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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Biological Products (7):
Recent article
Biological Products
Abstract
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Abstract
Natural Product Reports (28)1 2011
Abstract
The main methods for the simplification of the NMR of complex mixtures by selective attenuation/suppression of the signals of certain components are presented. The application of relaxation, diffusion and PSR filters and other techniques to biological samples, pharmaceuticals, foods, living organism...
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PMID: 20936238
PDF is available here.
PDF is available here.
Natural Product Reports (28)1 2011
Abstract
Naturally-occurring nitro compounds display great structural diversity, and a wide range of biological activities. This review summarizes current information on the structures of naturally-occurring nitro compounds and on the biosynthesis of the nitro group.
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PMID: 21127810
PDF is available here.
PDF is available here.
Natural Product Reports (28)1 2011
Abstract
A review with 187 references, describing natural products that exhibit bioactive properties relevant to the treatment of protein aggregation-related neurodegenerative diseases (e.g., Huntington's, Parkinson's, and prion diseases) and comparing the chemical properties of these secondary metabolite le...
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PMID: 20927454
PDF is available here.
PDF is available here.
Natural Product Reports (28)1 2011
Abstract
This review will detail the motivations, experimental approaches, and growing list of successful cases associated with the heterologous production of complex natural products.
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PMID: 21060956
PDF is available here.
PDF is available here.
Natural Product Reports (28)1 2011
Abstract
This review focuses on recent developments in the use of natural products as therapeutics for Alzheimer's disease. The compounds span a diverse array of structural classes and are organized according to their mechanism of action, with the focus primarily on the major hypotheses. Overall, the review...
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PMID: 21072430
PDF is available here.
PDF is available here.
Journal of Internal Medicine (269)1 2011
Abstract
Journal of Internal Medicine (269)1 2011
Abstract
Seton Hall law review (41)2 2011
Abstract
Seton Hall law review (41)2 2011
Abstract
Seton Hall law review (41)2 2011
Abstract
This book of the Seton Hall Law Review presents the contributions to Follow-On Biologics: Implementation Challenges and Opportunities, a one-day roundtable event hosted by Seton Hall University School of Law in the fall of 2010. The roundtable fostered an international dialogue regarding the future o...
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PMID: 21739728
PDF is available here.
PDF is available here.
Abstract
Abstract
A wide range of 5-substituted thiazoles are easily accessible via cross coupling of thiazolyl triflates. These activated thiazoles can be obtained by Ugi reactions using thioacids (thio-Ugi-reaction) and subsequent cyclisation of the endo thiopeptides formed with triflic anhydride. In addition, cycl...
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PMID: 20927467
PDF is available here.
PDF is available here.
Abstract
Synthesis of cyclopenta[b]pyrane derivatives via Achmatowicz oxidative cyclization of furanols followed by intramolecular Knoevenagel condensation of the β-ketoester arm is examined. The extent of diastereoselectivity was dependent on the nature of the chiral atom within the tethering carbon of the...
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PMID: 20856942
PDF is available here.
PDF is available here.
Abstract
The synthesis of 3a-substituted hexahydropyrrolo[2,3-b]indole derivatives via nucleophilic substitution at the C3a position is reported. Nitrogen-, oxygen-, sulfur-, fluoro- and carbon-based nucleophiles have been employed, using both conventional organic solvents and ionic liquids. The C3a-substitu...
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PMID: 20856944
PDF is available here.
PDF is available here.
Abstract
Abstract
MMW Fortschritte der Medizin (152)44 2010
Abstract
Abstract
We review also the possibilities by loss of efficacy of an anti-TNF therapy, such as dose increase or re-induction therapy.
© Georg Thieme Verlag KG Stuttgart · New York....
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PMID: 21046532
PDF is available here.
PDF is available here.
Annals of Neurology (68)5 2010
Abstract
Market exclusivity given to biologics puts burdens on healthcare and new development.
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PMID: 21031566
PDF is available here.
PDF is available here.
Abstract
Synthetic studies directed toward the allenediyne antibiotic marasin are presented. Different approaches to the installation of the optically active chiral allenediyne motif were explored en route to the synthesis of the natural product. The stereoselectivity for the construction of the chiral allen...
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PMID: 20725668
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)42 2010
Abstract
Recenti progressi in medicina (101)10 2010
Abstract
Inflammatory Bowel Diseases (IBD) affect mainly younger people. Biologic therapies are safe and effective in inducing and maintain remission in that patients. We reviewed herein the current knowledge about the safety and the effectiveness of biologic therapies in managing pregnant IBD patients.
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PMID: 21137576
PDF is available here.
PDF is available here.
Nature Biotechnology (28)10 2010
Abstract
YAKUGAKU ZASSHI (130)10 2010
Abstract
We paid an attention to inhibitors against three enzymes, ubiquitin-activating enzyme (E1), ubiquitin-conjugating enzyme (E2), and ubiquitin-protein ligase (E3), which are required for polyubiquitination of proteins and prerequisite to proteasome-mediated protein degradation. We succeeded in isolati...
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PMID: 20930478
PDF is available here.
PDF is available here.
Rinsho Ketsueki (51)10 2010
Abstract
Natural Product Reports (27)9 2010
Abstract
Carbohydrate Research (345)13 2010
Abstract
A convenient semi-synthesis of (8R,8'R)-matairesinol 4,4'-di-O-beta-d-glucopyranoside (MDG), found in the stems of Trachelospermum asiaticum var. intermedium, is described starting from the readily available starting materials d-glucose and hydroxymatairesinol. By this approach the synthesis of MDG...
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PMID: 20655039
PDF is available here.
PDF is available here.
Pediatric Research (68)3 2010
Abstract
We conclude that improvements in lung mechanics, gas exchange, and changes in CBF are comparable for a porcine-derived and peptide-containing synthetic surfactant, despite instilled volumes differing by 2-fold. Intrapulmonary distribution of surfactant is more uniform after a larger volume is instil...
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PMID: 20531255
PDF is available here.
PDF is available here.
The Lancet (376)9740 2010
Abstract
Abstract
Natural products have been the source of many drugs used in modern therapeutics, and particularly in the case of anticancer drugs, more than 50 % originally came from natural products. Their importance as a source of leads for new drugs therefore cannot be underestimated. However, due to the painsta...
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PMID: 20486069
PDF is available here.
PDF is available here.
Abstract
We present a concept, which takes advantage of methods of molecular diagnostics to identify predictive markers at the DNA, mRNA, and protein levels. Markers with prognostic value concerning treatment response and patient survival can then be used as targets to develop optimized drugs. We focus on th...
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PMID: 20486071
PDF is available here.
PDF is available here.
Der Hautarzt (61)8 2010
Abstract
Recently, inhibitors of the epidermal growth factor receptor (EGFR), such as erlotinib, gefitinib, cetuximab or panitumumab, have been successfully established in the therapy of a variety of solid tumors. Cutaneous adverse effects are the most frequent side-effects of these so-called targeted cancer...
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PMID: 20628713
PDF is available here.
PDF is available here.
Bioresource Technology (101)15 2010
Abstract
Partially hydrolyzed extracts from blood meal, feather meal, and meat and bone meal, as well as a variety of common surplus agricultural proteins were tested for their ability to promote the flocculation of clay. Partial alkaline or enzymatic hydrolyses of blood meal, feather meal, and meat and bone...
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PMID: 20236820
PDF is available here.
PDF is available here.
Abstract
We demonstrated, using a murine colon cancer model, that yoghurt consumption inhibited tumour growth by decreasing the inflammatory response by increasing IL-10-secreting cells, cellular apoptosis and diminishing procarcinogenic enzymes. Milk fermented with Lactobacillus helveticus R389 delayed brea...
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PMID: 20550747
PDF is available here.
PDF is available here.
Abstract
Commensal bacteria are important in intestinal homeostasis and appear to play a role in early tolerance to foreign antigens. The requirement for homeostatic balance between tolerance and immunity poses a unique regulatory challenge to mucosal immune systems. Dysregulation of this balance can contrib...
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PMID: 20416121
PDF is available here.
PDF is available here.
Abstract
We prospectively assessed all data from RA patients who underwent in-patient treatment for septic complications in the 3-year period from 01.01.2006 to 31.12.2009. All disease- and infection-specific data were gathered and analysed.
Of the 36 cases in total, infection was localized in the rheumatoid...
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PMID: 20632179
PDF is available here.
PDF is available here.
Abstract
Abstract
We performed a Medline search for the period 2005 to March 2010, including the MeSH terms "SoJIA", "systemic juvenile idiopathic arthritis" and"biologicals", as well as an NIH study registry search. At Present there are scant and unconvincing data on the use of Etanercept or Adalimumab for the treat...
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PMID: 20668866
PDF is available here.
PDF is available here.
Abstract
In recent years, many peptide- and protein-based biotherapeutics have been approved for subcutaneous (SC) delivery. The mechanisms and factors affecting the uptake and distribution of such large molecules following SC administration are not well understood. This review outlines the factors influenci...
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PMID: 20677097
PDF is available here.
PDF is available here.
Rheumatology (49)8 2010
Abstract
We identified residents aged > or = 20 years who had received a diagnosis of RA at least twice during 2003-08. Valid point prevalence estimates by 31 December 2008 were obtained by linkage to the Swedish population register, and information on biological treatment was obtained from the South Swedish...
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PMID: 20444855
PDF is available here.
PDF is available here.
Abstract
Abstract
Abstract
We searched PubMed and identified 98 papers describing 116 studies (23 randomized) reporting on the effect of various systemic combination treatments. The most thoroughly investigated combination was retinoid and phototherapy. Further controlled research is needed to define the safest and most effec...
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PMID: 20574597
PDF is available here.
PDF is available here.
Abstract
Since the middle of 1990s, the development of combinatorial chemistry along with the high throughput screening have led to some lack of interest for natural products from the pharmaceutical industry. Moreover, purification and optimization of natural compounds are very often difficult and animal exp...
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PMID: 20637355
PDF is available here.
PDF is available here.
Phytotherapy Research (24)7 2010
Abstract
The transcription factor nuclear factor kappa B (NFkappaB) is found in nearly all animal cell types. It is involved in cellular responses to stimuli such as stress, cytokines, free radicals, ultraviolet irradiation, oxidized LDL and microbial antigens, and has been shown to regulate the expression o...
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PMID: 20577970
PDF is available here.
PDF is available here.
Abstract
The Developmental Therapeutics Program (DTP) of the U.S. National Cancer Institute (NCI), at its NCI-Frederick facility, has built perhaps the largest and most diverse natural products screening library in the world for drug discovery. Composed of plant, marine organism and microbial extracts, it cu...
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PMID: 20657375
PDF is available here.
PDF is available here.
Abstract
We investigated the use of an "explorative solid-phase extraction" (E-SPE) protocol using SAX, Oasis MAX, SCX, and LH-20 columns for targeted exploitation of chemical functionalities. E-SPE provides a minimum of fractions (15) for chemical and biological analyses and implicates development into a pr...
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PMID: 20509666
PDF is available here.
PDF is available here.
Abstract
I and II clinical trials. Our objective was to determine the effect of adding AE-941 to chemoradiotherapy on overall survival of patients with unresectable stage III non-small cell lung cancer (NSCLC). METHODS A randomized, double-blinded, placebo-controlled, phase III clinical trial was designed to...
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PMID: 20505152
PDF is available here.
PDF is available here.
Abstract
The rates of incident malignancy were 25.3 events/1,000 person-years in the anti-TNF cohort and 38.3/1,000 person-years in the DMARD cohort, generating an age- and sex-adjusted incidence rate ratio of 0.58 (95% confidence interval 0.23-1.43) for the anti-TNF-treated cohort compared with the DMARD co...
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PMID: 20535785
PDF is available here.
PDF is available here.
Deutsche Medizinische Wochenschrift (135)25-26 2010
Abstract
Medical Care (48)6 Suppl 2010
Abstract
The PS-based pooling method offered strong protection of patient privacy and a reasonable balance between analytic integrity and flexibility of study execution. We would recommend its use in other studies that require pooling of databases, multivariate adjustment, and privacy protection....
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PMID: 20473213
PDF is available here.
PDF is available here.
Abstract
The lipoteichoic acid (LTA) of the Streptococcus species DSM 8747 consists of a beta-d-galactofuranosyl diacylglycerol moiety (with different acyl groups) that is linked via 6-O to a poly(glycerophosphate) backbone; about 30% of the glycerophosphate moieties carry at 2-O hydrolytically labile d-alan...
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PMID: 20510791
PDF is available here.
PDF is available here.
Antiviral Research (86)3 2010
Abstract
Available treatments for many infectious diseases are limited. In particular, diseases caused by viral pathogens have demonstrated the need for new medicines, due to the increasing appearance of resistance to these available treatments. Thousands of novel compounds have been isolated from various ma...
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PMID: 20338196
PDF is available here.
PDF is available here.
Journal of Virological Methods (166)1-2 2010
Abstract
RNA silencing has been adopted to develop virus-resistant plants through expression of virus-derived hairpin RNAs. Due to the high sequence specificity of RNA silencing, this technology has been limited to the targeting of single viruses. Simultaneous targeting of multiple viruses or plant genes can...
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PMID: 20307576
PDF is available here.
PDF is available here.
Abstract
We have determined the experimental logP values of a set of 25 lamellarins, given it is the single most important parameter in determining multiple ADMET parameters. We also discuss the relationship between this natural product class, natural product derivatives in development and on the market, ora...
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PMID: 20167395
PDF is available here.
PDF is available here.
American Journal of Infection Control (38)5 Suppl 1 2010
Abstract
We conclude that although UVGI is microbiocidal, it is not "ready for prime time" as a primary intervention to kill or inactivate infectious microorganisms; rather, it should be considered an adjunct. Other factors, such as careful design of the built environment, installation and effective operatio...
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PMID: 20569852
PDF is available here.
PDF is available here.
Natural Product Reports (27)5 2010
Abstract
The actinobacteria of the genus Streptomyces are of immense importance to both ecological and human welfare. They produce a large number of enzymes and compounds such as antibiotics that have attracted the interest of industry over recent decades, resulting in their commercial manufacture and applic...
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PMID: 20372697
PDF is available here.
PDF is available here.
Abstract
These results demonstrate that extraction of DNA from processed animal protein is different for pure ingredients and fortified animal feeds. These results indicate that a method specifically developed using just animal-derived meat and bone meal may not yield a functional assay when used to detect a...
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PMID: 20537265
PDF is available here.
PDF is available here.