Patrick G Morris,
Clifford A Hudis,
Dilip Giri,
Monica Morrow,
Domenick J Falcone,
Xi Kathy Zhou,
Baoheng Du,
Edi Brogi,
Carolyn B Crawford,
Levy Kopelovich,
Kotha Subbaramaiah and
Andrew J Dannenberg
Abstract
We found increased numbers of CLS, activation of the NF-κB transcription factor, and elevated aromatase levels and activity in the mammary glands of obese mice. These preclinical findings raised the possibility that the obesity → inflammation axis is important for the development and progression...
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PMID: 21622727
PDF is available here.
Abstract
Previous analyses of interval breast cancers have been limited because of a lack of control for screening interval length and patient age, failure to restrict the interval group to 'true' intervals, and incomplete descriptions of pathology, adjuvant therapies and clinical outcomes....
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PMID: 21421519
PDF is available here.
Abstract
To determine the incidence of malignancy (invasive carcinoma or DCIS) in patients diagnosed with lobular neoplasia (B3) on core needle biopsy (CNB) of breast lesions by reviewing the published literature.
Medline, Embase, OVID-database and reference lists were searche...
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PMID: 21306860
PDF is available here.
Abstract
We classified tumor pairs from 50 patients with bilateral disease into molecular subgroups (luminal, triple-negative basal-like, and triple-negative unclassified). Synchronous tumors showed a slightly higher rate of concordant pairs than metachronous tumors, and luminal tumors were highly concordant...
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PMID: 21504707
PDF is available here.
Abstract
Free tissue transfer has become a mainstay in breast reconstruction, with the internal mammary system frequently used as the recipient vessels. Sacrificing the internal mammary artery, however, eliminates the potential to use this vessel as a coronary artery bypass conduit in the future and potentia...
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PMID: 21200197
PDF is available here.
Abstract
In this study, the authors evaluated the form stability of the Style 410 anatomically shaped cohesive silicone gel-filled breast implant after subglandular implantation.
Nine women who had undergone bilateral subglandular breast augmentation using Style 410 implants were examined in the prone and su...
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PMID: 21200237
PDF is available here.
Abstract
Necrosis with partial loss of mastectomy flaps is an all-too-common complication of otherwise advantageous skin-sparing mastectomies. Central to the problem of predictable flap viability is the thickness of the skin flaps. Seeking a balance between the preservation of adequate flap thickness and mai...
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PMID: 21200196
PDF is available here.
Abstract
Postoperative breast pain is a frequent complaint, reported by 50 percent of women following a breast procedure. Breast pain interferes with sexual activity, as reported by 48 percent of patients, exercise (36 percent), social activity (13 percent), and employment (6 percent).
To define neurogenic c...
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PMID: 21200198
PDF is available here.
Abstract
To estimate the effective dose of prospectively triggered computed tomography coronary angiography (CTCA) in step-and-shoot (SAS) mode, depending on the tube current and tube voltage modulation.
For dose measurements, an Alderson-Rando-phantom equipped with thermoluminescent dosimeters was used. The...
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PMID: 21104597
PDF is available here.
Abstract
Recent controversies over the recommendations for breast cancer screening have created some uncertainty about the best methods of providing this care for women, particularly women at average risk for breast cancer. This article reviews the current recommendations for breast cancer screening from var...
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PMID: 21099612
PDF is available here.
Abstract
We hypothesize that acellular cadaveric dermis decreases the inflammatory response and foreign body reaction normally seen around breast implants.
Twenty patients underwent tissue expander reconstruction using the "dual-plane" acellular cadaveric dermis technique (AlloDerm). During implant exchange,...
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PMID: 21124125
PDF is available here.
Abstract
Three-dimensional scanning offers new opportunities to enable objective and quantitative analysis of the breast. The authors introduce an innovative method of performing a thorough analysis of breast asymmetry by means of three-dimensional scanning.
One hundred breast augmentation patients underwent...
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PMID: 21124152
PDF is available here.
Abstract
Plastic surgeons routinely submit breast capsulectomy surgical specimens for pathologic evaluation. However, clinically significant findings are rarely identified. In an effort to reduce health care costs and the unnecessary use of hospital resources, this study reviews the efficacy of submitting br...
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PMID: 21124126
PDF is available here.
Abstract
Capsular contracture is one of the most common and trying complications associated with the placement of breast prostheses. The authors hypothesized that silicone implants have a higher rate of capsular contracture than saline implants when used for cosmetic, nonreconstructive breast augmentation. T...
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PMID: 20661169
PDF is available here.
Abstract
The postmastectomy reconstruction of large and/or ptotic breasts poses a more difficult aesthetic challenge than the reconstruction of small or moderately sized breasts because of an excessively large skin envelope in both horizontal and vertical dimensions. The Wise-pattern skin excision best addre...
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PMID: 21124123
PDF is available here.
Abstract
We describe an approach that utilizes the spatial information in the data set to select parameters for noise reduction without human input. Specifically, we expand on the Minimum Noise Fraction (MNF) approach in which data are forward transformed, eigenimages that correspond mostly to signal selecte...
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PMID: 20830324
PDF is available here.
Abstract
In vivo counting measurements, used for the monitoring of workers with internal contamination risks, are based on the use of calibration physical phantoms. However, such phantoms do not exist for female subjects. Computational calibration using numerical representations, Mesh and non-uniform rationa...
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PMID: 20938235
PDF is available here.
Abstract
We propose some classifications and guidelines to prevent synmastia....
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PMID: 20948424
PDF is available here.
Sharon J Pitteri,
Lynn M Amon,
Tina Busald Buson,
Yuzheng Zhang,
Melissa M Johnson,
Alice Chin,
Jacob Kennedy,
Chee-Hong Wong,
Qing Zhang,
Hong Wang,
Paul D Lampe,
Ross L Prentice,
Martin W McIntosh,
Samir M Hanash and
Christopher I Li
Abstract
We conducted 14 independent quantitative proteomics experiments comparing pooled plasma samples collected from 420 estrogen receptor-positive (ER(+)) breast cancer patients ≤17 months before their diagnosis and matched controls. Based on the more than 3.4 million tandem mass spectra collected in t...
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PMID: 20959476
PDF is available here.
Abstract
We found that the heritability of bra cup size was 56%. Of this genetic variance, one third is in common with genes influencing body mass index, and two thirds (41% of total variance) is unique to breast size, with some directional evidence of non-additive genetic variation. The implications of thes...
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PMID: 20874466
PDF is available here.
Abstract
We report a female patient, aged 12 years and 6 months, suffering from juvenile breast hypertrophy, who presented at the third month of symptoms and benefited from tamoxifen treatment.
In experienced clinics, use of tamoxifen in the treatment of juvenile breast hypertrophy during the brisk growth pe...
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PMID: 20813327
PDF is available here.
Abstract
We identified PASH in 80 patients. Median follow-up was 3.71 years (range, 0.45-9.42). Age ranged from 12 to 65 (median, 45) and 95% were female. Lesions were palpable in 56% and found on imaging in the remainder. Core biopsy was performed in 65 of 80 patients (81%), which confirmed a diagnosis of P...
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PMID: 20708765
PDF is available here.
Abstract
We use monochromatic and high-intensity synchrotron radiation computed tomography (SR CT) to evaluate the linear attenuation coefficients of surgical breast tissues in the energy range from 15 to 26.5 keV. X-ray detection is performed by a custom digital silicon micro-strip device, developed in the...
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PMID: 20702925
PDF is available here.
Abstract
Skin-sparing mastectomy has been associated with flap ischemia and necrosis. Current clinical methods for assessment of flap viability following mastectomy are largely subjective and lack objective data to guide intraoperative decisions. Intraoperative laser-assisted indocyanine green angiography (L...
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PMID: 20539977
PDF is available here.
Abstract
Persistent postsurgical pain (PPSP) after surgery for breast cancer has a prevalence of 20% to 52%. Neuroplastic changes may play a role in the aetiology of this pain. The principal objective of this study was to examine the relationship between acute pain after surgery for breast cancer and the lik...
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PMID: 20639740
PDF is available here.
Abstract
We investigated the relation between common genetic variation in IGF1, IGFBP1, and IGFBP3, and mammographic density among 819 women of Hawaiian, European, and Japanese ancestry from the Multiethnic Cohort Study. Mammographic density was assessed using a quantitative computer-assisted method. Previou...
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PMID: 20039319
PDF is available here.
Abstract
Our findings did not support the hypothesis that lipophilic antioxidant micronutrients found in fruits and vegetables protect against breast cancer, at least in postmenopausal women....
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PMID: 20039325
PDF is available here.
Abstract
The preliminary study demonstrates the feasibility of RICS for faithfully reconstructing uptake curves and improving temporal resolution of breast DCE-MRI without degrading the spatial resolution....
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PMID: 20964216
PDF is available here.
Abstract
We have sought to determine the need for geometric magnification for the evaluation of clusters of microcalcifications.
Eighty-eight clusters of microcalcifications were reviewed by two experienced radiologists using electronic zoom (ZOOM) and geometric magnification (MAG). The following criteria we...
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PMID: 20814375
PDF is available here.
Abstract
We demonstrate the first description of a delivery system for localized doxorubicin chemotherapy to the breast tissue. The hyaluronan-doxorubicin nanoconjugate exhibits a sustained release characteristic in vitro and in vivo in the breast tissues of rodents bearing human breast cancer xenografts. In...
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PMID: 20403395
PDF is available here.
Abstract
We conclude that Taiwanese girls with PT more often developed within the first two years of life. Activation of hypothalamic-pituitary-gonadal axis with predominant FSH activity during infancy may contribute to its development. In addition, PT is not always a benign self-limited condition, and clini...
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PMID: 21175086
PDF is available here.
Abstract
A small field of view, high resolution gamma camera has been integrated into a dedicated breast, single photon emission computed tomography (SPECT) device. The detector can be flexibly positioned relative to the breast and image beyond the chest wall, allowing the system to capture direct views of t...
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PMID: 20671354
PDF is available here.
Abstract
We investigate the effect of varying the glandular/adipose proportion of the breast tissue on dose distributions. The dose to the PTV (skin) decreases (increases) with the increasing adipose proportion inside the breast. In a complete geometry and compared to a TG43-like situation, the average PTV D...
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PMID: 20668347
PDF is available here.
Abstract
In this work, a computational code for the study of imaging systems and dosimetry in conventional and digital mammography through Monte Carlo simulations is described. The developed code includes interference and Doppler energy broadening for simulation of elastic and inelastic photon scattering, re...
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PMID: 20647608
PDF is available here.
Abstract
This first scientific approach of dynamic contrast-enhanced breast magnetic resonance imaging at 7 Tesla demonstrates the complexity of ultra-high-field breast magnetic resonance imaging and countenances the implementation of further advanced bilateral coil concepts to circumvent current limitations...
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PMID: 20599158
PDF is available here.
Abstract
We report the case of a patient who developed an AVL, vascular type, 4 years after lumpectomy and radiation therapy for ductal carcinoma in situ of the breast. The patient underwent wide local excision with 1-cm margins with subsequent pathologic examination confirming complete excision of the resid...
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PMID: 20138394
PDF is available here.
Abstract
This study presents a finite element-based computational model to simulate the three-dimensional deformation of a breast and fibroglandular tissues under compression. The simulation was based on 3D MR images of the breast, and craniocaudal and mediolateral oblique compression, as used in mammography...
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PMID: 20601773
PDF is available here.
Abstract
Self-reported benign breast biopsy history was associated with statistically significantly reduced mammography performance. The difference in performance was likely because of tissue characteristics rather than the biopsy itself....
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PMID: 20601590
PDF is available here.
Abstract
Seroma were found on palpation in 37 patients (23%) and on CT in 105 patients (65%; median volume, 26.3 mL). Interval between BCS and CT was significantly shorter in patients with palpable seroma (median, 33 days) or CT-seroma (33 days) compared with those with no palpable seroma (36.5 days; p = 0.0...
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PMID: 19836152
PDF is available here.
Lauren B Shomaker,
Marian Tanofsky-Kraff,
David M Savastano,
Merel Kozlosky,
Kelli M Columbo,
Laura E Wolkoff,
Jaclyn M Zocca,
Sheila M Brady,
Susan Z Yanovski,
Melissa K Crocker,
Asem Ali and
Jack A Yanovski
Abstract
The observed intake patterns are congruent with known sexual dimorphisms for body composition, peak growth velocity, and pubertal development. Consistent with their higher energy requirements, males can consume significantly larger amounts of food than females, especially during later puberty. This...
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PMID: 20504975
PDF is available here.
Abstract
We report a case of GCA affecting the breast and review previous reports on this condition in an attempt to summarize the features that distinguish this disease from other vascular diseases of the breast....
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PMID: 19459029
PDF is available here.
Abstract
We assessed genomic profiles of glandular tissue and established tumors from MMTV-neu mice fed adequate (250 IU/kg) or high (5000 IU/kg) vitamin D (cholecalciferol). Genomic profiles were also obtained in murine mammary cells that differentially express VDR that were cultured in vitro with 100 nM 1,...
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PMID: 20412854
PDF is available here.
Abstract
We hypothesize that the inhibition of estrogen synthesis and signaling by calcitriol and its anti-inflammatory actions will play an important role in the use of calcitriol for the prevention and/or treatment of BCa.
Copyright (c) 2010 Elsevier Ltd. All rights reserved....
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PMID: 20156557
PDF is available here.
Abstract
The polymorphisms in codon 72 of the tumor suppressor protein p53 (P53) gene and codon 655 of the human epidermal growth factor receptor 2 (HER2) gene have been suggested to play roles in most cancers. The purpose of this study was to investigate the association between common variants of HER-2 and...
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PMID: 20380571
PDF is available here.