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Hepatic Stellate Cells (0):
Recent article
Hepatic Stellate Cells
Nature Medicine (17)12 2011
Abstract
We report that fibrogenic hepatic stellate cells (HSCs) in the liver are negative regulators of hepatocyte regeneration. This negative regulatory function requires stimulation of the 5-hydroxytryptamine 2B receptor (5-HT(2B)) on HSCs by serotonin, which activates expression of transforming growth fa...
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PMID: 22120177
PDF is available here.
PDF is available here.
| < More recent | Older article > |
Nature Medicine (17)12 2011
Abstract
We report that fibrogenic hepatic stellate cells (HSCs) in the liver are negative regulators of hepatocyte regeneration. This negative regulatory function requires stimulation of the 5-hydroxytryptamine 2B receptor (5-HT(2B)) on HSCs by serotonin, which activates expression of transforming growth fa...
|
PMID: 22120177
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We report that fibrogenic hepatic stellate cells (HSCs) in the liver are negative regulators of hepatocyte regeneration. This negative regulatory function requires stimulation of the 5-hydroxytryptamine 2B receptor (5-HT(2B)) on HSCs by serotonin, which activates expression of transforming growth fa...
|
PMID: 22120177
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We report that fibrogenic hepatic stellate cells (HSCs) in the liver are negative regulators of hepatocyte regeneration. This negative regulatory function requires stimulation of the 5-hydroxytryptamine 2B receptor (5-HT(2B)) on HSCs by serotonin, which activates expression of transforming growth fa...
|
PMID: 22120177
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We report that fibrogenic hepatic stellate cells (HSCs) in the liver are negative regulators of hepatocyte regeneration. This negative regulatory function requires stimulation of the 5-hydroxytryptamine 2B receptor (5-HT(2B)) on HSCs by serotonin, which activates expression of transforming growth fa...
|
PMID: 22120177
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We report that fibrogenic hepatic stellate cells (HSCs) in the liver are negative regulators of hepatocyte regeneration. This negative regulatory function requires stimulation of the 5-hydroxytryptamine 2B receptor (5-HT(2B)) on HSCs by serotonin, which activates expression of transforming growth fa...
|
PMID: 22120177
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We report that fibrogenic hepatic stellate cells (HSCs) in the liver are negative regulators of hepatocyte regeneration. This negative regulatory function requires stimulation of the 5-hydroxytryptamine 2B receptor (5-HT(2B)) on HSCs by serotonin, which activates expression of transforming growth fa...
|
PMID: 22120177
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We report that fibrogenic hepatic stellate cells (HSCs) in the liver are negative regulators of hepatocyte regeneration. This negative regulatory function requires stimulation of the 5-hydroxytryptamine 2B receptor (5-HT(2B)) on HSCs by serotonin, which activates expression of transforming growth fa...
|
PMID: 22120177
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We report that fibrogenic hepatic stellate cells (HSCs) in the liver are negative regulators of hepatocyte regeneration. This negative regulatory function requires stimulation of the 5-hydroxytryptamine 2B receptor (5-HT(2B)) on HSCs by serotonin, which activates expression of transforming growth fa...
|
PMID: 22120177
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We report that fibrogenic hepatic stellate cells (HSCs) in the liver are negative regulators of hepatocyte regeneration. This negative regulatory function requires stimulation of the 5-hydroxytryptamine 2B receptor (5-HT(2B)) on HSCs by serotonin, which activates expression of transforming growth fa...
|
PMID: 22120177
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We report that fibrogenic hepatic stellate cells (HSCs) in the liver are negative regulators of hepatocyte regeneration. This negative regulatory function requires stimulation of the 5-hydroxytryptamine 2B receptor (5-HT(2B)) on HSCs by serotonin, which activates expression of transforming growth fa...
|
PMID: 22120177
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We report that fibrogenic hepatic stellate cells (HSCs) in the liver are negative regulators of hepatocyte regeneration. This negative regulatory function requires stimulation of the 5-hydroxytryptamine 2B receptor (5-HT(2B)) on HSCs by serotonin, which activates expression of transforming growth fa...
|
PMID: 22120177
PDF is available here.
PDF is available here.
Biomaterials (32)32 2011
Abstract
We have developed a size-controllable spheroidal hepatosphere and heterosphere model by mono-culturing of primary hepatocytes and by co-culturing primary hepatocytes and hepatic stellate cells (HSCs). We demonstrated that uniform-sized heterospheres, which self-aggregated from primary hepatocytes an...
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PMID: 21813175
PDF is available here.
PDF is available here.
Abstract
We identify the chemokine CCL5 (also known as RANTES), which is induced in murine and human liver after injury, as a central mediator of this interaction. First, we showed in patients with liver fibrosis that CCL5 haplotypes and intrahepatic CCL5 mRNA expression were associated with severe liver fib...
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PMID: 20978355
PDF is available here.
PDF is available here.
Abstract
Hepatocyte injury is ubiquitous in clinical practice, and the mode of cell death associated with this injury is often apoptosis, especially by death receptors. Information from experimental systems demonstrates that hepatocyte apoptosis is sufficient to cause liver hepatic fibrogenesis. The mechanis...
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PMID: 20960379
PDF is available here.
PDF is available here.
Thrombosis and Haemostasis (104)3 2010
Abstract
Although ADAMTS13, the von Willebrand factor (VWF)-cleaving protease, is expressed in a range of tissues, the physiological significance of tissue-specific ADAMTS13 alternative splicing isoforms have yet to be clarified. Screening a panel of human tissues and cell lines revealed a spliced ADAMTS13 t...
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PMID: 20664912
PDF is available here.
PDF is available here.
Abstract
Almost 80% of hepatocellular carcinoma (HCC) cases are associated with chronic hepatitis and cirrhosis resulting from inflammation and fibrosis. A three-step process of "inflammation-fibrosis-carcinoma" is believed to be involved in hepatocarcinogenesis. The activation of hepatic ste...
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PMID: 20652939
PDF is available here.
PDF is available here.
Abstract
It has been documented that chemokines can positively regulate liver regeneration at the tissue level after partial hepatectomy. However, the precise mechanism of the effects of chemokines on regeneration at the cellular level remains poorly defined. In this study, 8 cell types from rat regenerating...
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PMID: 20725148
PDF is available here.
PDF is available here.
Abstract
We summarize current knowledge on the genetic and functional importance of the chemokine network in injury and highlight their potential for intervening in the inflammation and fibrosis that drives liver disease progression.
Copyright Thieme Medical Publishers....
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PMID: 20665374
PDF is available here.
PDF is available here.
Abstract
Liver injury causes vascular disorganization and local tissue hypoxia starting early in disease course. In this context, hypoxia acts not only as an aggravating factor of cell damage and inflammation, but also as an inhibitor of liver regeneration, a major stimulus of angiogenesis and fibrogenesis,...
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PMID: 20665378
PDF is available here.
PDF is available here.
Abstract
Fibrosis is a common feature of chronic liver injury and is initiated by cell death inside the liver. Hepatocyte death results in apoptotic bodies and other cellular debris, which are phagocytosed by hepatic stellate cells (HSCs), resulting in their activation, proliferation, differentiation, and ma...
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PMID: 20665375
PDF is available here.
PDF is available here.
Abstract
We review mechanisms by which TLR4 and TLR4 ligands from the intestinal microbiota contribute to hepatic injury, inflammation, hepatic stellate cell activation, and fibrosis.
Copyright Thieme Medical Publishers....
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PMID: 20665376
PDF is available here.
PDF is available here.
Abstract
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology (18)8 2010
Abstract
I synthesis by hepatic stellate cells. Hydroxyproline excreted by LX2 was increased by CYP2E1. COL-1mRNA had no difference among the groups (F=0.73, P>0.05)....
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PMID: 20825710
PDF is available here.
PDF is available here.
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology (18)8 2010
Abstract
I significantly increased HSCs migration: for haptotactic migration cells: 127.20+/-6.47 VS 102.93+/-1.01, F=41.01, P is less than 0.05; for chemotactic migration cells: 201.52+/-11.28 vs 102.93+/-1.01, F=36.49, P<0.05; however, collagen type IV had no effect on HSCs migration. Serum-starved, untrea...
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PMID: 20825711
PDF is available here.
PDF is available here.
Abstract
An asymptomatic 17-month-old male infant was incidentally found to have a hepatic mass measuring 12cm in maximum dimension. The histopathologic appearance of the resected mass was that of a typical mesenchymal hamartoma. Spindle cells that comprised a predominant cellular constituent of the lesion w...
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PMID: 20399572
PDF is available here.
PDF is available here.
Abstract
We first investigated the effects of XN on hepatocytes and hepatic stellate cells (HSC), the central mediators of liver fibrogenesis. XN inhibited the activation of primary human HSC and induced apoptosis in activated HSC in vitro in a dose dependent manner (0-20 microM). In contrast, XN doses as hi...
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PMID: 20087858
PDF is available here.
PDF is available here.
Abstract
We examined the dynamics of liver repair by using a reproducible liver injury model in plasminogen gene-deficient mice and their wild-type littermates.
Liver injury was induced by photochemical reaction and the subsequent responses were histologically analyzed.
In wild-type animals, the area of the...
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PMID: 20345714
PDF is available here.
PDF is available here.
Gastroenterology (139)1 2010
Abstract
In a mouse model of NASH, TLR9 signaling induces production of IL-1beta by Kupffer cells, leading to steatosis, inflammation, and fibrosis.
Copyright 2010 AGA Institute. Published by Elsevier Inc. All rights reserved....
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PMID: 20347818
PDF is available here.
PDF is available here.
Hepatology (52)1 2010
Abstract
We identified two novel mediators of MF-HSC accumulation: Ras-related C3 botulinum toxin substrate 1 (Rac1) and Hedgehog (Hh). It is unclear whether Rac1 and Hh interact to regulate the accumulation of MF-HSCs. We evaluated the hypothesis that Rac1 promotes activation of the Hh pathway, thereby stim...
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PMID: 20578145
PDF is available here.
PDF is available here.
Hepatology (52)1 2010
Abstract
We identified two novel mediators of MF-HSC accumulation: Ras-related C3 botulinum toxin substrate 1 (Rac1) and Hedgehog (Hh). It is unclear whether Rac1 and Hh interact to regulate the accumulation of MF-HSCs. We evaluated the hypothesis that Rac1 promotes activation of the Hh pathway, thereby stim...
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PMID: 20578145
PDF is available here.
PDF is available here.
Hepatology (52)1 2010
Abstract
We identified two novel mediators of MF-HSC accumulation: Ras-related C3 botulinum toxin substrate 1 (Rac1) and Hedgehog (Hh). It is unclear whether Rac1 and Hh interact to regulate the accumulation of MF-HSCs. We evaluated the hypothesis that Rac1 promotes activation of the Hh pathway, thereby stim...
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PMID: 20578145
PDF is available here.
PDF is available here.
Hepatology (52)1 2010
Abstract
We identified two novel mediators of MF-HSC accumulation: Ras-related C3 botulinum toxin substrate 1 (Rac1) and Hedgehog (Hh). It is unclear whether Rac1 and Hh interact to regulate the accumulation of MF-HSCs. We evaluated the hypothesis that Rac1 promotes activation of the Hh pathway, thereby stim...
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PMID: 20578145
PDF is available here.
PDF is available here.
Hepatology (52)1 2010
Abstract
We identified two novel mediators of MF-HSC accumulation: Ras-related C3 botulinum toxin substrate 1 (Rac1) and Hedgehog (Hh). It is unclear whether Rac1 and Hh interact to regulate the accumulation of MF-HSCs. We evaluated the hypothesis that Rac1 promotes activation of the Hh pathway, thereby stim...
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PMID: 20578145
PDF is available here.
PDF is available here.
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology (18)7 2010
Abstract
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition (41)4 2010
Abstract
To investigate the effect of visfatin on the expression of basic fibroblast growth factor (FGF-2) in rat hepatic stellate cells (HSCs).
Culture-activated rat HSCs were incubated with visfatin under different dose (50, 100, 200 ng/mL) for 6, 12, 24 and 36 hours respect...
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PMID: 20848781
PDF is available here.
PDF is available here.
Abstract
We demonstrate that hepatic stellate cells (HSC) isolated from Lewis rats have in vitro antigen-presentation cell (APC) functionality and are able to process and present exogenous antigens. We show activation of a major histocompatibility complex II (RT1BI)-restricted T-cell hybridoma specific for g...
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PMID: 20403338
PDF is available here.
PDF is available here.
Abstract
We investigated the protective effect of resveratrol on hepatic injury induced by dimethylnitrosamine (DMN) in rats. Oral administration of resveratrol (20 mg/kg daily for 4 weeks) remarkably prevented the DMN-induced loss in body and liver weight, and inhibited the elevation of serum alanine transa...
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PMID: 20607498
PDF is available here.
PDF is available here.
Abstract
We observed the effect of short hairpin RNA (shRNA) expression vectors targeting rat AngII on collagen synthesis in hepatic stellate cells (HSCs). According to rat AngII gene sequences, three AngII targeted shRNA expression vectors were designed and constructed. Using liposomes as transfection reage...
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PMID: 20372825
PDF is available here.
PDF is available here.
Chinese Medical Journal (123)6 2010
Abstract
The differentially expressed genes identified included six upregulated genes and six downregulated genes. The representative upregulated genes included short chain dehydrogenase (CY5/CY3 = 2.265) and pulmonary surfactant protein A1 (CY5/CY3 = 2.036). The significant downregulated gene encoded hepati...
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PMID: 20368094
PDF is available here.
PDF is available here.
Hepatology (52)1 2010
Abstract
We identified two novel mediators of MF-HSC accumulation: Ras-related C3 botulinum toxin substrate 1 (Rac1) and Hedgehog (Hh). It is unclear whether Rac1 and Hh interact to regulate the accumulation of MF-HSCs. We evaluated the hypothesis that Rac1 promotes activation of the Hh pathway, thereby stim...
|
PMID: 20578145
PDF is available here.
PDF is available here.
Abstract
Circulating levels of the fibronectin isoforms were significantly higher in patients with chronic hepatitis C compared to healthy controls [oncofetal fibronectin (oFN) 2.45 +/- 0.17 versus 1.76 +/- 0.16 mg/l, P < 0.005; extra domain-A (EDA) 1.05 +/- 0.06 versus 0.86 +/- 0.06 mg/l, P < 0.05; and extr...
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PMID: 20017652
PDF is available here.
PDF is available here.
Abstract
There was no significant reduction in fibrosis scores after 24+/-18 months (2.5+/-0.93 vs. 2.0+/-0.53, P=0.2012). There was an important decrease in inflammation: portal (2.6+/-0.74 vs. 1.3+/-0.89, P=0.0277), periportal/periseptal (3.0+/-0.76 vs. 1.4+/-1.06, P=0.0277), and lobular (2.8+/-1.04 vs. 0....
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PMID: 20009940
PDF is available here.
PDF is available here.
Abstract
We previously reported that the anti-transforming growth factor-beta1 (TGF-beta1) ribozymes directed by T7 and CMV promoters could reverse the character of activated hepatic stellate cells (HSCs) in vitro and improve fibrotic pathology in vivo. However, nonspecific elimination of the effects of TGF-...
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PMID: 19890714
PDF is available here.
PDF is available here.
Journal of Hepatology (52)3 2010
Abstract
The demonstration of advanced glycation end product-induced reactive oxygen species generation in hepatic stellate cells unveils a potential new route through which advanced glycation end products induce liver fibrosis in the metabolic syndrome.
Copyright (c) 2010 European Association for the Study...
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PMID: 20133001
PDF is available here.
PDF is available here.
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology (18)3 2010
Abstract
MTT assay indicated that HCPT significantly inhibited the proliferation of HSC-T6 and BRL-3A in a dose-dependent manner. 24 h after the treatment with different concentrations of HCPT (0.25, 0.5, 1 mg/L), the apoptosis rate (13.46%+/-2.42%, 26.25%+/-5.65%, 47.05%+/-8.76%, respectively) in HSC-T6 was...
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PMID: 20380797
PDF is available here.
PDF is available here.
Developmental Cell (18)2 2010
Abstract
Embryonic development of the liver has been studied intensely, yielding insights that impact diverse areas of developmental and cell biology. Understanding the fundamental mechanisms that control hepatogenesis has also laid the basis for the rational differentiation of stem cells int...
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PMID: 20159590
PDF is available here.
PDF is available here.
Abstract
Liver fibrosis is the common sequel of chronic liver diseases and is associated with high morbidity and mortality in affected patients. In recent years, the contribution of chemokines and their receptors to liver fibrosis has been delineated. Chemokines are a family of chemotactic and immunomodulato...
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PMID: 20072995
PDF is available here.
PDF is available here.
Cell Transplantation (19)6 2010
Abstract
Maintenance of freshly isolated porcine liver cells in vitro is limited for a short period of time. Therefore, establishment of easy handling cell lines is extremely important for in vitro study for liver cells and their possible utilization for cell differentiation and growth of stem cells. Porcine...
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PMID: 20955660
PDF is available here.
PDF is available here.
Abstract
We report in this study that treatment of quiescent HSCs with GW4064, a synthetic FXR agonist, significantly inhibited the HSC transdifferentiation, which was associated with an inhibition of the upregulation of ET-1 expression. These GW4064-treated cells also showed reduced contractile response to...
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PMID: 21085652
PDF is available here.
PDF is available here.
Molecular Cancer (9)1 2010
Abstract
We identified and validated HSC and PSC specific markers. Moreover, novel target genes of tumor- and inflammation associated stellate cells were discovered. Our data may be instrumental in developing new tailored organ- or disease-specific targeted therapies and stellate cell biomarkers....
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PMID: 20416094
PDF is available here.
PDF is available here.
Pancreatology (10)4 2010
Abstract
We report the isolation, characterization, and immortalization of stellate cell lines from rat and mouse origin.
These cell lines display morphological and molecular markers as well as non-tumorigenic characteristics similar to the frequently used hepatic counterparts. In addition, we have tested th...
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PMID: 20847583
PDF is available here.
PDF is available here.
BMC Gastroenterology (10)1 2010
Abstract
Species-specific differences exist with respect to the histopathological and molecular pathogenesis of chronic liver disease. CCl4-induced chronic liver injury in A/J mice has important differences compared to human cirrhosis leading to HCC....
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PMID: 20618941
PDF is available here.
PDF is available here.
Chinese Medical Journal (122)23 2009
Abstract
Abstract
This study was designed to investigate the effect of curcumin (diferuloylmethane) on the proliferation and apoptosis of hepatic stellate cells (HSC). The cell line HSC-T6 (1.25 x 10(5) cells/mL) was incubated with curcumin and HSC proliferation was detected by a methyl thiazolyl tetrazolium colorime...
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PMID: 19918672
PDF is available here.
PDF is available here.
Abstract
In the course of screening antifibrotic activity of natural products employing HSC-T6, a rat hepatic stellate cell line, as an in vitro assay system, the methanolic extract of aerial parts of Euscaphis japonica (Tunb.) Kantiz (Staphyleaceae) showed significant inhibitory activity on HSC proliferatio...
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PMID: 19807218
PDF is available here.
PDF is available here.
Abstract
Our data showed various gene expression profiles during activation of human HSC.
The up-regulated expression of FZD10 and CAMK2A suggests that the Wnt/Ca(2+) signaling pathway is active in hTERT HSCs and may participate in HSC activation and proliferation....
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PMID: 20037267
PDF is available here.
PDF is available here.
Abstract
The up-regulated expression of FZD10 and CAMK2A suggests that the Wnt/Ca(2+) signaling pathway is active in hTERT HSCs and may participate in HSC activation and proliferation....
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PMID: 20037267
PDF is available here.
PDF is available here.
Abstract
We aimed to construct a recombinant adeno-associated virus (AAV) carrying small interfering RNAs (siRNAs) of TIMP-1 and investigate the long-term effects of RNA interference upon the TIMP-1 gene in rat hepatic stellate cells (HSCs). Five siRNA oligomers targeting rat TIMP-1 were designed and transfe...
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PMID: 19787203
PDF is available here.
PDF is available here.
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology (17)11 2009
Abstract
Curcumine reduced the level and activity of MMP-2 expression in activated HSC in a dose-dependent manner. When treated with 25, 50 or 100 micromol/L curcumine, the expression of MMP-2 was reduced by 21.8%+/-5.1%, 65.5%+/-9.2% or 87.9%+/-11.5% (P < 0.05), and the activity of MMP-2 was also significan...
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PMID: 19958643
PDF is available here.
PDF is available here.