Abstract
Controversy has surrounded the role of isolated limb perfusion (ILP) for unresectable extremity sarcomas. However, there remains a group of sarcoma patients for whom amputation is the only potential treatment. Because systemic therapies are limited, the authors evaluated ILP in an effort to provide a...
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PMID: 21246524
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Abstract
We identified cutaneous angiosarcomas in 10 children and assessed clinical (patient age, tumor site, tumor size, and tumor focality) and histologic features including growth pattern (vasoformative vs. solid), mitotic rate (mitotic figures per 10 high power field), necrosis (present vs. absent), and...
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PMID: 21164289
PDF is available here.
Abstract
We report a series of 13 cases of primary cutaneous epithelioid angiosarcoma and analyze their clinicopathologic features. The tumors arising in the conventional settings for cutaneous angiosarcoma (ie, in the head and neck region of elderly patients, and those occurring postradiation or associated...
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PMID: 21164288
PDF is available here.
Abstract
Advances in medical knowledge and treatment have resulted in improved five-year survival rates for some forms of cancer. However, pain syndromes resulting from chemotherapy, radiotherapy, surgery or interventional procedures continue to have a significant effect on cancer survivors'...
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PMID: 21329131
PDF is available here.
Abstract
We investigated the antioxidant protective effects of melatonin on skeletal muscles of Wistar albino-type rats with acute ischemia/reperfusion (I/R) injury.
Twenty-eight Wistar albino-type male rats weighing between 334 to 422 g were included in this experimental study. The rats were randomly alloca...
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PMID: 21067499
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Abstract
I present a general model of character evolution enabling rate heterogeneity among branches. This model is employed in assessing the extent to which the assumption of uniform transition rates affects reconstructions of ancestral limb morphology in the scincid lizard clade Lerista and, accordingly, t...
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PMID: 20889732
PDF is available here.
Abstract
Severe generalized dystrophic epidermolysis bullosa is described via a clinical case in an adult male. From the time of birth his skin was characterized by extensive blistering, slowly developing into chronic wounds with the formation of pseudosyndactyly. As he grew older extracutaneous involvement...
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PMID: 21092724
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Abstract
We therefore intend to give an introduction to amphibian regeneration and the common evolutionary roots of regeneration and human wound healing, as we believe that Plastic Surgery takes a unique advantage of performing basic research on amphibian regeneration....
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PMID: 20948421
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Abstract
We show experimentally the strength of the contribution of the seta surface architecture to superhydrophobicity by maintaining identical surface chemistry (thin and thick coating of the setae with polydimethylsiloxane). Atomic force microscopy-based force and adhesion measurements of single uncoated...
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PMID: 20417737
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Abstract
These results suggest that the motor comparators implicated in AHP are functioning, but not at optimum levels. Moreover, because the current findings reveal a deficit in awareness for reaches with the unimpaired limb, it is suggestive of common right hemisphere networks for motor awareness in both l...
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PMID: 20667488
PDF is available here.
Abstract
The purpose of this study was to develop a model for a routine genetic evaluation of claw health traits and to develop an index including data on claw health and conformation traits. Claw health data comprised observations on 40,536 dairy cows of claw traits recorded by claw trimmers. Claw health tr...
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PMID: 20855023
PDF is available here.
Abstract
Extremity sarcomas are most common in older children. RMS is more common in younger children, but is associated with lower survival, and is an independent prognostic indicator of mortality.
Copyright © 2010 Elsevier Inc. All rights reserved....
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PMID: 20638678
PDF is available here.
Abstract
We studied patients with combat-related injuries that required delayed amputation at least 4 months after the initial injury due to dysfunction, persistent pain, and patient desires. Late amputations were performed 22 times in 22 patients (21 men, 1 woman) since 2003. Fourteen patients underwent tra...
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PMID: 20839713
PDF is available here.
Abstract
Anaemia and poor nutrition are common and not recognised in vascular patients presenting with critical limb ischaemia. Anaemia is associated with and increased length of hospital stay....
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PMID: 20513273
PDF is available here.
Abstract
The field of regenerative medicine holds tremendous promise for the treatment of chronic diseases. While the adult mammalian heart has limited regenerative capacity, previous studies have focused on cellular therapeutic strategies in an attempt to modulate cardiac regeneration. An al...
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PMID: 20559775
PDF is available here.
Abstract
The field of regenerative medicine holds tremendous promise for the treatment of chronic diseases. While the adult mammalian heart has limited regenerative capacity, previous studies have focused on cellular therapeutic strategies in an attempt to modulate cardiac regeneration. An al...
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PMID: 20559775
PDF is available here.
Abstract
We used DNA microarrays to compare the mRNAs in E13.5 mouse Lmx1b mutant and wild-type limbs. We report 14 genes that require Lmx1b for their normal expression in the dorsal limb or the restriction of their expression to the ventral limb....
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PMID: 20589901
PDF is available here.
Abstract
We analyzed presence of FLS, the two subcategories of FLS, and SB in 1,117 macaques monitored for up to 3 years, and 781 macaques observed for 8 min of structured data collection. The Papio sample size was insufficient for statistical analysis. Both sampling methodologies found FLS and FLS subcatego...
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PMID: 20568078
PDF is available here.
Abstract
Recent genetic and functional analysis of vertebrate limb development begins to reveal how the functions of particular genes and regulatory hierarchies can drastically change over time. The temporal and spatial interplay of the two instructive signalling centres are part of a larger signalling syste...
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PMID: 20537528
PDF is available here.
Abstract
Plasma MDA concentration in the group S was significantly higher at 20 min ATR in comparison with the groups T and R (6.78 +/- 0.33 micromolL-1(-1) vs. 4.07 +/- 1.53 and 3.22 +/- 0.9. micromolL-1(-1), respectively). There was a significant difference in MDA concentration in erytrocythes between the...
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PMID: 20845670
PDF is available here.
Abstract
Desert locusts show extreme phenotypic plasticity and can change reversibly between two phases that differ radically in morphology, physiology and behaviour. Solitarious locusts are cryptic in appearance and behaviour, walking slowly with the body held close to the ground. Gregarious locusts are con...
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PMID: 20416321
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Abstract
We have to choose a specific technique and which advantages are offered by each of them. We performed a review of the clinical trials from the last three years (January 2007-September 2009), finding 644 articles on this topic. Even if many clinical trials underline a better efficacy of ultrasound (U...
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PMID: 20661204
PDF is available here.
Abstract
We describe a 71-year-old woman who was admitted with pneumonia. She quickly developed severe pain and gangrene in all four extremities and had several fingers and crurae amputated. Pheochromocytoma was diagnosed by a 2 x 2 24-hour urine collection, computerized axial tomography and MIBG scintigraph...
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PMID: 20654282
PDF is available here.
Abstract
We show that two zebrafish proteins, which we name actinodin 1 and 2 (And1 and And2), are essential structural components of elastoidin. The presence of actinodin sequences in several teleost fishes and in the elephant shark (Callorhinchus milii, which occupies a basal phylogenetic position), but no...
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PMID: 20574421
PDF is available here.
Abstract
While the peri-infarct cortex is thought to be responsible for functional recovery, the site is also a strong candidate for post-stroke seizures. Since it is crucial to identify the conditions when the site is changed with such beneficial or detrimental results, the peri-infarct changes were investi...
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PMID: 19682409
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Abstract
We conclude that the complete resection of large SNABTE, excepting lipofibromas and some neurofibromas, is always possible and associated with an improved outcome. The nerve preservation should be attempted in all cases, particularly in those with conserved functionality of a major nerve trunk....
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PMID: 20350365
PDF is available here.
Abstract
Phylogenetic approaches to inferring ancestral character states are becoming increasingly sophisticated; however, the potential remains for available methods to yield strongly supported but inaccurate ancestral state estimates. The consistency of ancestral states inferred for two or more characters...
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PMID: 20007166
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Abstract
We address this apparent paradox, highlighting two factors that predict benefits for compliant gaits: (i) minimizing cost of work associated with bouncing viscera; and (ii) leg control for robust stability in uneven terrain. We show that consideration of the effects of bouncing viscera predicts an e...
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PMID: 20335198
PDF is available here.
Abstract
We report that overexpression of SOST leads to loss of posterior structures of the zeugopod and autopod by perturbing anterior-posterior and proximal-distal signaling centers in the developing limb. Mutant mice that overexpress SOST in combination with Grem1 and Lrp6 mutations display more severe li...
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PMID: 20359476
PDF is available here.
Abstract
We present experimental evidence for the relative importance of two putative agents of selection in shaping the adaptive landscape for a classic island radiation. We manipulated whole-island populations of the brown anole lizard, Anolis sagrei, to measure the relative importance of predation versus...
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PMID: 20453837
PDF is available here.
Abstract
This study shows significant therapeutic effects of pregabalin on both sensorial and motor symptoms in restless legs syndrome. Treatment with pregabalin was associated with an improvement of sleep architecture and periodic limb movements. Adverse events included unsteadiness and sleepiness and shoul...
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PMID: 20427750
PDF is available here.
Abstract
The methods were similar but not completely reliable for measuring intracompartmental pressure in trauma patients. Although all methods appeared useful as aids in diagnosis of compartment syndrome, intracompartmental pressure data, especially single readings, must be interpreted in view of clinical...
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PMID: 20502219
PDF is available here.
Abstract
Our results indicate that a smoking cessation intervention program during the first six weeks after acute fracture surgery decreases the risk of postoperative complications....
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PMID: 20516308
PDF is available here.
Abstract
We found that, in the development of ball-and-socket joints in the Drosophila leg, the two sides of ECM form sequentially. We show that distinct cell populations produce the 'ball' and the 'socket', and that these cells undergo extensive shape changes while depositing ECM. We propose that shape chan...
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PMID: 20501594
PDF is available here.
Abstract
Regeneration of lost structures typically involves distinct events: wound healing at the damaged site, the accumulation of cells that will be used as future building blocks and, finally, the initiation of molecular signaling pathways that dictate the form and pattern of the regenerated structures. A...
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PMID: 20455655
PDF is available here.
Abstract
It is not known whether H(2)S can promote angiogenesis with improvement of regional blood flow in ischemic organs. Sodium hydrosulfide (NaHS, a H(2)S donor) was administered once a day for 4 w following femoral artery ligation. Collateral vessel growth, capillary density, regional tissue blood flow,...
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PMID: 19842913
PDF is available here.
Abstract
We have now analyzed the regulatory significance of the region upstream of the SHOX gene. By comparative genomic analyses, we identified several conserved non-coding elements, which subsequently were tested in an in ovo enhancer assay in both chicken limb bud and cornea, where SHOX is also expressed...
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PMID: 19997128
PDF is available here.
Abstract
Whether extraction of a calf in longitudinal anterior presentation should be carried out by simultaneous or alternate traction on the forelimbs remains controversial. Because most recommendations are based on empirical observations rather than on scientific studies, the aim of this study was to deve...
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PMID: 20116838
PDF is available here.
Abstract
The NTE group was significantly older, had lower income, and had greater medical comorbidity, preamputation pain, and physical disability. The etiology groups did not differ significantly in mean levels of outcome variables except that the TE group reported greater aversive emotional support at 6 an...
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PMID: 20496967
PDF is available here.
Abstract
During their annual breeding migration the Christmas Island land crab Gecarcoidea natalis sustains locomotion aerobically for up to 12 h per day compared with just 10 min during the dry season when their muscles quickly become anaerobic. A seasonal transition to an endurance-muscle phenotype would t...
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PMID: 20435825
PDF is available here.
Abstract
Species of various insect orders possess specialised tarsal adhesive structures covered by a thin liquid film, which is deposited in the form of footprints. This adhesive liquid has been suggested to be chemically and physiologically related to the epicuticular lipid layer, which naturally covers th...
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PMID: 20361192
PDF is available here.
Abstract
We use the paradigm of hand and foot evolution to argue that the consideration of the regulatory mechanisms controlling developmental gene expression is essential to resolve comparative conundrums. In this context, we discuss the adaptive relevance of evolving stepwise, distinct developmental regula...
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PMID: 20412768
PDF is available here.
Abstract
While studying detailed lower limb mechanics of dynamic sports manoeuvres like side cutting it is often desirable but practically difficult to directly measure velocity profiles of the whole-body centre of mass (CoM). In the current study, representations of CoM, either based on a single marker plac...
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PMID: 20299222
PDF is available here.
Abstract
We tested the effects of substrate diameter and orientation on quadrupedal kinematics in a small arboreal marsupial (the sugar glider, Petaurus breviceps). P. breviceps individuals were filmed moving across a flat horizontal surface and on horizontal, inclining and declining poles of diameter 2.5, 1...
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PMID: 20153016
PDF is available here.
Abstract
In experiment was investigated ultrastructure of the capillaries endothelial cells and histological peculiarities of muscular tissue on various stages after transplantation of hemopoietic stem cells of fetal liver (HSCFL). There was proved, that in ischemic environment HSCFL stimulate processes of a...
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PMID: 20568510
PDF is available here.
Abstract
Sea star tube feet consist of an enlarged and flattened distal extremity (the disc), which makes contact with the substratum, and a proximal contractile cylinder (the stem), which acts as a tether. In this study, the different forces brought into play during tube foot functioning were investigated i...
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PMID: 20228353
PDF is available here.
Abstract
Desmurget et al. (Reports, 8 May 2009, p. 811) applied direct electrical stimulation (DES) to the human cortex to study the origin of movement intention. Their interpretation assumed that DES causes cortical activation, whereas it is possible that it actually evokes deactivation. The...
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PMID: 20203033
PDF is available here.
Abstract
Liposarcoma accounted for 6 [27.3%] of 22 cases of soft tissue sarcomas seen within the study period. All 6 were males with a M:F of 6:0. The age range was 36- 59 years. Lesions were mostly located in the thigh 5/6 (83.3%). The most common histologic type was myxoid seen in 3/6 [50%]. All presented...
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PMID: 20348979
PDF is available here.
Abstract
We show that interpositus neuronal activity can parse out the directional from the scalar component (i.e., the movement speed) of the velocity vector. Moreover, a differential role for the anterior and posterior portion of interpositus in encoding these parameters emerged from these data, since the...
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PMID: 20013085
PDF is available here.
Abstract
The DECTs of peripheral regions showed excellent image quality, while the image quality was poor in the regions of the trunk. Patients (n) and regions (r) with a score of 3 (n = 23, r = 44), 4 (n = 5, r = 8) and 1 (n = 2, r = 2) showed a highly significant correlation (p < 0.01) with the currently a...
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PMID: 19862652
PDF is available here.
Abstract
The association between proximal humeral osteosarcoma and poor survival could be the result of unresponsiveness to chemotherapy, which was expressed by a tumor volume increase in our patients....
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PMID: 19921336
PDF is available here.
Abstract
We identified and cloned a mouse double homeobox gene (Duxbl), which encodes two homeodomains. Duxbl gene, a tandem triplicate produces two major transcripts, Duxbl and Duxbl-s. The amino acid sequences of Duxbl homeodomains are most similar to those of human DUX4 protein, associated with facioscapu...
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PMID: 20063414
PDF is available here.
Abstract
We have treated 81 patients with extremity lesions between 1982 and 2003, 62 of which have been followed up for at least 5 years. The cases that were lost to follow-up and our more recent cases have not been included in this study. Medical records of these 62 patients were reviewed retrospectively....
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PMID: 20179482
PDF is available here.