Find your PDFs fast.
Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Chemotactic Factors (4):
Recent article
Chemotactic Factors
Abstract
We show that the endocytic adaptor protein Numb, previously characterized for its role in cell proliferation, subsequently plays an important role in cell migration. In neural precursors stimulated with the chemotactic factor BDNF, Numb binds to activated TrkB, the BDNF receptor, and functions both...
|
PMID: 21571219
PDF is available here.
PDF is available here.
| < More recent | Older article > |
Abstract
We are interested to determine whether similar GPCR pathways can be used for chemosensory transduction in Tetrahymena. To confirm our procedures, we tested the known chemoattractant proteose peptone (at 1.0 mg/ml), which caused hyperpolarization and increased forward swimming speed in Tetrahymena, c...
|
PMID: 21091443
PDF is available here.
PDF is available here.
EMBO Journal (29)20 2010
Abstract
We compared intracellular responses mediated by both types of ligands and developed a new mathematical model for signalling by indirectly binding ligands. We show that indirect binding allows cells to better control sensitivity to specific ligands in response to their nutrient environment and to coo...
|
PMID: 20834231
PDF is available here.
PDF is available here.
Abstract
The effects of chemotactic stimuli on motility ability of viable Campylobacter to pass through a 0.45 microm pore size filter in viscous condition were investigated. Reference strains including C. jejuni ATCC 33291, C. coli MUMT 18407, C. lari ATCC 43675, and C. upsaliensis DMST 19055 were used. The...
|
PMID: 20561959
PDF is available here.
PDF is available here.
Abstract
We observed attraction toward microscale pulses of DMSP and related compounds among several motile strains of phytoplankton, heterotrophic bacteria, and bacterivore and herbivore microzooplankton. Because microbial DMSP cycling is the main natural source of cloud-forming sulfur aerosols, our results...
|
PMID: 20647471
PDF is available here.
PDF is available here.
Journal of Immunology (184)12 2010
Abstract
We evaluated the responsiveness of blood and airway eosinophils to chemoattractants (FMLP, platelet-activating factor, CCL11, CCL5, CXCL8) with respect to degranulation, adherence to fibronectin, or Ras-ERK signaling cascade activation. When compared with blood eosinophils, airway eosinophils exhibi...
|
PMID: 20495064
PDF is available here.
PDF is available here.
Abstract
We review growth factors and chemotactic factors expressed by parasitic helminths and discuss their recognised and potential roles in immunomodulation and/or parasite development.
(c) 2010 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved....
|
PMID: 20359480
PDF is available here.
PDF is available here.
Kidney International (77)9 2010
Abstract
We received 285 renal amyloid samples, of which 31 remained unclassified. In an effort to determine whether any of the latter samples were LECT2 related, tandem mass spectrometry was performed. In all, 7 of the 31 cases were identified as an amyloid LECT2 (ALECT2), a finding confirmed immunohistoche...
|
PMID: 20182418
PDF is available here.
PDF is available here.
Malaria Journal (9) 2010
Abstract
Carbon dioxide (CO2) plays an important role in the host-seeking process of opportunistic, zoophilic and anthropophilic mosquito species and is, therefore, commonly added to mosquito sampling tools. The African malaria vector Anopheles gambiae sensu stricto is attracted to human volatiles augmented...
|
PMID: 20973963
PDF is available here.
PDF is available here.
Abstract
We summarize recent progress regarding the involvement of chemoattractants and their receptors in Alzheimer's disease and their potential as therapeutic targets....
|
PMID: 20036964
PDF is available here.
PDF is available here.
Science Signaling (3)141 2010
Abstract
We directly measured the mobilities of cyclic adenosine monophosphate (cAMP) receptor 1 (cAR1), a chemoattractant receptor, and a G protein βγ subunit in live cells. We found that cAR1 diffused more slowly in the plasma membrane than did Gβγ. Upon binding of ligand to the receptor, the mobility...
|
PMID: 20876874
PDF is available here.
PDF is available here.
Abstract
We have determined that in the absence of calcium ions the S100A2 protein can bind three zinc ions per each monomer. Besides that it was determined that the thermodynamics of zinc binding to different binding sites on the S100A2 are significantly different. Zinc binding to the first two sites on the...
|
PMID: 21090249
PDF is available here.
PDF is available here.
Abstract
The high toxicity and low selectivity of carmustine restrict its application in anticancer therapy. Therefore, proline analogs of nitrosourea have been synthesized to obtain compounds whose action on neoplastic cells is characterized by higher selectivity. The present studies have aimed at examining...
|
PMID: 19995309
PDF is available here.
PDF is available here.
Abstract
Our data revealed, for the first time, that HLJDT could inhibit biosynthesis of eicosanoids derived from different lipoxygenases. Also, HLJDT may exert its anti-inflammatory effects by its suppression on eicosanoid generation, NO production and gene transcription of chemotactic factors, which suppor...
|
PMID: 19958594
PDF is available here.
PDF is available here.
Journal of Immunology (183)10 2009
Abstract
We examined the involvement of chemokine-like receptor-1 (CMKLR1) in experimental autoimmune encephalomyelitis (EAE), a model of human multiple sclerosis. Upon EAE induction by active immunization with myelin oligodendrocyte glycoprotein amino acids 35-55 (MOG(35-55)), microglial cells and CNS-infil...
|
PMID: 19864606
PDF is available here.
PDF is available here.
FEBS Journal (276)22 2009
Abstract
Antimicrobial peptides participate in innate host defense by directly eliminating pathogens as a result of their ability to damage the microbial membrane and by providing danger signals that will recruit innate immune cells to the site of infection. Dermaseptin DA4 (DRS-DA4), a new a...
|
PMID: 19843179
PDF is available here.
PDF is available here.
Abstract
Expression of S100A2 mRNA in ESCC was positive in 77.5% of samples, which was lower than that in normal mucosa (100%) by ISH (P = 0.002). The expression level of S100A2 mRNA was closely related to differentiation and and node-metastasis (P = 0.012, P = 0.008). Expression of S100A2 protein was positi...
|
PMID: 19725154
PDF is available here.
PDF is available here.
Abstract
We review the temporal and spatial regulation of PI3K in chemotaxing cells with particular emphasis on the amoeba Dictyostelium as well as neutrophils. We also briefly discuss one model used to elucidate the PI3K pathway....
|
PMID: 20835994
PDF is available here.
PDF is available here.
Abstract
Pyrroloquinoline quinone (PQQ) is a novel biofactor for which a proposition can be made for physiological importance. PQQ was first recognized as an enzyme cofactor in bacteria. It has recently been tentatively identified as a component of interstellar dust. Thus, PQQ may have been present throughou...
|
PMID: 19803551
PDF is available here.
PDF is available here.
Abstract
We demonstrate that treatment of CT26 cells with RAW 264.7 conditioned medium induces cell migration, invasion and metastasis. Inflammatory gene microarray analysis indicated CT26-stimulated RAW 264.7 macrophages upregulate SDF-1alpha and VEGF, and that these cytokines contribute to CT26 migration i...
|
PMID: 19696929
PDF is available here.
PDF is available here.
Abstract
The significance of chemotaxis in directing bacterial migration toward contaminants in natural porous media was investigated under groundwater flow conditions. A laboratory-scale column, with a coarse-grained sand core surrounded by a fine-grained annulus, was used to simulate natural aquifers with...
|
PMID: 19731698
PDF is available here.
PDF is available here.
Abstract
We found that there is a dramatic shift in the formation of 5-lipoxygenase products during this process. Freshly isolated neutrophils rapidly convert leukotriene B(4) (LTB(4)) and 5-hydroxy-6,8,11,14-eicosatetraenoic acid (5-HETE) to their biologically inactive omega-oxidation products. However, ome...
|
PMID: 19376220
PDF is available here.
PDF is available here.
Inflammation Research (58)5 2009
Abstract
Exposure of neutrophils to either LTC(4) or LTD(4) alone had modest effects on Ca(2+) mobilization, while superoxide generation and elastase release were unaffected. However, relative to the responses of neutrophils activated with fMLF in the absence of the CysLTs, pre-treatment of the cells with ei...
|
PMID: 19184354
PDF is available here.
PDF is available here.
Abstract
We found altered S100A2 immunostaining in photodamaged human skin, and crosslinking of S100A2 after ultraviolet A (UVA) irradiation of normal human keratinocytes (NHK). Skin from mice, rats, and rabbits did not contain S100A2 protein, whereas skin samples from pigs, frogs and humans were strongly po...
|
PMID: 18773213
PDF is available here.
PDF is available here.
Abstract
The EF-hand protein S100A2 is a cell cycle regulator involved in tumorigenesis, acting through regulation of the p53 activation state. Metal ion-free S100A2 is homodimeric and contains two Ca(2+)-binding sites and two Zn(2+)-binding sites per subunit, whereby the Zn(2+) ion binding to one of the sit...
|
PMID: 19267779
PDF is available here.
PDF is available here.
Abstract
Formylpeptide receptors (FPRs) are implicated in a variety of immunological and inflammatory response cascades. Further understanding of FPR-family ligand interactions could play an integral role in biological and therapeutic discovery. Fluorescent reporter ligands for the family are desirable exper...
|
PMID: 19006074
PDF is available here.
PDF is available here.
Abstract
We implemented a flow-cytometry-based high-throughput screening (HTS) approach for identifying selective small molecule FPR and FPRL1 ligands. The screening assay measured the ability of test compounds to competitively displace a high-affinity, fluorescein- labeled peptide ligand from FPR, FPRL1, or...
|
PMID: 18785269
PDF is available here.
PDF is available here.
Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale (38)1 2009
Abstract
Our results suggest that the assessment of S100A2 status at diagnosis may identify a subset of LSCC patients highly susceptible to neck node metastases and may thus help define therapy accordingly....
|
PMID: 19344608
PDF is available here.
PDF is available here.
Abstract
We show that Hck coimmunoprecipitates with the cytoskeletal regulatory Wiskott-Aldrich syndrome protein (WASp) and mammalian diaphanous-related formin 1 (mDia1) in chemoattractant-stimulated neutrophils, and that the 3 proteins inducibly colocalize with one another at the leading edge of chemotaxing...
|
PMID: 19234535
PDF is available here.
PDF is available here.
BMC Microbiology (9)1 2009
Abstract
RNA was extracted from the human colonocyte line HCA-7 (clone 29) after incubation for 6 hours with Campylobacter jejuni boiled cell extract and was used to probe the Affymetrix Human Genome U133A array. Genes differentially affected by Campylobacter jejuni boiled cell extract were identified using...
|
PMID: 19193236
PDF is available here.
PDF is available here.
BMC Genomics (10)1 2009
Abstract
We describe a comparison of spretus and musculus with respect to genome organization and synteny, as well as V1R gene content and phylogeny, with reference to previous observations made between mouse and rat. Unlike the mouse-rat comparisons, synteny seems to be largely conserved between the two mou...
|
PMID: 19203383
PDF is available here.
PDF is available here.
Abstract
We investigated 65 stage I-III NSCLC tumours: 32 adenocarcinomas (ADC), 26 squamous cell carcinomas (SCC) and 7 large cell carcinomas (LCC). Using the real-time reverse transcription polymerase chain reaction (RT-PCR), we analysed the expression of the COX-2, hTERT, MDM2, LATS2 and S100A2 genes and...
|
PMID: 19238334
PDF is available here.
PDF is available here.
Abstract
We summarize the current state of knowledge regarding the chemotaxis pathways in E. coli and Bacillus subtilis, with a specific focus on the mechanisms for excitation and adaptation. The mechanisms vary widely, and the B. subtilis process, similar to those found in Thermotoga maritima and many archa...
|
PMID: 19494578
PDF is available here.
PDF is available here.
Abstract
We used an optical tweezers to study chemotaxis by observing the force response of a flagellated microorganism when placed in a gradient of attractive chemical substances. This report shows such observations for Leishmania amazonensis, responsible for leishmaniasis, a serious disease. We quantified...
|
PMID: 19345110
PDF is available here.
PDF is available here.
Autoimmunity (42)4 2009
Abstract
We previously demonstrated that HMGB1 is released by necrotic cells and has chemoattractant activity for inflammatory and stem cells, via binding to receptor for advanced glycation endproducts (RAGE). HMGB1 can be actively secreted by inflammatory cells. Here, we report that also HMGB2 can be secret...
|
PMID: 19811285
PDF is available here.
PDF is available here.
Abstract
Pre-incubation of neutrophils with montelukast resulted in dose-related inhibition of the generation of reactive oxygen species and leukotriene B(4) by chemoattractant-activated neutrophils, as well as release of elastase, all of which were maximal at 2 micromol x L(-1) (mean percentages of the cont...
|
PMID: 19068077
PDF is available here.
PDF is available here.
General Physiology and Biophysics (28 Spec No Focus) 2009
Abstract
We have surveyed 40 human melanoma tumor samples for the transcription of RAGE and five of its known S100 protein ligands. Compared to normal skin tissue, we found highly significant (p < 0.0001) over-expression of S100B and underexpression of S100A2, whereas no significant difference in transcripti...
|
PMID: 20093728
PDF is available here.
PDF is available here.
Abstract
We summarize our current knowledge of the ontogeny of mdDA axon projections in subsystems of the developing rodent central nervous system (CNS) and discuss the cellular and molecular mechanisms that mediate mdDA axon guidance in these CNS regions....
|
PMID: 19731554
PDF is available here.
PDF is available here.
Abstract
We describe an in vivo invasion assay that enables the collection of invasive cells from the primary tumor. In addition to determination of the endogenous, unstimulated invasive properties of cells in vivo, the assay can take advantage of the chemotactic properties of cancer cells. Microneedles are...
|
PMID: 19763970
PDF is available here.
PDF is available here.
Journal of Cell Biology (183)5 2008
Abstract
We show that the asymmetrical distribution of adenylyl cyclase (ACA) at the back of Dictyostelium discoideum cells, an essential determinant of their ability to migrate in a head-to-tail fashion, requires vesicular trafficking. This trafficking results in a local accumulation of ACA-containing intra...
|
PMID: 19047467
PDF is available here.
PDF is available here.
Abstract
We searched for the VNS-specific genes in the genomes of two early diverging vertebrate lineages: the sea lamprey from jawless fishes and the elephant shark from cartilaginous fishes. Genes encoding vomeronasal type 1 receptors (V1Rs) and Trpc2, two components of the vomeronasal signaling pathway, a...
|
PMID: 19008528
PDF is available here.
PDF is available here.
Developmental Biology (323)2 2008
Abstract
We have identified gap-3 as the to date missing Caenorhabditiselegans member of the p120 RasGAP family. By studying the genetic interaction of gap-3 with the two previously identified RasGAPs gap-1 and gap-2, we find that different combinations of RasGAPs are used to repress LET-60 RAS signaling dep...
|
PMID: 18805410
PDF is available here.
PDF is available here.
Abstract
We demonstrate that expression of the cytoskeletal regulator WASP, mutated in the Wiskott-Aldrich syndrome, provides selective advantage for the development of naturally occurring regulatory T cells, natural killer T cells, CD4(+) and CD8(+) T lymphocytes, marginal zone (MZ) B cells, MZ macrophages,...
|
PMID: 18772454
PDF is available here.
PDF is available here.
Abstract
Gram negative bacteria-derived and synthetic N-formyl peptides play a key role in host defense as chemotactic factors for phagocytic leukocytes. The first compound to be identified was N-formylmethionyl-leucyl-phenylalanine (fMLP) which contains highly potent leukocyte chemoattractant. Natural fMLP...
|
PMID: 19069235
PDF is available here.
PDF is available here.
Reproduction in Domestic Animals (43 Suppl 5) 2008
Abstract
The task of spermatozoa is to transport its DNA-load as efficiently and safely as possible from the male organism to the female. Before it reaches its destination, it has to pass almost through the entire female reproductive tract, a potentially hostile environment. During passage, it is confronted...
|
PMID: 19068027
PDF is available here.
PDF is available here.
Current Biology (18)20 2008
Abstract
We studied the effect of its misregulation by using cells with disrupted RasGAP activity. We identified an ortholog of mammalian NF1, DdNF1, as a major regulator of Ras activity in Dictyostelium. We show that disruption of nfaA leads to spatially and temporally unregulated Ras activity, causing cyto...
|
PMID: 18948008
PDF is available here.
PDF is available here.
FEMS Microbiology Letters (288)2 2008
Abstract
I or II. Genomovar II isolates were found to be more virulent than genomovar I isolates. The objective of the present study was to determine whether differences exist in the chemotactic response of these genomovars to mucus obtained from the skin, gills and intestines of healthy channel catfish usin...
|
PMID: 18801048
PDF is available here.
PDF is available here.
Biophysical Journal (95)9 2008
Abstract
We present novel microfluidic experiments to quantify population-scale transport parameters (chemotactic sensitivity chi(0) and random motility mu) of a population of bacteria. Previously, transport parameters have been derived theoretically from single-cell swimming behavior using probabilistic mod...
|
PMID: 18658218
PDF is available here.
PDF is available here.
Journal of Cell Science (121)Pt 21 2008
Abstract
We examined the potential contribution of PtdIns(3,4,5)P(3) to chemotaxis of wild-type cells. The results show that steep cAMP gradients (larger than 10% concentration difference across the cell) induce strong PtdIns(3,4,5)P(3) patches at the leading edge, which has little effect on the orientation...
|
PMID: 18840645
PDF is available here.
PDF is available here.
Experimental Cell Research (314)17 2008
Abstract
We have identified novel soluble signaling molecules that induce MSC chemotaxis present in conditioned medium of the breast carcinoma cell line MDA-MB231. Previous work has employed survey strategies using ELISA assay to identify known chemokines that promote MSC chemotaxis. While these studies prov...
|
PMID: 18722367
PDF is available here.
PDF is available here.
Journal of Immunology (181)8 2008
Abstract
We assessed whether transmigrating PMNs can regulate barrier function through epithelial PAR activation. Transepithelial resistance (TER) decreased significantly after PMN contact with basolateral surfaces of T84 monolayers or after incubation with PMN elastase and proteinase-3, but not cathepsin G....
|
PMID: 18832729
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (283)42 2008
Abstract
We identified Hsp70/Hsp90-organizing protein (Hop) and kinesin light chain (KLC) as novel targets of S100A2 and S100A6. Hop directly associates with Hsp70 and Hsp90 through the tetratricopeptide (TPR) domains and regulates Hop-Hsp70 and Hop-Hsp90 complex formation. We have found that S100A2 and S100...
|
PMID: 18669640
PDF is available here.
PDF is available here.
Human Reproduction (23)10 2008
Abstract
Taken together, the results suggest that progesterone is the main, if not the sole, chemoattractant secreted by human cumulus cells....
|
PMID: 18621752
PDF is available here.
PDF is available here.
Abstract
Experimental and clinical investigations using hyperosmotic solutions for resuscitation of hemorrhagic shock demonstrated modulation of the inflammatory response. Decreased postinjury hyperinflammation has been attributed to a reduction in neutrophil-mediated tissue damage. This study shows that cyt...
|
PMID: 18277949
PDF is available here.
PDF is available here.
Abstract
We focus on the chemokines upregulated in acute viral-induced exacerbation and examine their role in promoting the virus-induced pathophysiologic response in asthmatic individuals....
|
PMID: 18682112
PDF is available here.
PDF is available here.
Endocrine Regulations (42)4 2008
Abstract
We found reduced heart rate and rate dependent functions of the rat heart, early release of free radicals triggering the release of cytotoxic inflammatory cytokines (like TNF-? and IL-6) and chemoattractants (mcp-1) as an example of this type of pathogens, resulting in the initiation and progression...
|
PMID: 18999900
PDF is available here.
PDF is available here.
Abstract
Graves' disease, an autoimmune process associated with thyroid dysfunction, can also manifest as remodeling of orbital connective tissue. Affected tissues exhibit immune responses that appear to be orchestrated by resident cells and those recruited from the bone marrow through their expression and r...
|
PMID: 18713026
PDF is available here.
PDF is available here.
Abstract
We review the molecular traffic signals that govern the migration of DCs throughout their life cycle....
|
PMID: 18799141
PDF is available here.
PDF is available here.
Abstract
We have reasoned that unique properties of these cells might ultimately prove the basis for why the manifestations of Graves' disease occur in an anatomically selective manner. In this brief review we attempt to survey our findings. We believe that they might provide a "roadmap" for further discover...
|
PMID: 18788919
PDF is available here.
PDF is available here.