Abstract
We review how genetic factors, as identified by human genome-wide association studies, and incomplete correlations with various mouse studies, including knockout and strain analyses, fit into "pieces of the puzzle" in intimal calcification in human atherosclerosis, and artery tunica media calcificat...
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PMID: 21852556
PDF is available here.
Abstract
Vascular calcification increasingly afflicts our aging, dysmetabolic population. Once considered only a passive process of dead and dying cells, vascular calcification has now emerged as a highly regulated form of biomineralization organized by collagenous and elastin extracellular m...
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PMID: 21852555
PDF is available here.
Pál Soltész,
György Kerekes,
Henriett Dér,
Gabriella Szücs,
Sándor Szántó,
Emese Kiss,
Edit Bodolay,
Margit Zeher,
Orsolya Timár,
Péter Szodoray,
Gyula Szegedi and
Zoltán Szekanecz
Abstract
Numerous autoimmune-inflammatory rheumatic diseases have been associated with accelerated atherosclerosis or other types of vasculopathy leading to increased cardio- and cerebrovascular disease risk. Traditional risk factors, as well as the role of systemic inflammation including cyt...
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PMID: 21281743
PDF is available here.
Abstract
Platelets are dynamic cells with activities that extend beyond thrombosis including an important role in initiating and sustaining vascular inflammation. A role for platelets has been described in many physiologic and pathophysiologic processes such as atherosclerosis, stem cell traf...
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PMID: 21094986
PDF is available here.
Abstract
The efficacy of angiotensin receptor blockers (ARBs) in the management of hypertension is well established. Whether these agents induce pleiotropic effects that promote the amelioration of vascular disorders independent of blood pressure reduction remains controversial. This review e...
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PMID: 21214721
PDF is available here.
Abstract
Adiponectin is a protein secreted by adipose tissue. Unlike other adipocytokines produced by adipose tissue, adiponectin appears to have anti-inflammatory, anti-diabetic, and anti-atherogenic properties. Although secreted solely by adipose tissue, plasma levels of adiponectin are generally negativel...
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PMID: 21176748
PDF is available here.
Abstract
We aim to provide a comprehensive review of recent studies on the genetics of SSc, including genes associated with autoimmunity, fibrosis, and vascular disease. We also discuss the most relevant data obtained in genetic association studies of large populations that included a replication strategy, o...
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PMID: 21586222
PDF is available here.
Abstract
We conclude that total and primary vascular, cancer and respiratory mortality in older British people of both sexes is predicted by several biochemical indices of redox-modulatory nutrients, some of which may reflect the respondents' acute-phase status at baseline, whereas others may reflect the hea...
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PMID: 20807458
PDF is available here.
Abstract
We identified an alternative pathway by demonstrating that nonadsorbing macromolecules can also have a marked impact on the adhesion efficiency of red blood cells with enhanced phosphatidylserine exposure to endothelial cells. It is concluded that this adhesion-promoting effect originates from macro...
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PMID: 20952392
PDF is available here.
Abstract
Chronic kidney disease-mineral and bone disorder (CKD-MBD) defines a triad of interrelated abnormalities of serum biochemistry, bone and the vasculature associated with chronic kidney disease (CKD). The new kidney disease: improving global outcomes (KDIGO) guidelines define the quality and depth of...
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PMID: 21084045
PDF is available here.
Abstract
Widespread vascular calcification is a ubiquitous feature of aging and is prevalent in association with several atherosclerotic diseases. HMG-CoA reductase inhibitors (statins) have been shown to exert protective potentials against cardiovascular diseases via the lipid-lowering and/or their independ...
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PMID: 21037393
PDF is available here.
Abstract
Vascular calcification is an active process similar to physiological mineralization of skeletal tissues. Not only apoptosis, cellular senescence, and osteochondrogenic transdifferentiation of vascular smooth muscle cells, but also degeneration and degradation of elastin may play an important role in...
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PMID: 21037380
PDF is available here.
Abstract
Vascular calcification often associates with bone-cartilage formation. Artery sclerotic lesions accompany the expression of bone matrix proteins such as osteopontin, osteocalcin and matrix Gla protein and transcription factors including Runx2, osterix and Sox9. These lesions also express BMP, osteop...
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PMID: 21037387
PDF is available here.
Abstract
High-frequency severe atherosclerosis/calcinosis is observed in aging, diabetes mellitus and chronic dialysis, which leads to cardiovascular events. Recent progress in basic research has revealed certain similarities between processes of bone calcification and calcifications of vascular tissues whic...
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PMID: 21037392
PDF is available here.
Ahmed Dahmani,
Ludmilla de Plater,
Charlotte Guyader,
Jean-Jacques Fontaine,
Aurélie Berniard,
Franck Assayag,
Philippe Beuzeboc,
Elisabetta Marangoni,
Fariba Némati,
Marie-France Poupon,
Christophe Pasik,
Stéphane Oudard and
Didier Decaudin
Abstract
Androgen-dependent and castration-resistant prostate cancer (PC) is usually sensitive to docetaxel chemotherapy. Nevertheless, docetaxel resistance frequently appears after several cycles of treatment, raising the problem of salvage treatment for docetaxel-resistant PC patients. Although the combina...
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PMID: 20827173
PDF is available here.
Abstract
We reported that Notch signaling induces osteogenic differentiation and mineralization of SMC....
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PMID: 21037383
PDF is available here.
Abstract
Analysis of animal models is indispensable to elucidate the molecular mechanism in vascular calcification (VC) as well as to develop new therapies for VC. Various gene-modified mice that show VC have been reported, and considerable progress has been made through the analyses of these animals. Mice o...
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PMID: 21037386
PDF is available here.
Abstract
Hyperphosphatemia with decline of kidney function has been associated with increased mortality and the development of cardiovascular calcification. Sevelamer hydrochloride was the first synthetic non-aluminum and calcium-free phosphate binder commercially available. Sevelamer is as effective as calc...
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PMID: 21037391
PDF is available here.
Abstract
The aim of this study was to find out the relationship between Malnutrition-Inflammation score (MIS) and the endothelial function parameters, including measurements of flow-mediated vasodilatation (FMD) in the brachial artery and serum vascular cell adhesion molecule-1 (VCAM-1). Furthermore, predict...
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PMID: 20663689
PDF is available here.
Abstract
A widespread misconception has been developing among the Canadian public and among physicians. It is increasingly believed that consumption of dietary cholesterol and egg yolks is harmless. There are good reasons for long- standing recommendations that dietary cholesterol should be limited to less t...
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PMID: 21076725
PDF is available here.
Abstract
Patients affected by chronic kidney disease (CKD) suffer by secondary hyperparathyroidism and hyperphosphatemia. The new KDIGO guidelines identify a new definition in CKD-MBD (Mineral Bone Disorder), in which vascular calcification plays a central role. In fact, CKD patients that present vascular ca...
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PMID: 21197764
PDF is available here.
Abstract
To study the management and outcome of children with extrahepatic portal vein obstruction (EHPVO) in a whole country population.
A nationwide multicenter retrospective case series of children with EHPVO was conducted. Data on demographics, radiographic studies, laboratory workup, endoscopic and surg...
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PMID: 20954284
PDF is available here.
Sophia Zoungas,
Anushka Patel,
John Chalmers,
Bastiaan E de Galan,
Qiang Li,
Laurent Billot,
Mark Woodward,
Toshiharu Ninomiya,
Bruce Neal,
Stephen MacMahon,
Diederick E Grobbee,
Andre Pascal Kengne,
Michel Marre,
Simon Heller and
ADVANCE Collaborative Group
Abstract
We analyzed data from a large study of intensive glucose lowering to explore the relationship between severe hypoglycemia and adverse clinical outcomes.
We examined the associations between severe hypoglycemia and the risks of macrovascular or microvascular events and death among 11,140 patients wit...
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PMID: 20925543
PDF is available here.
Abstract
Insulin plays an important role in the stimulation of vascular nitric oxide production, with both short term (vasomotility and anti-thrombotic effects) and long term (smooth muscle cell growth and migration inhibition) benefits. Impaired vasodilatory response to insulin, the hallmark...
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PMID: 20802503
PDF is available here.
Abstract
A total of 526 TICH patients were seen in T1 and T2 (age, 77.6 vs 77.5 years; not significant [NS]), with the rate doubling from 6.2% to 12.3% of all trauma activations (P < .01). There was no increase in atrial fibrillation, warfarin use, or CHADS(2) scores in atrial fibrillation patients on antico...
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PMID: 20727562
PDF is available here.
Abstract
The transient systemic low perfusion that occurs during cardiovascular surgery leads to oxidative stress and the production of free radicals. A systemic increase of various markers of oxidative stress has been shown to occur during cardiopulmonary bypass (CPB). However, these markers have not been a...
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PMID: 20975766
PDF is available here.
Abstract
We evaluated the changes in the GCX thicknesses of the retinal and choroidal capillaries in rats with diabetes and hypertension by cationic colloidal iron staining using a transmission electron microscope. In the control group, the mean (standard error of the mean) thicknesses of retinal and choroid...
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PMID: 20975760
PDF is available here.
Abstract
We used microarray to probe the platelet transcriptome in patients with SLE and healthy controls, and the gene and protein expression of a subset of differentially expressed genes was further investigated and correlated to platelet activation status. Real-time PCR was used to confirm a type I interf...
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PMID: 20538795
PDF is available here.
Abstract
Although chemokines, as chemotactic factors, were already known in 70's of the past century, it was only the progress in molecular biology, genetics and immunology which occurred in the past few years that opened the way to discover new molecules, their chemical structure and biological functions. F...
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PMID: 19388544
PDF is available here.
Abstract
The discovery of gas in the portal system related to indolent clinical settings has increased in recent years due to a growth in the performance of imaging tests. We report the first case of spontaneous resolution of portal pneumatosis due to acute gastroenteritis described in the literature.
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PMID: 20883074
PDF is available here.
Abstract
This review aims to highlight recent advances in pathogenesis, clinical presentation and treatment of interstitial lung diseases (ILDs).
Acute exacerbation is increasingly recognized as a major complication in the course of idiopathic pulmonary fibrosis. It is precipitated by a variety of intrinsic...
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PMID: 20473169
PDF is available here.
Abstract
We documented 363 cases of CHD, 187 cases of stroke, 79 amputations and 641 cases of all-cause death, of which 382 were vascular. In multivariate-adjusted models, alcohol consumption was inversely associated with CHD (p(linear trend)=0.007) and stroke (p(linear trend)=0.051) with respective hazard r...
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PMID: 20537650
PDF is available here.
Abstract
We aim to summarize current strategies of using RNAi for analysis of gene function in endothelial (in vitro loss-of-function analysis) and of exploiting RNAi for therapeutic purposes in order to suppress disrupted gene expression ("RNAi therapeutics"). With respect to the latter, we will summarize r...
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PMID: 20144624
PDF is available here.
Abstract
Stem cells represent one of the most promising areas in biological and medical research. All stem cells are defined as having two basic properties: unlimited self-renewal and the broad potential to differentiate in vitro, via "progenitor cells", into somatic cells of many tissue types, in which smoo...
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PMID: 20539914
PDF is available here.
Abstract
Systemic sclerosis (SSc) is characterized by vascular alterations, activation of the immune system and tissue fibrosis. Vascular insufficiency manifests early in the disease, and although there is evidence of an active repair process, capillaries deteriorate and regress. Factors that contribute to t...
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PMID: 20585340
PDF is available here.
Abstract
There are controversial results and insufficient knowledge in the literature about the genetics of diabetes mellitus complications in the Turkish population and endothelial nitric oxide synthase (eNOS) gene polymorphisms may act as a potential modifier of diabetic vascular complications.
The objecti...
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PMID: 20642368
PDF is available here.
Abstract
The natural history of patients with intermittent claudication (IC) has been reported, but little is known about that of claudicant patients after endovascular therapy (EVT).
A total of 271 consecutive patients (mean age, 68+/-6 years, 82% men) with IC were treated with EVT for a de novo iliofemoral...
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PMID: 20574137
PDF is available here.
Abstract
We used HCII(+/-) mice and found that they manifested augmentation of intimal hyperplasia and increased thrombosis after cuff or wire injury to the femoral arteries. HCII(+/-) mice with vascular injury showed augmentation of inflammatory cytokines and chemokines and oxidative stress. These abnormal...
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PMID: 20671370
PDF is available here.
Abstract
In all, 27 patients were analyzed. The 3 most consistent features in our patients were 1) history of drug exposure (100%); 2) a morbilliform cutaneous eruption in 81.5% of the patients; and 3) systemic involvement with hepatitis (96.3%), hematologic abnormalities (81.5%), and fever (77.8%) being mos...
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PMID: 20605253
PDF is available here.
Abstract
Minnesota has led the nation in development of evidence-based guidelines and in public reporting of performance on quality measures. A recent qualitative study explored what 21 Minnesota clinics and their affiliated medical groups are doing to provide patients with optimal diabetes and vascular care...
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PMID: 20862876
PDF is available here.
Abstract
After failure to retrieve the foreign object during cardiac catheterization, the patient underwent sternotomy, removal of foreign metallic object, and closure of patent foramen ovale. CONCLUSION: Close multidisciplinary collaboration allowed for proper diagnosis and the safe retrieval of the missing...
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PMID: 20628330
PDF is available here.
Abstract
The recognition of a central role for the endothelium in the development of kidney disease or the development of vascular lesions in patients with established renal dysfunction has led to the emergence of methods to test different aspects of endothelium function, including in endothe...
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PMID: 20498676
PDF is available here.
Abstract
Cardiovascular complications due to accelerated atherosclerosis and arterial stiffening are the principal cause of morbidity and mortality in patients with dialysis. Both are frequently associated with vascular calcification. Uremia-specific factors are considered to play an important role in promot...
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PMID: 20585185
PDF is available here.
Abstract
KDIGO published the first clinical practice guideline on CKD-MBD in 2009. The work group for this guideline consisted of well-known international experts including Masafumi Fukagawa from Japan and truly global in nature. This guideline is based on strict systemic evidence review and explore a new cl...
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PMID: 20585180
PDF is available here.
Abstract
Disturbances in bone and mineral metabolism in patients with chronic kidney disease (CKD) affect not only the bone diseases but also other organ disorders in the whole body and deteriorate the survival of these patients. The term CKD-Mineral and Bone Disorder (CKD-MBD) has been established describin...
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PMID: 20585177
PDF is available here.
Abstract
The final goal of CKD-MBD (chronic kidney disease, mineral and bone disorder) is to reduce the risk of death in uremic patients. To achieve this objective, it is of importance to manage laboratory abnormalities, bone abnormalities, and vascular calcification appropriately. Many observation studies s...
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PMID: 20585187
PDF is available here.
Abstract
Cinacalcet, a calcium receptor modulator, reduces serum phosphate levels as well as parathyroid hormone (PTH) and serum calcium levels, and improve the control of mineral metabolic disorder, which is a major problem by the active vitamin D sterols in the treatment of secondary hyperparathyroidism. I...
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PMID: 20585188
PDF is available here.
Abstract
We aimed to examine the influence of history of vascular disease on cognition in preclinical and early AD.
Participants from a population-based study were assessed twice with a test of global cognition. The study sample was nondemented at baseline. Three years later, 138 persons were diagnosed with...
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PMID: 20523048
PDF is available here.