMID: 21618694
PDF is available here.
PDF is available here.
Abstract
Clinical relevance of relations among blood pressure (BP), inflammation, endothelial dysfunction and sympathetic activation is unknown. Study aimed, whether in patients with diagnosed and treated essential arterial hypertension (HTN) biomarkers of inflammation (hs-C-reactive protein,...
|
PMID: 21515487
PDF is available here.
PDF is available here.
Abstract
The cardiorenal syndromes comprise a group of disorders in which impairment of either the heart or the kidney results in injury to the other. Although the pathophysiology is not yet well understood, the clinical consequences are increasingly recognized. In congestive heart failure, t...
|
PMID: 21380936
PDF is available here.
PDF is available here.
Abstract
We have employed two-dimensional electrophoresis to detect and quantitate gene expression effects of candidate chemoprevention compounds in the livers of treated rats. Oltipraz, an inducer of several phase II enzymes, affected a series of at least 26 proteins, most of which were slightly decreased b...
|
PMID: 8538186
PDF is available here.
PDF is available here.
Abstract
We were able to showed that PGC1-α expression is dramatically reduced in GRMD compared to healthy muscle. Collectively, these results provide novel insights into the molecular pathology of the clinically relevant animal model of DMD, and indicate that defective energy metabolism is a central hallma...
|
PMID: 21410286
PDF is available here.
PDF is available here.
Abstract
The aim of this study is to compare salivary and serum biomarker levels and degrees of matrix metalloproteinase (MMP) activation between patients with acute myocardial infarction (AMI) and systemically healthy patients (non-AMI) with similar periodontal conditions.
A...
|
PMID: 21091346
PDF is available here.
PDF is available here.
Abstract
We hypothesized that BNP might be useful in the early diagnosis and risk stratification of patients with acute chest pain.
In a prospective, international multicenter study, BNP was measured in 1075 unselected patients with acute chest pain. The final diagnosis was adjudicated by 2 i...
|
PMID: 21531234
PDF is available here.
PDF is available here.