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Blood Coagulation Factors (23):
- Thrombin
- Prothrombin
- Kallikreins
- Kininogens
- Plasminogen Activator Inhibitor 2
- Plasminogen Activator Inhibitor 1
- Factor XI
- Platelet Factor 4
- Platelet Factor 3
- Fibrinopeptide B
- Fibrinopeptide A
- Factor VIII
- Fibrinogen
- Plasminogen Activators
- Factor IX
- von Willebrand Factor
- Factor X
- Factor VII
- Factor V
- beta-Thromboglobulin
- Factor XII
- Thromboplastin
- Factor XIII
Recent article
Blood Coagulation Factors
Journal of Proteomics (74)5 2011
Abstract
We herein identified the aberrant plasma proteins in NPC patients. We first removed the top-seven abundant proteins from plasma samples of healthy controls and NPC patients, and then labeled the samples with different fluorescent cyanine dyes. The labeled samples were then mixed equally and fraction...
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PMID: 21376147
PDF is available here.
PDF is available here.
| < More recent | Older article > |
Journal of Trauma (70)1 2011
Abstract
We hypothesize that the hemostatic potential (HP) of freshly thawed (FFP-0) was superior to plasma stored for 5 days (FFP-5).
FFP from 30 single donors were thawed at 37°C and kept at 1°C to 6°C for 5 days. HP was evaluated at day 0 and 5 by measuring kinetics of thrombin generation (TG), kinetic...
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PMID: 21217484
PDF is available here.
PDF is available here.
Abstract
Abstract
We prospectively followed 343 patients after a first episode of objectively proven VTE. We excluded all patients with VTE at unusual sites, older than 70 years old, with neoplasia, liver or renal chronic disease and antiphospholipid syndrome. Predictors for recurrence were evaluated by Cox model. Th...
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PMID: 20829682
PDF is available here.
PDF is available here.
Abstract
Acute coronary syndromes are characterized by increased endothelial activation. The aim of this study was to investigate the behavior of coagulation factors V, VII, VIII and normal inhibitors antithrombin III and protein C during the acute phase of myocardial infarction. Thirty-six patients (27 men,...
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PMID: 20885133
PDF is available here.
PDF is available here.
Abstract
We studied 46 hemostatic parameters in 566 participants: 280 patients with mucocutaneous bleeding and 286 controls. The F12 -4T allele, associated with reduced levels of FXII (P < 0.001), also significantly delayed the activated partial thromboplastin time (aPTT) expressed as aPTTr (ratio sample pla...
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PMID: 20814302
PDF is available here.
PDF is available here.
Abstract
The objective of the present study was to systematically evaluate the impact of methodology on thromboelastometry with canine whole blood. Thromboelastometry was performed on citrated blood using a variety of combinations of clotting activators [ex-tem (tissue factor or TF), in-tem (ellagic acid), d...
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PMID: 20739876
PDF is available here.
PDF is available here.
Abstract
Abstract
We hypothesize that soluble clotting factors released during a mechanical thrombectomy procedure may be responsible for creating a localized hypercoagulable state and could be one of the underlying causes of recurrent thrombosis.
Blood samples were obtained from 20 participants with no history of hy...
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PMID: 19671559
PDF is available here.
PDF is available here.
Abstract
To investigate the haemostatic parameters and to assesss their relationship with microvascular complications in type 2 diabetes mellitus.
Coagulation and fibrinolysis parameters were measured in 60 type 2 diabetic patients (M:F 1:1) with (n=40) and without (n=20) diabetic microvascular complications...
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PMID: 21189694
PDF is available here.
PDF is available here.
Thrombosis and Haemostasis (104)2 2010
Abstract
We investigated thrombin generation profiles in RA patients and their dependence on plasma factor/inhibitor composition. Plasma factor (F) compositions (II, V, VII, VIII, IX, X), antithrombin and free tissue factor pathway inhibitor (TFPI) from 46 consecutive RA patients with no cardiovascular event...
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PMID: 20593110
PDF is available here.
PDF is available here.
Haemophilia (16) 2010
Abstract
SUMMARY: During the last two decades major advances have been achieved in the management of haemophilia. Modern approaches aimed at preventing the recurrent bleedings and their sequelae have been widely adopted. Major challenges of intensive treatment regimens employed today, such a short half life...
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PMID: 20590852
PDF is available here.
PDF is available here.
Haemophilia (16) 2010
Abstract
SUMMARY: Despite major advances in diagnosis and treatment, the management of patients with mild haemophilia (MH) remains a major challenge. Mild haemophilia is defined by factor levels between 0.05 and 0.40 IU mL(-1). The bleeding associated with mild haemophilia is most frequently episodic, occurr...
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PMID: 20590864
PDF is available here.
PDF is available here.
Haemophilia (16) 2010
Abstract
SUMMARY: Anamestic inhibitors represent the major complication of haemophilia therapy now that clotting factor concentrates are virtually free of pathogen-transmission risk. Conventional clotting factor replacement is usually insufficient to prevent or treat bleeding in a haemophilia patient with a...
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PMID: 20590857
PDF is available here.
PDF is available here.
Haemophilia (16) 2010
Abstract
SUMMARY: Variant Creutzfeldt-Jakob disease (CJD) is an emerging form of human prion disease caused by oral exposure to the bovine spongiform encephalopathy agent. Most cases have occurred in the UK, but smaller numbers of cases have been identified in 10 other countries worldwide. All confirmed case...
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PMID: 20590878
PDF is available here.
PDF is available here.
Haemophilia (16) 2010
Abstract
SUMMARY: Prophylaxis is recommended as preventive therapy for young boys with severe haemophilia in countries where safe factor concentrates are available. This recommendation is supported by results from a randomized, controlled study that compared on-demand therapy with full-dose prophylaxis (Manc...
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PMID: 20590879
PDF is available here.
PDF is available here.
Haemophilia (16) 2010
Abstract
SUMMARY: The rationale for long-term prophylaxis in more severe forms of von Willebrand's disease (VWD) is obvious, as mucosal bleeding and haemophilia-like joint bleeds resulting in chronic morbidity may occur. However, the experience with prophylactic treatment in this group is scanty. An internat...
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PMID: 20590880
PDF is available here.
PDF is available here.
Haemophilia (16) 2010
Abstract
SUMMARY: Bleeding disorders may present during the neonatal period, however, absent patient history along with unique physical signs, physiologically decreased levels of plasma proteins and laboratory variations of platelet function tests may render any diagnosis difficult to establish. Intra crania...
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PMID: 20590877
PDF is available here.
PDF is available here.
Abstract
The proverb that probably best exemplifies my career in research is attributable to Yogi Berra (http://www.yogiberra.com/), ie, "when you come to a fork in the road ... take it." My career is a consequence of chance interactions with great mentors and talented students and the opport...
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PMID: 20554951
PDF is available here.
PDF is available here.
Haemophilia (16 Suppl 5) 2010
Abstract
Haemophilia (16 Suppl 5) 2010
Abstract
SUMMARY: Most bleeding disorders encountered in clinical practice will be diagnosed, at least initially, by phenotypic assays. However, since the characterization of the genes that encode coagulation factors in the 1980s, significant progress has been made in translating this knowledge for diagnosti...
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PMID: 20590854
PDF is available here.
PDF is available here.
Haemophilia (16 Suppl 5) 2010
Abstract
Gene Therapy (17)7 2010
Abstract
We show that the adenoviral-associated humoral and innate cytokine immune responses are significantly reduced when HAdV-5 vector carrying human bovine chimeric fibers (HAdV-5-F2/BAdV-4) is intravenously injected into mice. Fiber pseudotyping modified its interaction with blood coagulation factors, a...
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PMID: 20393506
PDF is available here.
PDF is available here.
Neurocritical Care (12)3 2010
Abstract
We aim to review the literature regarding the use of prothrombin complex concentrates in patients with warfarin-related intracranial hemorrhage. A comprehensive review of the literature was conducted using PUBMED and Google Scholar databases to identify the use of PCC in patients with warfarin-relat...
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PMID: 19967567
PDF is available here.
PDF is available here.
Abstract
We discuss a complicated issue of multiple coagulopathies in patients with advanced liver dysfunction....
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PMID: 20513645
PDF is available here.
PDF is available here.
Abstract
APC could augment the anti-coagulation and anti-inflammatory activity by up-regulating EPCR and TM expressions, thus attenuating the severity of SAP....
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PMID: 19680809
PDF is available here.
PDF is available here.
Abstract
Sepsis is one of the main causes of death in critically ill patients. The pathophysiology of sepsis is complex and not completely understood. The proinflammatory and anti-inflammatory response leads to cell and organ dysfunction and, in many cases, death. Thus, the goal of the intervention is to res...
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PMID: 20427984
PDF is available here.
PDF is available here.
Critical Care Medicine (38)6 2010
Abstract
Physiological and hematologic parameters were continuously recorded and biochemical analyses were performed in batch after completion. Systemic vascular resistance, cardiac index and lactate changed significantly more in the NmLPS+ than in the NmLPS- group (p < .05). Mean pulmonary artery pressure i...
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PMID: 20400898
PDF is available here.
PDF is available here.
Abstract
The development of hemostasis research at Karolinska Institutet is described, focusing first on the initial findings of the fibrinogen structure and the hereditary bleeding disorders, hemophilia A and von Willebrand's disease. Basic research has focused on new biomarkers for cardiovascular/thromboem...
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PMID: 20494125
PDF is available here.
PDF is available here.
Abstract
In order to limit the blood loss associated with surgery and the management of uncontrolled bleeding, PCC is an important addition to our therapeutic armamentarium in the reversal of vitamin K antagonists....
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PMID: 20077167
PDF is available here.
PDF is available here.
Abstract
We report our initial experience using Profilnine SD, a 3-Factor prothrombin complex concentrate (PCC) in combination with fresh frozen plasma and vitamin K in seven patients admitted to our neurointensive care unit with oral anticoagulation therapy-related intracranial haemorrhage over a six-month...
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PMID: 20514955
PDF is available here.
PDF is available here.
Journal of Trauma (68)5 2010
Abstract
In a pilot study involving an in vivo large-animal model of spleen trauma, PCC accelerated hemostasis and augmented thrombin generation compared with rFVIIa. Further investigations are warranted on PCC as a hemostatic agent in trauma....
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PMID: 19996804
PDF is available here.
PDF is available here.
Abstract
Abstract
We describe our experience of managing a patient with a chylothorax following oesophagectomy, and the use of a blood patch (a novel technique) to overcome persistent leakage following re-operation. The authors feel that this technique has the potential for a wider application in the treatment of chy...
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PMID: 20501000
PDF is available here.
PDF is available here.
Abstract
Hereditary thrombophilias are present in a significant number of thromboembolic events. Preoperative vigilance on the part of the plastic surgeon may help to identify patients with undiagnosed hereditary thrombophilias and thereby decrease the incidence of venous thromboembolism....
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PMID: 20440173
PDF is available here.
PDF is available here.
Thrombosis Research (125)5 2010
Abstract
We investigated the exact location of these two cleavages, by substitution of arginines by glutamine within the R(x1)-region (R501, R505 or R510) and the R(x2)-region (R313, R316, R317 or R321). Immunoblot and kinetic analyses of the inactivation of activated R(x1)-mutants by APC revealed that using...
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PMID: 20051284
PDF is available here.
PDF is available here.
Abstract
We obtained data from 266 adults for VWF: Ag, 371 adults for FVIII, and minimum 136 adults for the rest. Reference interval for VWF was 51-176% (52-155% in blood group O and 71-186% for non-O). Reference interval for FVIII was 64-197% (55-150% in O and 77-205% in non-O). Reference interval for FII w...
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PMID: 20160641
PDF is available here.
PDF is available here.
Pharmacotherapy (30)4 2010
Abstract
Pregnant women required a mean UFH dose of 236.9 units/kg/day to achieve the targeted antifactor Xa level of 0.1-0.3 unit/ml. The required UFH doses correlated with patient weight, and most antifactor Xa levels were within the desired target range. These findings may assist clinicians in more precis...
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PMID: 20334457
PDF is available here.
PDF is available here.
Transfusion (50)4 2010
Abstract
Plasma proteins demonstrated different sensitivities to riboflavin and UV treatment. The amount of total protein remained unchanged. After treatment, fibrinogen (antigen) showed 99% retention; Factor (F)XII, FXIII, ADAMTS-13, and von Willebrand factor (ristocetin cofactor) 96% to 100%. Fibrinogen re...
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PMID: 20051060
PDF is available here.
PDF is available here.
Thrombosis Research (125 Suppl 2) 2010
Abstract
Thrombosis and Haemostasis (103)4 2010
Abstract
We establish gestational age-specific reference intervals for coagulation tests during normal pregnancy. Eight hundred one women with expected normal pregnancies were included in the study. Of these women, 391 had no complications during pregnancy, vaginal delivery, or postpartum period. Plasma samp...
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PMID: 20174768
PDF is available here.
PDF is available here.
Abstract
Abstract
We propose several strategies for the post-analytical reporting of hemostasis assays, and how this may provide the final opportunity to prevent serious clinical errors in diagnosis. This report should be of interest to both the laboratory scientists working in hemostasis and clinicians that request...
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PMID: 20014957
PDF is available here.
PDF is available here.
Neurosurgery (66)3 2010
Abstract
The objective of this study was to define the relative contributions of three major pro- and anti-coagulation pathways (heparin-antithrombin, protein C, and tissue factor (TF)) in the thrombogenic responses that occur in large and small vessels of the brain.
Cerebral venous sinus thrombosis was indu...
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PMID: 20124931
PDF is available here.
PDF is available here.
Thrombosis and Haemostasis (103)3 2010
Abstract
We build upon and expand substantially our observations surrounding nucleic acids as antithrombotic agents....
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PMID: 20135076
PDF is available here.
PDF is available here.
Transfusion (50)2 2010
Abstract
With buffy coat (BC) processing of whole blood (WB) donations, the preparation of plasma occurs within 24 hours rather than 8 hours of collection. The effect of this change on coagulation factor function in plasma and cryoprecipitate was evaluated during the validation of this produc...
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PMID: 19843287
PDF is available here.
PDF is available here.
Transfusion (50)2 2010
Abstract
Transfusion (50)2 2010
Abstract
American Surgeon (76)2 2010
Abstract
We prospectively examined 16 patients who underwent major abdominal surgery. Patients were divided into a preoperative fast group (Group F, n = 7, mean period of preoperative fasting 8.7 days) and a control group (Group C, n = 9). We did not administer vitamin K and initiated feeding after the seven...
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PMID: 20336894
PDF is available here.
PDF is available here.
Thrombosis and Haemostasis (103)2 2010
Abstract
Prolonged standing activates the coagulation cascade by the activation of endothelial cells, and probably the haemoconcentration effect contributes to this "orthostatic hypercoagulability". It was the objective of this study to assess whether rehydration (haemodilution) prevents or attenuates orthos...
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PMID: 20126831
PDF is available here.
PDF is available here.
Thrombosis and Haemostasis (103)2 2010
Abstract
Our results indicate that thrombophilic disorders are associated with the development of retinal vein occlusion in patients < or =45 years by the time of the RVO or a previous thromboembolic event, in patients with a family history of thromboembolism, or in patients without cardiovascular risk facto...
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PMID: 20126828
PDF is available here.
PDF is available here.
Abstract
BACKGROUND. Venous thromboembolism is known to be an important social and health care problem because of its high incidence among patients who undergo surgery. For instance, 20-30% of patients develop this problem after general surgical operations, while 5.5% of patients have this complication when...
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PMID: 20234158
PDF is available here.
PDF is available here.
Abstract
Platelet aggregation was inhibited by 20% after the first session and by 40% (P < 0.001) after the eighth session. Thrombin activity was unchanged after the first session (10.7 +/- 0.85 s to 10.43 +/- 0.56 s) and decreased after the eighth session (12.5 +/- 1.98 s to 11.1 +/- 1.7 s; P < 0.0003). Ant...
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PMID: 20486534
PDF is available here.
PDF is available here.
Critical Care (14)2 2010
Abstract
We report the treatment of major trauma using mainly coagulation factor concentrates.
This retrospective analysis included trauma patients who received >or= 5 units of red blood cell concentrate within 24 hours. Coagulation management was guided by thromboelastometry (ROTEM). Fibrinogen concentrate...
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PMID: 20374650
PDF is available here.
PDF is available here.
Abstract
The coagulation and fibrinolytic pathways regulate hemostasis and thrombosis, and an imbalance in these pathways may result in pathologic hemophilia or thrombosis. The plasminogen system is the primary proteolytic pathway for fibrinolysis, but also has important proteolytic functions in cell migrati...
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PMID: 20407627
PDF is available here.
PDF is available here.
BMC Gastroenterology (10) 2010
Abstract
We compared bleeding tests and coagulation parameters, including von Willebrand multimers, from a group of 23 patients with anemia caused by bleeding from angioectasias, with the results from a control group lacking angioectasias.
No significant differences between the two groups were found in coagu...
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PMID: 20920209
PDF is available here.
PDF is available here.
Abstract
We present an algorithm-based approach in managing coagulopathy and hemorrhage in a fatal case of histopathologically proven AFE. Thrombelastometry was used for rapid evaluation of the coagulation status. Stop of extensive hyperfibrinolysis with tranexamic acid, stabilization of initial clot formati...
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PMID: 20040855
PDF is available here.
PDF is available here.
Abstract
Venous thromboembolism accounts for approximately 600,000 hospitalizations and 50,000 deaths per year in the United States. Many inherited blood disorders predispose patients to this disorder. The most common of these disorders is factor V Leiden. Factor V Leiden thrombophilia is an inherited disord...
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PMID: 20010186
PDF is available here.
PDF is available here.
Renal Failure (32)9 2010
Abstract
Hypercoagulability is an important risk factor for thrombosis and its complications in hemodialysis patients. This study was designed to investigate the effects of l-carnitine supplement on plasma coagulation and anticoagulation factors in hemodialysis patients.
Thirty-six hemodialysis patients were...
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PMID: 20863217
PDF is available here.
PDF is available here.
Orthopaedic Nursing (29)3 2010
Abstract
Hemophilia is a genetic disorder characterized by spontaneous or excessive bleeding predominantly into the weight-bearing joints or muscles. Synovial bleeding can lead to joint damage and disability. Recent studies have shown that prophylactic therapy may prevent joint damage in children with severe...
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PMID: 20505489
PDF is available here.
PDF is available here.