Abstract
The objective of this article is to describe the formulation and evaluation of dermal semisolid drugs--carbopol hydrogels containing the solution of Bukofit, zinc chloride and the local anaesthetic lidocaine. The hydrogels were evaluated after 2, 7, 14 and 28 days after their preparation and stored a...
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PMID: 21650010
PDF is available here.
Abstract
We concluded that tramadol can be used as an alternative drug to lidocaine in local anesthesia and has the ability to decrease the demand for post operative analgesics....
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PMID: 21991727
PDF is available here.
Abstract
Failure to achieve profound anesthesia during dental treatment can be a significant problem for dental clinicians, especially for endodontic procedures on teeth in the mandibular arch with irreversible pulpitis. A number of supplemental local anesthesia techniques exist, the most eff...
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PMID: 21337861
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Abstract
This prospective, randomized, double blind study was designed to determine whether reduction in volume from 20 to 10 mL of ropivacaine 0.5% for ultrasound-guided interscalene block might decrease the incidence of diaphragmatic paresis and preserve pulmonary function....
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PMID: 21751435
PDF is available here.
Abstract
We tested Xybrex (Orthocon, Inc., Irvington, NY), a slow-release formulation of lidocaine that blocks rat sciatic nerve for 1-2 days, for its ability to suppress postincisional pain.
A plantar paw incision was made in rats, either along the midline (Brennan model) or at the lateral edge, 30 min afte...
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PMID: 21169797
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Abstract
We addressed whether performance on an implicit mental rotation task reflects these RA-induced changes in body schema brain representations. Studying these changes in healthy volunteers may shed light on normal function and the central mechanisms of pain.
Performance pattern was studied in upper lim...
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PMID: 21169795
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Abstract
A 5-year-old castrated male domestic shorthair cat was examined because of presumptive lidocaine intoxication. Thirty minutes earlier, the cat had received an SC injection of approximately 140 mg of lidocaine hydrochloride (20 mg/kg [9.1 mg/lb]) to facilitate closure of a wound on the left pelvic li...
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PMID: 21155686
PDF is available here.
Abstract
Fibromyalgia syndrome (FM) is a highly prevalent musculoskeletal disorder that is often accompanied by somatic hyperalgesia (enhanced pain from noxious stimuli). Neural mechanisms of somatic hyperalgesia have been analyzed via quantitative sensory testing of FM patients. Results of these studies sug...
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PMID: 20882373
PDF is available here.
Abstract
To compare the efficacy and side effects profile of topical 2% lidocaine gel with injectable 2% lidocaine solution as local anaesthetics for incision and curettage of chalazion.
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PMID: 21809603
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Abstract
The concentration-response and time-response relationships of lipid emulsions used to reverse bupivacaine-induced asystole are poorly defined.
Concentration response across a range of lipid concentrations (0-16%) to reverse bupivacaine-induced asystole were observed using isolated rat heart Langendo...
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PMID: 21068661
PDF is available here.
Abstract
Results from previous studies have shown favorable effects from the addition of buprenorphine to local anesthetics used for interscalene or axillary perivascular brachial plexus blocks. The main objective of the current study was to determine whether addition of buprenorphine could enhance bupivacai...
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PMID: 21042200
PDF is available here.
Abstract
Systemic toxicity, usually from overdose or intravascular dose, is feared because it mainly affects the heart and brain, and may be acutely life-threatening.
Pharmacological studies of local anesthetic toxicity have largely been reviewed primarily relating to the evaluation of ropivacaine and levobu...
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PMID: 20738226
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Abstract
We thus conclude that a constant i.v. infusion of procaine should no longer be recommended for pain relief in patients with acute pancreatitis anymore.
© Georg Thieme Verlag KG Stuttgart · New York....
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PMID: 21064010
PDF is available here.
Abstract
Autologous fat transplantation is a well-established technique in surgery. Moreover, the use of preadipocytes in soft-tissue engineering is currently being intensely investigated. Current efforts focus on identifying maneuvers that may minimize resorption and provide predictable late...
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PMID: 20639800
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Abstract
Reducing postoperative pain following abdominoplasty is essential for shortening the length of recovery time, reducing the use of narcotics, promoting quicker return to normal activities, and maximizing overall patient satisfaction. The extended use of narcotics and pain pumps is often unacceptable...
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PMID: 21042130
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Abstract
We recommend steroid injections in all degrees of TMJ osteoarthritis....
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PMID: 20659360
PDF is available here.
Abstract
We prospectively investigated the analgesic effect of ultrasound-guided continuous supraclavicular BPB with ropivacaine at different infusion rates.
Thirty-nine patients scheduled to undergo shoulder surgery were randomly assigned to four groups; receiving no continuous BPB (control group, n = 10),...
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PMID: 21077306
PDF is available here.
Abstract
We tested the hypothesis that patients who receive combined propofol/paravertebral anesthesia-analgesia (propofol/paravertebral) exhibited reduced levels of protumorigenic cytokines and matrix metalloproteinases (MMPs) and elevated levels of antitumorigenic cytokines compared with patients receiving...
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PMID: 20975461
PDF is available here.
Abstract
We present our experience with ultrasound-guided TAP perineural catheter insertion and subsequent management of ambulatory TAP local anesthetic infusions after inguinal hernia repair.
Three patients scheduled for unilateral open inguinal hernia repair underwent preoperative posterior TAP catheter pl...
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PMID: 20975474
PDF is available here.
Abstract
We tested the hypothesis that a circumferential spread of LA and/or intraneural injection could lead to rapid surgical block.
Patients (n = 100) scheduled for foot or ankle surgery underwent popliteal sciatic nerve block using nerve stimulation according to Borgeat's technique and injection of ropiv...
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PMID: 20975475
PDF is available here.
Abstract
This study was performed to determine the minimum effective volume of ropivacaine 0.75% required to produce effective shoulder analgesia for an ultrasound (US)-guided block at the C7 root level with assessment of pulmonary function.
Using the Dixon and Massey up-and-down method study design, 20 pati...
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PMID: 20975468
PDF is available here.
Abstract
The heated lidocaine/tetracaine patch (Synera; ZARS Pharma, Inc, Salt Lake City, UT) is among the local topical anesthetic formulations used to prevent procedural pain. This study was conducted to determine the depth and duration of anesthesia provided by the patch and to evaluate safety and tolerab...
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PMID: 20975464
PDF is available here.
Abstract
We measured mean arterial pressure, heart rate, and right and left brachial artery blood flow (BABF) before and after thoracic sympathetic block in 24 dogs. The experimental protocol was designed as follows: (1) left thoracic sympathetic block by 1.0 mL of 2% mepivacaine (n = 8), (2) left thoracic s...
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PMID: 20975467
PDF is available here.
Abstract
We compared the action of lidocaine, articaine, ropivacaine and mepivacaine in a dose 2.5 or 5mg/kg/ml/h infused from 10min before left anterior descending coronary artery occlusion until the end of the experiment. In the rat ischemia- and re-perfusion-induced arrhythmia models, the following parame...
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PMID: 20615402
PDF is available here.
Author(s) unavailable
Abstract
Caution must be used when applying anaesthetic ointments to large areas of skin prior to cosmetic procedures such as laser hair removal. Overdose can have arrhythmogenic and proconvulsant effects. The deaths of two young women have been reported.
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PMID: 21180381
PDF is available here.
Abstract
We report the feasibility of a new patient position and long-axis nerve scan with ultrasound (US) for controlling perineural catheter placement for continuous mid-femoral sciatic nerve block in a pediatric case. We think that long-axis view of the sciatic nerve with US during placement of perineural...
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PMID: 21153937
PDF is available here.
Abstract
We present herein a gravida with ankylosing spondylitis who had a cesarean delivery performed under spinal anesthesia....
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PMID: 21526675
PDF is available here.
Abstract
We reviewed the provocation lumbar diskogram (PLD) features and redo-fusion outcome in our patients evaluated for recurrent/persistent LBP after technically successful fusion. LD was performed in 27 patients with recurrent/persistent LBP after prior successful lumbar surgical fusion (31 fused levels...
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PMID: 20977869
PDF is available here.
Abstract
We use intra-articular injections delivered directly into the soft tissue of the knee. Our current intra-articular injection is 60 mL of 0.5% ropivacaine with 0.5 mg of epinephrine. In patients with a normal renal function, 30 mg of ketorolac is added. The injection is administered throughout all of...
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PMID: 20839683
PDF is available here.
Abstract
We compared the analgesic efficacy of dilute topical proparacaine with placebo in emergency department patients with acute corneal injuries.
We conducted a prospective randomized controlled trial of adults with corneal injuries presenting to one of 2 tertiary care emergency departments in London, On...
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PMID: 20880433
PDF is available here.
Abstract
We thereby believe that this is a reliable test with low morbidity and can predict the potential benefit of total hip arthroplasty in this diagnostically challenging group of patients.
Copyright 2010 Elsevier Inc. All rights reserved....
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PMID: 20570105
PDF is available here.
Abstract
DeltaPsim was depolarized and [pH]in was increased by lidocaine, mepivacaine, bupivacaine, and procaine in a dose-dependent manner. Significantly, a relationship between DeltaPsim and [pH]in was observed for lidocaine, mepivacaine, bupivacaine, procaine, and NH(4)Cl perfusion. In contrast, QX-314 di...
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PMID: 20686005
PDF is available here.
Abstract
Epinephrine seemed to be necessary for return of spontaneous circulation, but was subsequently associated with declining hemodynamic variables in this rabbit model of bupivacaine-induced cardiac arrest. Further study is required to define the role of epinephrine in lipid-based resuscitation from loc...
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PMID: 20547820
PDF is available here.
Abstract
These findings indicate that lidocaine can directly act on microglia. Lidocaine, by inhibiting the increase of intracellular calcium, also inhibited p38 MAPK activation and attenuated the production of proinflammatory cytokines (including TNF-alpha, IL-1beta, and IL-6), which were triggered by extra...
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PMID: 20686009
PDF is available here.
Abstract
Data from 65 patients were included in the study. The groups were comparable in terms of age, weight, surgical duration, and intraoperative morphine doses. There were no significant differences between the control and treatment groups in the proportion of patients with inadequate analgesia either at...
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PMID: 20547822
PDF is available here.
Abstract
We report onset and duration of ultrasound-guided axillary brachial plexus block using 1 mL of 2% lidocaine with 1:200,000 epinephrine per nerve (total local anesthetic volume 4 mL). Block performance time, block onset time, duration of surgery, and block duration were measured. Seventeen consecutiv...
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PMID: 20686008
PDF is available here.
Abstract
To determine the effects of infiltration of the incision site with bupivacaine hydrochloride as part of a multimodal analgesia protocol (incisional block) on postoperative analgesia and incisional healing.
Randomized controlled clinical trial.
92 shelter-owned female dogs undergoing routine ovariohy...
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PMID: 20707749
PDF is available here.
Abstract
For the superficial zone of surface-intact chondrocytes, bupivacaine with methylparaben caused a significantly higher percentage of chondrocyte death at 5 minutes (47.7%) than did bupivacaine (23.6%) or CCCM (25.4%). Bupivacaine (53.8%) and bupivacaine with methylparaben (62.5%) caused a significant...
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PMID: 20673085
PDF is available here.
Abstract
Ropivacaine induced tonic inhibition of peak Na(+) currents of both subtypes in a dose- and frequency-dependent manner. rNav1.5 appeared to be more sensitive to ropivacaine. In addition, for both Na(+) channel subtypes, the steady-state inactivation curves, but not the activation curves, were signif...
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PMID: 20651810
PDF is available here.
Abstract
To investigate the efficacy and safety of lidocaine nasal spray before nasogastric tube insertion in an emergency department.
Double-blind, randomised controlled study.
Emergency department of a major regional hospital in Hong Kong.
A total of 206 adult patients, for whom nasogastric tube insertion...
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PMID: 20683071
PDF is available here.
Abstract
A simple and rapid high-performance liquid chromatography method coupled with UV detector was developed and validated for the simultaneous determination of ropivacaine, bupivacaine and dexamethasone in biodegradable poly(lactic-co-glycolic acid) (PLGA) microspheres within 11 min. Chromatographic sep...
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PMID: 20686210
PDF is available here.
Abstract
These results suggest that use of preclinical training models in local anesthesia teaching may have beneficial effects....
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PMID: 20679457
PDF is available here.
Abstract
Multiple injections are required to anesthetize the maxilla for periodontal surgery that involves a quadrant or multiple teeth across the midline. The anterior middle superior alveolar (AMSA) field block was reported to effectively anesthetize the central incisors to the mesial aspect of the first m...
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PMID: 20450369
PDF is available here.
Abstract
I clinical trials are the next steps to ensuring the efficacy of the treatment.
(c) 2010 Wiley-Liss, Inc. and the American Pharmacists Association...
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PMID: 20213834
PDF is available here.
Abstract
The term "peripheral neuropathic pain syndromes" summarizes several chronic pain syndromes, which can occur focally or generalized in the peripheral nervous system in the course of an impairment of afferent neurons. Controlled clinical trials gave distinct indications for systemic treatments with an...
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PMID: 20628765
PDF is available here.
Abstract
We explored local GABA(B)R activation by integrating optical tools for monitoring receptor conformation and synaptic vesicle release at individual presynaptic boutons of hippocampal neurons. Utilizing fluorescence resonance energy transfer (FRET) spectroscopy, we detected a wide range of FRET values...
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PMID: 20670833
PDF is available here.
Abstract
Recent research has focused on the use of intravenous local anesthetics to improve bowel function after surgery or trauma, to protect the central nervous system, to find new clues about local anesthetic effects in chronic neuropathic pain, and to investigate the long-term effect of anesthesia/analge...
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PMID: 20610984
PDF is available here.