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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Blood-Retinal Barrier (0):
Recent article
Blood-Retinal Barrier
Abstract
RPE has mechanisms for maintaining low concentrations of VEGF in the subretinal space that include endocytosis and degradation and fluid-phase transcytosis in the apical-to-basal direction. RPE tight junctions are selective for K(+) over Na(+) and Cl(-). Permeability and selectivity of the junctions...
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PMID: 20042644
PDF is available here.
PDF is available here.
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Abstract
We investigated the effect of high glucose and IL-1beta on the IL-1RI regulation in retinal endothelial cells. A time-dependent downregulation of IL-1RI protein levels was detected in retinal endothelial cells exposed (1-24h) to high glucose, mannitol or IL-1beta. Long-term exposure (7days) to high...
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PMID: 20034811
PDF is available here.
PDF is available here.
Molecular Vision (16) 2010
Abstract
Changes in retinal expression of AQP1 and AQP4 during EAU were primarily due to inflammatory lesions, contrasting with major modulation of AQP expression in BRB detected in other models of BRB breakdown. However, our data showed that TNF-alpha treatment strongly modulates AQP1 expression in B6-RPE07...
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PMID: 20383338
PDF is available here.
PDF is available here.
Molecular Vision (16) 2010
Abstract
To evaluate the effect of the recombinant adeno-associated virus (rAAV) vector that expresses human pigment epithelium-derived factor (hPEDF) on reducing blood-retinal barrier (BRB) breakdown in the experimental diabetic rat model.
Diabetes was induced by an intraperitoneal (i.p.) injection of strep...
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PMID: 21139695
PDF is available here.
PDF is available here.
Molecular Vision (16) 2010
Abstract
We investigated the effect of ATP (ATP) encapsulated in liposomes (ATP-liposomes) on the level of inflammation and neuronal death in the retina induced by ischemia reperfusion (IR).
Primary retinal ganglion cells treated with ATP-liposomes, empty liposomes, and phosphate buffer solution (PBS) were d...
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PMID: 21203410
PDF is available here.
PDF is available here.
Molecular Vision (16) 2010
Abstract
These results suggest that elevated cAMP opposes the TNF-alpha-induced loss in barrier integrity of the corneal endothelium. This effect follows inhibition of the cytokine-induced activation of p38 MAP kinase and its downstream signaling involved in the disruption of AJC and PAMR, as well as the dis...
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PMID: 20824160
PDF is available here.
PDF is available here.
Abstract
The retinal pigment epithelium (RPE) is an specialized epithelium lying in the interface between the neural retina and the choriocapillaris where it forms the outer blood-retinal barrier (BRB). The main functions of the RPE are the following: (1) transport of nutrients, ions, and water, (2) absorpti...
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PMID: 20182540
PDF is available here.
PDF is available here.
Nanotechnology (20)50 2009
Abstract
We demonstrated that intravenously administered gold nanoparticles could pass through the BRB and are distributed in all retinal layers without cytotoxicity. After intravenous injection of gold nanoparticles into C57BL/6 mice, 100 nm nanoparticles were not detected in the retina whereas 20 nm nanopa...
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PMID: 19923650
PDF is available here.
PDF is available here.
Abstract
We will address the fact that numerous basic scientific publications point to a rationale for this practice although it is often difficult to derive clear-cut evidence from clinical epidemiological studies for the preventive use of yellow artificial lenses. In the first part we refer to studies show...
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PMID: 19603376
PDF is available here.
PDF is available here.
Abstract
These data identify alpha 4 integrin/CD49d as a mediator of leukocyte adhesion and the resultant early signature abnormalities of diabetic retinopathy. Inhibition of this signaling pathway may hold promise for clinical activity in patients with diabetes....
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PMID: 19553613
PDF is available here.
PDF is available here.
Abstract
Leukocyte-endothelial interaction plays an important role in the early phase of the development of diabetic retinopathy. It has been studied extensively linking inflammatory processes to its development conducted to date in rats and mice, and have focused on insulin-deficient models. The molecular a...
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PMID: 19619127
PDF is available here.
PDF is available here.
Diabetes Care (32)8 2009
Abstract
Abstract
We have investigated the effect of lovastatin on blood-retinal barrier and inflammatory status in the retina of db/db mice and in cultured retinal cells. Male C57BL/KsJ db/db mice were randomly chosen to receive gastric gavage of lovastatin (10mg/kg/day) or vehicle control for 6 weeks. Retinal vascu...
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PMID: 19254713
PDF is available here.
PDF is available here.
Abstract
We compared transcription levels in entire rat retina of genes related to these pathways between control conditions and after 6 and 12 weeks of streptozotocin-induced diabetes, as well as in bovine retinal endothelial cells (BRECs) exposed to VEGF and bovine retinal pericytes (BRPCs), using real-tim...
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PMID: 19284967
PDF is available here.
PDF is available here.
Abstract
We showed that blockade of Ang II attenuates vascular endothelial growth factor (VEGF)-mediated BRB breakdown in DR. In streptozotocin-induced diabetes, retinal vascular permeability increased with upregulation of VEGF, where Ang II and its receptors were upregulated. Ang II induced VEGF expression...
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PMID: 19107135
PDF is available here.
PDF is available here.
Vestnik oftalmologii (125)5 2009
Abstract
IgM, IgG, IgA, and IgE in the subretinal fluid (SRF) of the subpopulational composition of peripheral blood T lymphocytes and the parameters of a leukocyte migration inhibition test (LMIT) were comparatively studied in patients with posttraumatic and regmatogenic retinal detachments (RD) complicated...
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PMID: 19916335
PDF is available here.
PDF is available here.
Molecular Vision (15) 2009
Abstract
In vitro inner BRB model study revealed that Müller glial cell-derived factors modulate endothelial cell functions including the induction of anti-angiogenic PAI-1 and the suppression of pro-angiogenic Id2. Therefore, Müller cells appear to be one of the modulators of retinal angiogenesis....
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PMID: 19247458
PDF is available here.
PDF is available here.
Abstract
No clinically relevant differences in foveal thickness or macular volume were observed after biaxial microincision and coaxial small incision clear corneal cataract surgery. The blood-retinal barrier did not seem to be influenced by either procedure....
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PMID: 19882577
PDF is available here.
PDF is available here.
Current Eye Research (34)1 2009
Abstract
The radio-chemical purity of labeled ofloxacin was found to be 90-95% with the labeling efficiency of 90%. The static anterior planar images of verapamil pre-treated group showed marginal increase in the uptake of labeled ofloxacin, and dynamic images showed less systemic pool as compared to its con...
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PMID: 19172473
PDF is available here.
PDF is available here.
Ophthalmic Research (41)1 2009
Abstract
FA revealed multiple leaking points at 30 min, and prominent diffuse leakage at 4 h when scotopic b-waves showed significant differences between the study and control eyes. Multiple focal disruptions of the blood vessels by fat vacuoles were found with electron microscopic study. ERG improved at 12...
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PMID: 18849637
PDF is available here.
PDF is available here.
Ophthalmology (116)1 2009
Abstract
In the examined patients, a petaloid pattern and a honeycomb pattern of hyperfluorescence observed in FA were found to correlate to characteristic changes in HD OCT, whereas a diffuse leakage pattern was associated with nonuniform changes in retinal morphologic features. FINANCIAL DISCLOSURE(S): The...
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PMID: 19118697
PDF is available here.
PDF is available here.
Abstract
These results indicate that melatonin prevents the clinical, biochemical, histological, ultrastructural, and functional consequences of experimental uveitis, likely through a nuclear factor kappaB-dependent mechanism, and support the use of melatonin as a new therapeutic strategy for the treatment o...
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PMID: 19008374
PDF is available here.
PDF is available here.
Abstract
The blood-retinal barrier (BRB) plays an important role in the homeostatic regulation of the microenvironment in the retina. It consists of inner and outer components, the inner BRB (iBRB) being formed by the tight junctions between neighbouring retinal capillary endothelial cells and the outer barr...
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PMID: 18940262
PDF is available here.
PDF is available here.
NMR in Biomedicine (21)9 2008
Abstract
These studies show that subtle differences in retinovascular function between patients with diabetes and non-diabetic individuals, including changes that occur in advance of the clinical appearance of diabetic retinopathy, can be detected with MRI. These results, together with previous extensive pre...
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PMID: 18821575
PDF is available here.
PDF is available here.
Abstract
The mean visual acuity decreased with 16 letters at follow-up, and in 15 eyes visual loss was substantial, with a decrease of 15 letters or more, corresponding to at least 3 lines. The baseline permeability was significantly higher in eyes with substantial visual loss than in eyes with more stable v...
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PMID: 18661143
PDF is available here.
PDF is available here.
Abstract
Early diagnosis and appropriate treatment with intravitreous antibiotics are the most important factors for the successful management of endophthalmitis. The intraocular concentration of antibiotics after intravitreous injection is far greater than that achieved by any other modality. The organisms...
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PMID: 19107050
PDF is available here.
PDF is available here.
Ugeskrift for laeger (170)38 2008
Abstract
The special relationship between the eye and the immune system rests on a number of anatomical, physiological and immunological mechanisms. These mechanisms prevent the delicate structures of the eye from potentially damaging immunogenic inflammation while protecting against pathogens. Rather than i...
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PMID: 18808747
PDF is available here.
PDF is available here.
FASEB Journal (22)9 2008
Abstract
One of the major complications of diabetes is the alteration of the blood-retinal barrier, leading to retinal edema and consequent vision loss. The aim of this study was to evaluate the role of the urokinase plasminogen activator (uPA)/uPA receptor (uPAR) system in the regulation of retinal vascular...
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PMID: 18559877
PDF is available here.
PDF is available here.
Ophthalmology (115)9 2008
Abstract
Fourier-domain OCT examinations showed detailed morphologic changes in eyes with acute CSC including an RPE defect within the PED at a leakage site through which fluid might pass from the sub-RPE to the subretinal area. Fourier-domain OCT findings may offer new information to facilitate understandin...
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PMID: 18394706
PDF is available here.
PDF is available here.
Abstract
We investigated the effect of dexamethasone on leukocyte accumulation, vascular permeability and the expression of vascular endothelial growth factor (VEGF) and intercellular adhesion molecule-1 (ICAM-1) in streptozotocin-diabetic rats. Accumulated leukocytes were counted in vivo by acridine orange...
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PMID: 18670086
PDF is available here.
PDF is available here.
Abstract
Abstract
These data suggest that NOX2 activity has a primary role in retinal vascular inflammation during acute and chronic conditions associated with retinal vascular inflammatory reactions. Targeting this enzyme could be a novel therapeutic strategy for treatment of the retinopathies associated with vascul...
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PMID: 18378574
PDF is available here.
PDF is available here.
Abstract
These results suggest that simvastatin protects against the early signs of diabetic retinopathy by preventing NADPH oxidase-mediated activation of STAT3....
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PMID: 18378570
PDF is available here.
PDF is available here.
Abstract
Thus, the combined effect of variables P, D, and F are important factors that should be considered in order to determine drug dosage. This study could be used to estimate the drug distribution and elimination for (1) wide range of physicochemical properties of drugs and (2) normal and abnormally ele...
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PMID: 18476798
PDF is available here.
PDF is available here.
Abstract
An intact retinal pigment epithelium (RPE) represents an essential condition for the visual process. This post-mitotic RPE monolayer combines different functions such as degradation of photoreceptor outer segments, vitamin A cycle, support of retinal metabolism and maintenance of the outer blood-ret...
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PMID: 18516775
PDF is available here.
PDF is available here.
Abstract
We characterized DHA transport and its corresponding transporter in a rat Müller cell line (TR-MUL5 cells). [(14)C]DHA uptake by TR-MUL5 cells took place in a time-dependent and Na(+)-independent manner. [(14)C]DHA uptake was inhibited by substrates and inhibitors of GLUTs, suggesting that Müller...
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PMID: 18353508
PDF is available here.
PDF is available here.
Abstract
The data suggest that occludin regulates tight junction permeability in response to changes in hydrostatic pressure. Furthermore, these data suggest that occludin also contributes to the control of cell division, demonstrating a novel function for this tight junction protein....
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PMID: 18263810
PDF is available here.
PDF is available here.
Developmental Biology (317)2 2008
Abstract
We report that septate junctions (SJs), the vertebrate analogs of TJs, are present in the adult ommatidia and are formed between and among the cone and pigment cells. We show that the localization of Neurexin IV (Nrx IV), a SJ-specific protein, coincides with the location of SJs in the cone and pigm...
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PMID: 18407259
PDF is available here.
PDF is available here.
Abstract
Optimal retinal neuronal cell function requires an appropriate, tightly regulated environment, provided by cellular barriers, which separate functional compartments, maintain their homeostasis, and control metabolic substrate transport. Correctly regulated hemodynamics and delivery of oxygen and met...
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PMID: 18448380
PDF is available here.
PDF is available here.
Abstract
In control rats, BK (0.1-10 nmol) dose-dependently increased plasma extravasation, which was inhibited by Hoe140 (0.2 nmol), whereas des-Arg(9)-BK (0.1 and 1 nmol) was without effect. B(1) receptor mRNA was markedly increased in retinas of diabetic rats, and this was prevented by N-acetyl-L-cysteine...
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PMID: 18311190
PDF is available here.
PDF is available here.
Documenta Ophthalmologica (116)3 2008
Abstract
There is ample evidence that the retinal pigment epithelium (RPE) is affected in diabetes, and that epitheliopathy may be among the early changes. The fast oscillation (FO) of the electro-oculogram (EOG) reflects the activity of the RPE, most notably the mechanisms responsible for pumping fluid and...
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PMID: 17960441
PDF is available here.
PDF is available here.
Abstract
Intravitreal injection of TA stabilizes the BRB in association with regulation of Vegf-a, Flk-1, and Flt-1 expression in retinas in the early stages of diabetes....
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PMID: 18174522
PDF is available here.
PDF is available here.
Abstract
The neurosensory retina is a highly specialized sense organ that is subjected to constant exposure of systemic toxins, oxidative stress and focused light rays. Important advances have been made in recent decades in unravelling a myriad of defence mechanisms against such insults and consequently in i...
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PMID: 18352876
PDF is available here.
PDF is available here.
Abstract
Monitoring changes in the corneal TEER, according to the electrophysiologic method with the application of antiallergic eyedrops, is useful for predicting corneal epithelial breakdown caused by their instillation....
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PMID: 18205544
PDF is available here.
PDF is available here.
Abstract
Macular edema typically occurs as the final ocular manifestation of many intraocular or systemic diseases with fluid collection within the macular layers due to the breakdown of the blood-retinal barrier. This could be chemically mediated by VEGF, because increased VEGF has been shown to increase bl...
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PMID: 18401327
PDF is available here.
PDF is available here.
Abstract
Azurocidin increases retinal vascular permeability and is effectively blocked by aprotinin. The inhibition of VEGF-induced and early diabetic BRB breakdown with aprotinin indicates that azurocidin may be an important mediator of leukocyte-dependent BRB breakdown secondary to VEGF. Azurocidin may bec...
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PMID: 18235021
PDF is available here.
PDF is available here.
Abstract
These data demonstrate that apoptosis is an major contributor to neuronal cell death in the early course of diabetic retinopathy (DR). The upregulation of EpoR may be a compensatory response of retinal cells and tissue to diabetic stresses. The EPO/EpoR system as a maintenance-survival mechanism of...
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PMID: 18235022
PDF is available here.
PDF is available here.
Abstract
Latanoprost may lead to disruption of the blood-retinal barrier in pseudophakic patients, and is more probable to occur in patients with ruptured posterior capsule....
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PMID: 19039454
PDF is available here.
PDF is available here.
Molecular Vision (14) 2008
Abstract
In 12-week-old rats, the number of BrdU-positive retinal cells was higher in SHR than in WKY rats. After 15 days of diabetes mellitus, there was a marked reduction in cell replication only in diabetic SHR (p=0.007). The BrdU-positive cells expressed neural, glial, or vascular progenitor markers. The...
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PMID: 18806882
PDF is available here.
PDF is available here.
Abstract
The findings show that NID has high permeability to retina compared with NIF, which has less fat solubility than NID, and neuroprotective effect to retinal cells. NID might be useful for the treatment of glaucoma or other retinal diseases that have some relation to apoptosis....
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PMID: 18203091
PDF is available here.
PDF is available here.
Abstract
The purpose of this study was to elucidate the mechanism of methyltetrahydrofolate (MTF) transport at the inner blood-retinal barrier (inner BRB). The characteristics and function of MTF transport at the inner BRB were examined using a conditionally immortalized rat retinal capillary endothelial cel...
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PMID: 18762716
PDF is available here.
PDF is available here.
Abstract
Qualitatively, the AC, the PC or the vitreous did not show immediate contrast enhancement on the first and the second set of post-contrast T1WIs. However, the AC and the PC showed delayed contrast enhancement for both groups of cats on the second pre-contrast T1WIs. No enhancement or minimally delay...
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PMID: 18525222
PDF is available here.
PDF is available here.
Abstract
We specifically searched for relevant information regarding the laboratory as well as clinical use of PB and BBG. To evaluate the effect of PB and BBG on the RPE, PB and BBG have been added to an in vitro model of the outer blood-retinal barrier to assess dye-associated barrier properties. Two conce...
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PMID: 18535384
PDF is available here.
PDF is available here.
Klinika oczna (110)4-6 2008
Abstract
The eyes which received TA-assisted PPV showed significantly less breakdown of the blood-ocular barrier than those with routine PPV. Intraoperative administration TA facilitates postoperative recovery after surgery lowering the inflammatory reaction....
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PMID: 18655452
PDF is available here.
PDF is available here.
Ophthalmologica (222)1 2008
Abstract
This study establishes a practical rat model of BRB breakdown induced by anterior segment intraocular surgery.
(c) 2007 S. Karger AG, Basel....
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PMID: 18097180
PDF is available here.
PDF is available here.
Ophthalmic Research (40)3-4 2008
Abstract
These results demonstrate that PlGF-1 can reproduce alterations of the RPE barrier occurring during diabetic retinopathy.
2008 S. Karger AG, Basel....
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PMID: 18421240
PDF is available here.
PDF is available here.
Microvascular Research (75)1 2008
Abstract
The purpose of this study was to quantify gene expression levels of the ATP-binding cassette (ABC) transporter A and C subfamilies ABCA1-A9, and ABCC1-6/Mrp1-6, C10/Mrp7 in mouse retinal vascular endothelial cells (RVEC) using a combination of a magnetic isolation method for mouse RVEC and real-time...
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PMID: 17574281
PDF is available here.
PDF is available here.
Abstract
Tubulointerstitial nephritis and uveitis (TINU) generally occurs at young age and has a female preponderance. Renal biopsy reveals interstitial infiltration of inflammatory cells and edema, and the associated intraocular inflammation typically consists of an anterior, bilateral uveitis. The pathogen...
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PMID: 18379944
PDF is available here.
PDF is available here.
Journal of Anatomy (211)6 2007
Abstract
The outer blood-retinal barrier is composed of a monolayer of retinal pigment epithelium, Bruch's membrane and the choriocapillaris which is fenestrated. Endothelial proliferation and breaching of Bruch's membrane leads to the neovascular form of age-related macula degeneration (ARMD). The aim of th...
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PMID: 17922819
PDF is available here.
PDF is available here.
Abstract
The outer part of the blood-retina barrier was most sensitive to light exposure (6000 lx, 6 h) during photodamage. It was manifested in hemodynamic disturbances, endothelial dysfunction, and focal death of the pigment epithelium. The photo effects increased during alloxan diabetes. The specific area...
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PMID: 18856217
PDF is available here.
PDF is available here.