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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Inflammation Mediators (3):
Recent article
Inflammation Mediators
Journal of Neuroscience (31)33 2011
Abstract
We observed that small heat shock proteins (sHsps) are associated with Aβ deposits in AD. In this study the molecular chaperones Hsp20, HspB8 and HspB2B3 were found to colocalize with CAA and capCAA in AD brains. In addition, Hsp20, HspB8 and HspB2B3 colocalized with intercellular adhesion molecule...
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PMID: 21849559
PDF is available here.
PDF is available here.
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Abstract
We previously demonstrated that serum vascular endothelial growth factor (VEGF) is elevated in cystic fibrosis (CF) patients and declines with therapy for pulmonary exacerbation. We hypothesized that VEGF is elevated early in the course of CF and is associated with markers of tissue hypoxia. A prosp...
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PMID: 21365780
PDF is available here.
PDF is available here.
Cancer Biology & Therapy (12)1 2011
Abstract
We investigated the effect of GT on NF-ĸB signaling in HT-29 and HCT-116 human colon cancer cells. DNA binding assays revealed significant suppression of tumor necrosis factor (TNF-α)-induced NFĸB activation which correlated with the inhibition of IĸBα phosphorylation and degradation. Sequentia...
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PMID: 21532339
PDF is available here.
PDF is available here.
Abstract
We characterized levels of acute-phase reactants (C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), white blood cell (WBC) count), adhesion molecules (E-selectin, vascular cell adhesion molecule-1), and coagulation products (fibrinogen, plasminogen activator inhibito...
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PMID: 21233809
PDF is available here.
PDF is available here.
Abstract
End-stage renal disease (ESRD) causes oxidative stress, inflammation, low-density lipoprotein (LDL) oxidation, high-density lipoprotein (HDL) deficiency and accelerated atherosclerosis. Uptake of oxidized LDL by macrophages results in foam cell and plaque formation. HDL mitigates ath...
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PMID: 21830637
PDF is available here.
PDF is available here.
Abstract
We investigated the immunomodulatory activity of a neutral plant polysaccharide Galactomannan on human monocyte-derived DCs (MDDC). MDDCs were stimulated with Galactomannan (GLM) from Caesalpinia spinosa and both phenotypic and functional activities were assessed by flow cytometry and real-time PCR....
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PMID: 21255695
PDF is available here.
PDF is available here.
Abstract
We hypothesized that obese youth would demonstrate reduced endothelial function and increased inflammation and oxidative stress following acute glucose ingestion and that transient elevations in plasma glucose would correlate with endothelial dysfunction, inflammation, and oxidative stress. Thirty-f...
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PMID: 21233813
PDF is available here.
PDF is available here.
Abstract
These results suggest that embelin has an anti-inflammatory effect at colorectal sites that is due to the down-regulations of the productions and expressions of inflammatory mediators, and that it may have therapeutic value in the setting of inflammatory bowel disease (IBD).
Copyrigh...
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PMID: 21296695
PDF is available here.
PDF is available here.
Abstract
We have recently established a short-term sepsis model in rats induced by cecal ligation and incision (CLI). This retrospective study was conducted in order to identify similarities and differences between both experimental approaches. 32 anesthetized/ventilated male rats from the following four gro...
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PMID: 21296198
PDF is available here.
PDF is available here.
Abstract
We generated TERT-over-expressing endothelial cells (ECs) and analyzed in vitro their (1) barrier function; (2) low-density lipoprotein uptake; (3) expression pattern of six selected marker proteins; (4) angiogenic potential in four assays; and (5) inflammatory responses. In contrast to investigatio...
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PMID: 21558092
PDF is available here.
PDF is available here.
Abstract
Clinical relevance of relations among blood pressure (BP), inflammation, endothelial dysfunction and sympathetic activation is unknown. Study aimed, whether in patients with diagnosed and treated essential arterial hypertension (HTN) biomarkers of inflammation (hs-C-reactive protein,...
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PMID: 21515487
PDF is available here.
PDF is available here.
Abstract
We emphasize the major role of the Th17/IL-23 axis in dictating the perpetuation of intestinal inflammation, augmented by a failure of physiological control by regulatory T-cells. In conclusion, there is a central genesis of the defects underlying IBD, which therefore, in our opinion, is best accomm...
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PMID: 21651357
PDF is available here.
PDF is available here.
Cancer Cell (19)5 2011
Abstract
We report a tumor-suppressor function of Shp2. Hepatocyte-specific deletion of Shp2 promotes inflammatory signaling through the Stat3 pathway and hepatic inflammation/necrosis, resulting in regenerative hyperplasia and development of tumors in aged mice. Furthermore, Shp2 ablation dramatically enhan...
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PMID: 21575863
PDF is available here.
PDF is available here.
Abstract
Macrophage migration inhibitory factor (MIF) was originally described as a cytokine that inhibits migration of macrophages at the site of inflammation. Subsequently it was also identified as a stress-induced hormone released from the anterior pituitary lobe in response to some pro-in...
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PMID: 21091281
PDF is available here.
PDF is available here.
Autoimmunity Reviews (10)7 2011
Abstract
Inflammation is classically recognized as an essential step for the control of microbial invasion or tissue injury as well as for the maintenance of tissue homeostasis under a variety of noxious conditions. One of the most intriguing aspect of studying inflammation is the plurality o...
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PMID: 21195808
PDF is available here.
PDF is available here.
Transplantation (91)8 2011
Abstract
We studied early transcriptional changes of inflammatory mediators in the grafts during combined auxiliary liver-kidney transplantation using microarrays and real-time polymerase chain reaction. The results were correlated to clinical data.
Liver and kidney grafts both exhibited an u...
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PMID: 21494202
PDF is available here.
PDF is available here.
Abstract
Nonalcoholic fatty liver disease (NAFLD) describes a range of disorders characterized by excess accumulation of triglyceride within the liver. While simple steatosis may be clinically stable, nonalcoholic steatohepatitis (NASH) can be progressive. Inflammation is believed to be the d...
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PMID: 21476914
PDF is available here.
PDF is available here.
Abstract
Our data demonstrate that subclinical endotoxemia is associated with systemic and AT inflammation in obese pregnant women. Recognition of bacterial pathogens may contribute to the combined dysfunction of innate immunity and the metabolic systems in AT....
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PMID: 20930711
PDF is available here.
PDF is available here.
Mucosal Immunology (4)2 2011
Abstract
We find that exposure of bronchiolar epithelial cells to pyocyanin results in MUC2/MUC5AC induction and mucin secretion through release of inflammatory cytokines and growth factors (interleukin (IL)-1β, IL-6, heparin-bound epidermal growth factor, tissue growth factor-α, tumor necrosis factor-α)...
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PMID: 20962773
PDF is available here.
PDF is available here.
FEBS Letters (585)6 2011
Abstract
We investigated the involvement of microRNAs in oxLDL accumulation and inflammatory response in macrophages. The expression of miR-146a decreases under oxLDL stimulation. MiR-146a significantly reduces intracellular LDL cholesterol content and secretion of interleukin 6, interleukin 8, chemokine (C-...
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PMID: 21329689
PDF is available here.
PDF is available here.
Liver Transplantation (17)2 2011
Abstract
We investigated ER stress signaling and blockade in the mediation of CIR injury in severely steatotic rodent allografts. Steatotic allografts from genetically leptin-resistant rodents had increased ER stress responses and increased markers of hepatocellular injury after liver transplantation into st...
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PMID: 21280192
PDF is available here.
PDF is available here.
Abstract
Dendritic cells generally play an important role as sentinels in the immune system. They are also very important in protecting the airways from invading pathogens and harmful particles and antigens. This review discusses current knowledge about dendritic cell function and the interac...
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PMID: 21150432
PDF is available here.
PDF is available here.
Abstract
There is evidence from both epidemiology and laboratory studies that perfluorinated compounds may be immunotoxic, affecting both cell-mediated and humoral immunity. The overall goal of this study was to investigate the mechanisms underlying the immunotoxic effects of perfluorooctane sulfonate (PFOS)...
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PMID: 21075133
PDF is available here.
PDF is available here.
Abstract
We have shown that curcumin is capable of eradicating Hp-infection in mice. Here we examine the mechanism by which curcumin protects Hp infection in cultured cells and mice. Since, MMP-3 and -9 are inflammatory molecules associated to the pathogenesis of Hp-infection, we investigated the role of cur...
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PMID: 21283694
PDF is available here.
PDF is available here.
TRIF is a critical negative regulator of TLR agonist mediated activation of dendritic cells in vivo.
Abstract
We have analyzed the molecular mechanisms underlying rEA activity in mice, and confirmed that rEA activates multiple immune cell types, including DCs, macrophages, NK, B, and T cells. The rEA adjuvant also elicits the induction of pleiotropic pro-inflammatory cytokines, responses that completely dep...
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PMID: 21760953
PDF is available here.
PDF is available here.
British Journal of Nutrition (105)1 2011
Abstract
The ingestion of fatty meals is associated with a transient, low-grade systemic inflammatory response in human subjects, involving the activation of circulating monocytes and the secretion of pro-inflammatory cytokines. However, it is not yet clear how different foodstuffs may promote inflammatory s...
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PMID: 20849668
PDF is available here.
PDF is available here.
Clinical Nephrology (75)1 2011
Abstract
We conducted a prospective, observational cohort study to clarify the relationship between insulin resistance and erythropoietin responsiveness in HD patients. Insulin resistance as assessed by the homeostasis model assessment for insulin resistance (HOMA-IR), levels of adiponectin and inflammatory...
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PMID: 21176750
PDF is available here.
PDF is available here.
Abstract
We first assessed the effect of CD40 deficiency on neointima formation in 2 injury models, carotid artery ligation and femoral artery denudation injury. Compared with wild-type mice, CD40 deficiency significantly reduced neointima formation and lumen stenosis in two different models. Further, we inv...
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PMID: 21876738
PDF is available here.
PDF is available here.
Abstract
Our results show that human serum extracts enriched with endogenous long-chain hydroxy fatty acids possess anti-inflammatory and anti-proliferative activity. These findings support a hypothesis that the reduction of these metabolites with age may result in a compromised ability to defend against unc...
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PMID: 21586136
PDF is available here.
PDF is available here.
Molecular Pharmacology (79)1 2010
Abstract
We reported previously that nicotine suppresses constitutive nuclear factor κB (NF-κB) activity and thereby proinflammatory cytokine (PIC) production in SHEP1 cells stably transfected with α4β2 nicotinic receptors. Here, we report the anti-inflammatory effects of nicotine pretreatment in lipopol...
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PMID: 20943775
PDF is available here.
PDF is available here.
EMBO Journal (29)24 2010
Abstract
We show that FoxO1 promotes inflammation by enhancing Tlr4-mediated signalling in mature macrophages. By means of chromatin immunoprecipitation (ChIP) combined with massively parallel sequencing (ChIP-Seq), we show that FoxO1 binds to multiple enhancer-like elements within the Tlr4 gene itself, as w...
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PMID: 21045807
PDF is available here.
PDF is available here.
Abstract
Postinjury multiple organ failure (MOF) is the net result of a dysfunctional immune response to injury characterized by a hyperactive innate system and a suppressed adaptive system. Acute lung injury (ALI) is the first clinical manifestation of organ failure, followed by renal and hepatic dysfunctio...
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PMID: 21146002
PDF is available here.
PDF is available here.
Abstract
Abstract
This study was aimed at examining the therapeutic effects of marine collagen peptides (MCPs) from fish hydrolysate in Chinese patients with type 2 diabetes mellitus (T2DM). A total of 100 diabetic patients and 50 healthy controls were recruited. Diabetic patients were randomized into...
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PMID: 21164551
PDF is available here.
PDF is available here.
Abstract
We hypothesized that activation of cytosolic phospholipase A2 (cPLA2) and cyclooxygenase (COX-2) by ethanol in astrocytes enhanced the secretion of inflammatory agents via the interactive tyrosine phosphorylation of toll-like receptor 4 (TLR4) and Src kinase. To test this hypothesis, we treated prim...
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PMID: 20379791
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)45 2010
Abstract
We now present evidence that the formylated peptide f-Met-Leu-Phe (fMLP), a bacterial chemoattractant, synergizes with TNFα to induce NF-κB activation and the resultant inflammatory response in vitro and in vivo. The mechanism of synergistic activation of NF-κB by bacterial fMLP and TNFα may be...
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PMID: 20729202
PDF is available here.
PDF is available here.
Abstract
It remains unclear whether habitual physical activity in sickle cell trait (SCT) carriers modulates the levels of resting and postexercise vascular adhesion and inflammatory molecules.
Plasma levels of pro-inflammatory (interleukin (IL)-4, IL-5, IL-8, sCD40L, and tumor necrosis factor α) and anti-i...
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PMID: 20386338
PDF is available here.
PDF is available here.
Abstract
High-fiber diets have been shown to reduce plasma concentrations of inflammation markers. Increased production of fermentation-derived short-chain fatty acids (SCFAs) is one of the factors that could exert these positive effects. This review examines the effects of SCFAs on immune cells and discusse...
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PMID: 20823773
PDF is available here.
PDF is available here.
Abstract
Tissue injury is associated with the local release of inflammatory and nociceptive mediators and the development of hyperalgesia. It is unclear whether interrupting neuronal signaling using regional anesthetic techniques at the time of the injury modifies local nociceptive and inflammatory processes...
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PMID: 20975465
PDF is available here.
PDF is available here.
Abstract
More than half a million Americans die each year from coronary heart disease (CHD), 26 million suffer from chronic kidney disease (CKD), and a large proportion have periodontal disease, a chronic infection of the tissues surrounding teeth. Chronic inflammation contributes to CHD and CKD occurrence a...
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PMID: 20948377
PDF is available here.
PDF is available here.
Circulation Journal (74)11 2010
Abstract
Circulation Journal (74)11 2010
Abstract
Angiotensin II and insulin resistance (IR) have clinical implications in the pathophysiology of chronic heart failure (CHF). However, it is still unclear whether the combination of an angiotensin-receptor blocker and angiotensin-converting enzyme inhibitor (ACEI) improves IR in CHF patients who do n...
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PMID: 20827028
PDF is available here.
PDF is available here.
Abstract
To investigate the effect of aqueous extract from Mangifera indica L. (MIE) on dextran sulfate sodium (DSS)-induced colitis in rats.
MIE (150 mg/kg) was administered in two different protocols: (1) rectally, over 7 d at the same time as DSS administration; and (2) once daily over 14 d (by oral gavag...
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PMID: 20954278
PDF is available here.
PDF is available here.
Abstract
We demonstrated that coagulation factor X (FX) binds to Ad5-hexon protein at high affinity to mediate hepatocyte transduction after intravascular delivery. We developed novel genetically FX-binding ablated Ad5 vectors with lower liver transduction. Here, we demonstrate that FX-binding ablated Ad5 pr...
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PMID: 20610817
PDF is available here.
PDF is available here.
Histology and histopathology (25)10 2010
Abstract
Secretion is a fundamental cell process underlying different physiological and pathological events. In cells from the human immune system such as eosinophils, secretion of mediators generally occurs by means of piecemeal degranulation, an unconventional secretory pathway characterized by vesicular t...
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PMID: 20712018
PDF is available here.
PDF is available here.
Food and Chemical Toxicology (48)10 2010
Abstract
These results suggest that phloroglucinol can provide a therapeutic potential for prevention of chronic inflammation.
Copyright (c) 2010 Elsevier Ltd. All rights reserved....
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PMID: 20667461
PDF is available here.
PDF is available here.
Oral Diseases (16)7 2010
Abstract
It has been slightly more than a decade since the classic mechanistic paradigm that defined the pathogenesis of mucositis was revised. A five-stage sequence of linked biological events forms the basis for our current understanding of how regimen-related mucosal injury occurs. The first stage is the...
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PMID: 20846150
PDF is available here.
PDF is available here.
Abstract
We review the current understanding of the regulatory role of the nervous system in the maintenance of barrier function in healthy state, or during pathological conditions of, for instance, stress-induced colitis, surgical trauma or inflammation. We will discuss the clinical potential for advances i...
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PMID: 20932148
PDF is available here.
PDF is available here.
Abstract
To determine the relationship between plasma adiponectin levels and obesity, inflammation, blood lipids and insulin resistance in type 2 diabetics (T2DM) and non-diabetics in a patient population in Trinidad.
A cohort study of a total of 126 type 2 diabetic (42 males...
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PMID: 20580627
PDF is available here.
PDF is available here.
Abstract
Research on asthma pathophysiology over the past decade has expanded the complex repertoire involved in the pathophysiology of asthma to include inflammatory, immune and structural cells, as well as a wide range of mediators. Studies have identified a role for connective and other me...
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PMID: 20923340
PDF is available here.
PDF is available here.
Innate Immunity (16)5 2010
Abstract
We compared cytokine induction in human monocytes and mouse macrophages by planktonic and biofilm bacteria. We compared Pseudomonas aeruginosa and Staphylococcus aureus, two bacteria often colonizing the airways of cystic fibrosis patients. Planktonic and biofilm S. aureus induced equivalent amounts...
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PMID: 19710099
PDF is available here.
PDF is available here.
Abstract
We evaluated several markers of systemic inflammation from healthy adults and tested the hypothesis that two formulations of encapsulated fruit and vegetable juice powder concentrate with added berry powders (FVB) or without (FV) could impact markers of inflammatory load. Using a double-blind, place...
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PMID: 20425759
PDF is available here.
PDF is available here.
Journal of Immunology (185)6 2010
Abstract
We sought to determine the function of netrin-1 and its receptor UNC5B in ischemia-reperfusion-induced inflammation. Renal ischemia-reperfusion caused a rapid decrease in serum netrin-1 levels. Administration of recombinant netrin-1 before or after renal ischemia-reperfusion reduced kidney injury, a...
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PMID: 20693423
PDF is available here.
PDF is available here.
Journal of Immunology (185)6 2010
Abstract
We report that IL-33 directly stimulates eosinophil differentiation from CD117(+) progenitors in an IL-5-dependent manner. Although resting eosinophils expressed moderate levels of the IL-33R alpha-chain (ST2L), eosinophils that accumulated in the airways of mice with OVA-induced asthma expressed in...
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PMID: 20693421
PDF is available here.
PDF is available here.
Abstract
We conclude that adipocytes express TLR 1-10 and react to agonists specific for TLR 1-6. As a consequence proinflammatory cytokine are induced, in particular, IL-6, IL-8, and MCP-1. Since stimulation is followed by decreased insulin-induced glucose uptake and increased lipolysis we conclude that TLR...
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PMID: 20603780
PDF is available here.
PDF is available here.
Abstract
Inflammation in adipose tissue is a characteristic of obesity and the metabolic syndrome. It is suggested that the endocannabinoid system is involved in the regulation of inflammatory and angiogenic processes within the tissue. Human subcutaneous preadipocytes (Zen Bio) were used as the source of hu...
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PMID: 20603779
PDF is available here.
PDF is available here.
Atherosclerosis (212)1 2010
Abstract
Atherosclerosis (212)1 2010
Abstract
We focus on a subsequent event in plaque development--the migration of smooth muscle cells (SMCs) from the media to the intima of inflamed vessels. Here we report our investigation of the expression of F11R in atherosclerotic arteries of coronary artery disease (CAD) patients, and of the role of F11...
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PMID: 20627246
PDF is available here.
PDF is available here.
Atherosclerosis (212)1 2010
Abstract
We investigated the relationship between intima-media thickening (IMT) as an expression of preclinical atherosclerosis and coronary risk factors, including the autonomic nervous system and inflammation markers, in depressed subjects free from coronary artery disease.
We studied 391 asymptomatic subj...
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PMID: 20510416
PDF is available here.
PDF is available here.
Abstract
The objective of this study was to characterize a mouse model of lung inflammation and determine the effect of surfactant protein A (SP-A, or sftpa) on the transfer of inflammatory mediators from these injured lungs into the systemic circulation. Lung inflammation was induced in either sftpa-deficie...
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PMID: 20715984
PDF is available here.
PDF is available here.