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Antigen-Presenting Cells (2):
Recent article
Antigen-Presenting Cells
New England Journal of Medicine (365)12 2011
Abstract
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Abstract
We have shown, both in vitro and in vivo, that NF-κB blockade on DCs by andrographolide or rosiglitazone can significantly enhance the tolerogenic capacity of DCs. Furthermore, we have observed that expression ratio of the activating FcγRIII or the inhibitory FcγRIIb is determinant for the tolero...
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PMID: 20941620
PDF is available here.
PDF is available here.
Abstract
Cancer Biology & Therapy (11)10 2011
Abstract
We developed a new tumor vaccine, FAPτ-MT, which was produced by conjugating 1-MT to a tumor associated antigen, fibroblast activation protein α (FAPα). The results in vitro confirmed that 1-MT could be dissociated from the FAPτ-MT vaccine and inhibit intracellular IDO activity. In an FAPα-posi...
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PMID: 21372637
PDF is available here.
PDF is available here.
Abstract
We have used a mouse transplantation model to demonstrate the presence of cells expressing both donor MHC class I/II molecules, and a donor MHC class II peptide in the context of a recipient MHC class II molecule. This would allow indirectly activated CD4(+) T cells to regulate directly activated CD...
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PMID: 21401861
PDF is available here.
PDF is available here.
Abstract
We offer a new perspective on how immune responses are regulated. We do not cover how they are turned on and off, but focus instead on the second major aspect of an immune response: the control of effector class. Although it is generally thought that the class of an immune response is tailored to fi...
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PMID: 21350581
PDF is available here.
PDF is available here.
Abstract
We describe a possible genetic impact on the expression level of the histamine H4 receptor and summarize the current data regarding the activity of the histamine H4 receptor on the key effector cells in atopic dermatitis. We do so in the context of whether the histamine H4 receptor offers a novel ta...
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PMID: 21104170
PDF is available here.
PDF is available here.
Abstract
We demonstrate here the impact of CD11(+)DCs on the antigen-specific differentiation of CD4(+)Foxp3(+)iT(regs) from CD4(+)Foxp3(-)T cells under steady-state and inflammatory conditions. CD11c(+)DCs promoted the transforming growth factor (TGF)-β1-mediated conversion of CD4(+)Foxp3(-)T cells into CD...
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PMID: 20941606
PDF is available here.
PDF is available here.
Abstract
We provide the tools to study PDC development from bone marrow cultures, their antigen presentation properties, and their interactions with Treg under a tolerogenic setting of sterile inflammation....
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PMID: 20941607
PDF is available here.
PDF is available here.
Abstract
The eye is one of the immune privilege sites of the body that is consequently protected from the detrimental and potentially blinding influences of immunologic inflammation. Within the eye, the anterior chamber has been recognized for its immune privilege property for many years now; however, a simi...
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PMID: 20941626
PDF is available here.
PDF is available here.
Abstract
We generated two transgenic (Tg) murine models with constitutive Tl1a expression in either lymphoid or myeloid cells. Compared to wildtype (WT) mice, constitutive expression of Tl1a in either lymphoid or myeloid cells showed mild patchy inflammation in the small intestine, which was more prominent i...
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PMID: 21264313
PDF is available here.
PDF is available here.
Abstract
We have evaluated the immunostimulatory role of the highly-conserved outer membrane lipoprotein P6 from non-typeable Haemophilus influenzae (NTHI) to determine whether the presence of the lipid motif plays a critical role on its immunogenicity. We undertook a systematic analysis of the role that the...
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PMID: 21611194
PDF is available here.
PDF is available here.
Abstract
EMBO Journal (29)23 2010
Abstract
We show that, during activation of human T lymphocytes by APCs, chemokines and LFA-1 establish cell polarity independently of TCR triggering. Chemokine-induced LFA-1 activation results in fast recruitment of MTOC and mitochondria towards the potential APC, a process required to amplify TCR Ca(2+) si...
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PMID: 20953162
PDF is available here.
PDF is available here.
Nature Medicine (16)12 2010
Abstract
We observed increased ATP concentrations in the peritoneal fluid after total body irradiation, and during the development of GVHD in mice and in humans. Stimulation of antigen-presenting cells (APCs) with ATP led to increased expression of CD80 and CD86 in vitro and in vivo and actuated a cascade of...
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PMID: 21102458
PDF is available here.
PDF is available here.
Abstract
We studied 5 individuals who had survived EBV infection and found CD8(+) T-cell responses numerically comparable with healthy donors. However, further investigation of in vitro-derived CD8(+) T-cell clones established from 2 of these donors showed they efficiently recognized SLAM ligand-negative tar...
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PMID: 20644117
PDF is available here.
PDF is available here.
Abstract
High-fiber diets have been shown to reduce plasma concentrations of inflammation markers. Increased production of fermentation-derived short-chain fatty acids (SCFAs) is one of the factors that could exert these positive effects. This review examines the effects of SCFAs on immune cells and discusse...
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PMID: 20823773
PDF is available here.
PDF is available here.
Abstract
We highlight how adjuvants can be used to influence the magnitude and alter the quality of the adaptive response in order to provide maximum protection against specific pathogens. Despite the impressive success of currently approved adjuvants for generating immunity to viral and bacterial infections...
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PMID: 21029960
PDF is available here.
PDF is available here.
Abstract
We show, using single-cell biochemical analyses, that tolerance is characterized by transient signaling events downstream of T-cell receptor engagement in the mammalian target of rapamycin (mTOR) and NF-κB pathways. Parallel studies done by live cell imaging show that the key difference between tol...
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PMID: 20921406
PDF is available here.
PDF is available here.
Innate Immunity (16)5 2010
Abstract
We demonstrate that macrophages and dendritic cells (DCs), the most prevalent professional antigen-presenting cells involved in the formation of abscesses, secrete Interleukin (IL)-6 and are incorporated in the abscess capsule. Sp1 inhibits apoptosis of CD4+ T-cells and causes IL-17 expression by CD...
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PMID: 19897529
PDF is available here.
PDF is available here.
Abstract
We observed the positive correlations between the levels of IL-12 and IFN-γ as well as IL-12 and IL-10 in cultures of mononuclear cells. As IL-10 and IL-12 are produced by dendritic cells and activated macrophages, we examined their contribution to the production of these cytokines. Macrophages, CD...
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PMID: 20819132
PDF is available here.
PDF is available here.
Journal of Immunology (185)7 2010
Abstract
We studied the role of Tregs on IL-17 production in the absence of exogenous cytokines and insults. Using in vitro and in vivo approaches, we determined that under neutral conditions, simultaneous activation of Tregs and naive CD4(+) conventional T cells in the presence of APCs resulted in conversio...
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PMID: 20817874
PDF is available here.
PDF is available here.
Journal of Immunology (185)7 2010
Abstract
We investigated the role of host APCs in the suppression of GVHD by donor Tregs. We found that alloantigen expression by the host APCs is necessary and sufficient for induction of GVHD protection by donor Tregs. This requirement was independent of their effect on the maintenance of Treg numbers and...
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PMID: 20810991
PDF is available here.
PDF is available here.
Abstract
The 'Nanopatch' (NP) comprises arrays of densely packed projections with a defined geometry and distribution designed to physically target vaccines directly to thousands of epidermal and dermal antigen presenting cells (APCs). These miniaturized arrays are two orders of magnitude smaller than standa...
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PMID: 20665754
PDF is available here.
PDF is available here.
Nature Immunology (11)8 2010
Abstract
We show that MAIT cells were activated by cells infected with various strains of bacteria and yeast, but not cells infected with virus, in both humans and mice. This activation required cognate interaction between the invariant TCR and MR1, which can present a bacteria-derived ligand. In humans, we...
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PMID: 20581831
PDF is available here.
PDF is available here.
Abstract
Dendritic cells (DCs) are potent antigen-presenting cells capable of initiating a primary immune response and possess the ability to activate T cells and stimulate the growth and differentiation of B cells. DCs provide a direct connection between innate and adaptive immune response,...
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PMID: 20085824
PDF is available here.
PDF is available here.
Molecular Membrane Biology (27)4-6 2010
Abstract
We employ the phase-sensitive membrane dye di-4-ANEPPDHQ together with a variety of spectrally-resolved microscopy techniques, including 2-channel ratiometric TIRF microscopy and fluorescence lifetime imaging, to characterize membrane order at the T cell immunological synapse at high spatial and tem...
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PMID: 20540668
PDF is available here.
PDF is available here.
Abstract
Advances in understanding host innate/adaptive immunity and abrogation of immune privilege in ocular viral and bacterial infections have been accomplished using animal models. In Pseudomonas aeruginosa keratitis, mouse models have shown that IL-12-driven IFN-gamma production in Th1 responder strains...
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PMID: 20662654
PDF is available here.
PDF is available here.
Immunobiology (215)8 2010
Abstract
We will focus on apoptotic mechanisms of immunosuppression mediated by cannabinoids on different immune cell populations and discuss how activation of CB2 provides a novel therapeutic modality against inflammatory and autoimmune diseases as well as malignancies of the immune system, without exerting...
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PMID: 19457575
PDF is available here.
PDF is available here.
Immunology (130)4 2010
Abstract
We and others previously showed that ribosomal proteins, targeted in autoimmune disease, are also targets of anti-tumour T-cell responses. We asked whether particular properties of ribosomal proteins such as incorporation into RNP complexes or sub-cellular localization enhance ribosomal protein pres...
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PMID: 20331471
PDF is available here.
PDF is available here.
Journal of Nutrition (140)8 2010
Abstract
Vitamin A has been long associated with immune system competence. Vitamin A deficiency is known to compromise many aspects of both innate and adaptive immune responses. Recent advances in retinol uptake and metabolism have identified the antigen presenting cell (APC) as a central immune cell capable...
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PMID: 20554902
PDF is available here.
PDF is available here.
Abstract
The serum levels of sHSP60 in patients with chronic hepatitis B were statistically significantly higher than those in patients with chronic hepatitis C (P<.01), and the levels of sHSP60 were correlated with the HBV DNA levels (r = 0.532; P<.001) but not with the alanine aminotransferase levels. More...
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PMID: 20533879
PDF is available here.
PDF is available here.
Abstract
We discuss the advantages and shortcomings of a novel non-cell-based 'killer artificial antigen-presenting cell' strategy, developed to overcome obstacles related to current cell-based approaches for the treatment of T-cell-mediated autoimmunity....
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PMID: 20636007
PDF is available here.
PDF is available here.
DNA and Cell Biology (29)7 2010
Abstract
CD86 (B7-2), one of the costimulatory molecules on antigen-presenting cells, plays essential roles not only in autoimmunity and transplantation but also in tumor immunity. The purpose of this study was to investigate whether CD86 gene polymorphism was involved in predisposing an individual to colore...
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PMID: 20380573
PDF is available here.
PDF is available here.
Abstract
We demonstrate that CD4(+) memory T-cell responses can be terminated when cognate antigen is transgenically expressed in steady-state DC. Transfer of in-vitro-generated CD4(+) memory T cells establishes, in nontransgenic recipients, a stable and readily recalled memory response to cognate antigen. I...
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PMID: 20405475
PDF is available here.
PDF is available here.
Abstract
We summarize what is known regarding basophil function in allergy and parasite infection, examine the novel Ag-presenting function of basophils and discuss potential clinical implications of this finding....
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PMID: 20518033
PDF is available here.
PDF is available here.
Abstract
We describe a novel mouse antigen (Ag)-presenting cell (APC), designated late-activator APC (LAPC). After pulmonary influenza A (H1N1) virus infection, LAPCs enter the lungs, capture viral Ag, and subsequently migrate to the draining lymph node (DLN) and spleen, with delayed kinetics relative to den...
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PMID: 20547825
PDF is available here.
PDF is available here.
Journal of Virology (84)13 2010
Abstract
We sought to determine their importance in the generation of immunity to a recombinant vaccine vector fowlpox virus (FPV). In analyzing the role of type I IFNs in immunity to FPV, we show that they are critical to the secretion of a number of innate and proinflammatory cytokines, including type I IF...
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PMID: 20410285
PDF is available here.
PDF is available here.
Abstract
We report the generation of a recombinant influenza virus carrying a GFP reporter gene in the NS segment (NS1-GFP virus). Although attenuated when compared with wild-type virus, the NS1-GFP virus replicates efficiently in murine lungs and shows pathogenicity in mice. Using whole-organ imaging and fl...
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PMID: 20534532
PDF is available here.
PDF is available here.
Abstract
While defective phagocytosis represents a distinctive feature of monocyte function in some patients with SLE, aberrant activation of the Mo/Mphi system may be a more appropriate concept to encompass the broad spectrum of Mo/Mphi disorders in SLE. Aberrant function of lupus Mo/Mphi appears to play a...
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PMID: 19147182
PDF is available here.
PDF is available here.
PLoS Pathogens (6)5 2010
Abstract
We show that the complete development of protective CD8+ T cell responses requires prolonged antigen presentation. Using TCR transgenic cells specific for the malaria circumsporozoite protein, a leading vaccine candidate, we found that sporozoite antigen persists for over 8 weeks after immunization-...
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PMID: 20463809
PDF is available here.
PDF is available here.
Chinese Medical Journal (123)7 2010
Abstract
We found that RAPA can convert peripheral CD4(+)CD25(-) naive T Cells to CD4(+)Foxp3(+) Treg cells using B cells as APCs, and this subtype of Treg can potently suppress Teff proliferation and maintain antigenic specificity. CONCLUSION: Our findings provide evidence that RAPA induces Treg cell conver...
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PMID: 20497692
PDF is available here.
PDF is available here.
Abstract
Our protocol delivers pure hybrid cell preparations with strong immunostimulatory potential. In subsequent experiments, the ability of hybrid cells to stimulate specific antitumoral T cell responses must be tested in vivo....
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PMID: 20309577
PDF is available here.
PDF is available here.
Seminars in Hematology (47)2 2010
Abstract
Rituximab, a chimeric monoclonal antibody that depletes B cells by binding to the CD20 cell-surface antigen, has been investigated extensively in autoimmune disorders. Following the encouraging results in immune thrombocytopenia (ITP), the use of this agent was explored in other autoimmune hematolog...
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PMID: 20350664
PDF is available here.
PDF is available here.
Human Gene Therapy (21)4 2010
Abstract
We apply PB transposition to express a chimeric antigen receptor (CAR) in primary human T cells. We demonstrate that T cells electroporated to introduce the PB transposon and transposase stably express CD19-specific CAR and when cultured on CD19(+) artificial antigen-presenting cells, numerically ex...
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PMID: 19905893
PDF is available here.
PDF is available here.
Cell Research (20)4 2010
Abstract
We demonstrate an unexpected finding that high doses of alpha-GC exacerbated, rather than ameliorated, EAE. Similar results were observed when MOG(35-55)-specific T cells treated with high-dose alpha-GC were transferred into naïve syngeneic recipient mice. Further study showed that high doses of al...
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PMID: 20084083
PDF is available here.
PDF is available here.
Journal of Immunology (184)7 2010
Abstract
Our findings lead to a model in which oxidation of carbohydrates from encapsulated microbes facilitates adaptive immune responses against microbial protein and carbohydrate Ags through promoting Ag processing for MHC II-mediated presentation as well as innate responses against released microbial DNA...
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PMID: 20200279
PDF is available here.
PDF is available here.
Abstract
We investigated whether collagen-specific Tol-APCs could induce suppression of CIA. We observed that Tol-APCs could suppress the development and severity of CIA and delay the onset of CIA. Treatment of Tol-APCs reduced the number of IFN-gamma- and IL-17-producing CD4(+) T cells and increased IL-4- a...
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PMID: 20164680
PDF is available here.
PDF is available here.
Anticancer Research (30)3 2010
Abstract
The antibody response to NY-ESO-1 was more frequent (20%) and strong compared to other investigated antigens, and was associated with progressive disease. Interestingly, it was also detected in several BPH patients (9%). Feeding dendritic cells with NY-ESO-1-expressing yeast cells resulted in effici...
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PMID: 20393012
PDF is available here.
PDF is available here.
Journal of Endodontics (36)3 2010
Abstract
These results suggest the signal of pulp inflammation induces neuronal activation in the CNS.
Copyright (c) 2010 American Association of Endodontists. Published by Elsevier Inc. All rights reserved....
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PMID: 20171363
PDF is available here.
PDF is available here.
Abstract
Immunology (129)3 2010
Abstract
We have previously shown that intake of antigenic dietary protein is critical for inducing maturation of the immune system as well as for the development of T helper type 1 (Th1) immunity. In this study, we show that administration of an amino acid (aa)-based diet during the development of the immun...
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PMID: 20002788
PDF is available here.
PDF is available here.
Immunology (129)3 2010
Abstract
We have previously shown that intake of antigenic dietary protein is critical for inducing maturation of the immune system as well as for the development of T helper type 1 (Th1) immunity. In this study, we show that administration of an amino acid (aa)-based diet during the development of the immun...
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PMID: 20002788
PDF is available here.
PDF is available here.
Immunology (129)3 2010
Abstract
We have previously shown that intake of antigenic dietary protein is critical for inducing maturation of the immune system as well as for the development of T helper type 1 (Th1) immunity. In this study, we show that administration of an amino acid (aa)-based diet during the development of the immun...
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PMID: 20002788
PDF is available here.
PDF is available here.
Immunology (129)3 2010
Abstract
We have previously shown that intake of antigenic dietary protein is critical for inducing maturation of the immune system as well as for the development of T helper type 1 (Th1) immunity. In this study, we show that administration of an amino acid (aa)-based diet during the development of the immun...
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PMID: 20002788
PDF is available here.
PDF is available here.
Immunology (129)3 2010
Abstract
We have previously shown that intake of antigenic dietary protein is critical for inducing maturation of the immune system as well as for the development of T helper type 1 (Th1) immunity. In this study, we show that administration of an amino acid (aa)-based diet during the development of the immun...
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PMID: 20002788
PDF is available here.
PDF is available here.
Immunology (129)3 2010
Abstract
We have previously shown that intake of antigenic dietary protein is critical for inducing maturation of the immune system as well as for the development of T helper type 1 (Th1) immunity. In this study, we show that administration of an amino acid (aa)-based diet during the development of the immun...
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PMID: 20002788
PDF is available here.
PDF is available here.
Abstract
Macrophages are central mediators of biomaterial-associated wound healing. Dendritic cells (DCs) link innate and adaptive immunity and are important in the context of the host response to combination products. Starting with human peripheral blood mononuclear cells (PBMCs), DCs were derived from mono...
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PMID: 19274715
PDF is available here.
PDF is available here.
Audio, Transactions of the IRE Professional Group on (Chapter 16) 2010
Abstract
The first issue in selecting a system for antigen-presentation experiments is to define the appropriate type of antigen-presenting cell (APC) to study. For some experiments, crude preparations such as splenocytes or peripheral blood mononuclear cells (PBMCs) may suffice to provide APC function for s...
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PMID: 20143315
PDF is available here.
PDF is available here.
Audio, Transactions of the IRE Professional Group on (Chapter 16) 2010
Abstract
Antigen processing and presentation experiments can be done with a wide variety of antigen-presenting cells (APCs). Most experiments will use one of the "professional" APC types: dendritic cells (DCs), macrophages, and B lymphocytes. Other types of cells may be used for antigen presentation in some...
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PMID: 20143316
PDF is available here.
PDF is available here.