Abstract
Metabolic syndrome (MetS) is characterized by accumulation of visceral fat associated with the clustering of metabolic and pathophysiological cardiovascular risk factors: impaired glucose tolerance, dyslipidemia, and hypertension. Although the definition of MetS is different among co...
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PMID: 21126197
PDF is available here.
Abstract
We elaborate currently known information about Ad malfunction and deficiency pertaining to cardiovascular disease risk (including atherosclerosis, endothelial dysfunction, and cardiac injury), as well as review evidence supporting Ad resistance as a novel risk factor for cardiovascular injury, provi...
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PMID: 21091079
PDF is available here.
Abstract
We hypothesized that a long interdialytic interval is associated with adverse events in patients receiving hemodialysis.
We studied 32,065 participants in the End-Stage Renal Disease Clinical Performance Measures Project, a nationally representative sample of U.S. patients receiving...
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PMID: 21992122
PDF is available here.
Abstract
We examined the association between ambulatory activity and biological markers of health in smokers.
Baseline data from 985 subjects enrolled in a pharmacologic smoking cessation trial were examined. Body size, blood pressure, total cholesterol (TC), low density lipoprotein cholester...
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PMID: 21885891
PDF is available here.
Abstract
Despite advances in the management of cardiovascular diseases, the incidence of cardiovascular diseases is increasing both in developed and developing world. This phenomenon is associated with the worldwide pandemic of obesity and type 2 diabetes; both are related to the life style o...
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PMID: 21835741
PDF is available here.
Abstract
We focus on emerging techniques that may form a coherently integrated pipeline to overcome present limitations to both the discovery and validation processes....
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PMID: 21817166
PDF is available here.
Abstract
The aim of this study was to describe international enrollment and participation in National Institutes of Health (NIH)-sponsored cardiovascular randomized controlled trials (RCTs).
RCTs provide the evidence base for major societal guidelines and profoundly influence...
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PMID: 21816301
PDF is available here.
Abstract
Angiogenesis represents the formation of new capillaries from existing vasculature, and as such plays a critical role in the response to ischemia in the setting of chronic coronary artery and peripheral vascular disease. Recent technological advances in non-invasive imaging modalitie...
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PMID: 21538181
PDF is available here.
Abstract
This study aimed to examine the participation of Australian Chinese in cardiovascular risk factor and cancer screening.
A telephone survey of a random sample of Chinese in New South Wales, Australia, was conducted. The presence of, and participation in screening for,...
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PMID: 21819359
PDF is available here.
Abstract
Multiple risk factor syndrome is a clustering of cardiovascular risk factors, such as diabetes, dyslipidemia, hypertension, and obesity associated epidemiologically with insulin resistance. This report describes the clinical course of a patient suffering from severe periodontitis wit...
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PMID: 21913601
PDF is available here.
Abstract
Highly active antiretroviral therapy (HAART) use has markedly reduced AIDS-related mortality and opportunistic illness. With improved survival, cardiovascular disease (CVD) has emerged as an important noninfectious chronic comorbidity among antiretroviral (ARV)-treated HIV-infected p...
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PMID: 21546831
PDF is available here.
Abstract
We characterized levels of acute-phase reactants (C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), white blood cell (WBC) count), adhesion molecules (E-selectin, vascular cell adhesion molecule-1), and coagulation products (fibrinogen, plasminogen activator inhibito...
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PMID: 21233809
PDF is available here.
Abstract
Our 3-month study in nondiabetic hypertensive patients showed a decrease in biomarkers of IR and chronic systemic inflammation with the PIO monotherapy and the PIRA combination only, which may help to explain some findings in other cardiovascular outcome trials.
© 2011 Diabetes Tech...
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PMID: 21880242
PDF is available here.
Abstract
Our 3-month study in nondiabetic hypertensive patients showed a decrease in biomarkers of IR and chronic systemic inflammation with the PIO monotherapy and the PIRA combination only, which may help to explain some findings in other cardiovascular outcome trials.
© 2011 Diabetes Tech...
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PMID: 21880242
PDF is available here.
Abstract
We report the design and discovery of a novel APJ antagonist. By using a bivalent ligand approach, we have designed compounds with two 'affinity' motifs and a short series of linker groups with different conformational and non-bonded interaction properties. One of these, cyclo(1-6)CRPRLC-KH-cyclo(9-...
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PMID: 21560248
PDF is available here.
Abstract
Our study shows that knowledge and awareness of MDCT findings relevant to the Ghent nosology give important clues for the diagnosis of Marfan syndrome that provides better patient care....
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PMID: 21503706
PDF is available here.
Abstract
We provide a comprehensive review of the actions of BAs on cardiovascular function. In the heart and the systemic circulation, BAs interact with plasma membrane G-protein-coupled receptors, for example, TGR5 and muscarinic receptors, and nuclear receptors, for example, the farnesoid (FXR) and pregna...
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PMID: 21707953
PDF is available here.
Abstract
This exploratory study set out to identify how communities in the Tufts University Clinical Translational Science Institute (CTSI) catchment area define health-related research priority areas.
Three focus groups comprising community stakeholders were conducted in thre...
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PMID: 21707945
PDF is available here.
Yves Y Vanrenterghem,
Barbara B Bresnahan,
Josep J Campistol,
Antoine A Durrbach,
Josep J Grinyó,
Hans-Hellmut HH Neumayer,
Philippe P Lang,
Christian P CP Larsen,
Eduardo E Mancilla-Urrea,
José Medina JM Pestana,
Alan A Block,
Tao T Duan,
Alan A Glicklich,
Sheila S Gujrathi and
Flavio F Vincenti
Abstract
Cardiovascular disease, the most common cause of death with a functioning graft among kidney transplant recipients, can be exacerbated by immunosuppressive drugs, particularly the calcineurin inhibitors. Belatacept, a selective co-stimulation blocker, may provide a better cardiovascu...
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PMID: 21372756
PDF is available here.
Katarzyna Stolarz-Skrzypek,
Tatiana Kuznetsova,
Lutgarde Thijs,
Valérie Tikhonoff,
Jitka Seidlerová,
Tom Richart,
Yu Jin,
Agnieszka Olszanecka,
Sofia Malyutina,
Edoardo Casiglia,
Jan Filipovský,
Kalina Kawecka-Jaszcz,
Yuri Nikitin,
Jan A Staessen and
European Project on Genes in Hypertension (EPOGH) Investigators
Abstract
Extrapolations from observational studies and short-term intervention trials suggest that population-wide moderation of salt intake might reduce cardiovascular events.
To assess whether 24-hour urinary sodium excretion predicts blood pressure (BP) and health outcomes....
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PMID: 21540421
PDF is available here.
Abstract
I Epidemiological Follow-Up Study (1971 to 1975) and of 12 420 participants of the NHANES III Linked Mortality Study (1988 to 1994) were used. The mean follow-up times were 17.5 and 14.2 years, respectively. In each cohort, the mortality rate was higher among hypertensive adults than nonhypertensive...
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PMID: 21518989
PDF is available here.
Zeneng Wang,
Elizabeth Klipfell,
Brian J Bennett,
Robert Koeth,
Bruce S Levison,
Brandon Dugar,
Ariel E Feldstein,
Earl B Britt,
Xiaoming Fu,
Yoon-Mi Chung,
Yuping Wu,
Phil Schauer,
Jonathan D Smith,
Hooman Allayee,
W H Wilson Tang,
Joseph A DiDonato,
Aldons J Lusis and
Stanley L Hazen
Abstract
We used a metabolomics approach to generate unbiased small-molecule metabolic profiles in plasma that predict risk for CVD. Three metabolites of the dietary lipid phosphatidylcholine--choline, trimethylamine N-oxide (TMAO) and betaine--were identified and then shown to predict risk for CVD in an ind...
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PMID: 21475195
PDF is available here.
Abstract
The common belief that signs of atherosclerosis and cardiovascular disease (CVD) are clinically relevant only during adult and elderly age is gradually changing. Increasing evidence supports the concept that CVD is initiated through developmental in utero processes beginning before b...
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PMID: 21221859
PDF is available here.
Abstract
We analyzed global protein expression patterns in plasma of control and sibutramine-treated rats using proteomic analysis for a better understanding of the two conflicting functions of this drug, appetite regulation, and cardiovascular risk. The control (n=6) and sibutramine-treated groups (n=6) wer...
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PMID: 21337517
PDF is available here.
Abstract
We prospectively identified incident cases of cardiovascular disease (coronary heart disease and stroke) in 3427 participants and matched them to risk-set-sampled controls according to age, sex, race, and smoking status. Toenail mercury and selenium concentrations were assessed with the use of neutr...
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PMID: 21428767
PDF is available here.
Hermann Haller,
Sadayoshi Ito,
Joseph L Izzo,
Andrzej Januszewicz,
Shigehiro Katayama,
Jan Menne,
Albert Mimran,
Ton J Rabelink,
Eberhard Ritz,
Luis M Ruilope,
Lars C Rump,
Giancarlo Viberti and
ROADMAP Trial Investigators
Abstract
We investigated whether treatment with an angiotensin-receptor blocker (ARB) would delay or prevent the occurrence of microalbuminuria in patients with type 2 diabetes and normoalbuminuria.
In a randomized, double-blind, multicenter, controlled trial, we assigned 4447 patients with t...
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PMID: 21388309
PDF is available here.
Abstract
Information relating the outcome of percutaneous coronary intervention to diabetes mellitus or hypertension is limited. The study objective was to describe the outcome in patients undergoing percutaneous coronary intervention in relation to diabetes and hypertension.
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PMID: 21396511
PDF is available here.
Abstract
Blood pressure variability in hypertension is an independent risk factor of cardiovascular complications, especially of stroke. Antihypertensive drugs/classes with powerful antihypertensive effect and suppression of blood pressure variability might have additional impact on the cardiovascular risk in...
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PMID: 21495416
PDF is available here.
Goodarz Danaei,
Mariel M Finucane,
John K Lin,
Gitanjali M Singh,
Christopher J Paciorek,
Melanie J Cowan,
Farshad Farzadfar,
Gretchen A Stevens,
Stephen S Lim,
Leanne M Riley,
Majid Ezzati and
Global Burden of Metabolic Risk Factors of Chronic Diseases Collaborating Group (Blood Pressure)
Abstract
We estimated worldwide trends in population mean systolic blood pressure (SBP).
We estimated trends and their uncertainties in mean SBP for adults 25 years and older in 199 countries and territories. We obtained data from published and unpublished health examination surveys and epide...
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PMID: 21295844
PDF is available here.
Abstract
Patients with rheumatoid arthritis (RA) are at high risk of cardiovascular events. Platelet biomarkers are involved in inflammation, atherosclerosis and thrombosis. Cardiovascular and RA-associated factors can alter the structure and function of platelets, starting from megakaryocyto...
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PMID: 20390282
PDF is available here.
Abstract
Since the discovery of vascular endothelial growth factor (VEGF), therapeutic angiogenesis has attracted interest as an alternative treatment for ischaemic heart and peripheral disease. In parallel, the view has also gained ground that angiogenesis has an important role in the pathogenesis of athero...
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PMID: 20884790
PDF is available here.
Abstract
Nociceptin/Orphanin FQ (N/OFQ) is the endogenous ligand for the N/OFQ receptor. N/OFQ acts directly on blood vessels to elicit vasodilation. This review will describe the peripheral cardiovascular effects of N/OFQ observed in studies conducted in vitro and in vivo, along with those d...
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PMID: 21070618
PDF is available here.
Abstract
We conducted a meta-analysis of randomised controlled clinical trials with duration of at least 12 months and the analysis of cardio- and cerebrovascular endpoints in participants aged 75 years and over. MEDLINE, CENTRAL (Cochrane Central Register of Controlled Trials) and the WHO-ISH Collaboration...
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PMID: 21650080
PDF is available here.
Abstract
Myristic acid, the 14-carbon saturated fatty acid (C14:0), usually accounts for small amounts (0.5%-1% weight of total fatty acids) in animal tissues. Since it is a relatively rare molecule in the cells, the specific properties and functional roles of myristic acid have not been fully studied and de...
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PMID: 20920594
PDF is available here.