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Reed-Sternberg Cells (0):
Recent article
Reed-Sternberg Cells
Abstract
Classical Hodgkin lymphoma (cHL) is now recognized as a B-cell-derived lymphoma which is characterized by only about 1% malignant pathognomonic Hodgkin and Reed-Sternberg (HRS) cells and an abundant infiltrate of reactive bystander cells. HRS cells are unique with respect to their lo...
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PMID: 21375490
PDF is available here.
PDF is available here.
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Experimental oncology (32)4 2010
Abstract
The hallmark of Hodgkin's lymphoma (HL) are mononucleated Hodgkin's cells and multinucleated Reed-Sternberg (HRS) cells, which usually account for only about 1% of cells in the tumor tissue. The majority of HRS cells in classical HL are derived from germinal centre B cells that have...
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PMID: 21270747
PDF is available here.
PDF is available here.
Cancer Science (101)11 2010
Abstract
We identified an SP in the HL cell lines, KMH2 and L428. This SP almost entirely consists of distinct small mononuclear cells, whereas the non-SP is a mixture of relatively large cells with H or RS cell-like morphology. Culture of the small mononuclear cells in the SP from KMH2 generated a non-SP. S...
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PMID: 20735433
PDF is available here.
PDF is available here.
Abstract
Because of its rarity, pathologic and clinical features of Hodgkin lymphoma-like posttransplant lymphoproliferative disorder (HL-like PTLD) are not well understood, and it is unclear whether its biological behavior is more closely related to classical Hodgkin disease or to monomorphic B-cell PTLD. T...
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PMID: 19578050
PDF is available here.
PDF is available here.
Abstract
We assessed the standardized BIOMED-2 IGH and IGK PCR primers for the detection of clonality using 50 consecutively diagnosed formalin-fixed, paraffin-embedded (FFPE) classic HL specimens. Without microdissection, clonality was detected in 23 of 47 assessable cases. The IGK assay was significantly m...
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PMID: 20551274
PDF is available here.
PDF is available here.
Abstract
All analyzable HL expressed the HDAC isoforms 2 (n = 194) and 3 (n = 207) in over 50%, mostly 100%, of HRSC and almost all background lymphocytes. HDAC1 was expressed in 169 of 179 analyzable HL in a mean of 82% and in 172 out of 179 analyzable cases in a mean of 83% of infiltrating lymphocytes. HDA...
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PMID: 20415600
PDF is available here.
PDF is available here.
Abstract
Mediastinal diffuse large B-cell lymphoma (Med-DLBCL) is a subtype of DLBCL that has morphologic and clinical similarities and phenotypic overlaps with classical Hodgkin lymphoma (CHL) involving the mediastinum. CD23 is a marker that has been previously reported in Med-DLBCI and is p...
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PMID: 19223373
PDF is available here.
PDF is available here.
New England Journal of Medicine (362)10 2010
Abstract
An increased number of tumor-associated macrophages was strongly associated with shortened survival in patients with classic Hodgkin's lymphoma and provides a new biomarker for risk stratification.
2010 Massachusetts Medical Society...
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PMID: 20220182
PDF is available here.
PDF is available here.
Collegium Antropologicum (34)1 2010
Abstract
We present 65-year-old female with Hodgkin's variant of Richter's syndrome. On the basis of clinical simptoms, cytological, hystological and immunohistological finding in April 2008 CLL/SLL were diagnosed. The patient was treated with 8 courses of R-CHOP. After 10 months, FNA of the one of the enlar...
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PMID: 20437646
PDF is available here.
PDF is available here.
Cell Cycle (9)4 2010
Abstract
We recently identified a novel gene, KLHDC8B, which appears responsible for some familial cases of cHL. KLHDC8B encodes a midbody kelch protein expressed during cytokinesis. Deficiency of KLHDC8B leads to binucleated cells, implicating its involvement in Reed-Sternberg cell formation. Interestingly,...
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PMID: 20107318
PDF is available here.
PDF is available here.
Acta Cytologica (54)5 Suppl 2010
Abstract
Hodgkin's lymphoma (HL) is a malignant neoplasm of lymphoid tissues. Cervical lymphadenopathy is the most common head and neck presentation for HL. Although uncommon, extranodal HL observed at the time of diagnosis is well documented and is typically associated with generalized disease or local spre...
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PMID: 21053594
PDF is available here.
PDF is available here.
Abstract
Despite the fact that classical Hodgkin lymphoma (HL) has been described more than 170 years ago, only over the last 15 years significant advances regarding its molecular pathogenesis have been achieved. The lack of a specific lineage profile in combination with the low number of the malignant monon...
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PMID: 19760557
PDF is available here.
PDF is available here.
La Tunisie medicale (87)9 2009
Abstract
Abstract
Hodgkin disease was first described more than 175 years ago. Clinically and histomorphologically, the features of Hodgkin lymphoma are unusual for a lymphoma or for other malignancies. The incidence of Hodgkin lymphoma is estimated to be 7400 new cases per year in the United States, resulting in an...
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PMID: 19577168
PDF is available here.
PDF is available here.
Abstract
Bone marrow evaluation plays a critical role in staging and predicting prognosis in patients with Hodgkin lymphoma or non-Hodgkin lymphoma. Bone marrow can be the initial site of detection of lymphoma in patients with unexplained symptoms or cytopenias. A comprehensive evaluation of bone marrow incl...
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PMID: 19577173
PDF is available here.
PDF is available here.
Abstract
Hodgkin and Reed-Sternberg (HRS) cells in classical Hodgkin lymphoma (HL) and lymphocytic and histiocytic (L&H) cells in nodular lymphocyte-predominant HL (NLPHL) are derived from germinal-center B cells. HRS cells have, however, largely lost their B cell phenotype and aberrantly express markers and...
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PMID: 19400691
PDF is available here.
PDF is available here.
Abstract
Hodgkin lymphoma (HL) is derived from mature B cells and subdivided into classical HL and nodular lymphocyte predominant HL (NLPHL). HL is unique among human B cell lymphomas because of the rarity of the lymphoma cells, the Hodgkin and Reed-Sternberg (HRS) cells in classical HL and the lymphocyte-pr...
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PMID: 20008234
PDF is available here.
PDF is available here.
Prague medical report (110)1 2009
Abstract
Hodgkin's lymphoma is a lymphoproliferative disease, which differs in its morphology and therapeutic response from other lymphomas. Neoplastic cells represent only a minor cell population of the tumour, while the major part of the tumour is formed by inflammatory cells. It results from the productio...
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PMID: 19591376
PDF is available here.
PDF is available here.
Abstract
Hodgkin's lymphoma was first described in 1832. The aetiology of this lymphoma, however, remained enigmatic for a long time. Only within the past 10 years has the B-cell nature of the pathognomonic Hodgkin and Reed-Sternberg (HRS) cells been revealed, along with several recurrent gen...
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PMID: 19078975
PDF is available here.
PDF is available here.
Molecular and Cellular Biochemistry (321)1-2 2009
Abstract
We investigated whether nitric oxide synthases (NOS) are expressed by H-RS cells, studied their association with EBV status and the expression of apoptotic proteins, and investigated their relationship to the clinical outcome of 171 patients. NOS1 and NOS2 were expressed in a large number of cases,...
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PMID: 18830569
PDF is available here.
PDF is available here.
Abstract
We report a case of a 55-year-old woman with cervical and mediastinal lymphadenopathy, fever, weight loss, and night sweats. A cervical lymph node biopsy revealed a composite lymphoma with classic Hodgkin lymphoma and peripheral T-cell lymphoma components. The bone marrow was not involved. The patie...
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PMID: 19115485
PDF is available here.
PDF is available here.
Abstract
We describe such a lesion involving the adenoids in a HIV-seropositive adolescent who acquired immunity against EBV during childhood. On microscopic examination, the marginal zone of B follicles and the interfollicular area were enlarged due to the accumulation of small or intermediate-sized lymphoc...
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PMID: 18788890
PDF is available here.
PDF is available here.
Oncology Research (17)7 2009
Abstract
We investigated the relationship of FDG uptake and the expressions of glucose transporter type 1 (Glut-1), glucose transporter type 3 (Glut-3), and hexokinase II (HK-II) in R-S cells of HL. There were 25 tissue-proven HL patients from January 2003 to July 2007 in our hospital. Of the 25 HL patients,...
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PMID: 19408578
PDF is available here.
PDF is available here.
Leukemia & Lymphoma (49)11 2008
Abstract
Abstract
The positive rate of CD20 is relatively low in HRS cells of CHL. It is higher in the patients aged > or =45 years than in those aged <45 years. However, according to our results, the expression of CD20 is not an independent prognostic factor for FFS and OS of naive CHL patients....
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PMID: 19000453
PDF is available here.
PDF is available here.
Annals of Oncology (19)11 2008
Abstract
Our results indicate that nm23-H1 expression is a prognostic factor for CHL and that it is as important as serum nm23-H1, both of which are useful for planning the treatment strategy....
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PMID: 18647967
PDF is available here.
PDF is available here.
Abstract
Classical Hodgkin lymphoma is now recognised as a B-cell lymphoma. Improved therapy has increased cure rates dramatically; however, relapse and death still occurs in a minority of patients. Much has been learned about the biology of Hodgkin and Reed Sternberg cells and their interactions with the mi...
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PMID: 18798102
PDF is available here.
PDF is available here.
Journal of Pathology (216)1 2008
Abstract
We used a non-viral vector-based method to express LMP1 in primary human GC B cells. Gene expression profiling revealed that LMP1 induced in GC B cells transcriptional changes characteristic of Hodgkin's lymphoma cell lines. Strikingly, LMP1 down-regulated the expression of B-cell-specific genes inc...
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PMID: 18566961
PDF is available here.
PDF is available here.
Abstract
High MCM6 antigen expression was a striking feature of Hodgkin's and Reed-Sternberg cells (median: 85%, range: 35 - 99%) in comparison with lower Ki-67 expression (median: 63.5%, range: 1 - 98%, P<0.001). This indicates that MCM6 is already expressed in the early G1 phase, a cell cycle fraction that...
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PMID: 18759521
PDF is available here.
PDF is available here.
Abstract
We investigated the capacity of curcumin to inhibit NF-kappaB and STAT3 in H-RS cells, characterizing the functional consequences. Curcumin is incorporated into H-RS cells and acts inhibiting both NF-kappaB and STAT3 activation, leading to a decreased expression of proteins involved in cell prolifer...
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PMID: 18386790
PDF is available here.
PDF is available here.
Abstract
We found that EBV infection increased the expression of the chemokine CCL20 in both primary Hodgkin and Reed-Sternberg cells and Hodgkin and Reed-Sternberg cell-derived cell lines. Additionally, this up-regulation could be mediated by the EBV nuclear antigen 1 protein. The higher levels of CCL20 in...
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PMID: 18502823
PDF is available here.
PDF is available here.
Abstract
Our studies here demonstrate that PRDM1/blimp-1 is also a target for microRNA (miRNA)-mediated down-regulation by miR-9 and let-7a in Hodgkin/Reed-Sternberg (HRS) cells of Hodgkin lymphoma (HL). MiRNA expression profiling by direct miRNA cloning demonstrated that both of these miRNAs are among the m...
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PMID: 18583325
PDF is available here.
PDF is available here.
Abstract
We present a unique case of a 57-year-old woman with secondary intracranial lymphoma infiltrating the dura. Her past medical history included Hodgkin's lymphoma from which she was deemed to be in remission at the time of presentation. Following an acute onset of seizures, she underwent radiological...
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PMID: 18568736
PDF is available here.
PDF is available here.
Abstract
We report a unique case with concurrent SMZL and cHL. The patient was a 63-year-old man who presented with fatigue and anemia, showing a splenomegaly and retroperitoneal lymphadenopathy. A splenectomy revealed monotonous marginal zone lymphocytic infiltrates and numerous large Reed-Sternberg-like ce...
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PMID: 18486899
PDF is available here.
PDF is available here.
Clinical Cancer Research (14)11 2008
Abstract
These findings establish a functional AP1 signature that includes Gal1 expression in cHL and ALCL and suggests a common mechanism for tumor immunotolerance in these diseases. In addition, the combination of Gal1 and c-Jun serve as diagnostic biomarkers that delineate cHL and ALCL from other lymphoma...
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PMID: 18519761
PDF is available here.
PDF is available here.
Leukemia & Lymphoma (49)6 2008
Abstract
Abstract
The BIOMED-2 primers demonstrate IGH gene clonality in 24% to 40% of cHLs without microdissection. In a subset of the cHL, the IGH gene rearrangement analysis might be useful for diagnosis, but can lead to confusion between cHLs and non-Hodgkin lymphomas if used as a discriminative criterion....
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PMID: 18382369
PDF is available here.
PDF is available here.
Abstract
We studied the prognostic impact of the phosphorylation status of STAT5 in HL.By using immunohistochemical analysis, we found phosphorylated STAT5 (pSTAT5) in 35 (38%) of 93 lymph node biopsy specimens of patients with HL. The detection of pSTAT5 in Hodgkin and Reed-Sternberg (HRS) cells in classica...
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PMID: 18285272
PDF is available here.
PDF is available here.
Tissue Antigens (71)3 2008
Abstract
I generally induces natural killer (NK) cell activation. The paucity of NK cells in the reactive infiltrate of cHL and the systemic NK cell deficiency observed in cHL patients led us to investigate the expression of human leukocyte antigen (HLA)-G, which is known to inhibit NK-cell- and CTL-mediated...
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PMID: 18257895
PDF is available here.
PDF is available here.
Abstract
We demonstrated that the CCL5 receptor (CCR5) is constitutively expressed by Hodgkin Lymphoma (HL)-derived cell lines (i.e. L-428, KM-H2, L-1236 and L-540) as shown by immunohistochemistry, flow cytometry and western blotting and also detected by immunohistochemistry on primary H-RS cells from lymph...
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PMID: 17935139
PDF is available here.
PDF is available here.
Abstract
We analyzed the secretome of HRS cells. Proteins in cell culture supernatant of 4 HL cell lines were identified using 1DGE followed by in-gel trypsin digestion and LC-MS/MS. In total, 1290 proteins, including 368 secreted proteins, were identified. Functional grouping of secreted proteins revealed 3...
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PMID: 18070985
PDF is available here.
PDF is available here.
Leukemia Research (32)2 2008
Abstract
We investigated the effects of bortezomib, a proteasome inhibitor, in HRS cells with a combination of functional assays and gene expression profiling (GEP). Exposure of KMH2 and L428 cells to bortezomib resulted in inhibition of proliferation and induction of apoptosis. Gene expression analysis of K...
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PMID: 17659339
PDF is available here.
PDF is available here.
Leukemia & Lymphoma (49)2 2008
Abstract
Clinical Cancer Research (14)3 2008
Abstract
A lower level of cytotoxic cells correlated with an increase of antiapoptotic mechanisms in H/RS cells, whereas the global infiltrated immune population correlated with the growth fraction of the tumor. Our collective data suggest a causal relationship between infiltrated immune response and concurr...
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PMID: 18245527
PDF is available here.
PDF is available here.
Abstract
We report here two cases of age-related EBV-associated LPD and demonstrate the histological evolution. Pathologically, the initial lymph node biopsy specimens from both cases showed the classical Hodgkin lymphoma-like polymorphous subtype. Hodgkin (H) and Reed-Sternberg (RS) cells were CD3-, CD20+,...
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PMID: 18187262
PDF is available here.
PDF is available here.
Abstract
Our results suggest that, as in many solid tumors, angiogenesis and angiogenic factors may play an important role in childhood HL. Larger series of patients are needed to determine the prognostic value of angiogenesis in childhood HL....
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PMID: 18207652
PDF is available here.
PDF is available here.
Acta clinica Belgica (63)6 2008
Abstract
We report the case of a 78-year-old woman, presenting with enlarged axillary lymph nodes. Histological analysis of the lymph nodes demonstrated the co-existence of locally advanced breast carcinoma, scleronodular Hodgkin's disease and tuberculous lymphadenitis.The association of the 3 disorders in t...
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PMID: 19170355
PDF is available here.
PDF is available here.
Modern Rheumatology (18)2 2008
Abstract
We describe here a rare case of SS in which the patient developed a Hodgkin lymphoma. We also review the literature on this subject....
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PMID: 18311531
PDF is available here.
PDF is available here.
Molecular Cancer (7)1 2008
Abstract
Murine monoclonal antibodies (mabs) were raised against the B3 sub clone of HL-derived cell line KM-H2. Two of these mabs (clone R23.1 mab and clone R24.1 mab) are IgG1 class antibodies that recognize a 21 kDa protein present at the cell membrane and in the cytoplasm in HL-derived cell lines. Clone...
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PMID: 18218123
PDF is available here.
PDF is available here.
Abstract
We report that tumour cells from Hodgkin lymphoma, the so called Hodgkin and Reed-Sternberg cells, can express tryptase. Hodgkin lymphoma cell lines expressed mRNA for both alpha- and beta-tryptase and also produced the protein, although at much lower concentrations than mast cells. However, the fre...
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PMID: 18021188
PDF is available here.
PDF is available here.
Abstract
Although the morphology of the pathognomonic Reed-Sternberg cells of Hodgkin lymphoma (HL) was described over a century ago, it was not until recently that their origin from B lymphocytes was recognised. The demonstration that a proportion of cases of HL harbour the Epstein-Barr virus (EBV) and that...
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PMID: 18042690
PDF is available here.
PDF is available here.
The AIDS reader (17)12 2007
Abstract
Abstract
The microscopic pathology of Hodgkin lymphoma has been recognized for well over a century; however, only in the past 15 years has the enigmatic nature of this peculiar neoplasm been somewhat unraveled. This has been accomplished via a combination of the acquisition, via microdissection, of the proto...
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PMID: 18020910
PDF is available here.
PDF is available here.
Laboratory Investigation (87)11 2007
Abstract
Mass spectrometry-based proteomics in conjunction with liquid chromatography and bioinformatics analysis provides a highly sensitive and high-throughput approach for the identification of proteins. Hodgkin lymphoma is a form of malignant lymphoma characterized by the proliferation of Reed-Sternberg...
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PMID: 17876297
PDF is available here.
PDF is available here.
Journal of Pathology (213)3 2007
Abstract
We show that, in contrast to normal GC B cells that expressed low but detectable ATM protein, ATM protein was not detected in HRS cells of 17/18 cases of paediatric cHL, all but one with nodular sclerosis (NS) subtype. A comprehensive analysis of the ATM gene in microdissected HRS cells of nine repr...
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PMID: 17876757
PDF is available here.
PDF is available here.
Abstract
Our results showed that virtually all Hodgkin and Reed-Sternberg cells in classical Hodgkin lymphoma lacked LyGDI protein expression. On the other hand, almost all non-Hodgkin lymphomas, except for anaplastic large cell lymphomas, expressed LyGDI protein. Transfection of the classical Hodgkin cell l...
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PMID: 17897297
PDF is available here.
PDF is available here.
Abstract
Hodgkin's lymphoma is a highly enigmatic lymphoma disease that still covers most of its secrets up to now. Much effort has been made to successfully wrest at least some of the pathogenetic particularities. The current diagnostic criteria are well established allowing hemato-pathologists to make a cl...
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PMID: 17908619
PDF is available here.
PDF is available here.
Abstract
It has been shown that differentiated lymphoid cells can display a broad developmental potential and might even differentiate into other cell types. Recent data implicate such processes in the pathogenesis of classical Hodgkin's lymphoma (HL). In the malignant, B cell-derived Hodgkin's and Reed-Ster...
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PMID: 17908620
PDF is available here.
PDF is available here.
Abstract
We describe interactions between Hodgkin's and Reed-Sternberg cells and the cells of the innate immune system: eosinophils, mast cells, neutrophils, and macrophages. These cells clearly contribute to the pathogenesis of this disease and to the prognosis. Cytokines and chemokines released from the ac...
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PMID: 17908621
PDF is available here.
PDF is available here.
Leukemia & Lymphoma (48)10 2007
Abstract
We explored whether culturing in a three-dimensional (3D) matrix could improve the quality of the model. We used a novel designer peptide based self-organizing matrix. The gene expression profile of the 3D-cultured HL derived cell-line L1236 was compared with that of suspension-cultured (2D) L1236,...
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PMID: 17917972
PDF is available here.
PDF is available here.