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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Heart (10):
Recent article
Heart
Journal of Cell Biology (194)3 2011
Abstract
The heart exhibits remarkable adaptive responses to a wide array of genetic and extrinsic factors to maintain contractile function. When compensatory responses are not sustainable, cardiac dysfunction occurs, leading to cardiomyopathy. The many forms of cardiomyopathy exhibit a set o...
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PMID: 21825071
PDF is available here.
PDF is available here.
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Abstract
We have investigated the evolution of myocardial leptin expression following myocardial infarction (MI) and evaluated the consequences of specific cardiac leptin inhibition on subsequent LV dysfunction. Anaesthetized rats were subjected to temporary coronary occlusion. An antisense oligodesoxynucleo...
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PMID: 20731748
PDF is available here.
PDF is available here.
Abstract
I (IGF-1) levels are closely associated with cardiac performance although the role of IGF-1 in alcoholic cardiac dysfunction is unknown. This study was designed to evaluate the impact of severe liver IGF-1 deficiency (LID) on chronic alcohol-induced cardiomyocyte contractile and intracellular Ca(2+)...
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PMID: 20731752
PDF is available here.
PDF is available here.
Proteomics (11)16 2011
Abstract
We analysed hearts of HCRs and LCRs from generation 22 of selection using DIGE and identified proteins from MS database searches. The running capacity of HCRs was six-fold greater than LCRs. DIGE resolved 957 spots and proteins were unambiguously identified in 369 spots. Protein expression profiling...
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PMID: 21751351
PDF is available here.
PDF is available here.
Abstract
Biochimica et Biophysica Acta (1808)5 2011
Abstract
The purine nucleoside adenosine is an important regulator within the cardiovascular system, and throughout the body. Released in response to perturbations in energy state, among other stimuli, local adenosine interacts with 4 adenosine receptor sub-types on constituent cardiac and va...
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PMID: 21094127
PDF is available here.
PDF is available here.
Abstract
To investigate whether telmisartan (Telm) pretreatment attenuates isoproterenol (Iso)-induced postinfarction remodeling (PIR) in rats, and whether the effect of Telm is associated with cardiac expression of adiponectin.
PIR was induced in male Wistar rats with two con...
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PMID: 21399654
PDF is available here.
PDF is available here.
Abstract
We will, therefore, describe different species of fish, amphibian, and reptile that are well-known examples of cardiac tolerance to O(2) deficiency. We will then focus on a subset of Antarctic fishes which have lost physiological transporters of O(2) such as hemoglobin and myoglobin (Mb) and that ha...
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PMID: 20518703
PDF is available here.
PDF is available here.
Abstract
We evaluated 343 diabetic and 618 nondiabetic subjects with New York Heart Association class II or III heart failure and a left ventricular ejection fraction ≤35% over a median follow-up of 17 months. A multivariable Cox proportional hazards model was used to examine the influence of clinical vari...
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PMID: 21193691
PDF is available here.
PDF is available here.
Abstract
Abstract
We define the gene expression network topology of cardiac hypertrophy and failure and the extent of recapitulation of fetal gene expression programs in failing and hypertrophied adult myocardium.
We assembled all myocardial transcript data in the Gene Expression Omnibus (n=1617). Bec...
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PMID: 21127201
PDF is available here.
PDF is available here.
Abstract
The whole heart can be scanned in one rotation using 320-row coronary computed tomography angiography (CCTA), which covers up to 16 cm. Since most hearts are smaller, the total radiation dose may be reduced by adjusting the CCTA range to the individual heart size defined on a low-dose calcium scan (...
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PMID: 20725881
PDF is available here.
PDF is available here.
Abstract
Abstract
We have generated a zebrafish line carrying a stop mutation in the kinase domain of the Tie-2 receptor. Mutant embryos lack Tie-2 protein, but do not display any defect in heart and vessel development. Simultaneous loss of Tie-1 and Tie-2, however, leads to a cardiac phenotype. Our study shows that...
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PMID: 21045210
PDF is available here.
PDF is available here.
Abstract
We analyze the effects of loss of Heart adaptor protein 1 (Hadp1), which we show is required for normal function and morphogenesis of the embryonic zebrafish heart. Hadp1 is a pleckstrin homology (PH)-domain-containing protein whose expression is enriched in embryonic cardiomyocytes. Knockdown of ha...
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PMID: 21628396
PDF is available here.
PDF is available here.
Abstract
We present an image-based approach for cardiac phase retrieval from coronary IVUS sequences without an ECG signal. A signal reflecting cardiac motion is computed by exploring the image intensity local mean evolution. The signal is filtered by a band-pass filter centered at the main cardiac frequency...
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PMID: 21244975
PDF is available here.
PDF is available here.
Abstract
We showed that C/EBPβ was downregulated with exercise, whereas the expression of CITED4 was increased. Reduction of C/EBPβ in vitro and in vivo resulted in a phenocopy of endurance exercise with cardiomyocyte hypertrophy and proliferation. This proliferation was mediated, at least in part, by the...
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PMID: 21183071
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)52 2010
Abstract
Abstract
The concept of regenerating diseased myocardium by implanting engineered heart tissue (EHT) is intriguing. Yet it was limited by immune rejection and difficulties to be generated at a size with contractile properties. Somatic cell nuclear transfer is proposed as a practical strategy...
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PMID: 20586830
PDF is available here.
PDF is available here.
Anesthesiology (113)6 2010
Abstract
The concentration-response and time-response relationships of lipid emulsions used to reverse bupivacaine-induced asystole are poorly defined.
Concentration response across a range of lipid concentrations (0-16%) to reverse bupivacaine-induced asystole were observed using isolated rat heart Langendo...
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PMID: 21068661
PDF is available here.
PDF is available here.
Anesthesiology (113)6 2010
Abstract
Although hypoxic late preconditioning (LPC) limits ischemia-reperfusion injury in vitro, its cardioprotective effect is not established in vivo.
In part 1, rats were exposed to 4 h of hypoxia (16%, 12%, 8% oxygen) before 24 h of reoxygenation. In part 2, normoxic rats received early preconditioning...
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PMID: 21068657
PDF is available here.
PDF is available here.
Abstract
We applied a heart positioner during operations to remove large mediastinal tumors. Fixing and lifting the tumor with this device allowed a good view behind the tumor. Separating the tumor from surrounding structures was easy and safe, with no risk of insult. The device caused no damage to the tumor...
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PMID: 21095374
PDF is available here.
PDF is available here.
Abstract
We exploited these variations to predict the function of two so far poorly annotated genes: Coiled-coil-helix-coiled-coil-helix domain containing 10 (CHCHD10) and glioblastoma amplified sequence (GBAS). We predicted both genes to be involved in oxidative phosphorylation. Through in vitro experiments...
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PMID: 20888800
PDF is available here.
PDF is available here.
Abstract
The efficacy of mesenchymal stem cell (MSC) therapy for myocardial regeneration is limited by the poor survival of stem cells after transplantation into the infarcted heart. To improve the cell survival of MSCs in the infarcted heart, MSCs were genetically engineered to overexpress phosphoinositide-...
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PMID: 20937252
PDF is available here.
PDF is available here.
Legal Medicine (12)6 2010
Abstract
We investigated the mRNA expression of IEGs, including C-fos, Fos-B, Fosl-1, Fosl-2, Dusp-1 and C-jun, in the mouse heart after once-daily high-dose (7.5 mg/kg) or low-dose (0.75 mg/kg) of Chl single and repeated (1-4 weeks) injections. We showed that single high-dose Chl administration induced IEGs...
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PMID: 20843724
PDF is available here.
PDF is available here.
Development (137)22 2010
Abstract
We identify in the mouse a subpopulation of the first (crescent-forming) field marked by endothelin receptor type A (Ednra) gene expression, which contributes to chamber myocardium through a unique type of cell behavior. Ednra-lacZ/EGFP-expressing cells arise in the ventrocaudal inflow region of the...
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PMID: 20929948
PDF is available here.
PDF is available here.
Free Radical Research (44)11 2010
Abstract
The aim was to evaluate the role of the combination of olmesartan, an angiotensin II (Ang II) receptor blocker (ARB), with daunorubicin (DNR) in reducing cardiac toxicity in rats. DNR was administered at a dose of 3 mg/kg/day every other day for 12 days. Olmesartan was administered orally every day...
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PMID: 20815778
PDF is available here.
PDF is available here.
Harvard Health Letter (36)1 2010
Abstract
Abstract
Our approach integrates a mathematical model of oxygen transport in SCA with: (1) the expression relating the solubility of deoxy-Hb S to SaO2, and (2) the kinetic expression relating the delay time to the solubility of deoxy-Hb S....
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PMID: 21141287
PDF is available here.
PDF is available here.
Pediatric Research (68)5 2010
Abstract
Complications after cardiac surgery in neonates can occur because of activation of the inflammatory system. This study used lipopolysaccharide (LPS) endotoxin exposure to cause cytokine activation in neonatal mice and examine left ventricular (LV) function and the effects of antioxidant treatment on...
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PMID: 20613681
PDF is available here.
PDF is available here.
Journal of Hypertension (28)11 2010
Abstract
Journal of Hypertension (28)11 2010
Abstract
Although the relationships between BMI and cardiac geometry and function have been established, information remains limited on the impact of BMI, waist circumference and body composition variations over time on echocardiographic changes in ageing adults.
Multiple linear regressions were used to corr...
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PMID: 20706135
PDF is available here.
PDF is available here.
Journal of Hypertension (28)11 2010
Abstract
We recently showed that coupling factor 6, a component of adenosine trisphosphate (ATP) synthase, induces hypertension by intracellular acidosis, which is related to reactive oxygen species generation. We investigated the effect of high-salt diet on the cardiac performance and reactive oxygen specie...
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PMID: 20811295
PDF is available here.
PDF is available here.
Critical Care Medicine (38)11 2010
Abstract
We recently demonstrated that transfusion of anemic animals up to 100 g/L hemoglobin with fresh blood protects the heart from ischemic injuries following myocardial infarction. Erythropoietin has cardioprotective effects independent of its erythropoietic activity. The objective of this study was to...
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PMID: 20693887
PDF is available here.
PDF is available here.
Abstract
We hypothesized that FA mitigated MI-induced injury, in part, by mitigating cardiac remodeling during chronic heart failure. Thus, MI was induced in 12-wk-old male C57BL/J mice by ligating the left anterior descending artery, and FA (0.03 g/l in drinking water) was administered for 4 wk after the su...
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PMID: 20802128
PDF is available here.
PDF is available here.
Abstract
We studied the transmural distribution of the VF activation rate (VFR) in the RV and LV and at the junction of RV, LV, and septum (Sep) during LDVF using plunge needle electrodes in opened-chest dogs. We also used optical mapping to analyze the Epi distribution of VFR, action potential duration (APD...
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PMID: 20802138
PDF is available here.
PDF is available here.
Abstract
We postulated that the combination of overexpression of CXCR4 in mesenchymal stem cells (MSC) with diprotin A would enhance MSC recruitment and penetration into ischemic myocardium, leading to an improvement in heart function after myocardial infarction (MI). Male rat MSC were genetically engineered...
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PMID: 20802132
PDF is available here.
PDF is available here.
Bulletin du cancer (97)11 2010
Abstract
Our laboratory has designed an EMT high-throughput screen of small molecular weight compounds and biologics in order to establish new therapeutic approaches that interfere with the plasticity of carcinoma cells. New therapeutic interventions are envisioned to delay tumor recurrence....
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PMID: 21084241
PDF is available here.
PDF is available here.
Abstract
Fetal hearts show a remarkable ability to develop under hypoxic conditions. The metabolic flexibility of fetal hearts allows sustained development under low oxygen conditions. In fact, hypoxia is critical for proper myocardial formation. Particularly, hypoxia inducible factor 1 (HIF-...
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PMID: 20712587
PDF is available here.
PDF is available here.
Abstract
We report eight homologs of mical family genes in zebrafish and their expression profiles during embryonic development. Consistent with the findings in Drosophila and mammals, most zebrafish mical family genes display expression in neural and musculature systems. In addition, five mical homologs are...
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PMID: 21035094
PDF is available here.
PDF is available here.
Abstract
Our results showed that stromal cells with the immunophenotypical (vimentin, CD34) and ultrastructural features of telocytes were present in the mouse heart since early embryonic to adult life, as well as in primary cultures of neonatal mouse cardiac cells. These cells formed an extended network of...
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PMID: 20977627
PDF is available here.
PDF is available here.
Abstract
We directly compared individually isolated CMCs to human fetal, neonatal, adult atrial and ventricular heart tissues. Real-time qPCR analysis of mRNA levels and protein staining of ion channels and cardiac markers showed in general a similar expression pattern in CMCs and human heart. Moreover, a si...
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PMID: 20802012
PDF is available here.
PDF is available here.
Hypertension Research (33)10 2010
Abstract
We tested the hypothesis that levosimendan, an inodilator that acts through calcium sensitization, opening of ATP-dependent potassium channels and phosphodiesterase III inhibition, improves cardiac function and survival in double transgenic rats harboring human renin and angiotensinogen genes (dTGRs...
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PMID: 20811386
PDF is available here.
PDF is available here.
Abstract
Abstract
Epilepsy and seizures can have a dramatic effect on the autonomic nervous system by involvement of the central autonomic control centers. The peri-ictal changes can lead to short-term alteration of cardiac functions in patients with seizures, and are partially hemispheric specific. Changes in heart...
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PMID: 20688543
PDF is available here.
PDF is available here.
Abstract
A multicenter trial involving 30 newborns with post-hypoxic myocardial lesions associated with I-II degree cerebral ischemia has revealed that the inclusion of cytoflavin infusions into the complex standard treatment leads, besides the improvement of general clinical status, to significantly more ra...
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PMID: 21254508
PDF is available here.
PDF is available here.
Abstract
Biological computations like electrocardiological modelling and simulation usually require high-performance computing environments. This paper introduces an implementation of parallel computation for computer simulation of electrocardiograms (ECGs) in a personal computer environment with an Intel CP...
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PMID: 20674066
PDF is available here.
PDF is available here.
American Naturalist (176)4 2010
Abstract
We examined embryonic development of fence lizards (Sceloporus undulatus) from three populations (Indiana, Mississippi, and Florida) that occur at different latitudes and therefore experience different temperatures and season lengths. These data reveal countergradient variation: at identical tempera...
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PMID: 20718676
PDF is available here.
PDF is available here.
La Revue du praticien (60)7 2010
Abstract
Heart failure is the common and final pathway of all the cardiovascular diseases. Its pathophysiology has progressed during the last 20 years; although the inotropy was the main target in the 80', new paradigms have emerged such as remodelling, neurohormonal activation, and more recently desynchroni...
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PMID: 21033483
PDF is available here.
PDF is available here.
Circulation (122)12 2010
Abstract
Journal of Proteomics (73)10 2010
Abstract
Exercise has been shown to improve function of the left ventricle (LV) following myocardial infarction (MI). The mechanisms to explain this benefit have not been fully delineated, but may involve improved mechanics resulting in unloading effects and increased endothelial nitric oxide...
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PMID: 20601275
PDF is available here.
PDF is available here.
Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences (368)1925 2010
Abstract
We discuss the use of a parametric modelling toolkit, called Nimrod, that makes it possible both to explore model behaviour as parameters are changed and also to tune parameters by optimizing model output. Importantly, Nimrod leverages computers on the Grid, accelerating experiments by using availab...
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PMID: 20643684
PDF is available here.
PDF is available here.
Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences (368)1925 2010
Abstract
Intracellular Ca(2+) dynamics provides excitation-contraction coupling in cardiac myocytes. Under pathological conditions, spontaneous Ca(2+) release events can lead to intracellular Ca(2+) travelling waves, which can break, giving transitory or persistent intracellular re-entrant Ca(2+) scroll wave...
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PMID: 20643687
PDF is available here.
PDF is available here.
Birth Defects Research (90)3 2010
Abstract
We focus on branching of the lung airways and bending of the heart tube to describe examples of mechanical and physical cues that guide cell fate decisions and organogenesis. We highlight recent technological advances to measure tissue elasticity and endogenous mechanical stresses in real time durin...
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PMID: 20860059
PDF is available here.
PDF is available here.
Birth Defects Research (90)3 2010
Abstract
We focus on branching of the lung airways and bending of the heart tube to describe examples of mechanical and physical cues that guide cell fate decisions and organogenesis. We highlight recent technological advances to measure tissue elasticity and endogenous mechanical stresses in real time durin...
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PMID: 20860059
PDF is available here.
PDF is available here.
Abstract
We summarize both the cardiogenic transcriptional network and the role of morphogens involved in early cardiogenesis. We review protocols of cardiac differentiation of pluripotent stem cells so far available. We finally discuss the translation of basic stem cell research into clinical applications....
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PMID: 20214559
PDF is available here.
PDF is available here.
FEBS Journal (277)18 2010
Abstract
We found that hypoxia/SD induced nuclear factor kappa Bp65-dependent IL-1β and TNF-α transcription. Furthermore, hypoxia/SD stimulated the translation of pro-IL-1β and its processing to mature IL-1β, although the translation of TNF-α was unchanged. Unexpectedly, the release of IL-1β and TNF-α...
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PMID: 20681988
PDF is available here.
PDF is available here.
Abstract
The aim of this study was to develop in situ hybridization for detection of Mycoplasma hyorhinis in formalin-fixed, paraffin-wax-embedded tissues from pigs with polyserositis. M. hyorhinis was isolated from the spleen (2 pigs) and pericardium (1 pig). M. hyorhinis DNA was detected 16 out of 20 pigs...
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PMID: 20424392
PDF is available here.
PDF is available here.
Nature Genetics (42)9 2010
Abstract
What is the best way to identify regulatory DNA sequences such as enhancers, promoters, insulators and silencers? A new study shows that specific binding by a coactivator protein identifies enhancers that are invisible to common detection methods based on evolutionary constraint....
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PMID: 20802475
PDF is available here.
PDF is available here.
Abstract
I and II and augmented unipolar limb leads aVL and aVF. The dominant pattern ofwaveforms of the QRS complexes were QS in leads I, II, III, and aVF, whereas in leads aVR and aVL, the pattern was always R. The T wave was slightly positive in leads I, II, and aVF. The average value of the heart mean el...
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PMID: 20945639
PDF is available here.
PDF is available here.